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5YHL
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BU of 5yhl by Molmil
Crystal structure of the human prostaglandin E receptor EP4 in complex with Fab and an antagonist Br-derivative
Descriptor: 4-[2-[[(2R)-2-(4-bromanylnaphthalen-1-yl)propanoyl]amino]-4-cyano-phenyl]butanoic acid, Heavy chain of Fab fragment, Light chain of Fab fragment, ...
Authors:Toyoda, Y, Morimoto, K, Suno, R, Horita, S, Iwata, S, Kobayashi, T.
Deposit date:2017-09-28
Release date:2018-12-05
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (4.2 Å)
Cite:Ligand binding to human prostaglandin E receptor EP4at the lipid-bilayer interface.
Nat. Chem. Biol., 15, 2019
5YWY
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BU of 5ywy by Molmil
Crystal structure of the human prostaglandin E receptor EP4 in complex with Fab and ONO-AE3-208
Descriptor: 4-[4-cyano-2-[[(2R)-2-(4-fluoranylnaphthalen-1-yl)propanoyl]amino]phenyl]butanoic acid, Heavy chain of Fab fragment, Light chain of Fab fragment, ...
Authors:Toyoda, Y, Morimoto, K, Suno, R, Horita, S, Iwata, S, Kobayashi, T.
Deposit date:2017-11-30
Release date:2018-12-05
Last modified:2018-12-19
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Ligand binding to human prostaglandin E receptor EP4at the lipid-bilayer interface.
Nat. Chem. Biol., 15, 2019
6KR8
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BU of 6kr8 by Molmil
Structure of the beta2 adrenergic receptor in the full agonist bound state
Descriptor: beta 2 adrenergic receptor
Authors:Imai, S, Shimada, I.
Deposit date:2019-08-21
Release date:2020-01-29
Last modified:2020-04-08
Method:SOLUTION NMR
Cite:Structural equilibrium underlying ligand-dependent activation of beta2-adrenoreceptor.
Nat.Chem.Biol., 16, 2020
6KUY
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BU of 6kuy by Molmil
Crystal structure of the alpha2A adrenergic receptor in complex with a partial agonist
Descriptor: (2~{S})-4-fluoranyl-2-(1~{H}-imidazol-5-yl)-1-propan-2-yl-2,3-dihydroindole, Alpha2A adrenergic receptor, DI(HYDROXYETHYL)ETHER
Authors:Qu, L, Zhou, Q.T, Wu, D, Zhao, S.W.
Deposit date:2019-09-02
Release date:2019-12-04
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Crystal structures of the alpha2A adrenergic receptor in complex with a partial agonist
To Be Published
6KUX
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BU of 6kux by Molmil
Crystal structures of the alpha2A adrenergic receptor in complex with an antagonist RSC.
Descriptor: (8~{a}~{R},12~{a}~{S},13~{a}~{S})-12-ethylsulfonyl-3-methoxy-5,6,8,8~{a},9,10,11,12~{a},13,13~{a}-decahydroisoquinolino[2,1-g][1,6]naphthyridine, CITRATE ANION, DI(HYDROXYETHYL)ETHER, ...
Authors:Qu, L, Zhou, Q.T, Wu, D, Zhao, S.W.
Deposit date:2019-09-02
Release date:2019-12-04
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Crystal structures of the alpha2A adrenergic receptor in complex with an antagonist RSC.
To Be Published
6N48
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BU of 6n48 by Molmil
Structure of beta2 adrenergic receptor bound to BI167107, Nanobody 6B9, and a positive allosteric modulator
Descriptor: (2S)-2,3-dihydroxypropyl (7Z)-tetradec-7-enoate, 8-[(1R)-2-{[1,1-dimethyl-2-(2-methylphenyl)ethyl]amino}-1-hydroxyethyl]-5-hydroxy-2H-1,4-benzoxazin-3(4H)-one, Camelid Antibody Fragment, ...
Authors:Liu, X, Masoudi, A, Kahsai, A.W, Huang, L.Y, Pani, B, Hirata, K, Ahn, S, Lefkowitz, R.J, Kobilka, B.K.
Deposit date:2018-11-17
Release date:2019-06-26
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Mechanism of beta2AR regulation by an intracellular positive allosteric modulator.
Science, 364, 2019
7SK9
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BU of 7sk9 by Molmil
Cryo-EM structure of human ACKR3 in complex with a small molecule partial agonist CCX662, and an intracellular Fab
Descriptor: (1R)-4-[7-(3-carboxypropoxy)-6-methylquinolin-8-yl]-1-{[2-(4-hydroxypiperidin-1-yl)-1,3-thiazol-4-yl]methyl}-1,4-diazepan-1-ium, Atypical chemokine receptor 3, CHOLESTEROL, ...
Authors:Yen, Y.C, Schafer, C.T, Gustavsson, M, Handel, T.M, Tesmer, J.J.G.
Deposit date:2021-10-19
Release date:2022-07-27
Method:ELECTRON MICROSCOPY (3.7 Å)
Cite:Structures of atypical chemokine receptor 3 reveal the basis for its promiscuity and signaling bias.
Sci Adv, 8, 2022
7SRQ
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BU of 7srq by Molmil
5-HT2B receptor bound to LSD obtained by cryo-electron microscopy (cryoEM)
Descriptor: (8alpha)-N,N-diethyl-6-methyl-9,10-didehydroergoline-8-carboxamide, 2-acetamido-2-deoxy-beta-D-glucopyranose, 5-hydroxytryptamine receptor 2B
Authors:Barros-Alvarez, X, Cao, C, Panova, O, Roth, B.L, Skiniotis, G.
Deposit date:2021-11-08
Release date:2022-09-21
Last modified:2022-10-19
Method:ELECTRON MICROSCOPY (2.7 Å)
Cite:Signaling snapshots of a serotonin receptor activated by the prototypical psychedelic LSD.
Neuron, 110, 2022
7TUY
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BU of 7tuy by Molmil
Cryo-EM structure of GSK682753A-bound EBI2/GPR183
Descriptor: 8-[(2E)-3-(4-chlorophenyl)prop-2-enoyl]-3-[(3,4-dichlorophenyl)methyl]-1-oxa-3,8-diazaspiro[4.5]decan-2-one, G-protein coupled receptor 183,Soluble cytochrome b562 fusion, anti-BRIL Fab Heavy chain, ...
Authors:Chen, H, Huang, W, Li, X.
Deposit date:2022-02-03
Release date:2022-04-13
Last modified:2022-07-20
Method:ELECTRON MICROSCOPY (2.98 Å)
Cite:Structures of oxysterol sensor EBI2/GPR183, a key regulator of the immune response.
Structure, 30, 2022
8WCC
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BU of 8wcc by Molmil
Cryo-EM structure of the CHA-bound mTAAR1 complex
Descriptor: CYCLOHEXYLAMMONIUM ION, Trace amine-associated receptor 1
Authors:Rong, N.K, Guo, L.L, Zhang, M.H, Li, Q, Yang, F, Sun, J.P.
Deposit date:2023-09-11
Release date:2023-12-27
Method:ELECTRON MICROSCOPY (3.04 Å)
Cite:Structural and signaling mechanisms of TAAR1 enabled preferential agonist design.
Cell, 186, 2023
8XBI
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BU of 8xbi by Molmil
Human GPR34 -Gi complex bound to M1, receptor focused
Descriptor: (2~{S})-2-azanyl-3-[[(2~{R})-1-ethoxy-3-[3-[2-[(3-phenoxyphenyl)methoxy]phenyl]propanoyloxy]propan-2-yl]oxy-oxidanyl-phosphoryl]oxy-propanoic acid, Probable G-protein coupled receptor 34
Authors:Kawahara, R, Shihoya, W, Nureki, O.
Deposit date:2023-12-06
Release date:2023-12-27
Method:ELECTRON MICROSCOPY (3.06 Å)
Cite:Cryo-EM structure of the Human GPR34-Gi complex bound to S3E-LysoPS
To Be Published
8W8S
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BU of 8w8s by Molmil
Cryo-EM structure of the AA14-bound GPR101 complex
Descriptor: 1-(4-methylpyridin-2-yl)-3-[3-(trifluoromethyl)phenyl]thiourea, Probable G-protein coupled receptor 101
Authors:Sun, J.P, Yu, X, Gao, N, Yang, F, Wang, J.Y, Yang, Z, Guan, Y, Wang, G.P.
Deposit date:2023-09-04
Release date:2024-01-03
Method:ELECTRON MICROSCOPY (3.3 Å)
Cite:Structure of GPR101-Gs enables identification of ligands with rejuvenating potential.
Nat.Chem.Biol., 2023
8WDT
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BU of 8wdt by Molmil
Crystal structure of the human adenosine A2A receptor in complex with photoresponsive ligand photoNECA(blue)
Descriptor: (2S,3S,4R,5R)-5-(6-amino-2-((E)-phenyldiazenyl)-9H-purin-9-yl)-N-ethyl-3,4-dihydroxytetrahydrofuran-2-carboxamide, Adenosine receptor A2a, Antibody Fab fragment heavy chain, ...
Authors:Araya, T, Asada, H, Iwata, S, Im, D.H.
Deposit date:2023-09-16
Release date:2024-01-17
Method:X-RAY DIFFRACTION (3.34 Å)
Cite:Crystal structure reveals the binding mode and selectivity of a photoswitchable ligand for the adenosine A 2A receptor.
Biochem.Biophys.Res.Commun., 695, 2023
7C4S
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BU of 7c4s by Molmil
Sphingosine-1-phosphate receptor 3 with a natural ligand.
Descriptor: (2S,3R,4E)-2-amino-3-hydroxyoctadec-4-en-1-yl dihydrogen phosphate, Antibody Fab fragment heavy chain, Antibody Fab fragment light chain, ...
Authors:Iwata, S, Maeda, S, Luo, F, Nango, E, hirata, K, Asada, H.
Deposit date:2020-05-18
Release date:2021-06-09
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Endogenous agonist-bound S1PR3 structure reveals determinants of G protein-subtype bias.
Sci Adv, 7, 2021
8EA0
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BU of 8ea0 by Molmil
CryoEM structure of miniGq-coupled hM3R in complex with iperoxo (local refinement)
Descriptor: 4-(4,5-dihydro-1,2-oxazol-3-yloxy)-N,N,N-trimethylbut-2-yn-1-aminium, CHOLESTEROL HEMISUCCINATE, Muscarinic acetylcholine receptor M3
Authors:Zhang, S, Fay, J.F, Roth, B.L.
Deposit date:2022-08-27
Release date:2022-11-30
Last modified:2022-12-21
Method:ELECTRON MICROSCOPY (2.56 Å)
Cite:Molecular basis for selective activation of DREADD-based chemogenetics.
Nature, 612, 2022
8E0G
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BU of 8e0g by Molmil
Re-refined model of active mu-opioid receptor (PDB 5c1m) as an adduct with BU72
Descriptor: (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, (2R,3S,3aR,5aR,6R,11bR,11cS)-3a-methoxy-3,14-dimethyl-2-phenyl-2,3,3a,6,7,11c-hexahydro-1H-6,11b-(epiminoethano)-3,5a-methanonaphtho[2,1-g]indol-10-ol, CHOLESTEROL, ...
Authors:Munro, T.A.
Deposit date:2022-08-09
Release date:2023-10-18
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Reanalysis of a mu opioid receptor crystal structure reveals a covalent adduct with BU72.
Bmc Biol., 21, 2023
8GGX
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BU of 8ggx by Molmil
Locally refined cryoEM structure of receptor from beta-2-adrenergic receptor in complex with GTP-bound Gs heterotrimer (transition intermediate #16 of 20)
Descriptor: (5R,6R)-6-(methylamino)-5,6,7,8-tetrahydronaphthalene-1,2,5-triol, Beta-2 adrenergic receptor
Authors:Papasergi-Scott, M.M, Skiniotis, G.
Deposit date:2023-03-08
Release date:2024-03-06
Last modified:2024-03-27
Method:ELECTRON MICROSCOPY (3.6 Å)
Cite:Time-resolved cryo-EM of G-protein activation by a GPCR.
Nature, 2024
8GGJ
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BU of 8ggj by Molmil
Locally refined cryoEM structure of receptor from beta-2-adrenergic receptor in complex with GTP-bound Gs heterotrimer (transition intermediate #2 of 20)
Descriptor: (5R,6R)-6-(methylamino)-5,6,7,8-tetrahydronaphthalene-1,2,5-triol, Beta-2 adrenergic receptor
Authors:Papasergi-Scott, M.M, Skiniotis, G.
Deposit date:2023-03-08
Release date:2024-03-06
Last modified:2024-03-27
Method:ELECTRON MICROSCOPY (3.5 Å)
Cite:Time-resolved cryo-EM of G-protein activation by a GPCR.
Nature, 2024
8GGO
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BU of 8ggo by Molmil
Locally refined cryoEM structure of receptor from beta-2-adrenergic receptor in complex with GTP-bound Gs heterotrimer (transition intermediate #7 of 20)
Descriptor: (5R,6R)-6-(methylamino)-5,6,7,8-tetrahydronaphthalene-1,2,5-triol, Beta-2 adrenergic receptor
Authors:Papasergi-Scott, M.M, Skiniotis, G.
Deposit date:2023-03-08
Release date:2024-03-06
Last modified:2024-03-27
Method:ELECTRON MICROSCOPY (3.2 Å)
Cite:Time-resolved cryo-EM of G-protein activation by a GPCR.
Nature, 2024
8GH1
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BU of 8gh1 by Molmil
Locally refined cryoEM structure of receptor from beta-2-adrenergic receptor in complex with GTP-bound Gs heterotrimer (transition intermediate #20 of 20)
Descriptor: (5R,6R)-6-(methylamino)-5,6,7,8-tetrahydronaphthalene-1,2,5-triol, Beta-2 adrenergic receptor
Authors:Papasergi-Scott, M.M, Skiniotis, G.
Deposit date:2023-03-08
Release date:2024-03-06
Last modified:2024-03-27
Method:ELECTRON MICROSCOPY (4.1 Å)
Cite:Time-resolved cryo-EM of G-protein activation by a GPCR.
Nature, 2024
8GGY
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BU of 8ggy by Molmil
Locally refined cryoEM structure of receptor from beta-2-adrenergic receptor in complex with GTP-bound Gs heterotrimer (transition intermediate #17 of 20)
Descriptor: (5R,6R)-6-(methylamino)-5,6,7,8-tetrahydronaphthalene-1,2,5-triol, Beta-2 adrenergic receptor
Authors:Papasergi-Scott, M.M, Skiniotis, G.
Deposit date:2023-03-08
Release date:2024-03-06
Last modified:2024-03-27
Method:ELECTRON MICROSCOPY (3.9 Å)
Cite:Time-resolved cryo-EM of G-protein activation by a GPCR.
Nature, 2024
8GGL
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BU of 8ggl by Molmil
Locally refined cryoEM structure of receptor from beta-2-adrenergic receptor in complex with GTP-bound Gs heterotrimer (transition intermediate #4 of 20)
Descriptor: (5R,6R)-6-(methylamino)-5,6,7,8-tetrahydronaphthalene-1,2,5-triol, Beta-2 adrenergic receptor
Authors:Papasergi-Scott, M.M, Skiniotis, G.
Deposit date:2023-03-08
Release date:2024-03-06
Last modified:2024-03-27
Method:ELECTRON MICROSCOPY (3.2 Å)
Cite:Time-resolved cryo-EM of G-protein activation by a GPCR.
Nature, 2024
8GGV
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BU of 8ggv by Molmil
Locally refined cryoEM structure of receptor from beta-2-adrenergic receptor in complex with GTP-bound Gs heterotrimer (transition intermediate #14 of 20)
Descriptor: (5R,6R)-6-(methylamino)-5,6,7,8-tetrahydronaphthalene-1,2,5-triol, Beta-2 adrenergic receptor
Authors:Papasergi-Scott, M.M, Skiniotis, G.
Deposit date:2023-03-08
Release date:2024-03-06
Last modified:2024-03-27
Method:ELECTRON MICROSCOPY (3.5 Å)
Cite:Time-resolved cryo-EM of G-protein activation by a GPCR.
Nature, 2024
8GH0
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BU of 8gh0 by Molmil
Locally refined cryoEM structure of receptor from beta-2-adrenergic receptor in complex with GTP-bound Gs heterotrimer (transition intermediate #19 of 20)
Descriptor: (5R,6R)-6-(methylamino)-5,6,7,8-tetrahydronaphthalene-1,2,5-triol, Beta-2 adrenergic receptor
Authors:Papasergi-Scott, M.M, Skiniotis, G.
Deposit date:2023-03-08
Release date:2024-03-06
Last modified:2024-03-27
Method:ELECTRON MICROSCOPY (4 Å)
Cite:Time-resolved cryo-EM of G-protein activation by a GPCR.
Nature, 2024
8GGM
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BU of 8ggm by Molmil
Locally refined cryoEM structure of receptor from beta-2-adrenergic receptor in complex with GTP-bound Gs heterotrimer (transition intermediate #5 of 20)
Descriptor: (5R,6R)-6-(methylamino)-5,6,7,8-tetrahydronaphthalene-1,2,5-triol, Beta-2 adrenergic receptor
Authors:Papasergi-Scott, M.M, Skiniotis, G.
Deposit date:2023-03-08
Release date:2024-03-06
Last modified:2024-03-27
Method:ELECTRON MICROSCOPY (3.2 Å)
Cite:Time-resolved cryo-EM of G-protein activation by a GPCR.
Nature, 2024

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数据于2024-03-27公开中

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