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8A1D
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BU of 8a1d by Molmil
Structure of murine perforin-2 (Mpeg1) pore in ring form
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, CYCLOHEXYL-HEXYL-BETA-D-MALTOSIDE, Macrophage-expressed gene 1 protein
Authors:Yu, X, Ni, T, Zhang, P, Gilbert, R.
Deposit date:2022-06-01
Release date:2022-07-20
Last modified:2022-12-14
Method:ELECTRON MICROSCOPY (3 Å)
Cite:Cryo-EM structures of perforin-2 in isolation and assembled on a membrane suggest a mechanism for pore formation.
Embo J., 41, 2022
8A1S
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BU of 8a1s by Molmil
Structure of murine perforin-2 (Mpeg1) pore in twisted form
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Macrophage-expressed gene 1 protein
Authors:Yu, X, Ni, T, Zhang, P, Gilbert, R.
Deposit date:2022-06-02
Release date:2022-07-20
Last modified:2023-10-18
Method:ELECTRON MICROSCOPY (4 Å)
Cite:Cryo-EM structures of perforin-2 in isolation and assembled on a membrane suggest a mechanism for pore formation.
Embo J., 41, 2022
5OWN
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BU of 5own by Molmil
Structure of TgPLP1 MACPF domain
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Perforin-like protein 1
Authors:Ni, T, Gilbert, R.J.C.
Deposit date:2017-09-01
Release date:2018-04-11
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (3.11 Å)
Cite:Structures of monomeric and oligomeric forms of theToxoplasma gondiiperforin-like protein 1.
Sci Adv, 4, 2018
5OUP
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BU of 5oup by Molmil
Structure of TgPLP1 MACPF domain
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Perforin-like protein 1
Authors:Ni, T, Gilbert, R.J.C.
Deposit date:2017-08-24
Release date:2018-04-11
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (2.03 Å)
Cite:Structures of monomeric and oligomeric forms of theToxoplasma gondiiperforin-like protein 1.
Sci Adv, 4, 2018
5OUQ
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BU of 5ouq by Molmil
Structure of TgPLP1 MACPF domain
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Perforin-like protein 1
Authors:Ni, T, Gilbert, R.J.C.
Deposit date:2017-08-24
Release date:2018-04-11
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (5.11 Å)
Cite:Structures of monomeric and oligomeric forms of theToxoplasma gondiiperforin-like protein 1.
Sci Adv, 4, 2018
5J69
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BU of 5j69 by Molmil
Structure of Astrotactin-2, a conserved vertebrate-specific and perforin-like membrane protein involved in neuronal development
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Astrotactin-2
Authors:Ni, T, Harlos, K, Gilbert, R.J.C.
Deposit date:2016-04-04
Release date:2016-05-25
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (3.63 Å)
Cite:Structure of astrotactin-2: a conserved vertebrate-specific and perforin-like membrane protein involved in neuronal development.
Open Biology, 6, 2016
2QQH
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BU of 2qqh by Molmil
Structure of C8a-MACPF reveals mechanism of membrane attack in complement immune defense
Descriptor: Complement component C8 alpha chain, NICKEL (II) ION, SULFATE ION
Authors:Hadders, M.A, Gros, P.
Deposit date:2007-07-26
Release date:2007-09-25
Last modified:2021-10-20
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structure of C8alpha-MACPF reveals mechanism of membrane attack in complement immune defense.
Science, 317, 2007
2QP2
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BU of 2qp2 by Molmil
Structure of a MACPF/perforin-like protein
Descriptor: CALCIUM ION, Unknown protein
Authors:Rosado, C.J, Buckle, A.M, Law, R.H.P, Butcher, R.E, Kan, W.T, Bird, C.H, Ung, K, Browne, K.A, Baran, K, Bashtannyk-Puhalovich, T.A, Faux, N.G, Wong, W, Porter, C.J, Pike, R.N, Ellisdon, A.M, Pearce, M.C, Bottomley, S.P, Emsley, J, Smith, A.I, Rossjohn, J, Hartland, E.L, Voskoboinik, I, Trapani, J.A, Bird, P.I, Dunstone, M.A, Whisstock, J.C.
Deposit date:2007-07-22
Release date:2007-09-04
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:A common fold mediates vertebrate defense and bacterial attack
Science, 317, 2007
6SB3
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BU of 6sb3 by Molmil
CryoEM structure of murine perforin-2 ectodomain in a pre-pore form
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Macrophage-expressed gene 1 protein
Authors:Ni, T, Yu, X, Gilbert, R.J.C.
Deposit date:2019-07-18
Release date:2020-02-05
Last modified:2020-07-29
Method:ELECTRON MICROSCOPY (3.5 Å)
Cite:Structure and mechanism of bactericidal mammalian perforin-2, an ancient agent of innate immunity.
Sci Adv, 6, 2020
6SB5
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BU of 6sb5 by Molmil
CryoEM structure of murine perforin-2 ectodomain in a pore form
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Macrophage-expressed gene 1 protein
Authors:Ni, T, Yu, X, Gilbert, R.J.C.
Deposit date:2019-07-18
Release date:2020-02-05
Last modified:2020-07-29
Method:ELECTRON MICROSCOPY (5 Å)
Cite:Structure and mechanism of bactericidal mammalian perforin-2, an ancient agent of innate immunity.
Sci Adv, 6, 2020
8B6U
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BU of 8b6u by Molmil
Mpf2Ba1 monomer
Descriptor: MAGNESIUM ION, Mpf2Ba1
Authors:Marini, G, Poland, B, Leininger, C, Lukoyanova, N, Spielbauer, D, Barry, J, Altier, D, Lum, A, Scolaro, E, Perez-Ortega, C, Yalpani, N, Sandahl, G, Mabry, T, Klever, J, Nowatzki, T, Zhao, J.Z, Sethi, A, Kassa, A, Crane, V, Lu, A, Nelson, M.E, Eswar, N, Topf, M, Saibil, H.R.
Deposit date:2022-09-27
Release date:2023-05-31
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2.134 Å)
Cite:Structural journey of an insecticidal protein against western corn rootworm.
Nat Commun, 14, 2023
8B6W
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BU of 8b6w by Molmil
Mpf2Ba1 pore
Descriptor: MAGNESIUM ION, Mpf2Ba1
Authors:Marini, G, Poland, B, Leininger, C, Lukoyanova, N, Spielbauer, D, Barry, J, Altier, D, Lum, A, Scolaro, E, Perez Ortega, C, Yalpani, N, Sandahl, G, Mabry, T, Klever, J, Nowatzki, T, Zhao, J.Z, Sethi, A, Kassa, A, Crane, V, Lu, A, Nelson, M.E, Eswar, N, Topf, M, Saibil, H.R.
Deposit date:2022-09-27
Release date:2023-05-31
Last modified:2023-07-26
Method:ELECTRON MICROSCOPY (2.6 Å)
Cite:Structural journey of an insecticidal protein against western corn rootworm.
Nat Commun, 14, 2023
8B6V
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BU of 8b6v by Molmil
Mp2Ba1 pre-pore
Descriptor: MAGNESIUM ION, Mpf2Ba1
Authors:Marini, G, Poland, B, Leininger, C, Lukoyanova, N, Spielbauer, D, Barry, J, Altier, D, Lum, A, Scolaro, E, Perez Ortega, C, Yalpani, N, Sandahl, G, Mabry, T, Klever, J, Nowatzki, T, Zhao, J.Z, Sethi, A, Kassa, A, Crane, V, Lu, A, Nelson, M.E, Eswar, N, Topf, M, Saibil, H.R.
Deposit date:2022-09-27
Release date:2023-05-31
Last modified:2023-07-26
Method:ELECTRON MICROSCOPY (3.1 Å)
Cite:Structural journey of an insecticidal protein against western corn rootworm.
Nat Commun, 14, 2023
6U2J
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BU of 6u2j by Molmil
EM structure of MPEG-1 (L425K, alpha conformation) soluble pre-pore complex
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Macrophage-expressed gene 1 protein
Authors:Pang, S.S, Bayly-Jones, C.
Deposit date:2019-08-20
Release date:2019-09-25
Last modified:2020-07-29
Method:ELECTRON MICROSCOPY (2.37 Å)
Cite:The cryo-EM structure of the acid activatable pore-forming immune effector Macrophage-expressed gene 1.
Nat Commun, 10, 2019
6U2W
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BU of 6u2w by Molmil
EM structure of MPEG-1(L425K) pre-pore complex bound to liposome
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Macrophage-expressed gene 1 protein
Authors:Pang, S.S, Bayly-Jones, C.
Deposit date:2019-08-20
Release date:2019-09-25
Last modified:2020-07-29
Method:ELECTRON MICROSCOPY (3.63 Å)
Cite:The cryo-EM structure of the acid activatable pore-forming immune effector Macrophage-expressed gene 1.
Nat Commun, 10, 2019
6U23
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BU of 6u23 by Molmil
EM structure of MPEG-1(w.t.) soluble pre-pore
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Macrophage-expressed gene 1 protein
Authors:Pang, S.S, Bayly-Jones, C.
Deposit date:2019-08-19
Release date:2019-09-25
Last modified:2020-07-29
Method:ELECTRON MICROSCOPY (3.49 Å)
Cite:The cryo-EM structure of the acid activatable pore-forming immune effector Macrophage-expressed gene 1.
Nat Commun, 10, 2019
6U2L
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BU of 6u2l by Molmil
EM structure of MPEG-1 (L425K, beta conformation) soluble pre-pore complex
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Macrophage-expressed gene 1 protein
Authors:Pang, S.S, Bayly-Jones, C.
Deposit date:2019-08-20
Release date:2019-09-25
Last modified:2020-07-29
Method:ELECTRON MICROSCOPY (2.83 Å)
Cite:The cryo-EM structure of the acid activatable pore-forming immune effector Macrophage-expressed gene 1.
Nat Commun, 10, 2019
6U2K
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BU of 6u2k by Molmil
EM structure of MPEG-1 (L425K, alpha conformation) soluble pre-pore complex
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Macrophage-expressed gene 1 protein
Authors:Pang, S.S, Bayly-Jones, C.
Deposit date:2019-08-20
Release date:2019-09-25
Last modified:2020-07-29
Method:ELECTRON MICROSCOPY (2.93 Å)
Cite:The cryo-EM structure of the acid activatable pore-forming immune effector Macrophage-expressed gene 1.
Nat Commun, 10, 2019
4V3N
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BU of 4v3n by Molmil
Membrane bound pleurotolysin prepore (TMH2 strand lock) trapped with engineered disulphide cross-link
Descriptor: PLEUROTOLYSIN A, PLEUROTOLYSIN B
Authors:Lukoyanova, N, Kondos, S.C, Farabella, I, Law, R.H.P, Reboul, C.F, Caradoc-Davies, T.T, Spicer, B.A, Kleifeld, O, Perugini, M, Ekkel, S, Hatfaludi, T, Oliver, K, Hotze, E.M, Tweten, R.K, Whisstock, J.C, Topf, M, Dunstone, M.A, Saibil, H.R.
Deposit date:2014-10-20
Release date:2015-02-18
Last modified:2017-08-23
Method:ELECTRON MICROSCOPY (14 Å)
Cite:Conformational Changes During Pore Formation by the Perforin-Related Protein Pleurotolysin.
Plos Biol., 13, 2015
4V2T
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BU of 4v2t by Molmil
Membrane embedded pleurotolysin pore with 13 fold symmetry
Descriptor: PLEUROTOLYSIN A, PLEUROTOLYSIN B
Authors:Lukoyanova, N, Kondos, S.C, Farabella, I, Law, R.H.P, Reboul, C.F, Caradoc-Davies, T.T, Spicer, B.A, Kleifeld, O, Perugini, M, Ekkel, S, Hatfaludi, T, Oliver, K, Hotze, E.M, Tweten, R.K, Whisstock, J.C, Topf, M, Dunstone, M.A, Saibil, H.R.
Deposit date:2014-10-15
Release date:2015-02-18
Last modified:2017-08-30
Method:ELECTRON MICROSCOPY (11 Å)
Cite:Conformational Changes During Pore Formation by the Perforin-Related Protein Pleurotolysin.
Plos Biol., 13, 2015
4V3A
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BU of 4v3a by Molmil
Membrane bound pleurotolysin prepore (TMH1 lock) trapped with engineered disulphide cross-link
Descriptor: PLEUROTOLYSIN A, PLEUROTOLYSIN B
Authors:Lukoyanova, N, Kondos, S.C, Farabella, I, Law, R.H.P, Reboul, C.F, CaradocDavies, T.T, Spicer, B.A, Kleifeld, O, Perugini, M, Ekkel, S, Hatfaludi, T, Oliver, K, Hotze, E.M, Tweten, R.K, Whisstock, J.C, Topf, M, Dunstone, M.A, Saibil, H.R.
Deposit date:2014-10-17
Release date:2015-02-18
Last modified:2017-08-30
Method:ELECTRON MICROSCOPY (15 Å)
Cite:Conformational Changes During Pore Formation by the Perforin-Related Protein Pleurotolysin.
Plos Biol., 13, 2015
4V3M
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BU of 4v3m by Molmil
Membrane bound pleurotolysin prepore (TMH2 helix lock) trapped with engineered disulphide cross-link
Descriptor: PLEUROTOLYSIN A, PLEUROTOLYSIN B
Authors:Lukoyanova, N, Kondos, S.C, Farabella, I, Law, R.H.P, Reboul, C.F, Caradoc-Davies, T.T, Spicer, B.A, Kleifeld, O, Perugini, M, Ekkel, S, Hatfaludi, T, Oliver, K, Hotze, E.M, Tweten, R.K, Whisstock, J.C, Topf, M, Dunstone, M.A, Saibil, H.R.
Deposit date:2014-10-20
Release date:2015-02-18
Last modified:2017-08-23
Method:ELECTRON MICROSCOPY (17 Å)
Cite:Conformational Changes During Pore Formation by the Perforin-Related Protein Pleurotolysin.
Plos Biol., 13, 2015
4OEJ
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BU of 4oej by Molmil
Structure of membrane binding protein pleurotolysin B from Pleurotus ostreatus
Descriptor: ACETATE ION, CHLORIDE ION, GLYCEROL, ...
Authors:Dunstone, M.A, Caradoc-Davies, T.T, Whisstock, J.C, Law, R.H.P.
Deposit date:2014-01-13
Release date:2015-02-18
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Conformational Changes during Pore Formation by the Perforin-Related Protein Pleurotolysin.
Plos Biol., 13, 2015
4OV8
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BU of 4ov8 by Molmil
Crystal Structure of the TMH1-lock mutant of the mature form of pleurotolysin B
Descriptor: CHLORIDE ION, GLYCEROL, Pleurotolysin B, ...
Authors:Kondos, S.C, Law, R.H.P, Whisstock, J.C, Dunstone, M.A.
Deposit date:2014-02-20
Release date:2015-02-18
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:Conformational Changes during Pore Formation by the Perforin-Related Protein Pleurotolysin
Plos Biol., 13, 2015
5J67
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BU of 5j67 by Molmil
Structure of Astrotactin-2, a conserved vertebrate-specific and perforin-like membrane protein involved in neuronal development
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Astrotactin-2, D-MYO-INOSITOL-1,4,5-TRIPHOSPHATE, ...
Authors:Ni, T, Harlos, K, Gilbert, R.J.C.
Deposit date:2016-04-04
Release date:2016-05-25
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (3.16 Å)
Cite:Structure of astrotactin-2: a conserved vertebrate-specific and perforin-like membrane protein involved in neuronal development.
Open Biology, 6, 2016

 

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