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4UZ0
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BU of 4uz0 by Molmil
Crystal Structure of apoptosis repressor with CARD (ARC)
Descriptor: GLYCEROL, NUCLEOLAR PROTEIN 3
Authors:Kim, S.H, Jeong, J.H, Jang, T.H, Kim, Y.G, Park, H.H.
Deposit date:2014-09-04
Release date:2015-07-01
Last modified:2017-07-12
Method:X-RAY DIFFRACTION (2.399 Å)
Cite:Crystal Structure of Caspase Recruiting Domain (Card) of Apoptosis Repressor with Card (Arc) and its Implication in Inhibition of Apoptosis.
Sci.Rep., 5, 2015
8XQK
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BU of 8xqk by Molmil
The Crystal Structure of Apaf from Biortus.
Descriptor: Apoptotic protease-activating factor 1, PHOSPHATE ION
Authors:Wang, F, Cheng, W, Lv, Z, Ju, C, Ni, C.
Deposit date:2024-01-05
Release date:2024-03-06
Method:X-RAY DIFFRACTION (2.85 Å)
Cite:The Crystal Structure of Apaf from Biortus.
To Be Published
1C15
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BU of 1c15 by Molmil
SOLUTION STRUCTURE OF APAF-1 CARD
Descriptor: APOPTOTIC PROTEASE ACTIVATING FACTOR 1
Authors:Zhou, P, Chou, J, Olea, R.S, Yuan, J, Wagner, G.
Deposit date:1999-07-20
Release date:1999-09-20
Last modified:2022-02-16
Method:SOLUTION NMR
Cite:Solution structure of Apaf-1 CARD and its interaction with caspase-9 CARD: a structural basis for specific adaptor/caspase interaction.
Proc.Natl.Acad.Sci.USA, 96, 1999
4RHW
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BU of 4rhw by Molmil
Crystal structure of Apaf-1 CARD and caspase-9 CARD complex
Descriptor: Apoptotic protease-activating factor 1, CHLORIDE ION, Caspase-9, ...
Authors:Hu, Q, Wu, D, Yan, C, Shi, Y.
Deposit date:2014-10-03
Release date:2014-10-15
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Molecular determinants of caspase-9 activation by the Apaf-1 apoptosome.
Proc. Natl. Acad. Sci. U.S.A., 111, 2014
3CRD
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BU of 3crd by Molmil
NMR STRUCTURE OF THE RAIDD CARD DOMAIN, 15 STRUCTURES
Descriptor: RAIDD
Authors:Chou, J.J, Matsuo, H, Duan, H, Wagner, G.
Deposit date:1998-07-24
Release date:1999-02-02
Last modified:2022-03-16
Method:SOLUTION NMR
Cite:Solution structure of the RAIDD CARD and model for CARD/CARD interaction in caspase-2 and caspase-9 recruitment.
Cell(Cambridge,Mass.), 94, 1998
2YGS
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BU of 2ygs by Molmil
CARD DOMAIN FROM APAF-1
Descriptor: APOPTOTIC PROTEASE ACTIVATING FACTOR 1
Authors:Shi, Y.
Deposit date:1999-05-08
Release date:2000-04-19
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Structural basis of procaspase-9 recruitment by the apoptotic protease-activating factor 1.
Nature, 399, 1999
5FNA
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BU of 5fna by Molmil
Cryo-EM reconstruction of caspase-1 CARD
Descriptor: Caspase-1
Authors:Li, Y, Lu, A, Schmidt, F.I, Yin, Q, Chen, S, Fu, T.M, Tong, A.B, Ploegh, H.L, Mao, Y, Wu, H.
Deposit date:2015-11-11
Release date:2016-03-30
Last modified:2019-09-11
Method:ELECTRON MICROSCOPY (4.8 Å)
Cite:Molecular Basis of Caspase-1 Polymerization and its Inhibition by a Novel Capping Mechanism
Nat.Struct.Mol.Biol., 23, 2016
4E9M
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BU of 4e9m by Molmil
NOD1 card domain with three disulfide-clinched, domain-swapped dimers in the asymmetric unit
Descriptor: CITRATE ANION, Nucleotide-binding oligomerization domain-containing protein 1
Authors:Berry, E.A, Huang, L.S, Walker-Kopp, N.
Deposit date:2012-03-21
Release date:2012-04-04
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:Crystal structure of nod1 card domain with three disulfide-clinched, domain-swapped dimers in the asymmetric unit
To be Published
8CZD
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BU of 8czd by Molmil
Cryo-EM structure of BCL10 R58Q filament
Descriptor: B-cell lymphoma/leukemia 10
Authors:David, L, Wu, H.
Deposit date:2022-05-24
Release date:2022-06-22
Last modified:2024-02-14
Method:ELECTRON MICROSCOPY (4.6 Å)
Cite:BCL10 Mutations Define Distinct Dependencies Guiding Precision Therapy for DLBCL.
Cancer Discov, 12, 2022
8CZO
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BU of 8czo by Molmil
Cryo-EM structure of BCL10 CARD - MALT1 DD filament
Descriptor: B-cell lymphoma/leukemia 10, Mucosa-associated lymphoid tissue lymphoma translocation protein 1
Authors:David, L, Wu, H.
Deposit date:2022-05-25
Release date:2022-06-22
Last modified:2022-08-17
Method:ELECTRON MICROSCOPY (4.3 Å)
Cite:BCL10 Mutations Define Distinct Dependencies Guiding Precision Therapy for DLBCL.
Cancer Discov, 12, 2022
2L9M
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BU of 2l9m by Molmil
Structure of cIAP1 CARD
Descriptor: Baculoviral IAP repeat-containing protein 2
Authors:Day, C.L, Rautureau, G.J.P, Hinds, M.G.
Deposit date:2011-02-21
Release date:2011-08-17
Last modified:2023-06-14
Method:SOLUTION NMR
Cite:CARD-mediated autoinhibition of cIAP1's E3 ligase activity suppresses cell proliferation and migration.
Mol.Cell, 42, 2011
1CWW
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BU of 1cww by Molmil
SOLUTION STRUCTURE OF THE CASPASE RECRUITMENT DOMAIN (CARD) FROM APAF-1
Descriptor: APOPTOTIC PROTEASE ACTIVATING FACTOR 1
Authors:Day, C.L, Dupont, C, Lackmann, M, Vaux, D.L, Hinds, M.G.
Deposit date:1999-08-26
Release date:2000-01-21
Last modified:2022-12-21
Method:SOLUTION NMR
Cite:Solution structure and mutagenesis of the caspase recruitment domain (CARD) from Apaf-1.
Cell Death Differ., 6, 1999
1CY5
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BU of 1cy5 by Molmil
CRYSTAL STRUCTURE OF THE APAF-1 CARD
Descriptor: BETA-MERCAPTOETHANOL, PROTEIN (APOPTOTIC PROTEASE ACTIVATING FACTOR 1), ZINC ION
Authors:Vaughn, D.E, Joshua-Tor, L.
Deposit date:1999-08-31
Release date:1999-09-13
Last modified:2018-01-31
Method:X-RAY DIFFRACTION (1.3 Å)
Cite:Crystal structure of Apaf-1 caspase recruitment domain: an alpha-helical Greek key fold for apoptotic signaling.
J.Mol.Biol., 293, 1999
5H8O
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BU of 5h8o by Molmil
Crystal structure of an ASC-binding nanobody in complex with the CARD domain of ASC
Descriptor: Apoptosis-associated speck-like protein containing a CARD, VHH nanobody
Authors:Lu, A, Schmidt, F.I, Ruan, J, Tang, C, Wu, H, Ploegh, H.L.
Deposit date:2015-12-23
Release date:2016-04-06
Last modified:2016-05-18
Method:X-RAY DIFFRACTION (4.206 Å)
Cite:A single domain antibody fragment that recognizes the adaptor ASC defines the role of ASC domains in inflammasome assembly.
J.Exp.Med., 213, 2016
1DGN
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BU of 1dgn by Molmil
SOLUTION STRUCTURE OF ICEBERG, AN INHIBITOR OF INTERLEUKIN-1BETA GENERATION
Descriptor: ICEBERG (PROTEASE INHIBITOR)
Authors:Humke, E.W, Shriver, S.K, Starovasnik, M.A, Fairbrother, W.J, Dixit, V.M.
Deposit date:1999-11-24
Release date:2000-10-09
Last modified:2022-02-16
Method:SOLUTION NMR
Cite:ICEBERG: a novel inhibitor of interleukin-1beta generation.
Cell(Cambridge,Mass.), 103, 2000
3KAT
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BU of 3kat by Molmil
Crystal Structure of the CARD domain of the human NLRP1 protein, Northeast Structural Genomics Consortium Target HR3486E
Descriptor: NACHT, LRR and PYD domains-containing protein 1
Authors:Forouhar, F, Abashidze, M, Seetharaman, J, Mao, M, Xiao, R, Ciccosanti, C, Shastry, R, Everett, J.K, Nair, R, Acton, T.B, Rost, B, Montelione, G.T, Tong, L, Hunt, J.F, Northeast Structural Genomics Consortium (NESG)
Deposit date:2009-10-19
Release date:2009-10-27
Last modified:2019-07-17
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Northeast Structural Genomics Consortium Target HR3486E
To be Published
6XKK
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BU of 6xkk by Molmil
Cryo-EM structure of the NLRP1-CARD filament
Descriptor: NACHT, LRR and PYD domains-containing protein 1
Authors:Hollingsworth, L.R, David, L, Li, Y, Sharif, H, Fontana, P, Fu, T, Wu, H.
Deposit date:2020-06-26
Release date:2020-11-25
Last modified:2024-03-06
Method:ELECTRON MICROSCOPY (3.72 Å)
Cite:Mechanism of filament formation in UPA-promoted CARD8 and NLRP1 inflammasomes.
Nat Commun, 12, 2021
6XKJ
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BU of 6xkj by Molmil
Cryo-EM structure of CARD8-CARD filament
Descriptor: Caspase recruitment domain-containing protein 8
Authors:Hollingsworth, L.R, David, L, Li, Y, Sharif, H, Fontana, P, Fu, T, Wu, H.
Deposit date:2020-06-26
Release date:2020-11-25
Last modified:2024-03-06
Method:ELECTRON MICROSCOPY (3.54 Å)
Cite:Mechanism of filament formation in UPA-promoted CARD8 and NLRP1 inflammasomes.
Nat Commun, 12, 2021
6E26
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BU of 6e26 by Molmil
NMR solution structure of the CARD9 CARD
Descriptor: Caspase recruitment domain-containing protein 9
Authors:Holliday, M.J, Dueber, E.C, Fairbrother, W.J.
Deposit date:2018-07-10
Release date:2018-09-26
Last modified:2023-06-14
Method:SOLUTION NMR
Cite:Picomolar zinc binding modulates formation of Bcl10-nucleating assemblies of the caspase recruitment domain (CARD) of CARD9.
J. Biol. Chem., 293, 2018
6E27
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BU of 6e27 by Molmil
The CARD9 CARD domain-swapped dimer with a zinc ion bound to one of the two zinc binding sites
Descriptor: Caspase recruitment domain-containing protein 9, ZINC ION
Authors:Holliday, M.J, Ferrao, R, Boenig, G, Deuber, E.C, Fairbrother, W.J.
Deposit date:2018-07-10
Release date:2018-09-26
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (1.811 Å)
Cite:Picomolar zinc binding modulates formation of Bcl10-nucleating assemblies of the caspase recruitment domain (CARD) of CARD9.
J. Biol. Chem., 293, 2018
6E28
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BU of 6e28 by Molmil
The CARD9 CARD domain-swapped dimer
Descriptor: Caspase recruitment domain-containing protein 9
Authors:Holliday, M.J, Ferrao, R, Boenig, G, Deuber, E.C, Fairbrother, W.J.
Deposit date:2018-07-10
Release date:2018-09-26
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (1.36 Å)
Cite:Picomolar zinc binding modulates formation of Bcl10-nucleating assemblies of the caspase recruitment domain (CARD) of CARD9.
J. Biol. Chem., 293, 2018
2B1W
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BU of 2b1w by Molmil
Solution structure of the NOD1 Caspase Activating and Recruitment Domain
Descriptor: Caspase recruitment domain protein 4
Authors:Manon, F, Favier, A, Simorre, J.P, Cusack, S.
Deposit date:2005-09-16
Release date:2006-09-26
Last modified:2020-02-26
Method:SOLUTION NMR
Cite:Solution structure of NOD1 CARD and mutational analysis of its interaction with the CARD of downstream kinase RICK.
J.Mol.Biol., 365, 2007
6E25
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BU of 6e25 by Molmil
NMR solution structure of the CARD9 CARD bound to zinc
Descriptor: Caspase recruitment domain-containing protein 9, ZINC ION
Authors:Holliday, M.J, Dueber, E.C, Fairbrother, W.J.
Deposit date:2018-07-10
Release date:2018-09-26
Last modified:2023-06-14
Method:SOLUTION NMR
Cite:Picomolar zinc binding modulates formation of Bcl10-nucleating assemblies of the caspase recruitment domain (CARD) of CARD9.
J. Biol. Chem., 293, 2018
2DBD
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BU of 2dbd by Molmil
Solution structure of the CARD domain in human caspase recruitment domain protein 4 (Nod1 protein)
Descriptor: Caspase recruitment domain protein 4
Authors:Saito, K, Inoue, M, Koshiba, S, Kigawa, T, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI)
Deposit date:2005-12-15
Release date:2006-12-19
Last modified:2022-03-09
Method:SOLUTION NMR
Cite:Solution structure of the CARD domain in human caspase recruitment domain protein 4 (Nod1 protein)
To be Published
3YGS
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BU of 3ygs by Molmil
APAF-1 CARD IN COMPLEX WITH PRODOMAIN OF PROCASPASE-9
Descriptor: APOPTOTIC PROTEASE ACTIVATING FACTOR 1, PROCASPASE 9
Authors:Qin, H, Srinivasula, S, Wu, G, Fernandes-Alnemri, T, Alnemri, E, Shi, Y.
Deposit date:1999-05-08
Release date:2000-04-19
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structural basis of procaspase-9 recruitment by the apoptotic protease-activating factor 1.
Nature, 399, 1999

 

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