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1U12
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BU of 1u12 by Molmil
M. loti cyclic nucleotide binding domain mutant
Descriptor: IODIDE ION, POTASSIUM ION, SULFATE ION, ...
Authors:Clayton, G.M, Silverman, W.R, Heginbotham, L, Morais-Cabral, J.H.
Deposit date:2004-07-14
Release date:2004-11-30
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Structural Basis of Ligand Activation in a Cyclic Nucleotide Regulated Potassium Channel
Cell(Cambridge,Mass.), 119, 2004
1VP6
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BU of 1vp6 by Molmil
M.loti ion channel cylic nucleotide binding domain
Descriptor: ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE, BROMIDE ION, Cyclic-nucleotide binding domain of mesorhizobium loti CNG potassium channel
Authors:Clayton, G.M, Silverman, W.R, Heginbotham, L, Morais-Cabral, J.H.
Deposit date:2004-10-14
Release date:2004-10-26
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Structural basis of ligand activation in a cyclic nucleotide regulated potassium channel.
Cell(Cambridge,Mass.), 119, 2004
1CX4
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BU of 1cx4 by Molmil
CRYSTAL STRUCTURE OF A DELETION MUTANT OF THE TYPE II BETA REGULATORY SUBUNIT OF CAMP-DEPENDENT PROTEIN KINASE
Descriptor: ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE, CAMP-DEPENDENT PROTEIN KINASE REGULATORY SUBUNIT TYPE II BETA
Authors:Diller, T.C, Xuong, N.H, Taylor, S.S.
Deposit date:1999-08-28
Release date:2001-03-07
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2.45 Å)
Cite:Molecular basis for regulatory subunit diversity in cAMP-dependent protein kinase: crystal structure of the type II beta regulatory subunit.
Structure, 9, 2001
4Z07
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BU of 4z07 by Molmil
Co-crystal structure of the tandem CNB (CNB-A/B) domains of human PKG I beta with cGMP
Descriptor: CYCLIC GUANOSINE MONOPHOSPHATE, ISOPROPYL ALCOHOL, SULFATE ION, ...
Authors:Kim, J.J, Reger, A.S, Arold, S.T, Kim, C.
Deposit date:2015-03-25
Release date:2016-04-13
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Crystal Structure of PKG I:cGMP Complex Reveals a cGMP-Mediated Dimeric Interface that Facilitates cGMP-Induced Activation.
Structure, 24, 2016
6NP6
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BU of 6np6 by Molmil
Crystal structure of the sensor domain of the transcriptional regulator HcpR from Porphyromonas Gingivalis
Descriptor: Crp/Fnr family transcriptional regulator, GLYCEROL
Authors:Musayev, F.N, Belvin, B.R, Escalante, C.R, Turner, J, Scarsdale, J.N, Lewis, J.P.
Deposit date:2019-01-17
Release date:2019-06-26
Last modified:2022-03-23
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Nitrosative Stress Sensing in Porphyromonas gingivalis: Structure and Mechanisms of the Heme Binding Transcriptional Regulator HcpR.
Acta Crystallogr D Struct Biol, 75, 2019
4QX5
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BU of 4qx5 by Molmil
Neutron diffraction reveals hydrogen bonds critical for cGMP-selective activation: Insights for PKG agonist design
Descriptor: ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE, IODIDE ION, cGMP-dependent protein kinase 1
Authors:Huang, G.Y, Gerlits, O.O, Blakeley, M.P, Sankaran, B, Kovalevsky, A.Y, Kim, C.
Deposit date:2014-07-18
Release date:2014-11-12
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (1.318 Å)
Cite:Neutron Diffraction Reveals Hydrogen Bonds Critical for cGMP-Selective Activation: Insights for cGMP-Dependent Protein Kinase Agonist Design.
Biochemistry, 53, 2014
4QXK
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BU of 4qxk by Molmil
Joint X-ray/neutron structure of PKGIbeta in complex with cGMP
Descriptor: CYCLIC GUANOSINE MONOPHOSPHATE, SODIUM ION, cGMP-dependent protein kinase 1
Authors:Kim, C, Gerlits, O, Kovalevsky, A, Huang, G.Y.
Deposit date:2014-07-21
Release date:2014-11-12
Last modified:2024-02-28
Method:NEUTRON DIFFRACTION (2.2 Å), X-RAY DIFFRACTION
Cite:Neutron Diffraction Reveals Hydrogen Bonds Critical for cGMP-Selective Activation: Insights for cGMP-Dependent Protein Kinase Agonist Design.
Biochemistry, 53, 2014
6BQ8
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BU of 6bq8 by Molmil
Joint X-ray/neutron structure of PKG II CNB-B domain in complex with 8-pCPT-cGMP
Descriptor: (4S)-2-METHYL-2,4-PENTANEDIOL, 2-(~2~H_2_)amino-8-[(4-chlorophenyl)sulfanyl]-9-[(2S,4aR,6R,7R,7aS)-2-hydroxy-7-(~2~H)hydroxy-2-oxotetrahydro-2H,4H-2lambda~5~-furo[3,2-d][1,3,2]dioxaphosphinin-6-yl](~2~H)-1,9-dihydro-6H-purin-6-one, STRONTIUM ION, ...
Authors:Kim, C, Kovalevsky, A, Gerlits, O.
Deposit date:2017-11-27
Release date:2018-03-21
Last modified:2023-05-17
Method:NEUTRON DIFFRACTION (2 Å), X-RAY DIFFRACTION
Cite:Neutron Crystallography Detects Differences in Protein Dynamics: Structure of the PKG II Cyclic Nucleotide Binding Domain in Complex with an Activator.
Biochemistry, 57, 2018
6CPB
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BU of 6cpb by Molmil
Crystal structure of the heme domain of CooA from Carboxydothermus hydrogenoformans
Descriptor: Carbon monoxide oxidation system transcription regulator CooA-1, GLYCEROL, SULFATE ION
Authors:Tripathi, S.M, Poulos, T.L.
Deposit date:2018-03-13
Release date:2018-05-16
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (1.155 Å)
Cite:Testing the N-Terminal Velcro Model of CooA Carbon Monoxide Activation.
Biochemistry, 57, 2018
6SYG
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BU of 6syg by Molmil
Crystal structure of the Cyclic Nucleotide-Binding Homology Domain of the human KCNH2 channel
Descriptor: Potassium voltage-gated channel subfamily H member 2
Authors:Ben-Bassat, A, Giladi, M, Haitin, Y.
Deposit date:2019-09-27
Release date:2020-03-04
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Structure of KCNH2 cyclic nucleotide-binding homology domain reveals a functionally vital salt-bridge.
J.Gen.Physiol., 152, 2020
2Z69
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BU of 2z69 by Molmil
Crystal Structure of the sensor domain of the transcriptional regulator DNR from Pseudomonas aeruginosa
Descriptor: DNR protein
Authors:Giardina, G, Johnson, K.A, Di Matteo, A.
Deposit date:2007-07-24
Release date:2008-03-18
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:NO sensing in Pseudomonas aeruginosa: structure of the transcriptional regulator DNR.
J.Mol.Biol., 378, 2008
2D93
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BU of 2d93 by Molmil
Solution structure of the cNMP_binding domain of human Rap guanine nucleotide exchange factor 6
Descriptor: Rap guanine nucleotide exchange factor 6
Authors:Inoue, K, Muto, Y, Hayashi, F, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI)
Deposit date:2005-12-08
Release date:2006-06-08
Last modified:2022-03-09
Method:SOLUTION NMR
Cite:Solution structure of the cNMP_binding domain of human Rap guanine nucleotide exchange factor 6
to be published
2K0G
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BU of 2k0g by Molmil
Solution Structure of a Bacterial Cyclic Nucleotide-Activated K+ Channel Binding Domain in Complex with cAMP
Descriptor: ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE, Mll3241 protein
Authors:Schunke, S, Stoldt, M, Willbold, D.
Deposit date:2008-02-02
Release date:2009-02-10
Last modified:2022-03-16
Method:SOLUTION NMR
Cite:Solution structure of the Mesorhizobium loti K1 channel cyclic nucleotide-binding domain in complex with cAMP.
Embo Rep., 10, 2009
2KXL
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BU of 2kxl by Molmil
Solution structure of a bacterial cyclic nucleotide-activated K+ channel binding domain in the unliganded state
Descriptor: Cyclic nucleotide-gated potassium channel mll3241
Authors:Schunke, S, Stoldt, M, Willbold, D.
Deposit date:2010-05-10
Release date:2011-04-20
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Structural insights into conformational changes of a cyclic nucleotide-binding domain in solution from Mesorhizobium loti K1 channel.
Proc.Natl.Acad.Sci.USA, 108, 2011
2MHF
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BU of 2mhf by Molmil
Solution structure of the cyclic-nucleotide binding homology domain of a KCNH channel
Descriptor: Uncharacterized protein
Authors:Li, Q, Ng, H.
Deposit date:2013-11-21
Release date:2014-04-02
Last modified:2022-08-24
Method:SOLUTION NMR
Cite:Solution structure of the cyclic-nucleotide binding homology domain of a KCNH channel.
J.Struct.Biol., 186, 2014
5T3N
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BU of 5t3n by Molmil
Sp-2Cl-cAMPS bound to PKAR CBD2
Descriptor: (2S,4aR,6R,7R,7aS)-6-(6-amino-2-chloro-9H-purin-9-yl)-7-hydroxy-2-sulfanyltetrahydro-2H,4H-2lambda~5~-furo[3,2-d][1,3,2]dioxaphosphinin-2-one, IODIDE ION, cAMP-dependent protein kinase regulatory subunit
Authors:Littler, D.R, Gilson, P.
Deposit date:2016-08-26
Release date:2016-10-12
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Disrupting the Allosteric Interaction between the Plasmodium falciparum cAMP-dependent Kinase and Its Regulatory Subunit.
J. Biol. Chem., 291, 2016
2MNG
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BU of 2mng by Molmil
Apo Structure of human HCN4 CNBD solved by NMR
Descriptor: Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4
Authors:Akimoto, M, Zhang, Z, Boulton, S, Selvaratnam, R, VanSchouwen, B, Gloyd, M, Accili, E.A, Lange, O.F, Melacini, G.
Deposit date:2014-04-03
Release date:2014-06-04
Last modified:2015-02-11
Method:SOLUTION NMR
Cite:A mechanism for the auto-inhibition of hyperpolarization-activated cyclic nucleotide-gated (HCN) channel opening and its relief by cAMP.
J.Biol.Chem., 289, 2014
2N7G
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BU of 2n7g by Molmil
Structure of the cyclic nucleotide-binding homology domain of the hERG channel
Descriptor: Potassium voltage-gated channel subfamily H member 2
Authors:Li, Y, Ng, H, Li, Q, Kang, C.
Deposit date:2015-09-10
Release date:2016-05-18
Last modified:2023-06-14
Method:SOLUTION NMR
Cite:Structure of the Cyclic Nucleotide-Binding Homology Domain of the hERG Channel and Its Insight into Type 2 Long QT Syndrome
Sci Rep, 6, 2016
2MPF
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BU of 2mpf by Molmil
Solution structure human HCN2 CNBD in the cAMP-unbound state
Descriptor: Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2
Authors:Saponaro, A, Pauleta, S.R, Cantini, F, Matzapetakis, M, Hammann, C, Banci, L, Thiel, G, Santoro, B, Moroni, A.
Deposit date:2014-05-16
Release date:2014-09-03
Last modified:2023-06-14
Method:SOLUTION NMR
Cite:Structural basis for the mutual antagonism of cAMP and TRIP8b in regulating HCN channel function.
Proc.Natl.Acad.Sci.USA, 111, 2014
5V30
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BU of 5v30 by Molmil
Crystal structure of the sensor domain of the transcriptional regulator HcpR from Porphyromonas Gingivalis
Descriptor: GLYCEROL, SULFATE ION, Transcriptional regulator
Authors:Musayev, F.N, Belvin, B.R, Escalante, C.R, Turner, J, Lewis, J.P.
Deposit date:2017-03-06
Release date:2018-06-13
Last modified:2022-03-23
Method:X-RAY DIFFRACTION (3.15 Å)
Cite:Nitrosative stress sensing in Porphyromonas gingivalis: structure of and heme binding by the transcriptional regulator HcpR.
Acta Crystallogr D Struct Biol, 75, 2019
2PTM
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BU of 2ptm by Molmil
Structure and rearrangements in the carboxy-terminal region of SpIH channels
Descriptor: ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE, COBALT HEXAMMINE(III), Hyperpolarization-activated (Ih) channel
Authors:Flynn, G.E, Black, K.D, Islas, L.D, Sankaran, B, Zagotta, W.N.
Deposit date:2007-05-08
Release date:2007-06-19
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (1.93 Å)
Cite:Structure and rearrangements in the carboxy-terminal region of SpIH channels.
Structure, 15, 2007
2PQQ
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BU of 2pqq by Molmil
Structural Genomics, the crystal structure of the N-terminal domain of a transcriptional regulator from Streptomyces coelicolor A3(2)
Descriptor: FORMIC ACID, Putative transcriptional regulator
Authors:Tan, K, Xu, X, Zheng, H, Savchenko, A, Edwards, A.M, Joachimiak, A, Midwest Center for Structural Genomics (MCSG)
Deposit date:2007-05-02
Release date:2007-06-05
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (2 Å)
Cite:The crystal structure of the N-terminal domain of a transcriptional regulator from Streptomyces coelicolor A3(2)
To be Published
2Q0A
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BU of 2q0a by Molmil
Structure and rearrangements in the carboxy-terminal region of SpIH channels
Descriptor: CYCLIC GUANOSINE MONOPHOSPHATE, Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2
Authors:Flynn, G.E, Black, K.D, Islas, L.D, Sankaran, B, Zagotta, W.N.
Deposit date:2007-05-21
Release date:2007-06-19
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Structure and rearrangements in the carboxy-terminal region of SpIH channels.
Structure, 15, 2007
5KHI
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BU of 5khi by Molmil
HCN2 CNBD in complex with purine riboside-3', 5'-cyclic monophosphate (cPuMP)
Descriptor: Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2, Purine riboside-3',5'-cyclic monophosphate
Authors:Ng, L.C.T, Putrenko, I, Baronas, V, Van Petegem, F, Accili, E.A.
Deposit date:2016-06-14
Release date:2016-09-14
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Cyclic Purine and Pyrimidine Nucleotides Bind to the HCN2 Ion Channel and Variably Promote C-Terminal Domain Interactions and Opening.
Structure, 24, 2016
5K8S
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BU of 5k8s by Molmil
cAMP bound PfPKA-R (297-441)
Descriptor: ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE, CAMP-dependent protein kinase regulatory subunit
Authors:Littler, D.R, Gilson, P.R, Crabb, B.S, Rossjohn, J.J.
Deposit date:2016-05-31
Release date:2016-10-12
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (1.15 Å)
Cite:Disrupting the Allosteric Interaction between the Plasmodium falciparum cAMP-dependent Kinase and Its Regulatory Subunit.
J. Biol. Chem., 291, 2016

217705

数据于2024-03-27公开中

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