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7ZIU
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BU of 7ziu by Molmil
Crystal structure of Ntaya virus NS5 polymerase domain
Descriptor: Genome polyprotein, ZINC ION
Authors:Krejcova, K, Klima, M, Boura, E.
Deposit date:2022-04-08
Release date:2023-04-19
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Crystal structure of Ntaya virus NS5 polymerase domain
To Be Published
7D6N
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BU of 7d6n by Molmil
Crystal structure of tick-borne encephalitis virus RNA-dependent RNA polymerase
Descriptor: MAGNESIUM ION, Tick-borne encephalitis virus RNA-dependent RNA polymerase, ZINC ION
Authors:Yang, J, Jing, X, Gong, P.
Deposit date:2020-10-01
Release date:2020-12-23
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (3.168 Å)
Cite:Crystal structure of tick-borne encephalitis virus
Nucleic Acids Res., 2020
6QSN
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BU of 6qsn by Molmil
Crystal structure of Yellow fever virus polymerase NS5A
Descriptor: Genome polyprotein, S-ADENOSYL-L-HOMOCYSTEINE, SULFATE ION, ...
Authors:Boura, E, Dubankova, A.
Deposit date:2019-02-21
Release date:2019-10-16
Method:X-RAY DIFFRACTION (3.004 Å)
Cite:Structure of the yellow fever NS5 protein reveals conserved drug targets shared among flaviviruses.
Antiviral Res., 169, 2019
4C11
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BU of 4c11 by Molmil
Dengue virus RNA dependent RNA polymerase with residues from the NS5 linker region
Descriptor: DENGUE VIRUS TYPE 3 RNA DEPENDENT RNA POLYMERASE, ZINC ION
Authors:Lim, S.P, Lescar, J.
Deposit date:2013-08-09
Release date:2013-08-21
Last modified:2018-04-04
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:A Crystal Structure of the Dengue Virus Ns5 Polymerase Delineates Inter-Domain Amino Acids Residues that Enhance its Thermostability and De Novo Initiation Activities.
J.Biol.Chem., 288, 2013
4MTP
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BU of 4mtp by Molmil
RdRp from Japanesese Encephalitis Virus
Descriptor: RNA dependent RNA polymerase, ZINC ION
Authors:Surana, P, Nair, D.T.
Deposit date:2013-09-20
Release date:2013-12-25
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (3.65 Å)
Cite:RNA-dependent RNA polymerase of Japanese encephalitis virus binds the initiator nucleotide GTP to form a mechanistically important pre-initiation state.
Nucleic Acids Res., 42, 2014
3VWS
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BU of 3vws by Molmil
Dengue serotype 3 RNA-dependent RNA polymerase bound to NITD-107
Descriptor: 5-{[(4-chlorophenyl)sulfonyl]amino}-2-methyl-1-benzofuran-3-carboxylic acid, DI(HYDROXYETHYL)ETHER, Non-structural protein 5, ...
Authors:Noble, C.G, Lescar, J.
Deposit date:2012-08-31
Release date:2013-02-27
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Conformational flexibility of the Dengue virus RNA-dependent RNA polymerase revealed by a complex with an inhibitor
J.Virol., 87, 2013
5WZ3
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BU of 5wz3 by Molmil
Crystal structure of Zika virus NS5 RNA-dependent RNA polymerase(RdRP)
Descriptor: NS5 RdRp, ZINC ION
Authors:Duan, W, Song, H, Qi, J, Shi, Y, Gao, G.F.
Deposit date:2017-01-16
Release date:2017-03-08
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (1.804 Å)
Cite:The crystal structure of Zika virus NS5 reveals conserved drug targets.
EMBO J., 36, 2017
4V0Q
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BU of 4v0q by Molmil
Dengue Virus Full Length NS5 Complexed with SAH
Descriptor: ACETATE ION, GLYCEROL, NS5 POLYMERASE, ...
Authors:Zhao, Y, Soh, S, Zheng, J, Phoo, W.W, Swaminathan, K, Cornvik, T.C, Lim, S.P, Shi, P.-Y, Lescar, J, Vasudevan, S.G, Luo, D.
Deposit date:2014-09-18
Release date:2015-01-28
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:A Crystal Structure of the Dengue Virus Ns5 Protein Reveals a Novel Inter-Domain Interface Essential for Protein Flexibility and Virus Replication.
Plos Pathog., 11, 2015
4V0R
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BU of 4v0r by Molmil
DENGUE VIRUS FULL LENGTH NS5 COMPLEXED WITH GTP AND SAH
Descriptor: FORMIC ACID, GLYCEROL, GUANOSINE-5'-TRIPHOSPHATE, ...
Authors:Zhao, Y, Soh, S, Zheng, J, Phoo, W.W, Swaminathan, K, Cornvik, T.C, Lim, S.P, Shi, P.-Y, Lescar, J, Vasudevan, S.G, Luo, D.
Deposit date:2014-09-18
Release date:2015-01-28
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:A Crystal Structure of the Dengue Virus Ns5 Protein Reveals a Novel Inter-Domain Interface Essential for Protein Flexibility and Virus Replication.
Plos Pathog., 11, 2015
5ZQK
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BU of 5zqk by Molmil
Dengue Virus Non Structural Protein 5
Descriptor: 1,2-ETHANEDIOL, GLYCEROL, MAGNESIUM ION, ...
Authors:El Sahili, A, Soh, T.S, Schiltz, J, Gharbi-Ayachi, A, Goh, B.C, Seh, C.C, Dedon, P.C, Shi, P.Y, Lim, S.P, Lescar, J.
Deposit date:2018-04-19
Release date:2019-06-12
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:NS5 from Dengue Virus Serotype 2 Can Adopt a Conformation Analogous to That of Its Zika Virus and Japanese Encephalitis Virus Homologues.
J.Virol., 94, 2019
7XD8
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BU of 7xd8 by Molmil
Crystal Structure of Dengue Virus Serotype 2 (DENV2) Polymerase Elongation Complex (Native Form)
Descriptor: GLYCEROL, NS5, RNA (30-mer), ...
Authors:Wu, J, Wang, X, Gong, P.
Deposit date:2022-03-26
Release date:2022-12-21
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (2.85 Å)
Cite:Structural basis of transition from initiation to elongation in de novo viral RNA-dependent RNA polymerases.
Proc.Natl.Acad.Sci.USA, 120, 2023
7XD9
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BU of 7xd9 by Molmil
Crystal Structure of Dengue Virus serotype 2 (DENV2) Polymerase Elongation Complex (CTP Form)
Descriptor: CYTIDINE-5'-TRIPHOSPHATE, GLYCEROL, MAGNESIUM ION, ...
Authors:Wu, J, Wang, X, Gong, P.
Deposit date:2022-03-26
Release date:2022-12-21
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (2.58 Å)
Cite:Structural basis of transition from initiation to elongation in de novo viral RNA-dependent RNA polymerases.
Proc.Natl.Acad.Sci.USA, 120, 2023
8GZP
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BU of 8gzp by Molmil
Cryo-EM structure of the NS5-SLA complex
Descriptor: GUANOSINE-5'-DIPHOSPHATE, Genome polyprotein, MAGNESIUM ION, ...
Authors:Osawa, T, Ehara, H, Sekine, S.
Deposit date:2022-09-27
Release date:2023-08-02
Last modified:2023-08-23
Method:ELECTRON MICROSCOPY (3.6 Å)
Cite:Structures of dengue virus RNA replicase complexes.
Mol.Cell, 83, 2023
5K5M
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BU of 5k5m by Molmil
Co-Crystal Structure of Dengue Virus Serotype 2 RNA Dependent RNA Polymerase with Compound 27
Descriptor: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 5-[5-(3-hydroxyprop-1-yn-1-yl)thiophen-2-yl]-2,4-dimethoxy-N-[(3-methoxyphenyl)sulfonyl]benzamide, RNA Dependent RNA Polymerase, ...
Authors:Arora, R, Benson, T.E.
Deposit date:2016-05-23
Release date:2016-08-24
Last modified:2024-03-06
Method:X-RAY DIFFRACTION (2.01 Å)
Cite:Potent Allosteric Dengue Virus NS5 Polymerase Inhibitors: Mechanism of Action and Resistance Profiling.
Plos Pathog., 12, 2016
5M2X
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BU of 5m2x by Molmil
Crystal structure of the full-length Zika virus NS5 protein (Human isolate Z1106033)
Descriptor: NS5, PHOSPHATE ION, S-ADENOSYL-L-HOMOCYSTEINE, ...
Authors:Ferrero, D.S, Ruiz-Arroyo, V.M, Soler, N, Uson, I, Verdaguer, N.
Deposit date:2016-10-13
Release date:2018-06-06
Last modified:2019-04-24
Method:X-RAY DIFFRACTION (4.991 Å)
Cite:Supramolecular arrangement of the full-length Zika virus NS5.
Plos Pathog., 15, 2019
6XD1
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BU of 6xd1 by Molmil
Dengue serotype 3 RNA-dependent RNA polymerase bound to NITD-640
Descriptor: (2R)-4-(butyl{[2'-(1H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl}carbamoyl)-1-(2,2-diphenylpropanoyl)piperazine-2-carboxylic acid, RNA-dependent RNA polymerase, ZINC ION
Authors:Arora, R, Benson, T.E, Liew, C.W, Lescar, J.
Deposit date:2020-06-09
Release date:2020-09-23
Last modified:2021-10-06
Method:X-RAY DIFFRACTION (1.954 Å)
Cite:Two RNA Tunnel Inhibitors Bind in Highly Conserved Sites in Dengue Virus NS5 Polymerase: Structural and Functional Studies.
J.Virol., 94, 2020
6XD0
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BU of 6xd0 by Molmil
Dengue serotype 3 RNA-dependent RNA polymerase bound to NITD-434
Descriptor: 2-[({2-[(2,6-dichlorophenyl)amino]phenyl}acetyl)amino]-2,3-dihydro-1H-indene-2-carboxylic acid, DI(HYDROXYETHYL)ETHER, GLYCEROL, ...
Authors:Arora, R, Benson, T.E, Liew, C.W, Lescar, J.
Deposit date:2020-06-09
Release date:2020-09-23
Last modified:2021-10-06
Method:X-RAY DIFFRACTION (2.012 Å)
Cite:Two RNA Tunnel Inhibitors Bind in Highly Conserved Sites in Dengue Virus NS5 Polymerase: Structural and Functional Studies.
J.Virol., 94, 2020
5M2Z
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BU of 5m2z by Molmil
Crystal structure of the full-length Zika virus NS5 protein (Human isolate Z1106033)
Descriptor: NS5, PHOSPHATE ION, S-ADENOSYL-L-HOMOCYSTEINE, ...
Authors:Ferrero, D.S, Ruiz-Arroyo, V.M, Soler, N, Uson, I, Verdaguer, N.
Deposit date:2016-10-13
Release date:2018-06-06
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (4.8 Å)
Cite:Supramolecular arrangement of the full-length Zika virus NS5.
Plos Pathog., 15, 2019
4HDH
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BU of 4hdh by Molmil
Crystal Structure of viral RdRp in complex with ATP
Descriptor: ADENOSINE-5'-TRIPHOSPHATE, Polyprotein, ZINC ION
Authors:Surana, P, Nair, D.T.
Deposit date:2012-10-02
Release date:2013-12-25
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2.28 Å)
Cite:RNA-dependent RNA polymerase of Japanese encephalitis virus binds the initiator nucleotide GTP to form a mechanistically important pre-initiation state.
Nucleic Acids Res., 42, 2014
4HHJ
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BU of 4hhj by Molmil
Dengue serotype 3 RNA-dependent RNA polymerase
Descriptor: DI(HYDROXYETHYL)ETHER, HEXAETHYLENE GLYCOL, Non-structural protein 5, ...
Authors:Noble, C.G, Lescar, J.
Deposit date:2012-10-10
Release date:2013-02-27
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (1.79 Å)
Cite:Conformational flexibility of the Dengue virus RNA-dependent RNA polymerase revealed by a complex with an inhibitor
J.Virol., 87, 2013
4HDG
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BU of 4hdg by Molmil
Crystal Structure of viral RdRp in complex with GTP
Descriptor: GUANOSINE-5'-TRIPHOSPHATE, Polyprotein, ZINC ION
Authors:Surana, P, Nair, D.T.
Deposit date:2012-10-02
Release date:2013-12-25
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2.38 Å)
Cite:RNA-dependent RNA polymerase of Japanese encephalitis virus binds the initiator nucleotide GTP to form a mechanistically important pre-initiation state.
Nucleic Acids Res., 42, 2014
4K6M
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BU of 4k6m by Molmil
Crystal Structure of the full-length Japanese encephalitis virus NS5
Descriptor: Polyprotein, S-ADENOSYL-L-HOMOCYSTEINE, SULFATE ION, ...
Authors:Lu, G, Gong, P.
Deposit date:2013-04-16
Release date:2013-08-28
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Crystal Structure of the full-length Japanese encephalitis virus NS5 reveals a conserved methyltransferase-polymerase interface
Plos Pathog., 9, 2013
5TFR
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BU of 5tfr by Molmil
Crystal structure of Zika Virus NS5 protein
Descriptor: Genome polyprotein, S-ADENOSYL-L-HOMOCYSTEINE, ZINC ION
Authors:Longenecker, K.L, Upadhyay, A.K.
Deposit date:2016-09-26
Release date:2016-10-12
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (3.05 Å)
Cite:Crystal structure of full-length Zika virus NS5 protein reveals a conformation similar to Japanese encephalitis virus NS5.
Acta Crystallogr F Struct Biol Commun, 73, 2017
5TMH
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BU of 5tmh by Molmil
Structure of Zika virus NS5
Descriptor: GLYCEROL, Polyprotein, S-ADENOSYL-L-HOMOCYSTEINE, ...
Authors:Wang, B, Tan, X, Song, J.
Deposit date:2016-10-12
Release date:2017-02-08
Last modified:2024-03-06
Method:X-RAY DIFFRACTION (3.278 Å)
Cite:The structure of Zika virus NS5 reveals a conserved domain conformation.
Nat Commun, 8, 2017
5U04
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BU of 5u04 by Molmil
Crystal structure of Zika virus NS5 RNA-dependent RNA polymerase
Descriptor: PHOSPHATE ION, ZINC ION, Zika Virus NS5 RdRp
Authors:Godoy, A.S, Lima, G.M.A, Oliveira, K.I.Z, Torres, N.U, Maluf, F.V, Guido, R.V.C, Oliva, G.
Deposit date:2016-11-22
Release date:2017-02-22
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Crystal structure of Zika virus NS5 RNA-dependent RNA polymerase.
Nat Commun, 8, 2017

 

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数据于2024-03-27公开中

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