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7UJJ
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BU of 7ujj by Molmil
Stx2a and DARPin complex
Descriptor: 1,2-ETHANEDIOL, 3-PYRIDINIUM-1-YLPROPANE-1-SULFONATE, DARPin, ...
Authors:Jiang, M, Zhang, J.
Deposit date:2022-03-30
Release date:2023-04-12
Method:ELECTRON MICROSCOPY (6.5 Å)
Cite:A Multi-Specific DARPin Potently Neutralizes Shiga Toxin 2 via Simultaneous Modulation of Both Toxin Subunits.
Bioengineering (Basel), 9, 2022
7U6V
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BU of 7u6v by Molmil
Cryo-EM structure of Shiga toxin 2 in complex with the native ribosomal P-stalk
Descriptor: C-terminal domain (CTD) from the Ribosomal P-stalk, Shiga toxin 2a subunit A (Stx2A), Shiga toxin 2a subunit B (Stx2B)
Authors:Kulczyk, A.W.
Deposit date:2022-03-06
Release date:2023-01-11
Method:ELECTRON MICROSCOPY (4.1 Å)
Cite:Cryo-EM structure of Shiga toxin 2 in complex with the native ribosomal P-stalk reveals residues involved in the binding interaction.
J.Biol.Chem., 299, 2022
7VHF
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BU of 7vhf by Molmil
Crystal structure of the STX2a complexed with RRA peptide
Descriptor: 3-PYRIDINIUM-1-YLPROPANE-1-SULFONATE, GLYCEROL, RRA peptide, ...
Authors:Senda, M, Takahashi, M, Nishikawa, K, Senda, T.
Deposit date:2021-09-22
Release date:2022-07-20
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:A unique peptide-based pharmacophore identifies an inhibitory compound against the A-subunit of Shiga toxin.
Sci Rep, 12, 2022
7VHD
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BU of 7vhd by Molmil
Crystal structure of the STX2a complexed with R4A peptide
Descriptor: 3-PYRIDINIUM-1-YLPROPANE-1-SULFONATE, ARG-ARG-ARG-ARG-ALA, Shiga toxin 2 B subunit, ...
Authors:Senda, M, Takahashi, M, Nishikawa, K, Senda, T.
Deposit date:2021-09-22
Release date:2022-07-20
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:A unique peptide-based pharmacophore identifies an inhibitory compound against the A-subunit of Shiga toxin.
Sci Rep, 12, 2022
7VHE
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BU of 7vhe by Molmil
Crystal structure of the STX2a complexed with RRRA peptide
Descriptor: 3-PYRIDINIUM-1-YLPROPANE-1-SULFONATE, GLYCEROL, RRRA peptide, ...
Authors:Senda, M, Takahashi, M, Nishikawa, K, Senda, T.
Deposit date:2021-09-22
Release date:2022-07-20
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:A unique peptide-based pharmacophore identifies an inhibitory compound against the A-subunit of Shiga toxin.
Sci Rep, 12, 2022
7VHC
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BU of 7vhc by Molmil
Crystal structure of the STX2a complexed with AR4A peptide
Descriptor: 3-PYRIDINIUM-1-YLPROPANE-1-SULFONATE, Shiga toxin 2 B subunit, inhibitor peptide, ...
Authors:Senda, M, Takahashi, M, Nishikawa, K, Senda, T.
Deposit date:2021-09-22
Release date:2022-07-20
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:A unique peptide-based pharmacophore identifies an inhibitory compound against the A-subunit of Shiga toxin.
Sci Rep, 12, 2022
7D6Q
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Crystal structure of the Stx2a
Descriptor: 3-PYRIDINIUM-1-YLPROPANE-1-SULFONATE, Shiga toxin 2 B subunit, rRNA N-glycosylase
Authors:Takahashi, M, Tamada, M, Hibino, M, Senda, M, Okuda, A, Miyazawa, A, Senda, T, Nishikawa, K.
Deposit date:2020-10-01
Release date:2021-04-14
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Identification of a peptide motif that potently inhibits two functionally distinct subunits of Shiga toxin.
Commun Biol, 4, 2021
7D6R
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BU of 7d6r by Molmil
Crystal structure of the Stx2a complexed with MMA betaAla peptide
Descriptor: 3-PYRIDINIUM-1-YLPROPANE-1-SULFONATE, MMA betaAla peptide, Shiga toxin 2 B subunit, ...
Authors:Takahashi, M, Tamada, M, Hibino, M, Senda, M, Okuda, A, Miyazawa, A, Senda, T, Nishikawa, K.
Deposit date:2020-10-01
Release date:2021-04-14
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Identification of a peptide motif that potently inhibits two functionally distinct subunits of Shiga toxin.
Commun Biol, 4, 2021
6X6H
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BU of 6x6h by Molmil
Structure of Shiga toxin 2 with a C-terminal peptide of ribosomal P stalk proteins
Descriptor: 1,2-ETHANEDIOL, ACETIC ACID, CHLORIDE ION, ...
Authors:Rudolph, M.J.
Deposit date:2020-05-28
Release date:2020-09-09
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (1.88 Å)
Cite:Structural basis for the interaction of Shiga toxin 2a with a C-terminal peptide of ribosomal P stalk proteins.
J.Biol.Chem., 295, 2020
6U3U
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BU of 6u3u by Molmil
Crystal Structure of Shiga Toxin 2K
Descriptor: 1,2-ETHANEDIOL, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, Shiga toxin 2K subunit A, ...
Authors:Zhang, Y.Z, He, X.H.
Deposit date:2019-08-22
Release date:2020-07-01
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.287 Å)
Cite:Structural and Functional Characterization of Stx2k, a New Subtype of Shiga Toxin 2.
Microorganisms, 8, 2019
6FE4
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Crystal structure of the complex between Shiga toxin Stx2 B subunit and neutralising Nb113
Descriptor: Nb113, Shiga-like toxin 2 subunit B
Authors:Bernedo, R, Muyldermans, S, Sterckx, Y.G.J.
Deposit date:2017-12-29
Release date:2018-03-07
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (3 Å)
Cite:Structural Basis for the Specific Neutralization of Stx2a with a Camelid Single Domain Antibody Fragment.
Toxins (Basel), 10, 2018
4P2C
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BU of 4p2c by Molmil
Complex of Shiga toxin 2e with a neutralizing single-domain antibody
Descriptor: Nanobody 1, Anti-F4+ETEC bacteria VHH variable region, Shiga toxin 2e, ...
Authors:Lo, A.W.H, Moonens, K, De Kerpel, M, Brys, L, Pardon, E, Remaut, H, De Greve, H.
Deposit date:2014-03-03
Release date:2014-07-30
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (2.818 Å)
Cite:The Molecular Mechanism of Shiga Toxin Stx2e Neutralization by a Single-domain Antibody Targeting the Cell Receptor-binding Domain.
J.Biol.Chem., 289, 2014
4M1U
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The crystal structure of Stx2 and a disaccharide ligand
Descriptor: 2-acetamido-2-deoxy-alpha-D-galactopyranose-(1-4)-methyl beta-D-galactopyranoside, 3-PYRIDINIUM-1-YLPROPANE-1-SULFONATE, Shiga toxin 2 A-subunit, ...
Authors:Yin, J, James, M.N.G, Jacobson, J.M, Kitov, P.I, Bundle, D.R, Mulvey, G, Armstrong, G.
Deposit date:2013-08-04
Release date:2013-11-20
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (1.56 Å)
Cite:The crystal structure of shiga toxin type 2 with bound disaccharide guides the design of a heterobifunctional toxin inhibitor.
J.Biol.Chem., 289, 2014
3MXG
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BU of 3mxg by Molmil
Structure of Shiga Toxin type 2 (Stx2) B Pentamer Mutant Q40L
Descriptor: D-xylose, Shiga-like toxin 2 subunit B
Authors:Kovall, R.A, Vander Wielen, B.D, Friedmann, D.R, Flagler, M.J.
Deposit date:2010-05-07
Release date:2011-01-12
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (2.49 Å)
Cite:Molecular basis of differential B-pentamer stability of Shiga toxins 1 and 2.
Plos One, 5, 2010
2XSC
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BU of 2xsc by Molmil
Crystal structure of the cell-binding B oligomer of verotoxin-1 from E. coli
Descriptor: SHIGA-LIKE TOXIN 1 SUBUNIT B, ZINC ION
Authors:Stein, P.E, Boodhoo, A, Tyrrell, G.J, Brunton, J.L, Oeffner, R.D, Bunkoczi, G, Read, R.J.
Deposit date:2010-09-27
Release date:2010-10-13
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.052 Å)
Cite:Crystal Structure of the Cell-Binding B Oligomer of Verotoxin-1 from E. Coli.
Nature, 355, 1992
2C5C
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BU of 2c5c by Molmil
Shiga-like toxin 1 B subunit complexed with a bivalent inhibitor
Descriptor: DIETHYL PROPANE-1,3-DIYLBISCARBAMATE, SHIGA-LIKE TOXIN 1 B SUBUNIT, SULFATE ION, ...
Authors:Dodd, R.B, Read, R.J.
Deposit date:2005-10-26
Release date:2006-11-27
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (2.94 Å)
Cite:Extensive Cross-Linking of the Shiga-Like Toxin 1 B Subunit by a Bivalent Ligand
To be Published
2GA4
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BU of 2ga4 by Molmil
Stx2 with adenine
Descriptor: 1,2-ETHANEDIOL, 3-PYRIDINIUM-1-YLPROPANE-1-SULFONATE, ADENINE, ...
Authors:Fraser, M.E.
Deposit date:2006-03-07
Release date:2006-07-11
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Binding of adenine to Stx2, the protein toxin from Escherichia coli O157:H7.
Acta Crystallogr.,Sect.F, 62, 2006
1R4P
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BU of 1r4p by Molmil
Shiga toxin type 2
Descriptor: 1,2-ETHANEDIOL, 3-PYRIDINIUM-1-YLPROPANE-1-SULFONATE, FORMIC ACID, ...
Authors:Fraser, M.E, Fujinaga, M, Cherney, M.M, Melton-Celsa, A.R, Twiddy, E.M, O'Brien, A.D, James, M.N.G.
Deposit date:2003-10-07
Release date:2004-05-11
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (1.77 Å)
Cite:Structure of Shiga Toxin Type 2 (Stx2) from Escherichia coli O157:H7.
J.Biol.Chem., 279, 2004
1R4Q
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BU of 1r4q by Molmil
Shiga toxin
Descriptor: SHT cytotoxin A subunit, Shigella toxin chain B
Authors:Fraser, M.E, Fujinaga, M, Cherney, M.M, Melton-Celsa, A.R, Twiddy, E.M, O'Brien, A.D, James, M.N.G.
Deposit date:2003-10-07
Release date:2004-05-11
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structure of Shiga Toxin Type 2 (Stx2) from Escherichia coli O157:H7.
J.Biol.Chem., 279, 2004
1D1I
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BU of 1d1i by Molmil
MUTATED SHIGA-LIKE TOXIN B SUBUNIT (W34A) COMPLEXED WITH RECEPTOR GB3 ANALOGUE
Descriptor: SHIGA TOXIN B-CHAIN, alpha-D-galactopyranose-(1-4)-beta-D-galactopyranose, alpha-D-galactopyranose-(1-4)-beta-D-galactopyranose-(1-4)-beta-D-glucopyranose
Authors:Ling, H, Boodhoo, A, Brunton, J.L, Read, R.J.
Deposit date:1999-09-17
Release date:2000-09-20
Last modified:2021-11-03
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Mutated Shiga-like Toxin B Subunit (W34A) Complexed with Receptor Gb3 Analogue
To be Published
1D1K
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BU of 1d1k by Molmil
MUTATED SHIGA-LIKE TOXIN B SUBUNIT (D17E/W34A) COMPLEXED WITH RECEPTOR GB3 ANALOGUE
Descriptor: SHIGA-LIKE TOXIN I SUBUNIT B, alpha-D-galactopyranose-(1-4)-beta-D-galactopyranose-(1-4)-alpha-D-glucopyranose
Authors:Ling, H, Brunton, J.L, Read, R.J.
Deposit date:1999-09-17
Release date:2000-09-20
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (2 Å)
Cite:Mutated Shiga-like toxin B subunit (D17E/W34A) complexed with receptor Gb3 analogue
To be Published
1C4Q
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BU of 1c4q by Molmil
MUTATED SHIGA-LIKE TOXIN B SUBUNIT (F30A/W34A) COMPLEXED WITH RECEPTOR GB3 ANALOGUE
Descriptor: PROTEIN (SHIGA-LIKE TOXIN I SUBUNIT B), alpha-D-galactopyranose-(1-4)-beta-D-galactopyranose-(1-4)-beta-D-glucopyranose
Authors:Ling, H, Brunton, J.L, Read, R.J.
Deposit date:1999-08-31
Release date:2000-09-20
Last modified:2023-08-09
Method:X-RAY DIFFRACTION (1.52 Å)
Cite:Identification of the Primary Receptor Binding Site of Shiga-Like Toxin B Subunits: Structures of Mutated Shiga-Like Toxin I B-Pentamer with and without Bound Carbohydrate
To be Published
1CZG
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BU of 1czg by Molmil
STRUCTURE OF THE G62T MUTANT OF SHIGA-LIKE TOXIN I B SUBUNIT
Descriptor: SHIGA TOXIN B-CHAIN
Authors:Ling, H, Bast, D, Brunton, J.L, Read, R.J.
Deposit date:1999-09-03
Release date:2000-09-13
Last modified:2021-11-03
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:STRUCTURE OF THE G62T MUTANT OF SHIGA-LIKE TOXIN I B SUBUNIT
To be Published
1CZW
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BU of 1czw by Molmil
STRUCTURE OF THE W34A MUTANT OF SHIGA-LIKE TOXIN I B SUBUNIT
Descriptor: SHIGA TOXIN B-CHAIN
Authors:Ling, H, Boodhoo, A, Brunton, J.L, Read, R.J.
Deposit date:1999-09-07
Release date:2000-09-08
Last modified:2018-03-14
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:A native structure of the W34A mutant at 2.5 A
To be Published
1C48
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BU of 1c48 by Molmil
MUTATED SHIGA-LIKE TOXIN B SUBUNIT (G62T)
Descriptor: PROTEIN (SHIGA-LIKE TOXIN I B SUBUNIT)
Authors:Ling, H, Bast, D, Brunton, J.L, Read, R.J.
Deposit date:1999-08-11
Release date:2000-08-16
Last modified:2023-08-09
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Identification of the Primary Receptor Binding Site of Shiga-Like Toxin B Subunits: Structures of Mutated Shiga-Like Toxin I B-Pentamer with and without Bound Carbohydrate
To be Published

 

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