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5HPG
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BU of 5hpg by Molmil
STRUCTURE AND LIGAND DETERMINANTS OF THE RECOMBINANT KRINGLE 5 DOMAIN OF HUMAN PLASMINOGEN
Descriptor: PLASMINOGEN
Authors:Tulinsky, A, Mochalkin, I, Castellino, F.J.
Deposit date:1997-09-19
Release date:1998-03-25
Last modified:2023-08-09
Method:X-RAY DIFFRACTION (1.66 Å)
Cite:Structure and ligand binding determinants of the recombinant kringle 5 domain of human plasminogen.
Biochemistry, 37, 1998
1B2I
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BU of 1b2i by Molmil
KRINGLE 2 DOMAIN OF HUMAN PLASMINOGEN: NMR SOLUTION STRUCTURE OF TRANS-4-AMINOMETHYLCYCLOHEXANE-1-CARBOXYLIC ACID (AMCHA) COMPLEX
Descriptor: PROTEIN (PLASMINOGEN), TRANS-4-AMINOMETHYLCYCLOHEXANE-1-CARBOXYLIC ACID
Authors:Marti, D.N, Schaller, J, Llinas, M.
Deposit date:1999-09-24
Release date:1999-11-19
Last modified:2023-12-27
Method:SOLUTION NMR
Cite:Solution structure and dynamics of the plasminogen kringle 2-AMCHA complex: 3(1)-helix in homologous domains.
Biochemistry, 38, 1999
7OCM
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BU of 7ocm by Molmil
K1K1H6, a potent recombinant minimal hepatocyte growth factor/scatter factor mimic
Descriptor: 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, Hepatocyte growth factor alpha chain,Hepatocyte growth factor alpha chain
Authors:de Jonge, H, de Nola, G, Gherardi, E.
Deposit date:2021-04-27
Release date:2021-07-07
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Dimerization of kringle 1 domain from hepatocyte growth factor/scatter factor provides a potent MET receptor agonist.
Life Sci Alliance, 5, 2022
7OCL
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BU of 7ocl by Molmil
K1K1, a potent recombinant minimal hepatocyte growth factor/scatter factor mimic
Descriptor: Hepatocyte growth factor alpha chain,Hepatocyte growth factor alpha chain
Authors:de Jonge, H, de Nola, G, Gherardi, E.
Deposit date:2021-04-27
Release date:2021-07-21
Last modified:2023-02-01
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Dimerization of kringle 1 domain from hepatocyte growth factor/scatter factor provides a potent MET receptor agonist.
Life Sci Alliance, 5, 2022
1TPK
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BU of 1tpk by Molmil
CRYSTAL STRUCTURE OF THE KRINGLE-2 DOMAIN OF TISSUE PLASMINOGEN ACTIVATOR AT 2.4-ANGSTROMS RESOLUTION
Descriptor: CHLORIDE ION, TISSUE PLASMINOGEN ACTIVATOR
Authors:De vos, A.M, Ultsch, M.H, Kelley, R.F, Padmanabhan, K, Tulinsky, A, Westbrook, M.L, Kossiakoff, A.A.
Deposit date:1991-09-24
Release date:1992-07-15
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Crystal structure of the kringle 2 domain of tissue plasminogen activator at 2.4-A resolution.
Biochemistry, 31, 1992
1URK
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BU of 1urk by Molmil
SOLUTION STRUCTURE OF THE AMINO TERMINAL FRAGMENT OF UROKINASE-TYPE PLASMINOGEN ACTIVATOR
Descriptor: PLASMINOGEN ACTIVATOR, alpha-L-fucopyranose
Authors:Hansen, A.P, Petros, A.M, Meadows, R.P, Nettesheim, D.G, Mazar, A.P, Olejniczak, E.T, Xu, R.X, Pederson, T.M, Henkin, J, Fesik, S.W.
Deposit date:1994-01-10
Release date:1995-05-08
Last modified:2020-07-29
Method:SOLUTION NMR
Cite:Solution structure of the amino-terminal fragment of urokinase-type plasminogen activator.
Biochemistry, 33, 1994
7TNG
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BU of 7tng by Molmil
Kringle domain of human Receptor Tyrosine Kinase-Like Orphan Receptor 1 (ROR1)
Descriptor: Inactive tyrosine-protein kinase transmembrane receptor ROR1
Authors:Guarino, S.R, Di Bello, A, Palamini, M, Forneris, F.
Deposit date:2022-01-21
Release date:2022-05-11
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:Crystal structure of the kringle domain of human receptor tyrosine kinase-like orphan receptor 1 (hROR1)
Acta Crystallogr.,Sect.F, 78, 2022
6OSV
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BU of 6osv by Molmil
Potent and Selective Antitumor Antibody Targeting a Membrane-Proximal Epitope of ROR2
Descriptor: Antibody heavy chain variable region, Antibody light chain variable region, Tyrosine-protein kinase transmembrane receptor ROR2
Authors:Park, H, Rader, C.
Deposit date:2019-05-02
Release date:2020-04-01
Last modified:2020-05-13
Method:X-RAY DIFFRACTION (1.34 Å)
Cite:Affinity maturation, humanization, and co-crystallization of a rabbit anti-human ROR2 monoclonal antibody for therapeutic applications.
J.Biol.Chem., 295, 2020
4KIV
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BU of 4kiv by Molmil
RECOMBINANT KRINGLE IV-10/W72R MUTANT OF HUMAN APOLIPOPROTEIN(A)
Descriptor: APOLIPOPROTEIN
Authors:Mochalkin, I, Tulinsky, A, Scanu, A.
Deposit date:1998-08-26
Release date:1999-05-18
Last modified:2018-03-14
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Recombinant kringle IV-10 modules of human apolipoprotein(a): structure, ligand binding modes, and biological relevance.
Biochemistry, 38, 1999
1CEA
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BU of 1cea by Molmil
THE STRUCTURE OF THE NON-COVALENT COMPLEX OF RECOMBINANT KRINGLE 1 DOMAIN OF HUMAN PLASMINOGEN WITH EACA (EPSILON-AMINOCAPROIC ACID)
Descriptor: 6-AMINOHEXANOIC ACID, PLASMINOGEN
Authors:Tulinsky, A, Mathews, I.I.
Deposit date:1995-12-03
Release date:1996-04-03
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (2.06 Å)
Cite:Crystal structures of the recombinant kringle 1 domain of human plasminogen in complexes with the ligands epsilon-aminocaproic acid and trans-4-(aminomethyl)cyclohexane-1-carboxylic Acid.
Biochemistry, 35, 1996
1CEB
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BU of 1ceb by Molmil
THE STRUCTURE OF THE NON-COVALENT COMPLEX OF RECOMBINANT KRINGLE 1 DOMAIN OF HUMAN PLASMINOGEN WITH AMCHA (TRANS-4-AMINOMETHYLCYCLOHEXANE-1-CARBOXYLIC ACID)
Descriptor: PLASMINOGEN, TRANS-4-AMINOMETHYLCYCLOHEXANE-1-CARBOXYLIC ACID
Authors:Tulinsky, A, Mathews, I.I.
Deposit date:1995-12-03
Release date:1996-04-03
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (2.07 Å)
Cite:Crystal structures of the recombinant kringle 1 domain of human plasminogen in complexes with the ligands epsilon-aminocaproic acid and trans-4-(aminomethyl)cyclohexane-1-carboxylic Acid.
Biochemistry, 35, 1996
5Z55
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BU of 5z55 by Molmil
NMR Solution Structure of the Kringle domain of human receptor tyrosine kinase-like orphan receptor 1 (ROR1)
Descriptor: Inactive tyrosine-protein kinase transmembrane receptor ROR1
Authors:Ma, X, Hu, K.F.
Deposit date:2018-01-17
Release date:2018-05-16
Last modified:2023-06-14
Method:SOLUTION NMR
Cite:Backbone and side-chain chemical shift assignments of the kringle domain of human receptor tyrosine kinase-like orphan receptor 1 (ROR1).
Biomol NMR Assign, 12, 2018
6BA5
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BU of 6ba5 by Molmil
Potent and Selective Antitumor Activity of a T-Cell Engaging Bispecific Antibody Targeting a Membrane-Proximal Epitope of ROR1
Descriptor: Inactive tyrosine-protein kinase transmembrane receptor ROR1, Variable domain Heavy chain, antibody R11, ...
Authors:Park, H, Rader, C.
Deposit date:2017-10-12
Release date:2018-06-13
Last modified:2019-12-04
Method:X-RAY DIFFRACTION (1.62 Å)
Cite:Potent and selective antitumor activity of a T cell-engaging bispecific antibody targeting a membrane-proximal epitope of ROR1.
Proc. Natl. Acad. Sci. U.S.A., 115, 2018
6BAN
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BU of 6ban by Molmil
Potent and Selective Antitumor Activity of a T-Cell Engaging Bispecific Antibody Targeting a Membrane-Proximal Epitope of ROR1
Descriptor: Inactive tyrosine-protein kinase transmembrane receptor ROR1, Variable domain R11 Heavy chain, Variable domain of R11 Light Chain
Authors:Park, H, Rader, C.
Deposit date:2017-10-14
Release date:2018-06-13
Last modified:2019-12-04
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Potent and selective antitumor activity of a T cell-engaging bispecific antibody targeting a membrane-proximal epitope of ROR1.
Proc. Natl. Acad. Sci. U.S.A., 115, 2018
3KIV
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BU of 3kiv by Molmil
RECOMBINANT KRINGLE IV-10/M66 VARIANT OF HUMAN APOLIPOPROTEIN(A)
Descriptor: 6-AMINOHEXANOIC ACID, APOLIPOPROTEIN
Authors:Mochalkin, I, Tulinsky, A, Scanu, A.
Deposit date:1998-09-08
Release date:1999-05-18
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Recombinant kringle IV-10 modules of human apolipoprotein(a): structure, ligand binding modes, and biological relevance.
Biochemistry, 38, 1999
2PK4
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BU of 2pk4 by Molmil
THE REFINED STRUCTURE OF THE EPSILON-AMINOCAPROIC ACID COMPLEX OF HUMAN PLASMINOGEN KRINGLE
Descriptor: 6-AMINOHEXANOIC ACID, HUMAN PLASMINOGEN KRINGLE 4
Authors:Tulinsky, A, Wu, T.-P.
Deposit date:1991-07-18
Release date:1993-10-31
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:The refined structure of the epsilon-aminocaproic acid complex of human plasminogen kringle 4.
Biochemistry, 30, 1991
6OSH
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BU of 6osh by Molmil
Potent and Selective Antitumor Antibody Targeting a Membrane-Proximal Epitope of ROR2
Descriptor: Antibody Light chain variable region, Antibody heavy chain variable region, Tyrosine-protein kinase transmembrane receptor ROR2
Authors:Park, H, Rader, C.
Deposit date:2019-05-01
Release date:2020-04-01
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (1.117 Å)
Cite:Affinity maturation, humanization, and co-crystallization of a rabbit anti-human ROR2 monoclonal antibody for therapeutic applications.
J.Biol.Chem., 295, 2020
6OSN
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BU of 6osn by Molmil
Potent and Selective Antitumor Antibody Targeting a Membrane-Proximal Epitope of ROR2
Descriptor: ACETATE ION, Tyrosine-protein kinase transmembrane receptor ROR2
Authors:Park, H, Rader, C.
Deposit date:2019-05-01
Release date:2020-04-01
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (1.083 Å)
Cite:Affinity maturation, humanization, and co-crystallization of a rabbit anti-human ROR2 monoclonal antibody for therapeutic applications.
J.Biol.Chem., 295, 2020
6RX7
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BU of 6rx7 by Molmil
Structure of the KIV type 2 (KIV-2) domain of lipoprotein (a)
Descriptor: Apolipoprotein(a), GLYCEROL, SULFATE ION
Authors:Santonastaso, A, Maggi, M, Scotti, C.
Deposit date:2019-06-07
Release date:2020-07-08
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (1.63 Å)
Cite:High resolution structure of human apolipoprotein (a) kringle IV type 2: beyond the lysine binding site.
J.Lipid Res., 61, 2020
2FEB
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BU of 2feb by Molmil
NMR Solution Structure, Dynamics and Binding Properties of the Kringle IV Type 8 module of apolipoprotein(a)
Descriptor: Apolipoprotein(a)
Authors:Chitayat, S, Kanelis, V, Koschinsky, M.L, Smith, S.P.
Deposit date:2005-12-15
Release date:2006-12-26
Last modified:2022-03-09
Method:SOLUTION NMR
Cite:Nuclear magnetic resonance (NMR) solution structure, dynamics, and binding properties of the kringle IV type 8 module of apolipoprotein(a).
Biochemistry, 46, 2007
1PK4
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BU of 1pk4 by Molmil
CRYSTAL AND MOLECULAR STRUCTURE OF HUMAN PLASMINOGEN KRINGLE 4 REFINED AT 1.9-ANGSTROMS RESOLUTION
Descriptor: PLASMINOGEN KRINGLE 4, SULFATE ION
Authors:Tulinsky, A, Mulichak, A.M.
Deposit date:1991-07-18
Release date:1993-10-31
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Crystal and molecular structure of human plasminogen kringle 4 refined at 1.9-A resolution.
Biochemistry, 30, 1991
1PKR
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BU of 1pkr by Molmil
THE STRUCTURE OF RECOMBINANT PLASMINOGEN KRINGLE 1 AND THE FIBRIN BINDING SITE
Descriptor: CHLORIDE ION, PLASMINOGEN
Authors:Wu, T.-P, Tulinsky, A.
Deposit date:1993-08-03
Release date:1994-01-31
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (2.48 Å)
Cite:The structure of recombinant plasminogen kringle 1 and the fibrin binding site.
Blood Coagulation Fibrinolysis, 5, 1994
1PML
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BU of 1pml by Molmil
KRINGLE-KRINGLE INTERACTIONS IN MULTIMER KRINGLE STRUCTURES
Descriptor: CHLORIDE ION, TISSUE PLASMINOGEN ACTIVATOR KRINGLE 2
Authors:Padmanabhan, K, Tulinsky, A.
Deposit date:1994-04-25
Release date:1994-06-22
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (2.38 Å)
Cite:Kringle-kringle interactions in multimer kringle structures.
Protein Sci., 3, 1994
2I9A
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BU of 2i9a by Molmil
Crystal structure of the free aminoterminal fragment of urokinase type plasminogen activator (ATF)
Descriptor: PHOSPHATE ION, Urokinase-type plasminogen activator
Authors:Lubkowski, J, Barinka, C.
Deposit date:2006-09-05
Release date:2006-11-28
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structural basis of interaction between urokinase-type plasminogen activator and its receptor.
J.Mol.Biol., 363, 2006
1PMK
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BU of 1pmk by Molmil
KRINGLE-KRINGLE INTERACTIONS IN MULTIMER KRINGLE STRUCTURES
Descriptor: PLASMINOGEN KRINGLE 4
Authors:Padmanabhan, K, Tulinsky, A.
Deposit date:1994-04-25
Release date:1994-06-22
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Kringle-kringle interactions in multimer kringle structures.
Protein Sci., 3, 1994

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数据于2024-03-27公开中

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