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9PTI
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BU of 9pti by Molmil
BASIC PANCREATIC TRYPSIN INHIBITOR (MET 52 OXIDIZED)
Descriptor: BOVINE PANCREATIC TRYPSIN INHIBITOR, PHOSPHATE ION
Authors:Eigenbrot, C, Randal, M, Kossiakoff, A.A.
Deposit date:1991-04-08
Release date:1992-04-15
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (1.22 Å)
Cite:

6YHY
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BU of 6yhy by Molmil
A lid blocking mechanism of a cone snail toxin revealed at the atomic level
Descriptor: Conk-S1
Authors:Saikia, C, Altman-Gueta, H, Dym, O, Frolow, F, Gurevitz, M, Gordon, D, Reuveny, E, Karbat, I.
Deposit date:2020-03-31
Release date:2021-04-14
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (1.55 Å)
Cite:A Molecular Lid Mechanism of K + Channel Blocker Action Revealed by a Cone Peptide.
J.Mol.Biol., 433, 2021
8PTI
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BU of 8pti by Molmil
CRYSTAL STRUCTURE OF A Y35G MUTANT OF BOVINE PANCREATIC TRYPSIN INHIBITOR
Descriptor: BOVINE PANCREATIC TRYPSIN INHIBITOR
Authors:Housset, D, Kim, K.-S, Fuchs, J, Woodward, C, Wlodawer, A.
Deposit date:1990-12-17
Release date:1991-04-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Crystal structure of a Y35G mutant of bovine pancreatic trypsin inhibitor.
J.Mol.Biol., 220, 1991
6F1F
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BU of 6f1f by Molmil
The methylene thioacetal BPTI (Bovine Pancreatic Trypsin Inhibitor) mutant structure
Descriptor: GLYCEROL, Pancreatic trypsin inhibitor, SULFATE ION
Authors:Lansky, S, Mousa, R, Metanis, N, Shoham, G.
Deposit date:2017-11-21
Release date:2018-07-18
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (1.716 Å)
Cite:BPTI folding revisited: switching a disulfide into methylene thioacetal reveals a previously hidden path.
Chem Sci, 9, 2018
6KZF
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BU of 6kzf by Molmil
Racemic X-ray Structure of Calcicludine
Descriptor: D-calcicludine, Kunitz-type serine protease inhibitor homolog calcicludine
Authors:Qu, Q, Gao, S, Liu, L.
Deposit date:2019-09-24
Release date:2019-11-06
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (2.52 Å)
Cite:Synthesis of Disulfide Surrogate Peptides Incorporating Large-Span Surrogate Bridges Through a Native-Chemical-Ligation-Assisted Diaminodiacid Strategy
Angew.Chem.Int.Ed.Engl., 59, 2020
5M4V
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BU of 5m4v by Molmil
X-ray structure of the mambaquaretin-1, a selective antagonist of the vasopressin type 2 receptor
Descriptor: CHLORIDE ION, Mambaquaretin-1, S-1,2-PROPANEDIOL
Authors:Stura, E.A, Vera, L, Ciolek, J, Mourier, G, Gilles, N.
Deposit date:2016-10-19
Release date:2017-05-03
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (1.06 Å)
Cite:Green mamba peptide targets type-2 vasopressin receptor against polycystic kidney disease.
Proc. Natl. Acad. Sci. U.S.A., 114, 2017
5NMV
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BU of 5nmv by Molmil
Crystal structure of 2F22 Fab fragment against TFPI1
Descriptor: Fab heavy chain, Fab light chain, GLYCEROL, ...
Authors:Svensson, L.A, Petersen, H.H.
Deposit date:2017-04-07
Release date:2018-03-28
Last modified:2018-05-09
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Factor Xa and VIIa inhibition by tissue factor pathway inhibitor is prevented by a monoclonal antibody to its Kunitz-1 domain.
J. Thromb. Haemost., 16, 2018
5EZD
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BU of 5ezd by Molmil
Crystal structure of a Hepatocyte growth factor activator inhibitor-1 (HAI-1) fragment covering the PKD-like 'internal' domain and Kunitz domain 1
Descriptor: ACETATE ION, Kunitz-type protease inhibitor 1, POTASSIUM ION
Authors:Hong, Z, Andreasen, P.A, Morth, J.P, Jensen, J.K.
Deposit date:2015-11-26
Release date:2016-05-18
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Crystal Structure of a Two-domain Fragment of Hepatocyte Growth Factor Activator Inhibitor-1: FUNCTIONAL INTERACTIONS BETWEEN THE KUNITZ-TYPE INHIBITOR DOMAIN-1 AND THE NEIGHBORING POLYCYSTIC KIDNEY DISEASE-LIKE DOMAIN.
J.Biol.Chem., 291, 2016
6NAN
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BU of 6nan by Molmil
NMR structure determination of Ixolaris and Factor X interaction reveals a noncanonical mechanism of Kunitz inhibition
Descriptor: Ixolaris
Authors:De Paula, V.S, Sgourakis, N.G, Francischetti, I.M.B, Almeida, F.C.L, Monteiro, R.Q, Valente, A.P.
Deposit date:2018-12-06
Release date:2019-06-12
Last modified:2023-06-14
Method:SOLUTION NMR
Cite:NMR structure determination of Ixolaris and factor X(a) interaction reveals a noncanonical mechanism of Kunitz inhibition.
Blood, 134, 2019
2ZJX
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BU of 2zjx by Molmil
Bovine pancreatic trypsin inhibitor (BPTI) containing only the [5,55] disulfide bond
Descriptor: Pancreatic trypsin inhibitor, SULFATE ION
Authors:Islam, M.M, Sohya, S, Noguchi, K, Yohda, M, Kuroda, Y.
Deposit date:2008-03-11
Release date:2008-10-21
Last modified:2021-11-10
Method:X-RAY DIFFRACTION (1.09 Å)
Cite:Crystal structure of an extensively simplified variant of bovine pancreatic trypsin inhibitor in which over one-third of the residues are alanines
Proc.Natl.Acad.Sci.Usa, 105, 2008
2ZVX
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Structure of a BPTI-[5,55] variant containing Gly/Val at the 14/38th positions
Descriptor: Pancreatic trypsin inhibitor, SULFATE ION
Authors:Islam, M.M, Sohya, S, Noguchi, K, Yohda, M, Kuroda, Y.
Deposit date:2008-11-24
Release date:2009-10-13
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (1.09 Å)
Cite:Thermodynamic and structural analysis of highly stabilized BPTIs by single and double mutations
Proteins, 77, 2009
6PTI
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BU of 6pti by Molmil
STRUCTURE OF FORM III CRYSTALS OF BOVINE PANCREATIC TRYPSIN INHIBITOR
Descriptor: PANCREATIC TRYPSIN INHIBITOR PRECURSOR, PHOSPHATE ION
Authors:Wlodawer, A.
Deposit date:1987-05-13
Release date:1987-10-16
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Structure of form III crystals of bovine pancreatic trypsin inhibitor.
J.Mol.Biol., 198, 1987
6Q61
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BU of 6q61 by Molmil
Pore-modulating toxins exploit inherent slow inactivation to block K+ channels
Descriptor: Kunitz-type conkunitzin-S1, SULFATE ION
Authors:Karbat, I, Gueta, H, Fine, S, Szanto, T, Hamer-Rogotner, S, Dym, O, Frolow, F, Gordon, D, Panyi, G, Gurevitz, M, Reuveny, E.
Deposit date:2018-12-10
Release date:2019-08-21
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (1.3 Å)
Cite:Pore-modulating toxins exploit inherent slow inactivation to block K+channels.
Proc.Natl.Acad.Sci.USA, 116, 2019
5PTI
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BU of 5pti by Molmil
STRUCTURE OF BOVINE PANCREATIC TRYPSIN INHIBITOR. RESULTS OF JOINT NEUTRON AND X-RAY REFINEMENT OF CRYSTAL FORM II
Descriptor: PHOSPHATE ION, TRYPSIN INHIBITOR, UNKNOWN ATOM OR ION
Authors:Wlodawer, A, Huber, R.
Deposit date:1984-10-05
Release date:1984-10-29
Last modified:2018-10-24
Method:NEUTRON DIFFRACTION (1 Å), X-RAY DIFFRACTION
Cite:Structure of bovine pancreatic trypsin inhibitor. Results of joint neutron and X-ray refinement of crystal form II
J.Mol.Biol., 180, 1984
6Q6C
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BU of 6q6c by Molmil
Pore-modulating toxins exploit inherent slow inactivation to block K+ channels
Descriptor: 1,2-ETHANEDIOL, Kunitz-type conkunitzin-S1, NITRATE ION, ...
Authors:Karbat, I, Gueta, H, Fine, S, Szanto, T, Hamer-Rogotner, S, Dym, O, Frolow, F, Gordon, D, Panyi, G, Gurevitz, M, Reuveny, E.
Deposit date:2018-12-10
Release date:2019-08-21
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (1.3 Å)
Cite:Pore-modulating toxins exploit inherent slow inactivation to block K+channels.
Proc.Natl.Acad.Sci.USA, 116, 2019
1AAL
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BU of 1aal by Molmil
STRUCTURAL EFFECTS INDUCED BY MUTAGENESIS AFFECTED BY CRYSTAL PACKING FACTORS: THE STRUCTURE OF A 30-51 DISULFIDE MUTANT OF BASIC PANCREATIC TRYPSIN INHIBITOR
Descriptor: BOVINE PANCREATIC TRYPSIN INHIBITOR, PHOSPHATE ION
Authors:Eigenbrot, C, Randal, M, Kossiakoff, A.A.
Deposit date:1992-04-09
Release date:1993-10-31
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Structural effects induced by mutagenesis affected by crystal packing factors: the structure of a 30-51 disulfide mutant of basic pancreatic trypsin inhibitor.
Proteins, 14, 1992
1AAP
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BU of 1aap by Molmil
X-RAY CRYSTAL STRUCTURE OF THE PROTEASE INHIBITOR DOMAIN OF ALZHEIMER'S AMYLOID BETA-PROTEIN PRECURSOR
Descriptor: ALZHEIMER'S DISEASE AMYLOID A4 PROTEIN
Authors:Hynes, T.R, Randal, M, Kennedy, L.A, Eigenbrot, C, Kossiakoff, A.A.
Deposit date:1990-09-14
Release date:1991-10-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:X-ray crystal structure of the protease inhibitor domain of Alzheimer's amyloid beta-protein precursor.
Biochemistry, 29, 1990
1ADZ
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BU of 1adz by Molmil
THE SOLUTION STRUCTURE OF THE SECOND KUNITZ DOMAIN OF TISSUE FACTOR PATHWAY INHIBITOR, NMR, 30 STRUCTURES
Descriptor: TISSUE FACTOR PATHWAY INHIBITOR
Authors:Burgering, M.J.M, Orbons, L.P.M.
Deposit date:1997-02-19
Release date:1998-02-25
Last modified:2021-11-03
Method:SOLUTION NMR
Cite:The second Kunitz domain of human tissue factor pathway inhibitor: cloning, structure determination and interaction with factor Xa.
J.Mol.Biol., 269, 1997
1B0C
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BU of 1b0c by Molmil
EVIDENCE OF A COMMON DECAMER IN THREE CRYSTAL STRUCTURES OF BPTI, CRYSTALLIZED FROM THIOCYANATE, CHLORIDE OR SULFATE
Descriptor: PROTEIN (PANCREATIC TRYPSIN INHIBITOR)
Authors:Hamiaux, C, Prange, T, Ries-Kautt, M, Ducruix, A, Lafont, S, Astier, J.P, Veesler, S.
Deposit date:1998-11-06
Release date:1998-11-11
Last modified:2023-08-09
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:The BPTI decamer observed in acidic pH crystal forms pre-exists as a stable species in solution.
J.Mol.Biol., 297, 2000
4PTI
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BU of 4pti by Molmil
THE GEOMETRY OF THE REACTIVE SITE AND OF THE PEPTIDE GROUPS IN TRYPSIN, TRYPSINOGEN AND ITS COMPLEXES WITH INHIBITORS
Descriptor: TRYPSIN INHIBITOR
Authors:Huber, R, Kukla, D, Ruehlmann, A, Epp, O, Formanek, H, Deisenhofer, J, Steigemann, W.
Deposit date:1982-09-27
Release date:1983-01-18
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:The Geometry of the Reactive Site and of the Peptide Groups in Trypsin, Trypsinogen and its Complexes with Inhibitors
Acta Crystallogr.,Sect.B, 39, 1983
4BQD
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BU of 4bqd by Molmil
KD1 of human TFPI in complex with a synthetic peptide
Descriptor: GLYCEROL, PEPTIDE, TISSUE FACTOR PATHWAY INHIBITOR (LIPOPROTEIN-ASSOCIATED COAGULATION INHIBITOR) VARIANT
Authors:Griessner, A, Brandstetter, H.
Deposit date:2013-05-30
Release date:2013-12-04
Last modified:2019-07-17
Method:X-RAY DIFFRACTION (2.48 Å)
Cite:Small Peptides Blocking Inhibition of Factor Xa and Tissue Factor-Factor Viia by Tissue Factor Pathway Inhibitor (Tfpi)
J.Biol.Chem., 289, 2014
3OFW
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BU of 3ofw by Molmil
Crystal structure of recombinant Kunitz Type serine protease Inhibitor-1 from the Carribean sea anemone stichodactyla helianthus
Descriptor: CHLORIDE ION, Kunitz-type proteinase inhibitor SHPI-1
Authors:Garcia-Fernandez, R, Redecke, L, Pons, T, Perbandt, M, Talavera, A, Gil, D, Gonzalez, Y, de los Angeles Chavez, M, Betzel, C.
Deposit date:2010-08-16
Release date:2011-08-17
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structure of the recombinant BPTI/Kunitz-type inhibitor rShPI-1A from the marine invertebrate Stichodactyla helianthus.
Acta Crystallogr.,Sect.F, 68, 2012
2CA7
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BU of 2ca7 by Molmil
Conkunitzin-S1 Is The First Member Of A New Kunitz-Type Neurotoxin Family- Structural and Functional Characterization
Descriptor: CONKUNITZIN-S1
Authors:Bayrhuber, M, Vijayan, V, Ferber, M, Graf, R, Korukottu, J, Imperial, J, Garrett, J.E, Olivera, B.M, Terlau, H, Zweckstetter, M, Becker, S.
Deposit date:2005-12-19
Release date:2006-01-05
Last modified:2020-01-15
Method:SOLUTION NMR
Cite:Conkunitzin-S1 is the first member of a new Kunitz-type neurotoxin family. Structural and functional characterization.
J. Biol. Chem., 280, 2005
4DTG
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BU of 4dtg by Molmil
Hemostatic effect of a monoclonal antibody mAb 2021 blocking the interaction between FXa and TFPI in a rabbit hemophilia model
Descriptor: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, GLYCEROL, Humanized recombinant FAB fragment, ...
Authors:Svensson, L.A, Breinholt, J, Krogh, B.O, Hilden, I.
Deposit date:2012-02-21
Release date:2012-06-13
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Hemostatic effect of a monoclonal antibody mAb 2021 blocking the interaction between FXa and TFPI in a rabbit hemophilia model.
Blood, 119, 2012
2DDI
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BU of 2ddi by Molmil
NMR structure of the second Kunitz domain of human WFIKKN1
Descriptor: WAP, follistatin/kazal, immunoglobulin, ...
Authors:Liepinsh, E, Otting, G.
Deposit date:2006-01-30
Release date:2006-12-19
Last modified:2022-03-09
Method:SOLUTION NMR
Cite:Second Kunitz-type protease inhibitor domain of the human WFIKKN1 protein
J.Biomol.Nmr, 35, 2006

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数据于2024-03-27公开中

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