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5OAK
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BU of 5oak by Molmil
Structure of the dmPar3 PDZ1 domain in complex with the dmPar6 PBM
Descriptor: Bazooka, isoform C,LD29223p, GLYCEROL
Authors:Bruekner, S.R, Wiesner, S.
Deposit date:2017-06-22
Release date:2018-02-21
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Structural basis for the interaction between the cell polarity proteins Par3 and Par6.
Sci Signal, 11, 2018
1BFE
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BU of 1bfe by Molmil
THE THIRD PDZ DOMAIN FROM THE SYNAPTIC PROTEIN PSD-95
Descriptor: PSD-95
Authors:Doyle, D.A, Lee, A, Lewis, J, Kim, E, Sheng, M, Mackinnon, R.
Deposit date:1998-05-20
Release date:1998-10-21
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Crystal structures of a complexed and peptide-free membrane protein-binding domain: molecular basis of peptide recognition by PDZ.
Cell(Cambridge,Mass.), 85, 1996
4UU6
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BU of 4uu6 by Molmil
CRYSTAL STRUCTURE OF THE PDZ DOMAIN OF PALS1
Descriptor: ACETATE ION, CHLORIDE ION, GLYCEROL, ...
Authors:Ivanova, M.E, Purkiss, A.G, McDonald, N.Q.
Deposit date:2014-07-24
Release date:2015-01-14
Last modified:2018-02-28
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structures of the human Pals1 PDZ domain with and without ligand suggest gated access of Crb to the PDZ peptide-binding groove.
Acta Crystallogr. D Biol. Crystallogr., 71, 2015
1B8Q
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BU of 1b8q by Molmil
SOLUTION STRUCTURE OF THE EXTENDED NEURONAL NITRIC OXIDE SYNTHASE PDZ DOMAIN COMPLEXED WITH AN ASSOCIATED PEPTIDE
Descriptor: PROTEIN (HEPTAPEPTIDE), PROTEIN (NEURONAL NITRIC OXIDE SYNTHASE)
Authors:Tochio, H, Zhang, Q, Mandal, P, Li, M, Zhang, M.
Deposit date:1999-02-01
Release date:1999-04-29
Last modified:2023-12-27
Method:SOLUTION NMR
Cite:Solution structure of the extended neuronal nitric oxide synthase PDZ domain complexed with an associated peptide.
Nat.Struct.Biol., 6, 1999
1BE9
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BU of 1be9 by Molmil
THE THIRD PDZ DOMAIN FROM THE SYNAPTIC PROTEIN PSD-95 IN COMPLEX WITH A C-TERMINAL PEPTIDE DERIVED FROM CRIPT.
Descriptor: CRIPT, PSD-95
Authors:Doyle, D.A, Lee, A, Lewis, J, Kim, E, Sheng, M, Mackinnon, R.
Deposit date:1998-05-20
Release date:1998-10-21
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (1.82 Å)
Cite:Crystal structures of a complexed and peptide-free membrane protein-binding domain: molecular basis of peptide recognition by PDZ.
Cell(Cambridge,Mass.), 85, 1996
8HCK
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BU of 8hck by Molmil
NMR fragment-based screening against the two PDZ do-mains of MDA-9
Descriptor: 4-BUTYL-1,2-DIPHENYL-PYRAZOLIDINE-3,5-DIONE, GLYCEROL, SULFATE ION, ...
Authors:Tang, H.
Deposit date:2022-11-01
Release date:2023-11-08
Method:X-RAY DIFFRACTION (2 Å)
Cite:NMR fragment-based screening against the two PDZ do-mains of MDA-9
To Be Published
4UU5
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BU of 4uu5 by Molmil
CRYSTAL STRUCTURE OF THE PDZ DOMAIN OF PALS1 IN COMPLEX WITH THE CRB PEPTIDE
Descriptor: 2,2,4,4,6,6,8-heptamethylnonane, CHLORIDE ION, MAGUK P55 SUBFAMILY MEMBER 5, ...
Authors:Ivanova, M.E, Purkiss, A.G, McDonald, N.Q.
Deposit date:2014-07-24
Release date:2015-01-14
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (1.23 Å)
Cite:Structures of the human Pals1 PDZ domain with and without ligand suggest gated access of Crb to the PDZ peptide-binding groove.
Acta Crystallogr. D Biol. Crystallogr., 71, 2015
1D5G
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BU of 1d5g by Molmil
SOLUTION STRUCTURE OF THE PDZ2 DOMAIN FROM HUMAN PHOSPHATASE HPTP1E COMPLEXED WITH A PEPTIDE
Descriptor: HUMAN PHOSPHATASE HPTP1E, PEPTIDE FADSEADENEQVSAV
Authors:Kozlov, G, Gehring, K, Ekiel, I.
Deposit date:1999-10-07
Release date:2002-07-24
Last modified:2022-02-16
Method:SOLUTION NMR
Cite:Solution Structure of the PDZ2 Domain from Cytosolic Human Phosphatase hPTP1E Complexed with a Peptide Reveals Contribution of the beta2-beta3 Loop to PDZ Domain-Ligand Interactions
J.Mol.Biol., 320, 2002
4WYU
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BU of 4wyu by Molmil
Crystal Structure of Scribble PDZ34 tandem in complex with its target peptide
Descriptor: IODIDE ION, Protein scribble homolog, peptide SER-TRP-PHE-GLN-THR-ASP-LEU
Authors:Ren, J.Q, Pei, H.H, Feng, W.
Deposit date:2014-11-18
Release date:2015-10-21
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Interdomain interface-mediated target recognition by the Scribble PDZ34 supramodule.
Biochem.J., 468, 2015
8HU2
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BU of 8hu2 by Molmil
Rattus Syntenin-1 PDZ domain with inhibitor
Descriptor: (2~{S})-2-(9~{H}-fluoren-9-ylmethoxycarbonylamino)-3-(4-oxidanylidene-5~{H}-pyrimidin-2-yl)propanoic acid, Syntenin-1
Authors:Heo, Y, Lee, J, Yun, J.H, Lee, W.
Deposit date:2022-12-22
Release date:2024-01-17
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Crystal structure of STNPDZ with inhibitor at 1.60 Angstroms resolution.
To Be Published
8OEP
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BU of 8oep by Molmil
Crystal structure of the PTPN3 PDZ domain bound to the HPV18 E6 oncoprotein C-terminal peptide
Descriptor: Protein E6, SODIUM ION, Tyrosine-protein phosphatase non-receptor type 3
Authors:Genera, M, Colcombet-Cazenave, B, Croitoru, A, Raynal, B, Mechaly, A, Caillet, J, Haouz, A, Wolff, N, Caillet-Saguy, C.
Deposit date:2023-03-11
Release date:2023-05-10
Last modified:2023-05-31
Method:X-RAY DIFFRACTION (1.87 Å)
Cite:Interactions of the protein tyrosine phosphatase PTPN3 with viral and cellular partners through its PDZ domain: insights into structural determinants and phosphatase activity.
Front Mol Biosci, 10, 2023
1G9O
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BU of 1g9o by Molmil
FIRST PDZ DOMAIN OF THE HUMAN NA+/H+ EXCHANGER REGULATORY FACTOR
Descriptor: NHE-RF
Authors:Karthikeyan, S, Leung, T, Birrane, G, Webster, G, Ladias, J.A.A.
Deposit date:2000-11-26
Release date:2001-05-23
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Crystal structure of the PDZ1 domain of human Na(+)/H(+) exchanger regulatory factor provides insights into the mechanism of carboxyl-terminal leucine recognition by class I PDZ domains.
J.Mol.Biol., 308, 2001
1GM1
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BU of 1gm1 by Molmil
Second PDZ Domain (PDZ2) of PTP-BL
Descriptor: PROTEIN TYROSINE PHOSPHATASE
Authors:Walma, T, Tessari, M, Aelen, J, Schepens, J, Hendriks, W, Vuister, G.W.
Deposit date:2001-09-06
Release date:2002-03-08
Last modified:2018-03-28
Method:SOLUTION NMR
Cite:Structure, dynamics and binding characteristics of the second PDZ domain of PTP-BL.
J. Mol. Biol., 316, 2002
6BXG
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BU of 6bxg by Molmil
1.45 Angstrom Resolution Crystal Structure of PDZ domain of Carboxy-Terminal Protease from Vibrio cholerae in Complex with Peptide.
Descriptor: CHLORIDE ION, IODIDE ION, LEU-ILE-ALA, ...
Authors:Minasov, G, Shuvalova, L, Filippova, E.V, Kiryukhina, O, Grimshaw, S, Kwon, K, Anderson, W.F, Satchell, K.J.F, Joachimiak, A, Center for Structural Genomics of Infectious Diseases (CSGID)
Deposit date:2017-12-18
Release date:2018-01-03
Method:X-RAY DIFFRACTION (1.45 Å)
Cite:1.45 Angstrom Resolution Crystal Structure of PDZ domain of Carboxy-Terminal Protease from Vibrio cholerae in Complex with Peptide.
To Be Published
6EEY
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BU of 6eey by Molmil
Crystal structure of human Scribble PDZ4 R1110G Mutant
Descriptor: Protein scribble homolog
Authors:Janezic, E.M, Hsu, P, Hague, C.
Deposit date:2018-08-15
Release date:2019-10-02
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (1.145 Å)
Cite:Scribble co-operatively binds multiple alpha1D-adrenergic receptor C-terminal PDZ ligands.
Sci Rep, 9, 2019
6EZI
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BU of 6ezi by Molmil
PDZK1 domain 4 in complex with C-terminal peptide of human PepT2.
Descriptor: GLYCEROL, Na(+)/H(+) exchange regulatory cofactor NHE-RF3, Solute carrier family 15 member 2
Authors:Loew, C, Flayhan, A, Pieprzyk, J.
Deposit date:2017-11-15
Release date:2018-09-26
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (1.503321 Å)
Cite:Probing the Architecture of a Multi-PDZ Domain Protein: Structure of PDZK1 in Solution.
Structure, 26, 2018
6ESP
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BU of 6esp by Molmil
Proteome-wide analysis of phospho-regulated PDZ domain interactions
Descriptor: Protein scribble homolog
Authors:Chi, N.C.
Deposit date:2017-10-24
Release date:2018-09-05
Last modified:2019-05-08
Method:SOLUTION NMR
Cite:Proteome-wide analysis of phospho-regulated PDZ domain interactions.
Mol. Syst. Biol., 14, 2018
5MZ7
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BU of 5mz7 by Molmil
Crystal Structure of the third PDZ domain from the synaptic protein PSD-95 with incorporated Azidohomoalanine
Descriptor: Disks large homolog 4
Authors:Kudlinzki, D, Lehner, F, Witt, K, Linhard, V.L, Silvers, R, Schwalbe, H.
Deposit date:2017-01-31
Release date:2017-10-04
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (1.53 Å)
Cite:Impact of Azidohomoalanine Incorporation on Protein Structure and Ligand Binding.
Chembiochem, 18, 2017
6GBE
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BU of 6gbe by Molmil
Murine Protein Tyrosine Phosphatase PTPN13 PDZ3 Domain-PRK2 Peptide Complex
Descriptor: Serine/threonine-protein kinase N2, Tyrosine-protein phosphatase non-receptor type 13
Authors:Kock, G, Stoll, R.
Deposit date:2018-04-13
Release date:2018-12-05
Last modified:2020-01-29
Method:SOLUTION NMR
Cite:Molecular Basis of Class III Ligand Recognition by PDZ3 in Murine Protein Tyrosine Phosphatase PTPN13.
J. Mol. Biol., 430, 2018
8GI4
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BU of 8gi4 by Molmil
Crystal structure of human LIMK2 PDZ domain
Descriptor: LIM domain kinase 2
Authors:Casanova Sepulveda, G, Boggon, T.J.
Deposit date:2023-03-13
Release date:2023-12-06
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (2.06 Å)
Cite:Autoregulation of the LIM kinases by their PDZ domain
Nat Commun, 14, 2023
6ZC8
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BU of 6zc8 by Molmil
Small-molecule inhibitors of the PDZ domain of Dishevelled proteins interrupt Wnt signalling
Descriptor: 2-[[3-chloranyl-4-[(1~{H}-indazol-3-ylcarbonylamino)methyl]phenyl]sulfonylamino]-5-methyl-benzoic acid, Segment polarity protein dishevelled homolog DVL-3
Authors:Roske, Y, Heinemann, U, Oschkinat, H.
Deposit date:2020-06-10
Release date:2021-06-23
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (2.76 Å)
Cite:Small-molecule inhibitors of the PDZ domain of Dishevelled proteins interrupt Wnt signalling
J.Magn.Reson., 2021
6ZBQ
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BU of 6zbq by Molmil
Small-molecule inhibitors of the PDZ domain of Dishevelled proteins interrupt Wnt signalling
Descriptor: 5-fluoranyl-2-(5,6,7,8-tetrahydronaphthalen-2-ylsulfonylamino)benzoic acid, Dishevelled, dsh homolog 3 (Drosophila), ...
Authors:Roske, Y, Heinemann, U, Oschkinat, H.
Deposit date:2020-06-09
Release date:2021-06-23
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (1.43 Å)
Cite:Small-molecule inhibitors of the PDZ domain of Dishevelled proteins interrupt Wnt signalling
J.Magn.Reson., 2021
6ZC4
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BU of 6zc4 by Molmil
Small-molecule inhibitors of the PDZ domain of Dishevelled proteins interrupt Wnt signalling
Descriptor: 5-bromanyl-2-(5,6,7,8-tetrahydronaphthalen-2-ylsulfonylamino)benzoic acid, Dishevelled, dsh homolog 3 (Drosophila), ...
Authors:Roske, Y, Heinemann, U, Oschkinat, H.
Deposit date:2020-06-09
Release date:2021-06-23
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Small-molecule inhibitors of the PDZ domain of Dishevelled proteins interrupt Wnt signalling
J.Magn.Reson., 2021
6ZBZ
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BU of 6zbz by Molmil
Small-molecule inhibitors of the PDZ domain of Dishevelled proteins interrupt Wnt signalling
Descriptor: 1,2-ETHANEDIOL, 2-[(3,4-dimethylphenyl)sulfonylamino]-5-fluoranyl-benzoic acid, Dishevelled, ...
Authors:Roske, Y, Heinemann, U, Oschkinat, H.
Deposit date:2020-06-09
Release date:2021-06-23
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Small-molecule inhibitors of the PDZ domain of Dishevelled proteins interrupt Wnt signalling
J.Magn.Reson., 2021
6ZC7
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BU of 6zc7 by Molmil
Small-molecule inhibitors of the PDZ domain of Dishevelled proteins interrupt Wnt signalling
Descriptor: 5-bromanyl-2-[(phenylmethyl)sulfonylamino]benzoic acid, Dishevelled, dsh homolog 3 (Drosophila), ...
Authors:Roske, Y, Heinemann, U, Oschkinat, H.
Deposit date:2020-06-09
Release date:2021-06-23
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (1.48 Å)
Cite:Small-molecule inhibitors of the PDZ domain of Dishevelled proteins interrupt Wnt signalling
J.Magn.Reson., 2021

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