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4ENE
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BU of 4ene by Molmil
Structure of the N- and C-terminal trimmed ClC-ec1 Cl-/H+ antiporter and Fab Complex
Descriptor: CHLORIDE ION, DECYL-BETA-D-MALTOPYRANOSIDE, H(+)/Cl(-) exchange transporter ClcA, ...
Authors:Lim, H.H, Shane, T, Miller, C.
Deposit date:2012-04-13
Release date:2012-12-26
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Intracellular proton access in a cl(-)/h(+) antiporter.
Plos Biol., 10, 2012
8TA3
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BU of 8ta3 by Molmil
Cryo-EM structure of the human CLC-2 chloride channel transmembrane domain Apo state with resolved N-terminal hairpin
Descriptor: CHLORIDE ION, Chloride channel protein 2
Authors:Xu, M, Neelands, T, Powers, A.S, Liu, Y, Miller, S, Pintilie, G, Du Bois, J, Dror, R.O, Chiu, W, Maduke, M.
Deposit date:2023-06-26
Release date:2024-01-31
Last modified:2024-02-28
Method:ELECTRON MICROSCOPY (2.46 Å)
Cite:CryoEM structures of the human CLC-2 voltage-gated chloride channel reveal a ball-and-chain gating mechanism.
Elife, 12, 2024
1OTS
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BU of 1ots by Molmil
Structure of the Escherichia coli ClC Chloride channel and Fab Complex
Descriptor: CHLORIDE ION, Fab fragment (heavy chain), Fab fragment (light chain), ...
Authors:Dutzler, R, Campbell, E.B, MacKinnon, R.
Deposit date:2003-03-22
Release date:2003-04-15
Last modified:2023-08-16
Method:X-RAY DIFFRACTION (2.51 Å)
Cite:Gating the Selectivity Filter in ClC Chloride Channels
Science, 300, 2003
8GA1
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BU of 8ga1 by Molmil
CLC-ec1 R230C/L249C/C85A at pH 4.5 100mM Cl Swap
Descriptor: CHLORIDE ION, H(+)/Cl(-) exchange transporter ClcA
Authors:Fortea, E, Lee, S, Argyos, Y, Chadda, R, Ciftci, D, Huysmans, G, Robertson, J.L, Boudker, O, Accardi, A.
Deposit date:2023-02-22
Release date:2024-02-07
Method:ELECTRON MICROSCOPY (2.6 Å)
Cite:Structural basis of pH-dependent activation in a CLC transporter.
Nat.Struct.Mol.Biol., 2024
8GA5
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BU of 8ga5 by Molmil
CLC-ec1 L25C/A450C/C85A at pH 4.5 100mM Cl Intermediate
Descriptor: CHLORIDE ION, H(+)/Cl(-) exchange transporter ClcA
Authors:Fortea, E, Lee, S, Argyos, Y, Chadda, R, Ciftci, D, Huysmans, G, Robertson, J.L, Boudker, O, Accardi, A.
Deposit date:2023-02-22
Release date:2024-02-07
Method:ELECTRON MICROSCOPY (2.6 Å)
Cite:Structural basis of pH-dependent activation in a CLC transporter.
Nat.Struct.Mol.Biol., 2024
7CQ5
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BU of 7cq5 by Molmil
Structure of the human CLCN7-OSTM1 complex with ATP
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ADENOSINE-5'-TRIPHOSPHATE, CHLORIDE ION, ...
Authors:Yang, G.H, Lu, Y.M, Zhang, Y.M, Jia, Y.T, Li, X.M, Lei, J.L.
Deposit date:2020-08-08
Release date:2020-11-11
Method:ELECTRON MICROSCOPY (2.6 Å)
Cite:Structure of the human CLCN7-OSTM1 complex with ATP
To Be Published
6V2J
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BU of 6v2j by Molmil
Crystal structure of ClC-ec1 triple mutant (E113Q, E148Q, E203Q)
Descriptor: CHLORIDE ION, H(+)/Cl(-) exchange transporter ClcA
Authors:Maduke, M, Mathews, I.I, Chavan, T.S.
Deposit date:2019-11-24
Release date:2020-05-20
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.62 Å)
Cite:A CLC-ec1 mutant reveals global conformational change and suggests a unifying mechanism for the CLC Cl - /H + transport cycle.
Elife, 9, 2020
6ADB
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BU of 6adb by Molmil
Crystal structure of the E148N mutant CLC-ec1 in 20mM bromide
Descriptor: BROMIDE ION, H(+)/Cl(-) exchange transporter ClcA, antibody Fab fragment, ...
Authors:Lim, H.-H, Park, K.
Deposit date:2018-07-31
Release date:2019-08-28
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (2.692 Å)
Cite:Mutation of external glutamate residue reveals a new intermediate transport state and anion binding site in a CLC Cl-/H+antiporter.
Proc.Natl.Acad.Sci.USA, 116, 2019
8TA2
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BU of 8ta2 by Molmil
Cryo-EM structure of the human CLC-2 chloride channel transmembrane domain with bound inhibitor AK-42
Descriptor: 2-[[2,6-bis(chloranyl)-3-phenylmethoxy-phenyl]amino]pyridine-3-carboxylic acid, CHLORIDE ION, Chloride channel protein 2
Authors:Xu, M, Neelands, T, Powers, A.S, Liu, Y, Miller, S, Pintilie, G, Du Bois, J, Dror, R.O, Chiu, W, Maduke, M.
Deposit date:2023-06-26
Release date:2024-01-31
Last modified:2024-02-28
Method:ELECTRON MICROSCOPY (2.74 Å)
Cite:CryoEM structures of the human CLC-2 voltage-gated chloride channel reveal a ball-and-chain gating mechanism.
Elife, 12, 2024
8TA4
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BU of 8ta4 by Molmil
Cryo-EM structure of the human CLC-2 chloride channel transmembrane domain with symmetric C-terminal
Descriptor: CHLORIDE ION, Chloride channel protein 2
Authors:Xu, M, Neelands, T, Powers, A.S, Liu, Y, Miller, S, Pintilie, G, Du Bois, J, Dror, R.O, Chiu, W, Maduke, M.
Deposit date:2023-06-26
Release date:2024-01-31
Last modified:2024-03-20
Method:ELECTRON MICROSCOPY (2.75 Å)
Cite:CryoEM structures of the human CLC-2 voltage-gated chloride channel reveal a ball-and-chain gating mechanism.
Elife, 12, 2024
8TA5
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BU of 8ta5 by Molmil
Title: Cryo-EM structure of the human CLC-2 chloride channel transmembrane domain with asymmetric C-terminal
Descriptor: Chloride channel protein 2
Authors:Xu, M, Neelands, T, Powers, A.S, Liu, Y, Miller, S, Pintilie, G, Du Bois, J, Dror, R.O, Chiu, W, Maduke, M.
Deposit date:2023-06-26
Release date:2024-01-31
Last modified:2024-03-20
Method:ELECTRON MICROSCOPY (2.76 Å)
Cite:CryoEM structures of the human CLC-2 voltage-gated chloride channel reveal a ball-and-chain gating mechanism.
Elife, 12, 2024
3DET
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BU of 3det by Molmil
Structure of the E148A, Y445A doubly ungated mutant of E.coli CLC_Ec1, Cl-/H+ antiporter
Descriptor: Fab fragment, Heavy chain, Light chain, ...
Authors:Jayaram, H, Accardi, A, Wu, F, Williams, C, Miller, C.
Deposit date:2008-06-10
Release date:2008-06-17
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Ion permeation through a Cl--selective channel designed from a CLC Cl-/H+ exchanger
Proc.Natl.Acad.Sci.USA, 105, 2008
7JM7
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BU of 7jm7 by Molmil
Structure of human CLC-7/OSTM1 complex
Descriptor: (2R)-3-{[(R)-hydroxy{[(1S,2R,3S,4S,5R,6R)-2,3,4,6-tetrahydroxy-5-(phosphonooxy)cyclohexyl]oxy}phosphoryl]oxy}propane-1,2-diyl dinonanoate, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Schrecker, M, Hite, R.
Deposit date:2020-07-31
Release date:2020-09-02
Method:ELECTRON MICROSCOPY (2.82 Å)
Cite:Cryo-EM structure of the lysosomal chloride-proton exchanger CLC-7 in complex with OSTM1.
Elife, 9, 2020
7XA9
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BU of 7xa9 by Molmil
Structure of Arabidopsis thaliana CLCa
Descriptor: ADENOSINE-5'-TRIPHOSPHATE, Chloride channel protein CLC-a, MAGNESIUM ION, ...
Authors:Ji, S, Jin, H, Kaiming, Z, Mingxing, W, Shanshan, L, Long, C.
Deposit date:2022-03-17
Release date:2023-03-22
Method:ELECTRON MICROSCOPY (2.84 Å)
Cite:Cryo-EM structure of the plant nitrate transporter AtCLCa reveals characteristics of the anion-binding site and the ATP-binding pocket.
J.Biol.Chem., 299, 2023
4KKL
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BU of 4kkl by Molmil
Structure of the E148A mutant of CLC-ec1 delta NC construct in 100mM fluoride
Descriptor: FLUORIDE ION, Fab, heavy chain, ...
Authors:Stockbridge, R.B, Lim, H.-H, Miller, C.
Deposit date:2013-05-06
Release date:2013-08-21
Last modified:2013-12-04
Method:X-RAY DIFFRACTION (2.85 Å)
Cite:Fluoride-dependent interruption of the transport cycle of a CLC Cl(-)/H(+) antiporter.
Nat.Chem.Biol., 9, 2013
4KK8
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BU of 4kk8 by Molmil
Structure of the E148Q mutant of CLC-ec1 deltaNC construct in 100mM fluoride
Descriptor: FLUORIDE ION, Fab, heavy chain, ...
Authors:Lim, H.-H, Miller, C.
Deposit date:2013-05-05
Release date:2013-08-21
Last modified:2013-11-13
Method:X-RAY DIFFRACTION (2.86 Å)
Cite:Fluoride-dependent interruption of the transport cycle of a CLC Cl(-)/H(+) antiporter.
Nat.Chem.Biol., 9, 2013
4KJQ
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BU of 4kjq by Molmil
Structure of the CLC-ec1 deltaNC construct in 100mM fluoride
Descriptor: FLUORIDE ION, Fab, heavy chain, ...
Authors:Lim, H.-H, Miller, C.
Deposit date:2013-05-03
Release date:2013-08-21
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (2.875 Å)
Cite:Fluoride-dependent interruption of the transport cycle of a CLC Cl(-)/H(+) antiporter.
Nat.Chem.Biol., 9, 2013
7CVT
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BU of 7cvt by Molmil
Crystal structure of the C85A/L194A/H234C mutant CLC-ec1 with Fab fragment
Descriptor: CHLORIDE ION, H(+)/Cl(-) exchange transporter ClcA, antibody Fab fragment heavy chain, ...
Authors:Park, K, Mersch, K, Robertson, J, Lim, H.-H.
Deposit date:2020-08-27
Release date:2021-09-01
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Altering CLC stoichiometry by reducing non-polar side-chains at the dimerization interface.
J.Mol.Biol., 433, 2021
8GAH
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BU of 8gah by Molmil
CLC-ec1 L25C/A450C/C85A at pH 4.5 100mM Cl Twist
Descriptor: CHLORIDE ION, H(+)/Cl(-) exchange transporter ClcA
Authors:Fortea, E, Lee, S, Argyos, Y, Chadda, R, Ciftci, D, Huysmans, G, Robertson, J.L, Boudker, O, Accardi, A.
Deposit date:2023-02-22
Release date:2024-02-07
Method:ELECTRON MICROSCOPY (2.9 Å)
Cite:Structural basis of pH-dependent activation in a CLC transporter.
Nat.Struct.Mol.Biol., 2024
3EJZ
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BU of 3ejz by Molmil
Structure of E203V mutant E.coli Cl-/H+ exchanger, CLC-ec1
Descriptor: BROMIDE ION, Fab fragment, Heavy chain, ...
Authors:Lim, H.-H, Miller, C.
Deposit date:2008-09-18
Release date:2009-02-17
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Intracellular proton-transfer mutants in a CLC Cl-/H+ exchanger.
J.Gen.Physiol., 133, 2009
7JM6
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BU of 7jm6 by Molmil
Structure of chicken CLC-7
Descriptor: (2R)-3-{[(R)-hydroxy{[(1S,2R,3S,4S,5R,6R)-2,3,4,6-tetrahydroxy-5-(phosphonooxy)cyclohexyl]oxy}phosphoryl]oxy}propane-1,2-diyl dinonanoate, ADENOSINE-5'-TRIPHOSPHATE, CHLORIDE ION, ...
Authors:Schrecker, M, Hite, R.
Deposit date:2020-07-31
Release date:2020-09-02
Last modified:2024-03-06
Method:ELECTRON MICROSCOPY (2.92 Å)
Cite:Cryo-EM structure of the lysosomal chloride-proton exchanger CLC-7 in complex with OSTM1.
Elife, 9, 2020
6AD7
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BU of 6ad7 by Molmil
Crystal structure of the E148D mutant CLC-ec1 in 20 mM bromide
Descriptor: BROMIDE ION, H(+)/Cl(-) exchange transporter ClcA, antibody Fab fragment heavy chain, ...
Authors:Lim, H.-H, Park, K.
Deposit date:2018-07-31
Release date:2019-08-28
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (2.95 Å)
Cite:Mutation of external glutamate residue reveals a new intermediate transport state and anion binding site in a CLC Cl-/H+antiporter.
Proc.Natl.Acad.Sci.USA, 116, 2019
8IAB
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BU of 8iab by Molmil
The Arabidopsis CLCa transporter bound with chloride, ATP and PIP2
Descriptor: ADENOSINE-5'-TRIPHOSPHATE, CHLORIDE ION, Chloride channel protein CLC-a, ...
Authors:Yang, Z, Zhang, X, Zhang, P.
Deposit date:2023-02-08
Release date:2023-08-02
Last modified:2023-08-30
Method:ELECTRON MICROSCOPY (2.96 Å)
Cite:Molecular mechanism underlying regulation of Arabidopsis CLCa transporter by nucleotides and phospholipids.
Nat Commun, 14, 2023
4LOU
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BU of 4lou by Molmil
Structure of the E148Q mutant of CLC-ec1 deltaNC construct in the absence of halide
Descriptor: Fab heavy chain, Fab light chain, H(+)/Cl(-) exchange transporter ClcA
Authors:Lim, H.-H, Miller, C.
Deposit date:2013-07-13
Release date:2013-08-28
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2.981 Å)
Cite:A fluoride interloper in a CLC-type Cl /H+ antiporter
Nat.Chem.Biol., 2013
4KK9
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BU of 4kk9 by Molmil
Structure of the E148A mutant of CLC-ec1 deltaNC construct in 100mM fluoride and 2mM Bromide
Descriptor: Fab, heavy chain, light chain, ...
Authors:Lim, H.-H, Miller, C.
Deposit date:2013-05-05
Release date:2013-08-21
Last modified:2013-11-13
Method:X-RAY DIFFRACTION (2.997 Å)
Cite:Fluoride-dependent interruption of the transport cycle of a CLC Cl(-)/H(+) antiporter.
Nat.Chem.Biol., 9, 2013

 

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数据于2024-03-27公开中

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