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4WA8
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Methanopyrus Kandleri FEN-1 nuclease
Descriptor: CHLORIDE ION, Flap endonuclease 1
Authors:Shah, S, Dunten, P, Horton, N.C.
Deposit date:2014-08-28
Release date:2014-11-12
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structure and specificity of FEN-1 from Methanopyrus kandleri.
Proteins, 83, 2015
4Q0W
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he catalytic core of Rad2 in complex with DNA substrate (complex II)
Descriptor: CALCIUM ION, DNA (5'-D(*TP*TP*AP*GP*GP*TP*GP*GP*AP*CP*GP*GP*AP*TP*CP*AP*TP*T)-3'), DNA (5'-D(*TP*TP*TP*GP*AP*TP*CP*CP*GP*TP*CP*CP*AP*CP*CP*TP*TP*T)-3'), ...
Authors:Mietus, M, Nowak, E, Jaciuk, M, Kustosz, P, Nowotny, M.
Deposit date:2014-04-02
Release date:2014-08-27
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Crystal structure of the catalytic core of Rad2: insights into the mechanism of substrate binding.
Nucleic Acids Res., 42, 2014
7QO1
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BU of 7qo1 by Molmil
complex of DNA ligase I and FEN1 on PCNA and DNA
Descriptor: ADENOSINE MONOPHOSPHATE, DNA ligase 1, Flap endonuclease 1, ...
Authors:Blair, K, Tehseen, M, Raducanu, V.S, Shahid, T, Lancey, C, Cruehet, R, Hamdan, S, De Biasio, A.
Deposit date:2021-12-23
Release date:2023-01-11
Method:ELECTRON MICROSCOPY (4.4 Å)
Cite:Mechanism of human Lig1 regulation by PCNA in Okazaki fragment sealing.
Nat Commun, 13, 2022
5KSE
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BU of 5kse by Molmil
Flap endonuclease 1 (FEN1) R100A with 5'-flap substrate DNA and Sm3+
Descriptor: DNA (5'-D(*AP*CP*CP*GP*TP*CP*C)-3'), DNA (5'-D(*AP*CP*TP*CP*TP*GP*CP*CP*TP*CP*AP*AP*GP*AP*CP*GP*GP*T)-3'), DNA (5'-D(P*TP*AP*AP*TP*TP*GP*AP*GP*GP*CP*AP*GP*AP*GP*T)-3'), ...
Authors:Tsutakawa, S.E, Arvai, A.S, Tainer, J.A.
Deposit date:2016-07-08
Release date:2017-06-28
Last modified:2024-03-06
Method:X-RAY DIFFRACTION (2.105 Å)
Cite:Phosphate steering by Flap Endonuclease 1 promotes 5'-flap specificity and incision to prevent genome instability.
Nat Commun, 8, 2017
1UL1
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BU of 1ul1 by Molmil
Crystal structure of the human FEN1-PCNA complex
Descriptor: Flap endonuclease-1, MAGNESIUM ION, Proliferating cell nuclear antigen
Authors:Sakurai, S, Kitano, K, Yamaguchi, H, Hamada, K, Okada, K, Fukuda, K, Uchida, M, Ohtsuka, E, Morioka, H, Hakoshima, T.
Deposit date:2003-09-05
Release date:2005-03-01
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Structural basis for recruitment of human flap endonuclease 1 to PCNA
EMBO J., 24, 2005
5K97
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Flap endonuclease 1 (FEN1) D233N with cleaved product fragment and Sm3+
Descriptor: 1,2-ETHANEDIOL, DNA (5'-D(*AP*CP*CP*GP*TP*CP*C)-3'), DNA (5'-D(*AP*CP*TP*CP*TP*GP*CP*CP*TP*CP*AP*AP*GP*AP*CP*GP*GP*T)-3'), ...
Authors:Tsutakawa, S.E, Arvai, A.S, Tainer, J.A.
Deposit date:2016-05-31
Release date:2017-06-28
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2.102 Å)
Cite:Phosphate steering by Flap Endonuclease 1 promotes 5'-flap specificity and incision to prevent genome instability.
Nat Commun, 8, 2017
2IZO
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BU of 2izo by Molmil
Structure of an Archaeal PCNA1-PCNA2-FEN1 Complex
Descriptor: DNA POLYMERASE SLIDING CLAMP B, DNA POLYMERASE SLIDING CLAMP C, FLAP STRUCTURE-SPECIFIC ENDONUCLEASE, ...
Authors:Dore, A.S, Kilkenny, M.L, Roe, S.M, Pearl, L.H.
Deposit date:2006-07-25
Release date:2006-09-06
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Structure of an Archaeal PCNA1-PCNA2-Fen1 Complex: Elucidating PCNA Subunit and Client Enzyme Specificity.
Nucleic Acids Res., 34, 2006
1MC8
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BU of 1mc8 by Molmil
Crystal Structure of Flap Endonuclease-1 R42E mutant from Pyrococcus horikoshii
Descriptor: Flap Endonuclease-1
Authors:Matsui, E, Musti, K.V, Abe, J, Yamazaki, K, Matsui, I, Harata, K.
Deposit date:2002-08-06
Release date:2002-10-16
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Molecular Structure and Novel DNA Binding Sites Located in Loops of Flap Endonuclease-1 from Pyrococcus horikoshii
J.BIOL.CHEM., 277, 2002
1RXV
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BU of 1rxv by Molmil
Crystal Structure of A. Fulgidus FEN-1 bound to DNA
Descriptor: 5'-d(*T*pA*pG*pC*pA*pT*pC*pG*pG), Flap structure-specific endonuclease
Authors:Chapados, B.R, Hosfield, D.J, Han, S, Qiu, J, Yelent, B, Shen, B, Tainer, J.A.
Deposit date:2003-12-18
Release date:2004-01-27
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structural Basis for FEN-1 Substrate Specificity and PCNA-Mediated Activation in DNA Replication and Repair
Cell(Cambridge,Mass.), 116, 2004
1RXW
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Crystal structure of A. fulgidus FEN-1 bound to DNA
Descriptor: 5'-d(*C*pG*pA*pT*pG*pC*pT*pA)-3', 5'-d(*T*pA*pG*pC*pA*pT*pC*pG*pG)-3', Flap structure-specific endonuclease
Authors:Chapados, B.R, Hosfield, D.J, Han, S, Qiu, J, Yelent, B, Shen, B, Tainer, J.A.
Deposit date:2003-12-18
Release date:2004-01-27
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural Basis for FEN-1 Substrate Specificity and PCNA-Mediated Activation in DNA Replication and Repair
Cell(Cambridge,Mass.), 116, 2004
6GRC
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BU of 6grc by Molmil
eukaryotic junction-resolving enzyme GEN-1 binding with Sodium
Descriptor: DNA (5'-D(*TP*AP*CP*CP*CP*AP*CP*CP*AP*CP*CP*GP*CP*TP*CP*A)-3'), DNA (5'-D(*TP*GP*AP*GP*CP*GP*GP*TP*GP*GP*TP*TP*GP*GP*T)-3'), MAGNESIUM ION, ...
Authors:Lilley, D.M.J, Liu, Y, Freeman, D.J.
Deposit date:2018-06-11
Release date:2018-09-26
Last modified:2019-02-13
Method:X-RAY DIFFRACTION (2.452 Å)
Cite:A monovalent ion in the DNA binding interface of the eukaryotic junction-resolving enzyme GEN1.
Nucleic Acids Res., 46, 2018
6GRD
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BU of 6grd by Molmil
eukaryotic junction-resolving enzyme GEN-1 binding with Cesium
Descriptor: CESIUM ION, DNA (5'-D(*TP*AP*CP*CP*CP*AP*CP*CP*AP*CP*CP*GP*CP*TP*CP*A)-3'), DNA (5'-D(*TP*GP*AP*GP*CP*GP*GP*TP*GP*GP*TP*TP*GP*GP*T)-3'), ...
Authors:Lilley, D.M.J, Liu, Y, Freeman, D.J.
Deposit date:2018-06-11
Release date:2018-09-26
Last modified:2018-11-28
Method:X-RAY DIFFRACTION (2.66 Å)
Cite:A monovalent ion in the DNA binding interface of the eukaryotic junction-resolving enzyme GEN1.
Nucleic Acids Res., 46, 2018
1A77
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BU of 1a77 by Molmil
FLAP ENDONUCLEASE-1 FROM METHANOCOCCUS JANNASCHII
Descriptor: FLAP ENDONUCLEASE-1 PROTEIN, MAGNESIUM ION
Authors:Hwang, K.Y, Baek, K, Kim, H, Cho, Y.
Deposit date:1998-03-20
Release date:1999-08-03
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2 Å)
Cite:The crystal structure of flap endonuclease-1 from Methanococcus jannaschii.
Nat.Struct.Biol., 5, 1998
1A76
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BU of 1a76 by Molmil
FLAP ENDONUCLEASE-1 FROM METHANOCOCCUS JANNASCHII
Descriptor: FLAP ENDONUCLEASE-1 PROTEIN, MANGANESE (II) ION
Authors:Hwang, K.Y, Baek, K, Kim, H, Cho, Y.
Deposit date:1998-03-20
Release date:1999-08-03
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2 Å)
Cite:The crystal structure of flap endonuclease-1 from Methanococcus jannaschii.
Nat.Struct.Biol., 5, 1998
6GRB
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BU of 6grb by Molmil
eukaryotic junction-resolving enzyme GEN-1 binding with Potassium
Descriptor: DNA (5'-D(*TP*AP*CP*CP*CP*AP*CP*CP*AP*CP*CP*GP*CP*TP*CP*A)-3'), DNA (5'-D(*TP*GP*AP*GP*CP*GP*GP*TP*GP*GP*TP*TP*GP*GP*T)-3'), MAGNESIUM ION, ...
Authors:Lilley, D.M.J, Liu, Y, Freeman, D.J.
Deposit date:2018-06-11
Release date:2018-09-26
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:A monovalent ion in the DNA binding interface of the eukaryotic junction-resolving enzyme GEN1.
Nucleic Acids Res., 46, 2018
1B43
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BU of 1b43 by Molmil
FEN-1 FROM P. FURIOSUS
Descriptor: PROTEIN (FEN-1)
Authors:Hosfield, D.J, Mol, C.D, Shen, B, Tainer, J.A.
Deposit date:1999-01-05
Release date:2000-01-12
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structure of the DNA repair and replication endonuclease and exonuclease FEN-1: coupling DNA and PCNA binding to FEN-1 activity.
Cell(Cambridge,Mass.), 95, 1998
5CNQ
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BU of 5cnq by Molmil
Crystal structure of the Holliday junction-resolving enzyme GEN1 (WT) in complex with product DNA, Mg2+ and Mn2+ ions
Descriptor: DNA (5'-D(*TP*GP*AP*GP*CP*GP*GP*TP*GP*GP*TP*TP*GP*GP*T)-3'), MANGANESE (II) ION, Nuclease-like protein, ...
Authors:Liu, Y.J, Freeman, A.D.J, Declais, A.C, Wilson, T.J, Gartner, A, Lilley, D.M.J.
Deposit date:2015-07-17
Release date:2015-12-30
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (2.602 Å)
Cite:Crystal Structure of a Eukaryotic GEN1 Resolving Enzyme Bound to DNA.
Cell Rep, 13, 2015
5CO8
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BU of 5co8 by Molmil
Crystal structure of the Holliday junction-resolving enzyme GEN1 (WT) in complex with product DNA and Mg2+ ion
Descriptor: DNA (31-MER), DNA (5'-D(*AP*GP*AP*CP*TP*GP*CP*AP*GP*TP*TP*GP*AP*GP*TP*C)-3'), DNA (5'-D(*TP*GP*AP*GP*CP*GP*GP*TP*GP*GP*TP*TP*GP*GP*A)-3'), ...
Authors:Liu, Y.J, Freeman, A.D.J, Declais, A.C, Wilson, T.J, Gartner, A, Lilley, D.M.J.
Deposit date:2015-07-20
Release date:2016-01-13
Last modified:2018-11-21
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Crystal Structure of a Eukaryotic GEN1 Resolving Enzyme Bound to DNA.
Cell Rep, 13, 2015
5FV7
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BU of 5fv7 by Molmil
Human Fen1 in complex with an N-hydroxyurea compound
Descriptor: 1-[(2S)-2,3-dihydro-1,4-benzodioxin-2-ylmethyl]-3-hydroxythieno[3,2-d]pyrimidine-2,4(1H,3H)-dione, FLAP ENDONUCLEASE 1, MAGNESIUM ION
Authors:Exell, J.C, Thompson, M.J, Finger, L.D, Shaw, S.K, Abbott, W.M, McWhirter, C, Debreczeni, J.E, Jones, C.D, Nissink, J.W.M, Ward, T.A, Sioberg, C.W.L, Molina, D.M, Durant, S.T, Grasby, J.A.
Deposit date:2016-02-03
Release date:2016-08-17
Last modified:2017-08-23
Method:X-RAY DIFFRACTION (2.84 Å)
Cite:Cellular Active N-Hydroxyurea Fen1 Inhibitors Block Substrate Entry to the Active Site
Nat.Chem.Biol., 12, 2016
4Q10
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BU of 4q10 by Molmil
The catalytic core of Rad2 in complex with DNA substrate (complex IV)
Descriptor: CALCIUM ION, DNA (5'-D(*TP*TP*TP*TP*CP*TP*GP*AP*GP*AP*CP*AP*AP*GP*GP*GP*AP*GP*CP*TP*TP*TP*T)-3'), DNA (5'-D(*TP*TP*TP*TP*GP*CP*TP*CP*CP*CP*TP*TP*GP*TP*CP*TP*CP*AP*GP*TP*TP*TP*T)-3'), ...
Authors:Mietus, M, Nowak, E, Jaciuk, M, Kustosz, P, Nowotny, M.
Deposit date:2014-04-02
Release date:2014-08-27
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Crystal structure of the catalytic core of Rad2: insights into the mechanism of substrate binding.
Nucleic Acids Res., 42, 2014
4Q0R
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BU of 4q0r by Molmil
The catalytic core of Rad2 (complex I)
Descriptor: DNA (5'-D(*CP*TP*GP*AP*GP*TP*CP*AP*GP*AP*GP*CP*AP*AP*A)-3'), DNA repair protein RAD2
Authors:Mietus, M, Nowak, E, Jaciuk, M, Kustosz, P, Nowotny, M.
Deposit date:2014-04-02
Release date:2014-08-27
Last modified:2017-08-09
Method:X-RAY DIFFRACTION (2.75 Å)
Cite:Crystal structure of the catalytic core of Rad2: insights into the mechanism of substrate binding.
Nucleic Acids Res., 42, 2014
4Q0Z
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BU of 4q0z by Molmil
The catalytic core of Rad2 in complex with DNA substrate (complex III)
Descriptor: CALCIUM ION, DNA (5'-D(*TP*CP*TP*GP*AP*GP*AP*CP*AP*AP*GP*GP*GP*AP*GP*CP*T)-3'), DNA (5'-D(*TP*GP*CP*TP*CP*CP*CP*TP*TP*GP*TP*CP*TP*CP*AP*GP*T)-3'), ...
Authors:Mietus, M, Nowak, E, Jaciuk, M, Kustosz, P, Nowotny, M.
Deposit date:2014-04-02
Release date:2014-08-27
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2.398 Å)
Cite:Crystal structure of the catalytic core of Rad2: insights into the mechanism of substrate binding.
Nucleic Acids Res., 42, 2014
5ZOF
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BU of 5zof by Molmil
Crystal Structure of D181A/R192F hFen1 in complex with DNA
Descriptor: DNA (5'-D(*AP*CP*TP*TP*TP*GP*AP*GP*GP*CP*AP*GP*AP*G)-3'), DNA (5'-D(*CP*CP*TP*CP*TP*GP*CP*CP*TP*CP*AP*AP*GP*AP*CP*GP*GP*G)-3'), DNA (5'-D(*GP*CP*CP*CP*GP*TP*CP*C)-3'), ...
Authors:Han, W, Hua, Y, Zhao, Y.
Deposit date:2018-04-13
Release date:2019-01-30
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (2.249 Å)
Cite:Structural basis of 5' flap recognition and protein-protein interactions of human flap endonuclease 1.
Nucleic Acids Res., 46, 2018
5ZOE
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BU of 5zoe by Molmil
Crystal Structure of D181A hFen1 in complex with DNA
Descriptor: DNA (5'-D(*AP*CP*TP*TP*TP*GP*AP*GP*GP*CP*AP*GP*AP*G)-3'), DNA (5'-D(*CP*CP*TP*CP*TP*GP*CP*CP*TP*CP*AP*AP*GP*AP*CP*GP*GP*G)-3'), DNA (5'-D(*GP*CP*CP*CP*GP*TP*CP*C)-3'), ...
Authors:Han, W, Hua, Y, Zhao, Y.
Deposit date:2018-04-13
Release date:2019-01-30
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Structural basis of 5' flap recognition and protein-protein interactions of human flap endonuclease 1.
Nucleic Acids Res., 46, 2018
5ZOD
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BU of 5zod by Molmil
Crystal Structure of hFen1 in apo form
Descriptor: Flap endonuclease 1, MAGNESIUM ION, POTASSIUM ION
Authors:Han, W, Hua, Y, Zhao, Y.
Deposit date:2018-04-13
Release date:2019-01-30
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structural basis of 5' flap recognition and protein-protein interactions of human flap endonuclease 1.
Nucleic Acids Res., 46, 2018

 

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