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1UG0
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BU of 1ug0 by Molmil
Solution structure of SURP domain in BAB30904
Descriptor: splicing factor 4
Authors:He, F, Muto, Y, Ushikoshi, R, Koshiba, S, Shirouzu, M, Terada, T, Kigawa, T, Inoue, M, Yabuki, T, Aoki, M, Seki, E, Matsuda, T, Hirota, H, Yoshida, M, Kobayashi, N, Tanaka, A, Osanai, T, Matsuo, Y, Hayashizaki, Y, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI)
Deposit date:2003-06-11
Release date:2004-08-03
Last modified:2023-12-27
Method:SOLUTION NMR
Cite:Solution structure of SURP domain in BAB30904
To be Published
7VH9
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BU of 7vh9 by Molmil
Solution structure of the chimeric peptide of the first SURP domain of Human SF3A1 and the interacting region of SF1.
Descriptor: Splicing factor 3A subunit 1,Splicing factor 1
Authors:Muto, Y, Kuwasako, K, Takizawa, M, Kobayashi, N, Sakamoto, T.
Deposit date:2021-09-21
Release date:2022-09-28
Last modified:2023-10-25
Method:SOLUTION NMR
Cite:Structural basis for the interaction between the first SURP domain of the SF3A1 subunit in U2 snRNP and the human splicing factor SF1.
Protein Sci., 31, 2022
1X4O
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BU of 1x4o by Molmil
Solution structure of SURP domain in splicing factor 4
Descriptor: Splicing factor 4
Authors:He, F, Muto, Y, Inoue, M, Kigawa, T, Shirouzu, M, Terada, T, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI)
Deposit date:2005-05-14
Release date:2005-11-14
Last modified:2022-03-02
Method:SOLUTION NMR
Cite:Solution structure of SURP domain in splicing factor 4
To be Published
2DT6
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BU of 2dt6 by Molmil
Solution structure of the first SURP domain of human splicing factor SF3a120
Descriptor: Splicing factor 3 subunit 1
Authors:Kuwasako, K, He, F, Inoue, M, Tanaka, A, Sugano, S, Guentert, P, Muto, Y, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI)
Deposit date:2006-07-11
Release date:2006-12-26
Last modified:2022-03-09
Method:SOLUTION NMR
Cite:Solution structures of the SURP domains and the subunit-assembly mechanism within the splicing factor SF3a complex in 17S U2 snRNP
Structure, 14, 2006
2E5Z
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BU of 2e5z by Molmil
Solution structure of the surp2 domain in splicing factor, arginine/serine-rich 8
Descriptor: Splicing factor, arginine/serine-rich 8
Authors:He, F, Muto, Y, Inoue, M, Kigawa, T, Shirouzu, M, Terada, T, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI)
Deposit date:2006-12-25
Release date:2007-06-26
Last modified:2022-03-09
Method:SOLUTION NMR
Cite:Solution structure of the surp2 domain in splicing factor, arginine/serine-rich 8
To be Published
2E60
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BU of 2e60 by Molmil
Solution structure of the surp1 domain in splicing factor, arginine/serine-rich 8
Descriptor: Splicing factor, arginine/serine-rich 8
Authors:He, F, Muto, Y, Inoue, M, Kigawa, T, Shirouzu, M, Terada, T, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI)
Deposit date:2006-12-25
Release date:2007-06-26
Last modified:2022-03-09
Method:SOLUTION NMR
Cite:Solution structure of the surp1 domain in splicing factor, arginine/serine-rich 8
To be Published
4DGW
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BU of 4dgw by Molmil
Crystal Structure of the SF3a splicing factor complex of U2 snRNP
Descriptor: Pre-mRNA-splicing factor PRP11, Pre-mRNA-splicing factor PRP21, Pre-mRNA-splicing factor PRP9, ...
Authors:Lin, P.C.
Deposit date:2012-01-26
Release date:2012-05-02
Last modified:2018-07-25
Method:X-RAY DIFFRACTION (3.112 Å)
Cite:Structure and assembly of the SF3a splicing factor complex of U2 snRNP
Embo J., 31, 2012
2DT7
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BU of 2dt7 by Molmil
Solution structure of the second SURP domain of human splicing factor SF3a120 in complex with a fragment of human splicing factor SF3a60
Descriptor: Splicing factor 3 subunit 1, Splicing factor 3A subunit 3
Authors:He, F, Kuwasako, K, Inoue, M, Guntert, P, Muto, Y, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI)
Deposit date:2006-07-11
Release date:2006-12-26
Last modified:2022-03-09
Method:SOLUTION NMR
Cite:Solution structures of the SURP domains and the subunit-assembly mechanism within the splicing factor SF3a complex in 17S U2 snRNP
Structure, 14, 2006
5NRL
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BU of 5nrl by Molmil
Structure of a pre-catalytic spliceosome.
Descriptor: 13 kDa ribonucleoprotein-associated protein, 23 kDa U4/U6.U5 small nuclear ribonucleoprotein component, 66 kDa U4/U6.U5 small nuclear ribonucleoprotein component, ...
Authors:Plaschka, C, Lin, P.-C, Nagai, K.
Deposit date:2017-04-24
Release date:2017-05-31
Last modified:2023-05-24
Method:ELECTRON MICROSCOPY (7.2 Å)
Cite:Structure of a pre-catalytic spliceosome.
Nature, 546, 2017
6G90
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BU of 6g90 by Molmil
Prespliceosome structure provides insight into spliceosome assembly and regulation (map A2)
Descriptor: 56 kDa U1 small nuclear ribonucleoprotein component, Cold sensitive U2 snRNA suppressor 1, Pre-mRNA-processing factor 39, ...
Authors:Plaschka, C, Lin, P.-C, Charenton, C, Nagai, K.
Deposit date:2018-04-10
Release date:2018-08-22
Method:ELECTRON MICROSCOPY (4 Å)
Cite:Prespliceosome structure provides insights into spliceosome assembly and regulation.
Nature, 559, 2018
6QX9
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BU of 6qx9 by Molmil
Structure of a human fully-assembled precatalytic spliceosome (pre-B complex).
Descriptor: 116 kDa U5 small nuclear ribonucleoprotein component, AdML pre-mRNA, GUANOSINE-5'-TRIPHOSPHATE, ...
Authors:Charenton, C, Wilkinson, M.E, Nagai, K.
Deposit date:2019-03-07
Release date:2019-04-17
Last modified:2020-10-07
Method:ELECTRON MICROSCOPY (3.28 Å)
Cite:Mechanism of 5' splice site transfer for human spliceosome activation.
Science, 364, 2019
8CH6
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BU of 8ch6 by Molmil
Structure of a late-stage activated spliceosome (BAqr) arrested with a dominant-negative Aquarius mutant (state B complex).
Descriptor: 116 kDa U5 small nuclear ribonucleoprotein component, BUD13 homolog, Cell division cycle 5-like protein, ...
Authors:Cretu, C, Schmitzova, J, Pena, V.
Deposit date:2023-02-07
Release date:2023-05-10
Last modified:2023-06-14
Method:ELECTRON MICROSCOPY (5.9 Å)
Cite:Structural basis of catalytic activation in human splicing.
Nature, 617, 2023
6FF7
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BU of 6ff7 by Molmil
human Bact spliceosome core structure
Descriptor: 116 kDa U5 small nuclear ribonucleoprotein component, ADENOSINE-5'-DIPHOSPHATE, BUD13 homolog, ...
Authors:Haselbach, D, Komarov, I, Agafonov, D, Hartmuth, K, Graf, B, Kastner, B, Luehrmann, R, Stark, H.
Deposit date:2018-01-03
Release date:2019-03-13
Last modified:2020-10-07
Method:ELECTRON MICROSCOPY (4.5 Å)
Cite:Structure and Conformational Dynamics of the Human Spliceosomal BactComplex.
Cell, 172, 2018
7OQE
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BU of 7oqe by Molmil
Saccharomyces cerevisiae spliceosomal pre-A complex (delta BS-A ACT1)
Descriptor: 56 kDa U1 small nuclear ribonucleoprotein component, ACT1 pre-mRNA (delta BS-A), Cold sensitive U2 snRNA suppressor 1, ...
Authors:Zhang, Z, Rigo, N, Dybkov, O, Fourmann, J, Will, C.L, Kumar, V, Urlaub, H, Stark, H, Luehrmann, R.
Deposit date:2021-06-03
Release date:2021-08-11
Last modified:2021-09-29
Method:ELECTRON MICROSCOPY (5.9 Å)
Cite:Structural insights into how Prp5 proofreads the pre-mRNA branch site.
Nature, 596, 2021
7OQB
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BU of 7oqb by Molmil
The U2 part of Saccharomyces cerevisiae spliceosomal pre-A complex (delta BS-A ACT1)
Descriptor: ACT1 pre-mRNA (delta-BS-A), Cold sensitive U2 snRNA suppressor 1, Pre-mRNA-processing ATP-dependent RNA helicase PRP5, ...
Authors:Zhang, Z, Rigo, N, Dybkov, O, Fourmann, J, Will, C.L, Kumar, V, Urlaub, H, Stark, H, Luehrmann, R.
Deposit date:2021-06-03
Release date:2021-08-11
Last modified:2021-09-22
Method:ELECTRON MICROSCOPY (9 Å)
Cite:Structural insights into how Prp5 proofreads the pre-mRNA branch site.
Nature, 596, 2021
7DCO
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BU of 7dco by Molmil
Cryo-EM structure of the activated spliceosome (Bact complex) at an atomic resolution of 2.5 angstrom
Descriptor: BJ4_G0014900.mRNA.1.CDS.1, BJ4_G0027490.mRNA.1.CDS.1, BJ4_G0037700.mRNA.1.CDS.1, ...
Authors:Bai, R, Wan, R, Yan, C, Qi, J, Zhang, P, Lei, J, Shi, Y.
Deposit date:2020-10-26
Release date:2021-03-17
Last modified:2024-03-27
Method:ELECTRON MICROSCOPY (2.5 Å)
Cite:Mechanism of spliceosome remodeling by the ATPase/helicase Prp2 and its coactivator Spp2.
Science, 371, 2021
7ABG
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BU of 7abg by Molmil
Human pre-Bact-1 spliceosome
Descriptor: 116 kDa U5 small nuclear ribonucleoprotein component, 7-METHYL-GUANOSINE-5'-TRIPHOSPHATE-5'-GUANOSINE, Cell division cycle 5-like protein, ...
Authors:Townsend, C, Kastner, B, Leelaram, M.N, Bertram, K, Stark, H, Luehrmann, R.
Deposit date:2020-09-07
Release date:2020-12-23
Last modified:2020-12-30
Method:ELECTRON MICROSCOPY (7.8 Å)
Cite:Mechanism of protein-guided folding of the active site U2/U6 RNA during spliceosome activation.
Science, 370, 2020
7ABI
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BU of 7abi by Molmil
Human pre-Bact-2 spliceosome
Descriptor: 116 kDa U5 small nuclear ribonucleoprotein component, BUD13 homolog, Beta-catenin-like protein 1, ...
Authors:Townsend, C, Kastner, B, Leelaram, M.N, Bertram, K, Stark, H, Luehrmann, R.
Deposit date:2020-09-07
Release date:2021-02-10
Method:ELECTRON MICROSCOPY (8 Å)
Cite:Mechanism of protein-guided folding of the active site U2/U6 RNA during spliceosome activation.
Science, 370, 2020
7VPX
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BU of 7vpx by Molmil
The cryo-EM structure of the human pre-A complex
Descriptor: 5SS, DnaJ homolog subfamily C member 8, PHD finger-like domain-containing protein 5A, ...
Authors:Zhang, X, Zhan, X, Shi, Y.
Deposit date:2021-10-18
Release date:2023-05-03
Method:ELECTRON MICROSCOPY (3 Å)
Cite:Mechanism for Branch Site Recognition and Proofreading During Prespliceosome Assembly
To Be Published
6Y53
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BU of 6y53 by Molmil
human 17S U2 snRNP low resolution part
Descriptor: HIV Tat-specific factor 1, Probable ATP-dependent RNA helicase DDX46, Small nuclear ribonucleoprotein E, ...
Authors:Zhang, Z, Will, C.L, Bertram, K, Luehrmann, R, Stark, H.
Deposit date:2020-02-24
Release date:2020-06-17
Last modified:2020-07-22
Method:ELECTRON MICROSCOPY (7.1 Å)
Cite:Molecular architecture of the human 17S U2 snRNP.
Nature, 583, 2020
6Y5Q
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BU of 6y5q by Molmil
human 17S U2 snRNP
Descriptor: HIV Tat-specific factor 1, PHD finger-like domain-containing protein 5A, Probable ATP-dependent RNA helicase DDX46, ...
Authors:Zhang, Z, Will, C.L, Bertram, K, Luehrmann, R, Stark, H.
Deposit date:2020-02-25
Release date:2020-06-17
Last modified:2020-07-22
Method:ELECTRON MICROSCOPY (7.1 Å)
Cite:Molecular architecture of the human 17S U2 snRNP.
Nature, 583, 2020
7EVO
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BU of 7evo by Molmil
The cryo-EM structure of the human 17S U2 snRNP
Descriptor: HIV Tat-specific factor 1, PHD finger-like domain-containing protein 5A, RNA helicase, ...
Authors:Zhang, X, Zhan, X, Shi, Y.
Deposit date:2021-05-21
Release date:2022-08-03
Last modified:2024-01-17
Method:ELECTRON MICROSCOPY (2.5 Å)
Cite:Structural insights into branch site proofreading by human spliceosome
Nat.Struct.Mol.Biol., 2024
8HK1
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BU of 8hk1 by Molmil
The cryo-EM structure of human pre-17S U2 snRNP
Descriptor: ATP-dependent RNA helicase DDX42, HIV Tat-specific factor 1, PHD finger-like domain-containing protein 5A, ...
Authors:Zhang, X, Zhan, X, Shi, Y.
Deposit date:2022-11-24
Release date:2023-03-08
Last modified:2023-08-16
Method:ELECTRON MICROSCOPY (2.7 Å)
Cite:Mechanisms of the RNA helicases DDX42 and DDX46 in human U2 snRNP assembly.
Nat Commun, 14, 2023
8QO9
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BU of 8qo9 by Molmil
Cryo-EM structure of a human spliceosomal B complex protomer
Descriptor: 116 kDa U5 small nuclear ribonucleoprotein component, MINX pre-mRNA, Microfibrillar-associated protein 1, ...
Authors:Zhang, Z, Kumar, V, Dybkov, O, Will, C.L, Urlaub, H, Stark, H, Luehrmann, R.
Deposit date:2023-09-28
Release date:2024-01-24
Method:ELECTRON MICROSCOPY (5.29 Å)
Cite:New insights into the functions of B complex proteins revealed by cryo-EM of dimerized spliceosomes
To Be Published
8Q7N
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BU of 8q7n by Molmil
cryo-EM structure of the human spliceosomal B complex protomer (tri-snRNP core region)
Descriptor: 116 kDa U5 small nuclear ribonucleoprotein component, MINX pre-mRNA, Microfibrillar-associated protein 1, ...
Authors:Zhang, Z, Kumar, V, Dybkov, O, Will, C.L, Urlaub, H, Stark, H, Luehrmann, R.
Deposit date:2023-08-16
Release date:2024-01-24
Method:ELECTRON MICROSCOPY (3.1 Å)
Cite:New insights into the functions of B complex proteins revealed by cryo-EM of dimerized spliceosomes
To Be Published

 

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