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5HK1
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BU of 5hk1 by Molmil
Human sigma-1 receptor bound to PD144418
Descriptor: (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, 3-(4-methylphenyl)-5-(1-propyl-3,6-dihydro-2H-pyridin-5-yl)-1,2-oxazole, SULFATE ION, ...
Authors:Schmidt, H.R, Zheng, S, Gurpinar, E, Koehl, A, Manglik, A, Kruse, A.C.
Deposit date:2016-01-13
Release date:2016-04-06
Last modified:2024-03-06
Method:X-RAY DIFFRACTION (2.5051 Å)
Cite:Crystal structure of the human sigma 1 receptor.
Nature, 532, 2016
5HK2
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BU of 5hk2 by Molmil
Human sigma-1 receptor bound to 4-IBP
Descriptor: (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, N-(1-benzylpiperidin-4-yl)-4-iodobenzamide, SULFATE ION, ...
Authors:Schmidt, H.R, Zheng, S, Gurpinar, E.G, Koehl, A, Manglik, A, Kruse, A.C.
Deposit date:2016-01-13
Release date:2016-04-06
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Crystal structure of the human sigma 1 receptor.
Nature, 532, 2016
6DK1
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BU of 6dk1 by Molmil
Human sigma-1 receptor bound to (+)-pentazocine
Descriptor: (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, (2S,6S,11S)-6,11-dimethyl-3-(3-methylbut-2-en-1-yl)-1,2,3,4,5,6-hexahydro-2,6-methano-3-benzazocin-8-ol, GLYCEROL, ...
Authors:Schmidt, H.R, Kruse, A.C.
Deposit date:2018-05-28
Release date:2018-10-17
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (3.12 Å)
Cite:Structural basis for sigma1receptor ligand recognition.
Nat. Struct. Mol. Biol., 25, 2018
6DK0
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BU of 6dk0 by Molmil
Human sigma-1 receptor bound to NE-100
Descriptor: (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, GLYCEROL, N-{2-[4-methoxy-3-(2-phenylethoxy)phenyl]ethyl}-N-propylpropan-1-amine, ...
Authors:Schmidt, H.R, Kruse, A.C.
Deposit date:2018-05-28
Release date:2018-10-17
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Structural basis for sigma1receptor ligand recognition.
Nat. Struct. Mol. Biol., 25, 2018
6DJZ
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BU of 6djz by Molmil
Human sigma-1 receptor bound to haloperidol
Descriptor: (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, 4-[4-(4-chlorophenyl)-4-hydroxypiperidin-1-yl]-1-(4-fluorophenyl)butan-1-one, GLYCEROL, ...
Authors:Schmidt, H.R, Kruse, A.C.
Deposit date:2018-05-28
Release date:2018-10-17
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (3.084 Å)
Cite:Structural basis for sigma1receptor ligand recognition.
Nat. Struct. Mol. Biol., 25, 2018
7W2F
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BU of 7w2f by Molmil
An open-like conformation of the sigma-1 receptor from Xenopus laevis complexed with PRE084 by co-crystallization
Descriptor: 2-morpholin-4-ylethyl 1-phenylcyclohexane-1-carboxylate, Sigma non-opioid intracellular receptor 1, octyl beta-D-glucopyranoside
Authors:Meng, F, Sun, Z, Zhou, X.
Deposit date:2021-11-23
Release date:2022-03-16
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:An open-like conformation of the sigma-1 receptor reveals its ligand entry pathway.
Nat Commun, 13, 2022
7W2D
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BU of 7w2d by Molmil
The closed conformation of the sigma-1 receptor from Xenopus laevis complexed with S1RA
Descriptor: 4-[2-(5-methyl-1-naphthalen-2-yl-pyrazol-3-yl)oxyethyl]morpholine, GOLD ION, Sigma non-opioid intracellular receptor 1
Authors:Meng, F, Sun, Z, Zhou, X.
Deposit date:2021-11-23
Release date:2022-03-16
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (3.471 Å)
Cite:An open-like conformation of the sigma-1 receptor reveals its ligand entry pathway.
Nat Commun, 13, 2022
7W2B
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BU of 7w2b by Molmil
The closed conformation of the sigma-1 receptor from Xenopus laevis
Descriptor: GOLD ION, Sigma non-opioid intracellular receptor 1, octyl beta-D-glucopyranoside
Authors:Meng, F, Sun, Z, Zhou, X.
Deposit date:2021-11-23
Release date:2022-03-16
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (3.203 Å)
Cite:An open-like conformation of the sigma-1 receptor reveals its ligand entry pathway.
Nat Commun, 13, 2022
7W2H
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BU of 7w2h by Molmil
A double cysteine variant of the sigma-1 receptor from Xenopus laevis complexed with S1RA
Descriptor: 4-[2-(5-methyl-1-naphthalen-2-yl-pyrazol-3-yl)oxyethyl]morpholine, Sigma non-opioid intracellular receptor 1
Authors:Meng, F, Sun, Z, Zhou, X.
Deposit date:2021-11-23
Release date:2022-03-16
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (3.796 Å)
Cite:An open-like conformation of the sigma-1 receptor reveals its ligand entry pathway.
Nat Commun, 13, 2022
7W2G
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BU of 7w2g by Molmil
An open-like conformation of the sigma-1 receptor from Xenopus laevis complexed with PRE084 by soaking
Descriptor: 2-morpholin-4-ylethyl 1-phenylcyclohexane-1-carboxylate, Sigma non-opioid intracellular receptor 1, octyl beta-D-glucopyranoside
Authors:Meng, F, Sun, Z, Zhou, X.
Deposit date:2021-11-23
Release date:2022-03-16
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (2.851 Å)
Cite:An open-like conformation of the sigma-1 receptor reveals its ligand entry pathway.
Nat Commun, 13, 2022
7W2C
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BU of 7w2c by Molmil
The closed conformation of the sigma-1 receptor from Xenopus laevis complexed with PRE084
Descriptor: 2-morpholin-4-ylethyl 1-phenylcyclohexane-1-carboxylate, GOLD ION, Sigma non-opioid intracellular receptor 1, ...
Authors:Meng, F, Sun, Z, Zhou, X.
Deposit date:2021-11-23
Release date:2022-03-16
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (3.335 Å)
Cite:An open-like conformation of the sigma-1 receptor reveals its ligand entry pathway.
Nat Commun, 13, 2022
7W2E
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BU of 7w2e by Molmil
An open-like conformation of the sigma-1 receptor from Xenopus laevis
Descriptor: Sigma non-opioid intracellular receptor 1
Authors:Meng, F, Sun, Z, Zhou, X.
Deposit date:2021-11-23
Release date:2022-03-16
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (3.557 Å)
Cite:An open-like conformation of the sigma-1 receptor reveals its ligand entry pathway.
Nat Commun, 13, 2022

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