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6VN4
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BU of 6vn4 by Molmil
USP7 IN COMPLEX WITH LIGAND COMPOUND 1
Descriptor: 3-({4-hydroxy-1-[(2R)-2-methyl-3-phenylpropanoyl]piperidin-4-yl}methyl)quinazolin-4(3H)-one, Ubiquitin carboxyl-terminal hydrolase 7
Authors:Leger, P.R, Wustrow, D.J, Hu, D.X, Krapp, S, Maskos, K, Blaesse, M.
Deposit date:2020-01-29
Release date:2020-04-29
Last modified:2020-06-10
Method:X-RAY DIFFRACTION (2.69 Å)
Cite:Discovery of Potent, Selective, and Orally Bioavailable Inhibitors of USP7 with In Vivo Antitumor Activity.
J.Med.Chem., 63, 2020
1VJV
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BU of 1vjv by Molmil
Crystal structure of Ubiquitin carboxyl-terminal hydrolase 6 (yfr010w) from Saccharomyces cerevisiae at 1.74 A resolution
Descriptor: Ubiquitin carboxyl-terminal hydrolase 6
Authors:Joint Center for Structural Genomics (JCSG)
Deposit date:2004-03-29
Release date:2004-09-21
Last modified:2023-01-25
Method:X-RAY DIFFRACTION (1.74 Å)
Cite:Crystal structure of Ubiquitin carboxyl-terminal hydrolase 6 (yfr010w) from Saccharomyces cerevisiae at 1.74 A resolution
To be published
8XPN
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BU of 8xpn by Molmil
The Crystal Structure of USP8 from Biortus.
Descriptor: 1,2-ETHANEDIOL, DI(HYDROXYETHYL)ETHER, Ubiquitin carboxyl-terminal hydrolase 8, ...
Authors:Wang, F, Cheng, W, Yuan, Z, Lin, D, Wang, J.
Deposit date:2024-01-04
Release date:2024-03-06
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:The Crystal Structure of USP8 from Biortus.
To Be Published
1NB8
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BU of 1nb8 by Molmil
Structure of the catalytic domain of USP7 (HAUSP)
Descriptor: Ubiquitin carboxyl-terminal hydrolase 7
Authors:Hu, M, Li, P, Li, M, Li, W, Yao, T, Wu, J.-W, Gu, W, Cohen, R.E, Shi, Y.
Deposit date:2002-12-02
Release date:2003-01-07
Last modified:2018-04-04
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Crystal structure of a UBP-family deubiquitinating enzyme in isolation and in complex with ubiquitin aldehyde
Cell(Cambridge,Mass.), 111, 2002
8HJE
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BU of 8hje by Molmil
Vismodegib binds to the catalytical domain of human Ubiquitin-Specific Protease 28
Descriptor: 2-chloranyl-~{N}-(4-chloranyl-3-pyridin-2-yl-phenyl)-4-methylsulfonyl-benzamide, Ubiquitin carboxyl-terminal hydrolase 28
Authors:Shi, L, Wang, H, Xu, Z, Xiong, B, Zhang, N.
Deposit date:2022-11-23
Release date:2023-05-03
Method:X-RAY DIFFRACTION (2.85 Å)
Cite:Structure-based discovery of potent USP28 inhibitors derived from Vismodegib.
Eur.J.Med.Chem., 254, 2023
2AYN
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BU of 2ayn by Molmil
Structure of USP14, a proteasome-associated deubiquitinating enzyme
Descriptor: Ubiquitin carboxyl-terminal hydrolase 14
Authors:Hu, M, Li, P, Jeffrey, P.D, Shi, Y.
Deposit date:2005-09-07
Release date:2005-10-18
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Structure and mechanisms of the proteasome-associated deubiquitinating enzyme USP14.
Embo J., 24, 2005
7R2G
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BU of 7r2g by Molmil
USP15 D1D2 in catalytically-competent state bound to mitoxantrone stack (isoform 2)
Descriptor: 1,4-DIHYDROXY-5,8-BIS({2-[(2-HYDROXYETHYL)AMINO]ETHYL}AMINO)-9,10-ANTHRACENEDIONE, GLYCEROL, Ubiquitin carboxyl-terminal hydrolase 15, ...
Authors:Priyanka, A, Sixma, T.K.
Deposit date:2022-02-04
Release date:2022-06-08
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (1.98 Å)
Cite:Mitoxantrone stacking does not define the active or inactive state of USP15 catalytic domain.
J.Struct.Biol., 214, 2022
2VHF
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BU of 2vhf by Molmil
Structure of the CYLD USP domain
Descriptor: UBIQUITIN CARBOXYL-TERMINAL HYDROLASE CYLD, ZINC ION
Authors:Komander, D, Lord, C.J, Scheel, H, Swift, S, Hofmann, K, Ashworth, A, Barford, D.
Deposit date:2007-11-21
Release date:2008-03-11
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:The Structure of the Cyld Usp Domain Explains its Specificity for Lys63-Linked Polyubiquitin and Reveals a B-Box Module
Mol.Cell.Biol., 29, 2008
4M5W
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BU of 4m5w by Molmil
Crystal structure of the USP7/HAUSP catalytic domain
Descriptor: BROMIDE ION, Ubiquitin carboxyl-terminal hydrolase 7
Authors:Molland, K.L, Mesecar, A.D, Zhou, Q.
Deposit date:2013-08-08
Release date:2014-03-12
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2.244 Å)
Cite:A 2.2 angstrom resolution structure of the USP7 catalytic domain in a new space group elaborates upon structural rearrangements resulting from ubiquitin binding.
Acta Crystallogr F Struct Biol Commun, 70, 2014
4M5X
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BU of 4m5x by Molmil
Crystal structure of the USP7/HAUSP catalytic domain
Descriptor: BROMIDE ION, Ubiquitin carboxyl-terminal hydrolase 7
Authors:Mesecar, A.D, Molland, K.L, Zhou, Q.
Deposit date:2013-08-08
Release date:2014-03-12
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2.187 Å)
Cite:A 2.2 angstrom resolution structure of the USP7 catalytic domain in a new space group elaborates upon structural rearrangements resulting from ubiquitin binding.
Acta Crystallogr F Struct Biol Commun, 70, 2014
6LVS
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BU of 6lvs by Molmil
USP14 catalytic domain mutant C114S
Descriptor: 1,2-ETHANEDIOL, BETA-MERCAPTOETHANOL, FORMIC ACID, ...
Authors:Lin, H.C, Lin, T.H, Chou, C.Y.
Deposit date:2020-02-04
Release date:2020-03-18
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (2.73 Å)
Cite:USP14 catalytic domain mutant C114S
To Be Published
6M1K
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BU of 6m1k by Molmil
USP7 in complex with a novel inhibitor
Descriptor: Ubiquitin carboxyl-terminal hydrolase 7, methyl 4-[[4-[[3-[4-(aminomethyl)phenyl]-2-methyl-7-oxidanylidene-pyrazolo[4,3-d]pyrimidin-6-yl]methyl]-4-oxidanyl-piperidin-1-yl]methyl]-3-chloranyl-benzoate
Authors:Liu, S.J, Zhou, X.Y, Li, M.L, Sun, H.B, Wen, X.A.
Deposit date:2020-02-26
Release date:2021-03-10
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (2.255 Å)
Cite:N-benzylpiperidinol derivatives as novel USP7 inhibitors: Structure-activity relationships and X-ray crystallographic studies.
Eur.J.Med.Chem., 199, 2020
2Y6E
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BU of 2y6e by Molmil
Structure of the D1D2 domain of USP4, the conserved catalytic domain
Descriptor: SULFATE ION, UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 4, ZINC ION
Authors:Luna-Vargas, M.P.A, Faesen, A.C, van Dijk, W.J, Rape, M, Fish, A, Sixma, T.K.
Deposit date:2011-01-20
Release date:2011-04-06
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:The Dusp-Ubl Domain of Usp4 Enhances its Catalytic Efficiency by Promoting Ubiquitin Exchange.
Nat.Commun., 5, 2014
6CRN
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BU of 6crn by Molmil
Structure of the USP15 deubiquitinase domain in complex with a high-affinity first-generation Ubv
Descriptor: Ubiquitin carboxyl-terminal hydrolase 15, Ubiquitin variant 15.2, ZINC ION
Authors:Singer, A.U, Teyra, J, Boehmelt, G, Lenter, M, Sicheri, F, Sidhu, S.S.
Deposit date:2018-03-19
Release date:2019-01-23
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structural and Functional Characterization of Ubiquitin Variant Inhibitors of USP15.
Structure, 27, 2019
6CPM
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BU of 6cpm by Molmil
Structure of the USP15 deubiquitinase domain in complex with a third-generation inhibitory Ubv
Descriptor: 1,2-ETHANEDIOL, CALCIUM ION, GLYCEROL, ...
Authors:Singer, A.U, Teyra, J, Boehmelt, G, Lenter, M, Sicheri, F, Sidhu, S.S.
Deposit date:2018-03-13
Release date:2019-01-23
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (2.011 Å)
Cite:Structural and Functional Characterization of Ubiquitin Variant Inhibitors of USP15.
Structure, 27, 2019
2GFO
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BU of 2gfo by Molmil
Structure of the Catalytic Domain of Human Ubiquitin Carboxyl-terminal Hydrolase 8
Descriptor: Ubiquitin carboxyl-terminal hydrolase 8, ZINC ION
Authors:Walker, J.R, Avvakumov, G.V, Xue, S, Newman, E.M, Finerty Jr, P.J, Butler-Cole, C, Weigelt, J, Sundstrom, M, Arrowsmith, C, Edwards, A, Bochkarev, A, Dhe-Paganon, S, Structural Genomics Consortium (SGC)
Deposit date:2006-03-22
Release date:2006-04-04
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (2 Å)
Cite:Amino-terminal Dimerization, NRDP1-Rhodanese Interaction, and Inhibited Catalytic Domain Conformation of the Ubiquitin-specific Protease 8 (USP8).
J.Biol.Chem., 281, 2006
6F5H
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BU of 6f5h by Molmil
Crystal structure of USP7 in complex with a 4-hydroxypiperidine based inhibitor
Descriptor: 3-[[4-oxidanyl-1-[(3~{R})-3-phenylbutanoyl]piperidin-4-yl]methyl]-6-(2-pyrrolidin-1-ylethylamino)pyrimidin-4-one, GLYCEROL, SULFATE ION, ...
Authors:Harrison, T, Gavory, G, O'Dowd, C, Helm, M, Flasz, J, Dossang, A, Hughes, C, Cassidy, E, McClelland, K, Odrzywol, E, Page, N, Barker, O, Miel, H, Feutron-Burton, S, Rountree, J.S.S.
Deposit date:2017-12-01
Release date:2018-04-11
Method:X-RAY DIFFRACTION (2.16 Å)
Cite:Identification and Structure-Guided Development of Pyrimidinone Based USP7 Inhibitors.
ACS Med Chem Lett, 9, 2018
7CM2
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BU of 7cm2 by Molmil
The Crystal Structure of human USP7 USP domain from Biortus
Descriptor: GLYCEROL, Ubiquitin carboxyl-terminal hydrolase 7
Authors:Wang, F, Cheng, W, Lv, Z, Lin, D, Zhu, B, Miao, Q, Bao, X, Shang, H.
Deposit date:2020-07-24
Release date:2020-08-05
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:The Crystal Structure of human USP7 USP domain from Biortus.
To Be Published
8D0A
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BU of 8d0a by Molmil
Crystal structure of human USP30 in complex with a covalent inhibitor 829 and a Fab
Descriptor: Ubiquitin carboxyl-terminal hydrolase 30, ZINC ION, mouse anti-huUSP30 Fab heavy chain, ...
Authors:Song, X, Butler, J, Li, C, Zhang, K, Zhang, D, Hao, Y.
Deposit date:2022-05-25
Release date:2023-02-01
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (3.19 Å)
Cite:TBD
To Be Published
8D1T
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BU of 8d1t by Molmil
Crystal structure of human USP30 in complex with a covalent inhibitor 552 and a Fab
Descriptor: (1R,2R,4S,7E)-7-[amino(sulfanyl)methylidene]-2-{[(1P)-3-chloro-3'-(1-cyanocyclopropyl)[1,1'-biphenyl]-4-carbonyl]amino}-7-azabicyclo[2.2.1]heptan-7-ium, 1,2-ETHANEDIOL, Ubiquitin carboxyl-terminal hydrolase 30, ...
Authors:Song, X, Butler, J, Li, C, Zhang, K, Zhang, D, Hao, Y.
Deposit date:2022-05-27
Release date:2023-02-01
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (2.94 Å)
Cite:TBD
To Be Published
8D4Z
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BU of 8d4z by Molmil
Crystal structure of USP7 in complex with allosteric inhibitor FX1-3763
Descriptor: 1-({(7M)-7-[1-(azetidin-3-yl)-6-chloro-1,2,3,4-tetrahydroquinolin-8-yl]thieno[3,2-b]pyridin-2-yl}methyl)pyrrolidine-2,5-dione, GLYCEROL, Ubiquitin carboxyl-terminal hydrolase 7
Authors:Bell, J.A.
Deposit date:2022-06-03
Release date:2023-09-20
Method:X-RAY DIFFRACTION (2.26 Å)
Cite:Novel USP7 inhibitors demonstrate potent anti-cancer activity in models of AML, synergy with BCL2 inhibition, and a differentiated mechanism of action
To Be Published
5WHC
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BU of 5whc by Molmil
USP7 in complex with Cpd2 (4-(3-(1-methylpiperidin-4-yl)-1,2,4-oxadiazol-5-yl)phenol)
Descriptor: 4-[3-(1-methylpiperidin-4-yl)-1,2,4-oxadiazol-5-yl]phenol, GLYCEROL, Ubiquitin carboxyl-terminal hydrolase 7
Authors:Murray, J.M, Rouge, L.
Deposit date:2017-07-16
Release date:2017-12-13
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (2.548 Å)
Cite:Discovery of Small-Molecule Inhibitors of Ubiquitin Specific Protease 7 (USP7) Using Integrated NMR and in Silico Techniques.
J. Med. Chem., 60, 2017
5WCH
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BU of 5wch by Molmil
Crystal structure of the catalytic domain of human USP9X
Descriptor: Probable ubiquitin carboxyl-terminal hydrolase FAF-X, UNKNOWN ATOM OR ION, ZINC ION
Authors:Dong, A, Zhang, Q, Walker, J.R, Bountra, C, Arrowsmith, C.H, Edwards, A.M, Tong, Y, Structural Genomics Consortium (SGC)
Deposit date:2017-06-30
Release date:2018-07-04
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Crystal structure and activity-based labeling reveal the mechanisms for linkage-specific substrate recognition by deubiquitinase USP9X.
Proc. Natl. Acad. Sci. U.S.A., 116, 2019
5CHT
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BU of 5cht by Molmil
Crystal structure of USP18
Descriptor: Ubl carboxyl-terminal hydrolase 18, ZINC ION
Authors:Fritz, G, Basters, A.
Deposit date:2015-07-10
Release date:2016-06-29
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structural basis of the specificity of USP18 toward ISG15.
Nat. Struct. Mol. Biol., 24, 2017
5UQV
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BU of 5uqv by Molmil
USP7 in complex with GNE6640 (4-(2-amino-4-ethyl-5-(1H-indazol-5-yl)pyridin-3-yl)phenol)
Descriptor: 4-[2-amino-4-ethyl-5-(1H-indazol-5-yl)pyridin-3-yl]phenol, Ubiquitin carboxyl-terminal hydrolase 7
Authors:Murray, J.M, Rouge, L.
Deposit date:2017-02-08
Release date:2017-10-25
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (2.84 Å)
Cite:USP7 small-molecule inhibitors interfere with ubiquitin binding.
Nature, 550, 2017

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