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1GOE
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BU of 1goe by Molmil
Monitoring the structural Consequences of Phe12-->D-Phe12 and Leu15-->Aib15 substitution in h/r Corticotropin Releasing Hormone: Implications for Design of CRH antagonists.
Descriptor: CORTICOTROPIN RELEASING HORMONE
Authors:Spyroulias, G.A, Papazacharias, S, Pairas, G, Cordopatis, P.
Deposit date:2001-10-20
Release date:2001-10-31
Last modified:2015-10-21
Method:SOLUTION NMR
Cite:Monitoring the Structural Consequences of Phe12-->D-Phe and Leu15-->Aib Substitution in Human/Rat Corticotropin Releasing Hormone
Eur.J.Biochem., 269, 2002
1GO9
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BU of 1go9 by Molmil
Monitoring the structural Consequences of Phe12-->D-Phe12 and Leu15-->Aib15 substitution in h/r Corticotropin Releasing Hormone: Implications for Design of CRH antagonists.
Descriptor: CORTICOTROPIN RELEASING HORMONE
Authors:Spyroulias, G.A, Papazacharias, S, Pairas, G, Cordopatis, P.
Deposit date:2001-10-20
Release date:2001-10-31
Last modified:2016-12-21
Method:SOLUTION NMR
Cite:Monitoring the Structural Consequences of Phe12-->D-Phe and Leu15-->Aib Substitution in Human/Rat Corticotropin Releasing Hormone. Implications for Design of Crh Antagonists.
Eur.J.Biochem., 269, 2002
2RMG
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BU of 2rmg by Molmil
Human Urocortin 2
Descriptor: Urocortin-2
Authors:Grace, C.R.R, Perrin, M.H, Cantle, J.P, Vale, W.W, Rivier, J.E, Riek, R.
Deposit date:2007-10-16
Release date:2008-01-01
Last modified:2022-03-16
Method:SOLUTION NMR
Cite:Common and divergent structural features of a series of corticotropin releasing factor-related peptides
J.Am.Chem.Soc., 129, 2007
2RMF
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BU of 2rmf by Molmil
Human Urocortin 1
Descriptor: Urocortin
Authors:Grace, C.R.R, Perrin, M.H, Cantle, J.P, Vale, W.W, Rivier, J.E, Riek, R.
Deposit date:2007-10-16
Release date:2008-01-01
Last modified:2022-03-16
Method:SOLUTION NMR
Cite:Common and divergent structural features of a series of corticotropin releasing factor-related peptides
J.Am.Chem.Soc., 129, 2007
2RMH
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BU of 2rmh by Molmil
Human Urocortin 3
Descriptor: Urocortin-3
Authors:Grace, C.R.R, Perrin, M.H, Cantle, J.P, Vale, W.W, Rivier, J.E, Riek, R.
Deposit date:2007-10-16
Release date:2008-01-01
Last modified:2022-03-16
Method:SOLUTION NMR
Cite:Common and divergent structural features of a series of corticotropin releasing factor-related peptides
J.Am.Chem.Soc., 129, 2007
3EHU
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BU of 3ehu by Molmil
Crystal structure of the extracellular domain of human corticotropin releasing factor receptor type 1 (CRFR1) in complex with CRF
Descriptor: 2-[BIS-(2-HYDROXY-ETHYL)-AMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, CALCIUM ION, Corticoliberin, ...
Authors:Pioszak, A.A, Xu, H.E.
Deposit date:2008-09-14
Release date:2008-09-30
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (1.96 Å)
Cite:Molecular Recognition of Corticotropin-releasing Factor by Its G-protein-coupled Receptor CRFR1.
J.Biol.Chem., 283, 2008
3EHT
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BU of 3eht by Molmil
Crystal structure of the extracellular domain of human corticotropin releasing factor receptor type 1 (CRFR1) in complex with CRF
Descriptor: Corticoliberin, FUSION PROTEIN OF CRFR1 EXTRACELLULAR DOMAIN AND MBP, alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose
Authors:Pioszak, A.A, Xu, H.E.
Deposit date:2008-09-14
Release date:2008-09-30
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (3.4 Å)
Cite:Molecular Recognition of Corticotropin-releasing Factor by Its G-protein-coupled Receptor CRFR1.
J.Biol.Chem., 283, 2008
3N96
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BU of 3n96 by Molmil
Crystal structure of human CRFR2 alpha extracellular domain in complex with Urocortin 1
Descriptor: Maltose binding protein-CRFR2 alpha, Urocortin, alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose
Authors:Pal, K, Swaminathan, K, Pioszak, A.A, Xu, H.E.
Deposit date:2010-05-28
Release date:2010-10-20
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (2.75 Å)
Cite:Structural basis of ligand selectivity in human CRFR1 and CRFR2 alpha extracellular domain
To be Published
3N93
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BU of 3n93 by Molmil
Crystal structure of human CRFR2 alpha extracellular domain in complex with Urocortin 3
Descriptor: GLYCEROL, Maltose binding protein-CRFR2 alpha, Urocortin-3, ...
Authors:Pal, K, Swaminathan, K, Pioszak, A.A, Xu, H.E.
Deposit date:2010-05-28
Release date:2010-10-20
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structural basis of ligand selectivity in human CRFR1 and CRFR2 alpha extracellular domain
To be Published
3N95
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BU of 3n95 by Molmil
Crystal structure of human CRFR2 alpha extracellular domain in complex with Urocortin 2
Descriptor: Maltose binding protein-CRFR2 alpha extracellular domain, Urocortin-2, alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose
Authors:Pal, K, Swaminathan, K, Pioszak, A.A, Xu, H.E.
Deposit date:2010-05-28
Release date:2010-10-20
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (2.72 Å)
Cite:Structural basis of ligand selectivity in human CRFR1 and CRFR2 alpha extracellular domain
To be Published
7TS0
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BU of 7ts0 by Molmil
Cryo-EM structure of corticotropin releasing factor receptor 2 bound to Urocortin 1 and coupled with heterotrimeric Go protein
Descriptor: Corticotropin-releasing factor receptor 2,Corticotropin-releasing factor receptor 2,Corticotropin-releasing factor receptor 2,Corticotropin-releasing factor receptor 2,Human corticotropin releasing factor receptor 2, Dominant negative Go alpha subunit, G protein gamma subunit, ...
Authors:Zhao, L.-H, Lin, J, Mao, C, Zhou, X.E, Ji, S, Shen, D, Xiao, P, Melcher, K, Zhang, Y, Yu, X, Xu, H.E.
Deposit date:2022-01-31
Release date:2022-11-09
Last modified:2022-11-16
Method:ELECTRON MICROSCOPY (2.8 Å)
Cite:Structure insights into selective coupling of G protein subtypes by a class B G protein-coupled receptor.
Nat Commun, 13, 2022
7TRY
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BU of 7try by Molmil
Cryo-EM structure of corticotropin releasing factor receptor 2 bound to Urocortin 1 and coupled with heterotrimeric G11 protein
Descriptor: Corticotropin-releasing factor receptor 2, G protein gamma subunit, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ...
Authors:Zhao, L.-H, Lin, J, Mao, C, Zhou, X.E, Ji, S, Shen, D, Xiao, P, Melcher, K, Zhang, Y, Yu, X, Xu, H.E.
Deposit date:2022-01-31
Release date:2022-11-09
Last modified:2022-11-16
Method:ELECTRON MICROSCOPY (3.7 Å)
Cite:Structure insights into selective coupling of G protein subtypes by a class B G protein-coupled receptor.
Nat Commun, 13, 2022
6PB0
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BU of 6pb0 by Molmil
Cryo-EM structure of Urocortin 1-bound Corticotropin-releasing factor 1 receptor in complex with Gs protein and Nb35
Descriptor: CHOLESTEROL, Corticotropin-releasing factor receptor 1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ...
Authors:Ma, S, Shen, Q, Zhao, L.-H, Mao, C, Zhou, X.E, Shen, D.-D, de Waal, P.W, Bi, P, Li, C, Jiang, Y, Wang, M.-W, Sexton, P.M, Wootten, D, Melcher, K, Zhang, Y, Xu, H.E.
Deposit date:2019-06-12
Release date:2020-02-12
Last modified:2020-02-19
Method:ELECTRON MICROSCOPY (3 Å)
Cite:Molecular Basis for Hormone Recognition and Activation of Corticotropin-Releasing Factor Receptors.
Mol.Cell, 77, 2020
6P9X
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BU of 6p9x by Molmil
CRF1 Receptor Gs GPCR protein complex with CRF1 peptide
Descriptor: Corticoliberin, Corticotropin-releasing factor receptor 1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ...
Authors:Belousoff, M.J, Liang, Y.L, Sexton, P, Danev, R.
Deposit date:2019-06-10
Release date:2020-02-05
Last modified:2020-02-19
Method:ELECTRON MICROSCOPY (2.91 Å)
Cite:Toward a Structural Understanding of Class B GPCR Peptide Binding and Activation.
Mol.Cell, 77, 2020
6PB1
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BU of 6pb1 by Molmil
Cryo-EM structure of Urocortin 1-bound Corticotropin-releasing factor 2 receptor in complex with Gs protein and Nb35
Descriptor: CHOLESTEROL, Corticotropin-releasing factor receptor 2, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ...
Authors:Ma, S, Shen, Q, Zhao, L.-H, Mao, C, Zhou, X.E, Shen, D.-D, de Waal, P.W, Bi, P, Li, C, Jiang, Y, Wang, M.-W, Sexton, P.M, Wootten, D, Melcher, K, Zhang, Y, Xu, H.E.
Deposit date:2019-06-12
Release date:2020-02-12
Last modified:2020-02-19
Method:ELECTRON MICROSCOPY (2.8 Å)
Cite:Molecular Basis for Hormone Recognition and Activation of Corticotropin-Releasing Factor Receptors.
Mol.Cell, 77, 2020

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数据于2024-03-27公开中

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