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5XNW
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Crystal structure of ExoY, a unique nucleotidyl cyclase toxin from Pseudomonas aeruginosa
Descriptor: Adenylate cyclase ExoY, GLYCEROL, SULFATE ION
Authors:Khanppnavar, B, Datta, S.
Deposit date:2017-05-24
Release date:2018-05-30
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (2.201 Å)
Cite:Crystal structure and substrate specificity of ExoY, a unique T3SS mediated secreted nucleotidyl cyclase toxin from Pseudomonas aeruginosa
Biochim. Biophys. Acta, 1862, 2018
1PK0
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BU of 1pk0 by Molmil
Crystal Structure of the EF3-CaM complexed with PMEApp
Descriptor: (ADENIN-9-YL-ETHOXYMETHYL)-HYDROXYPHOSPHINYL-DIPHOSPHATE, CALCIUM ION, Calmodulin, ...
Authors:Shen, Y, Tang, W.J.
Deposit date:2003-06-04
Release date:2004-02-10
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (3.3 Å)
Cite:Selective inhibition of anthrax edema factor by adefovir, a drug for chronic hepatitis B virus infection.
Proc.Natl.Acad.Sci.USA, 101, 2004
1S26
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BU of 1s26 by Molmil
Structure of Anthrax Edema Factor-Calmodulin-alpha,beta-methyleneadenosine 5'-triphosphate Complex Reveals an Alternative Mode of ATP Binding to the Catalytic Site
Descriptor: CALCIUM ION, Calmodulin, Calmodulin-sensitive adenylate cyclase, ...
Authors:Shen, Y, Zhukovskaya, N.L, Bohm, A, Tang, W.-J.
Deposit date:2004-01-08
Release date:2004-04-13
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (3 Å)
Cite:Structure of anthrax edema factor-calmodulin-adenosine-5'-(alpha,beta-methylene)-triphosphate complex reveals an alternative mode of ATP binding to the catalytic site
Biochem.Biophys.Res.Commun., 317, 2004
1SK6
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BU of 1sk6 by Molmil
Crystal structure of the adenylyl cyclase domain of anthrax edema factor (EF) in complex with calmodulin, 3',5' cyclic AMP (cAMP), and pyrophosphate
Descriptor: ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE, CALCIUM ION, Calmodulin, ...
Authors:Guo, Q, Shen, Y, Zhukovskaya, N.L, Tang, W.J.
Deposit date:2004-03-04
Release date:2004-06-08
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Structural and kinetic analyses of the interaction of anthrax adenylyl cyclase toxin with reaction products cAMP and pyrophosphate.
J.Biol.Chem., 279, 2004
1YRU
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BU of 1yru by Molmil
Crystal Structure analysis of the adenylyl cyclaes catalytic domain of adenylyl cyclase toxin of Bordetella pertussis in presence of c-terminal calmodulin and 1mM calcium chloride
Descriptor: Bifunctional hemolysin-adenylate cyclase, CALCIUM ION, Calmodulin
Authors:Guo, Q, Shen, Y, Tang, W.J.
Deposit date:2005-02-04
Release date:2005-09-27
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structural basis for the interaction of Bordetella pertussis adenylyl cyclase toxin with calmodulin
Embo J., 24, 2005
1YRT
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Crystal Structure analysis of the adenylyl cyclaes catalytic domain of adenylyl cyclase toxin of Bordetella pertussis in presence of c-terminal calmodulin
Descriptor: Bifunctional hemolysin-adenylate cyclase, CALCIUM ION, Calmodulin
Authors:Guo, Q, Shen, Y, Lee, Y.S, Gibbs, C.S, Mrksich, M, Tang, W.J.
Deposit date:2005-02-04
Release date:2006-01-17
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structural basis for the interaction of Bordetella pertussis adenylyl cyclase toxin with calmodulin.
Embo J., 24, 2005
1ZOT
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BU of 1zot by Molmil
crystal structure analysis of the CyaA/C-Cam with PMEAPP
Descriptor: (ADENIN-9-YL-ETHOXYMETHYL)-HYDROXYPHOSPHINYL-DIPHOSPHATE, CALCIUM ION, Calmodulin, ...
Authors:Guo, Q, Tang, W.J.
Deposit date:2005-05-13
Release date:2005-08-09
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structural basis for the interaction of Bordetella pertussis adenylyl cyclase toxin with calmodulin.
Embo J., 24, 2005
1K90
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BU of 1k90 by Molmil
Crystal structure of the adenylyl cyclase domain of anthrax edema factor (EF) in complex with calmodulin and 3' deoxy-ATP
Descriptor: 3'-DEOXYADENOSINE-5'-TRIPHOSPHATE, CALCIUM ION, CALMODULIN, ...
Authors:Drum, C.L, Yan, S.-Z, Bard, J, Shen, Y.-Q, Lu, D, Soelaiman, S, Grabarek, Z, Bohm, A, Tang, W.-J.
Deposit date:2001-10-26
Release date:2002-01-23
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2.75 Å)
Cite:Structural basis for the activation of anthrax adenylyl cyclase exotoxin by calmodulin.
Nature, 415, 2002
1K8T
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BU of 1k8t by Molmil
Crystal structure of the adenylyl cyclase domain of anthrax edema factor (EF)
Descriptor: CALMODULIN-SENSITIVE ADENYLATE CYCLASE, NICKEL (II) ION, SULFATE ION
Authors:Drum, C.L, Yan, S.-Z, Bard, J, Shen, Y.-Q, Lu, D, Soelaiman, S, Grabarek, Z, Bohm, A, Tang, W.-J.
Deposit date:2001-10-25
Release date:2002-01-23
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Structural basis for the activation of anthrax adenylyl cyclase exotoxin by calmodulin
Nature, 415, 2002
1K93
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BU of 1k93 by Molmil
Crystal structure of the adenylyl cyclase domain of anthrax edema factor (EF) in complex with calmodulin
Descriptor: CALCIUM ION, CALMODULIN, CALMODULIN-SENSITIVE ADENYLATE CYCLASE, ...
Authors:Drum, C.L, Yan, S.-Z, Bard, J, Shen, Y.-Q, Lu, D, Soelaiman, S, Grabarek, Z, Bohm, A, Tang, W.-J.
Deposit date:2001-10-26
Release date:2002-01-23
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2.95 Å)
Cite:Structural basis for the activation of anthrax adenylyl cyclase exotoxin by calmodulin.
Nature, 415, 2002
2COL
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BU of 2col by Molmil
Crystal structure analysis of CyaA/C-Cam with Pyrophosphate
Descriptor: Bifunctional hemolysin-adenylate cyclase, CALCIUM ION, Calmodulin, ...
Authors:Guo, Q, Tang, W.J, Shen, Y.
Deposit date:2005-05-18
Release date:2006-01-24
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structural basis for the interaction of Bordetella pertussis adenylyl cyclase toxin with calmodulin
Embo J., 24, 2005
1LVC
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BU of 1lvc by Molmil
Crystal structure of the adenylyl cyclase domain of anthrax edema factor (EF) in complex with calmodulin and 2' deoxy, 3' anthraniloyl ATP
Descriptor: 3'ANTHRANILOYL-2'-DEOXY-ADENOSINE-5'-TRIPHOSPHATE, CALCIUM ION, YTTERBIUM (III) ION, ...
Authors:Shen, Y, Lee, Y.-S, Soelaiman, S, Bergson, P, Lu, D, Chen, A, Beckingham, K, Grabarek, Z, Mrksich, M, Tang, W.-J.
Deposit date:2002-05-28
Release date:2002-12-04
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (3.6 Å)
Cite:Physiological calcium concentrations regulate calmodulin binding and catalysis of adenylyl cyclase exotoxins
Embo J., 21, 2002
1XFX
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BU of 1xfx by Molmil
Crystal structure of anthrax edema factor (EF) in complex with calmodulin in the presence of 10 millimolar exogenously added calcium chloride
Descriptor: CALCIUM ION, Calmodulin 2, Calmodulin-sensitive adenylate cyclase, ...
Authors:Shen, Y, Zhukovskaya, N.L, Guo, Q, Florian, J, Tang, W.J.
Deposit date:2004-09-15
Release date:2005-05-03
Last modified:2017-12-20
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Calcium-independent calmodulin binding and two-metal-ion catalytic mechanism of anthrax edema factor.
EMBO J., 24, 2005
1XFZ
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BU of 1xfz by Molmil
Crystal structure of anthrax edema factor (EF) in complex with calmodulin in the presence of 1 millimolar exogenously added calcium chloride
Descriptor: CALCIUM ION, Calmodulin 2, Calmodulin-sensitive adenylate cyclase, ...
Authors:Shen, Y, Zhukovskaya, N.L, Guo, Q, Florian, J, Tang, W.J.
Deposit date:2004-09-15
Release date:2005-05-03
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (3.25 Å)
Cite:Calcium-independent calmodulin binding and two-metal-ion catalytic mechanism of anthrax edema factor.
EMBO J., 24, 2005
1XFU
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BU of 1xfu by Molmil
Crystal structure of anthrax edema factor (EF) truncation mutant, EF-delta 64 in complex with calmodulin
Descriptor: CALCIUM ION, Calmodulin 2, Calmodulin-sensitive adenylate cyclase, ...
Authors:Shen, Y, Zhukovskaya, N.L, Guo, Q, Florian, J, Tang, W.J.
Deposit date:2004-09-15
Release date:2005-05-03
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (3.35 Å)
Cite:Calcium-independent calmodulin binding and two-metal-ion catalytic mechanism of anthrax edema factor.
EMBO J., 24, 2005
1XFY
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BU of 1xfy by Molmil
Crystal structure of anthrax edema factor (EF) in complex with calmodulin
Descriptor: CALCIUM ION, Calmodulin 2, Calmodulin-sensitive adenylate cyclase, ...
Authors:Shen, Y, Zhukovskaya, N.L, Guo, Q, Florian, J, Tang, W.J.
Deposit date:2004-09-15
Release date:2005-05-03
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (3.3 Å)
Cite:Calcium-independent calmodulin binding and two-metal-ion catalytic mechanism of anthrax edema factor.
EMBO J., 24, 2005
1XFV
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BU of 1xfv by Molmil
Crystal structure of anthrax edema factor (EF) in complex with calmodulin and 3' deoxy-ATP
Descriptor: 3'-DEOXYADENOSINE-5'-TRIPHOSPHATE, CALCIUM ION, Calmodulin 2, ...
Authors:Shen, Q, Zhukovskaya, N.L, Guo, Q, Florian, J, Tang, W.J.
Deposit date:2004-09-15
Release date:2005-05-03
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (3.35 Å)
Cite:Calcium-independent calmodulin binding and two-metal-ion catalytic mechanism of anthrax edema factor.
EMBO J., 24, 2005
1XFW
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BU of 1xfw by Molmil
Crystal structure of anthrax edema factor (EF) in complex with calmodulin and 3'5' cyclic AMP (cAMP)
Descriptor: ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE, CALCIUM ION, Calmodulin 2, ...
Authors:Shen, Y, Zhukovskaya, N.L, Guo, Q, Florian, J, Tang, W.J.
Deposit date:2004-09-15
Release date:2005-05-03
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (3.4 Å)
Cite:Calcium-independent calmodulin binding and two-metal-ion catalytic mechanism of anthrax edema factor.
EMBO J., 24, 2005
1Y0V
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BU of 1y0v by Molmil
Crystal structure of anthrax edema factor (EF) in complex with calmodulin and pyrophosphate
Descriptor: CALCIUM ION, Calmodulin, Calmodulin-sensitive adenylate cyclase, ...
Authors:Shen, Y, Zhukovskaya, N.L, Guo, Q, Florian, J, Tang, W.-J.
Deposit date:2004-11-16
Release date:2005-05-03
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (3.6 Å)
Cite:Calcium-independent calmodulin binding and two-metal-ion catalytic mechanism of anthrax edema factor
Embo J., 24, 2005
6VRA
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BU of 6vra by Molmil
Anthrax octamer prechannel bound to full-length edema factor
Descriptor: CALCIUM ION, Calmodulin-sensitive adenylate cyclase, Protective antigen
Authors:Zhou, K, Hardenbrook, N.J, Liu, S, Cui, Y.X, Krantz, B.A, Zhou, Z.H.
Deposit date:2020-02-07
Release date:2020-12-16
Last modified:2024-03-06
Method:ELECTRON MICROSCOPY (3.3 Å)
Cite:Atomic Structures of Anthrax Prechannel Bound with Full-Length Lethal and Edema Factors.
Structure, 28, 2020
7P1G
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BU of 7p1g by Molmil
Structure of the P. aeruginosa ExoY-F-actin complex
Descriptor: 3'-DEOXY-GUANOSINE-5'-TRIPHOSPHATE, ADENOSINE-5'-DIPHOSPHATE, Actin, ...
Authors:Belyy, A, Merino, F, Raunser, S.
Deposit date:2021-07-01
Release date:2021-11-17
Last modified:2021-12-01
Method:ELECTRON MICROSCOPY (3.2 Å)
Cite:Mechanism of actin-dependent activation of nucleotidyl cyclase toxins from bacterial human pathogens.
Nat Commun, 12, 2021
7P1H
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BU of 7p1h by Molmil
Structure of the V. vulnificus ExoY-G-actin-profilin complex
Descriptor: ADENOSINE-5'-TRIPHOSPHATE, Actin, cytoplasmic 1, ...
Authors:Belyy, A, Merino, F, Raunser, S.
Deposit date:2021-07-01
Release date:2021-11-17
Last modified:2021-12-01
Method:ELECTRON MICROSCOPY (3.9 Å)
Cite:Mechanism of actin-dependent activation of nucleotidyl cyclase toxins from bacterial human pathogens.
Nat Commun, 12, 2021
6UZB
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BU of 6uzb by Molmil
Anthrax toxin protective antigen channels bound to edema factor
Descriptor: CALCIUM ION, Calmodulin-sensitive adenylate cyclase, Protective antigen
Authors:Hardenbrook, N.J, Liu, S, Zhou, K, Zhou, Z.H, Krantz, B.A.
Deposit date:2019-11-14
Release date:2020-03-04
Last modified:2024-03-06
Method:ELECTRON MICROSCOPY (3.2 Å)
Cite:Atomic structures of anthrax toxin protective antigen channels bound to partially unfolded lethal and edema factors.
Nat Commun, 11, 2020
6UZE
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BU of 6uze by Molmil
Anthrax toxin protective antigen channels bound to edema factor
Descriptor: CALCIUM ION, Calmodulin-sensitive adenylate cyclase, Protective antigen
Authors:Hardenbrook, N.J, Liu, S, Zhou, K, Zhou, Z.H, Krantz, B.A.
Deposit date:2019-11-15
Release date:2020-03-04
Last modified:2024-03-06
Method:ELECTRON MICROSCOPY (3.4 Å)
Cite:Atomic structures of anthrax toxin protective antigen channels bound to partially unfolded lethal and edema factors.
Nat Commun, 11, 2020
6UZD
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BU of 6uzd by Molmil
Anthrax toxin protective antigen channels bound to edema factor
Descriptor: CALCIUM ION, Calmodulin-sensitive adenylate cyclase, Protective antigen
Authors:Hardenbrook, N.J, Liu, S, Zhou, K, Zhou, Z.H, Krantz, B.A.
Deposit date:2019-11-14
Release date:2020-03-04
Last modified:2024-03-06
Method:ELECTRON MICROSCOPY (3.4 Å)
Cite:Atomic structures of anthrax toxin protective antigen channels bound to partially unfolded lethal and edema factors.
Nat Commun, 11, 2020

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