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1GP1
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BU of 1gp1 by Molmil
THE REFINED STRUCTURE OF THE SELENOENZYME GLUTATHIONE PEROXIDASE AT 0.2-NM RESOLUTION
Descriptor: GLUTATHIONE PEROXIDASE
Authors:Epp, O, Ladenstein, R.
Deposit date:1985-06-11
Release date:1985-11-08
Last modified:2023-07-26
Method:X-RAY DIFFRACTION (2 Å)
Cite:The refined structure of the selenoenzyme glutathione peroxidase at 0.2-nm resolution.
Eur.J.Biochem., 133, 1983
5L71
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Crystal structure of mouse phospholipid hydroperoxide glutathione peroxidase 4 (GPx4)
Descriptor: 1,2-ETHANEDIOL, Phospholipid hydroperoxide glutathione peroxidase, mitochondrial
Authors:Janowski, R, Scanu, S, Madl, T, Niessing, D.
Deposit date:2016-06-01
Release date:2016-10-19
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Crystal and solution structural studies of mouse phospholipid hydroperoxide glutathione peroxidase 4.
Acta Crystallogr.,Sect.F, 72, 2016
7FC2
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BU of 7fc2 by Molmil
Crystal Structure of GPX6
Descriptor: Glutathione peroxidase 6, SULFATE ION
Authors:Sun, J.
Deposit date:2021-07-13
Release date:2022-07-20
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal Structure of GPX6
To Be Published
6ELW
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BU of 6elw by Molmil
High resolution structure of selenocysteine containing human GPX4
Descriptor: CHLORIDE ION, Phospholipid hydroperoxide glutathione peroxidase, mitochondrial
Authors:Kalms, J, Borchert, A, Kuhn, H, Scheerer, P.
Deposit date:2017-09-29
Release date:2018-06-20
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (1.3 Å)
Cite:Crystal structure and functional characterization of selenocysteine-containing glutathione peroxidase 4 suggests an alternative mechanism of peroxide reduction.
Biochim. Biophys. Acta, 1863, 2018
6VPD
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BU of 6vpd by Molmil
Crystal structure of Trgpx in apo form
Descriptor: Glutathione peroxidase
Authors:Adriani, P.P, De Oliveira, G.S, Paiva, F.C.R, Dias, M.V.B, Chambergo, F.S.
Deposit date:2020-02-03
Release date:2020-12-16
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.603 Å)
Cite:Structural and functional characterization of the glutathione peroxidase-like thioredoxin peroxidase from the fungus Trichoderma reesei.
Int.J.Biol.Macromol., 167, 2020
3KIJ
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BU of 3kij by Molmil
Crystal structure of the human PDI-peroxidase
Descriptor: Probable glutathione peroxidase 8, SULFATE ION
Authors:Nguyen, D.V, Ruddock, L.W.
Deposit date:2009-11-02
Release date:2011-01-12
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Two Endoplasmic Reticulum PDI Peroxidases Increase the Efficiency of the Use of Peroxide during Disulfide Bond Formation.
J.Mol.Biol., 406, 2011
6HN3
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wildtype form (apo) of human GPX4 with Se-Cys46
Descriptor: CHLORIDE ION, ETHANOL, GLYCEROL, ...
Authors:Hillig, R.C, Moosmayer, D, Hilpmann, A, Hoffmann, J, Schnirch, L, Eaton, J.K, Badock, V, Gradl, S.
Deposit date:2018-09-13
Release date:2020-04-01
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (1.01 Å)
Cite:Crystal structures of the selenoprotein glutathione peroxidase 4 in its apo form and in complex with the covalently bound inhibitor ML162.
Acta Crystallogr D Struct Biol, 77, 2021
6HKQ
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Human GPX4 in complex with covalent Inhibitor ML162 (S enantiomer)
Descriptor: (2~{S})-2-[2-chloranylethanoyl-(3-chloranyl-4-methoxy-phenyl)amino]-~{N}-(2-phenylethyl)-2-thiophen-2-yl-ethanamide, 1,2-ETHANEDIOL, DIMETHYL SULFOXIDE, ...
Authors:Hillig, R.C, Moosmayer, D, Hilpmann, A, Hoffmann, L, Schnirch, L, Eaton, J.K, Badock, V, Gradl, S.
Deposit date:2018-09-07
Release date:2020-04-01
Last modified:2022-12-07
Method:X-RAY DIFFRACTION (1.54 Å)
Cite:Crystal structures of the selenoprotein glutathione peroxidase 4 in its apo form and in complex with the covalently bound inhibitor ML162.
Acta Crystallogr D Struct Biol, 77, 2021
2V1M
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Crystal structure of Schistosoma mansoni glutathione peroxidase
Descriptor: ACETATE ION, GLUTATHIONE PEROXIDASE, LITHIUM ION, ...
Authors:Dimastrogiovanni, D, Miele, A.E, Angelucci, F, Boumis, G, Bellelli, A, Brunori, M.
Deposit date:2008-09-16
Release date:2009-09-08
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (1 Å)
Cite:Combining Crystallography and Molecular Dynamics: The Case of Schistosoma Mansoni Phospholipid Glutathione Peroxidase.
Proteins, 78, 2010
5H5Q
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BU of 5h5q by Molmil
Crystal structure of human GPX4 in complex with GXpep-1
Descriptor: GLYCEROL, GXpep-1, Phospholipid hydroperoxide glutathione peroxidase, ...
Authors:Sogabe, S, Kadotani, A, Lane, W, Snell, G.
Deposit date:2016-11-09
Release date:2016-12-07
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (1.1 Å)
Cite:Discovery of GPX4 inhibitory peptides from random peptide T7 phage display and subsequent structural analysis
Biochem. Biophys. Res. Commun., 482, 2017
5H5S
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BU of 5h5s by Molmil
Crystal structure of human GPX4 in complex with GXpep-3
Descriptor: GLYCEROL, GXpep-3, Phospholipid hydroperoxide glutathione peroxidase, ...
Authors:Sogabe, S, Kadotani, A, Lane, W, Snell, G.
Deposit date:2016-11-09
Release date:2016-12-07
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Discovery of GPX4 inhibitory peptides from random peptide T7 phage display and subsequent structural analysis
Biochem. Biophys. Res. Commun., 482, 2017
5H5R
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BU of 5h5r by Molmil
Crystal structure of human GPX4 in complex with GXpep-2
Descriptor: GLYCEROL, GXpep-2, Phospholipid hydroperoxide glutathione peroxidase, ...
Authors:Sogabe, S, Kadotani, A, Lane, W, Snell, G.
Deposit date:2016-11-09
Release date:2016-12-07
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (1.2 Å)
Cite:Discovery of GPX4 inhibitory peptides from random peptide T7 phage display and subsequent structural analysis
Biochem. Biophys. Res. Commun., 482, 2017
2VUP
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BU of 2vup by Molmil
Crystal structure of a type II tryparedoxin-dependant peroxidase from Trypanosoma brucei
Descriptor: GLUTATHIONE PEROXIDASE-LIKE PROTEIN
Authors:Alphey, M.S, Konig, J, Fairlamb, A.H.
Deposit date:2008-05-28
Release date:2008-06-17
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structural and Mechanistic Insights Into Type II Trypanosomatid Tryparedoxin-Dependent Peroxidases.
Biochem.J., 414, 2008
2WGR
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BU of 2wgr by Molmil
Combining crystallography and molecular dynamics: The case of Schistosoma mansoni phospholipid glutathione peroxidase
Descriptor: GLUTATHIONE PEROXIDASE, PYROPHOSPHATE 2-
Authors:Dimastrogiovanni, D, Anselmi, M, Miele, A.E, Boumis, G, Angelucci, F, Di Nola, A, Brunori, M, Bellelli, A.
Deposit date:2009-04-24
Release date:2009-09-08
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Combining Crystallography and Molecular Dynamics: The Case of Schistosoma Mansoni Phospholipid Glutathione Peroxidase.
Proteins, 78, 2010
2F8A
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BU of 2f8a by Molmil
Crystal structure of the selenocysteine to glycine mutant of human glutathione peroxidase 1
Descriptor: Glutathione peroxidase 1, MALONIC ACID
Authors:Kavanagh, K.L, Johansson, C, Smee, C, Gileadi, O, von Delft, F, Weigelt, J, Sundstrom, M, Edwards, A, Oppermann, U, Structural Genomics Consortium (SGC)
Deposit date:2005-12-02
Release date:2005-12-13
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Crystal structure of the selenocysteine to glycine mutant of human glutathione peroxidase 1
To be Published
2GS3
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BU of 2gs3 by Molmil
Crystal structure of the selenocysteine to glycine mutant of human glutathione peroxidase 4(GPX4)
Descriptor: CHLORIDE ION, Phospholipid hydroperoxide glutathione peroxidase
Authors:Johansson, C, Kavanagh, K.L, Rojkova, A, Gileadi, O, von Delft, F, Arrowsmith, C, Weigelt, J, Sundstrom, M, Edwards, A, Oppermann, U, Structural Genomics Consortium (SGC)
Deposit date:2006-04-25
Release date:2006-05-09
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Crystal structure of the selenocysteine to glycine mutant of human glutathione peroxidase 4(GPX4)
To be Published
3CYN
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BU of 3cyn by Molmil
The structure of human GPX8
Descriptor: GLYCEROL, Probable glutathione peroxidase 8, SULFATE ION
Authors:Kavanagh, K.L, Johansson, C, Yue, W.W, Kochan, G, Pike, A.C.W, Murray, J, Roos, A.K, Filippakopoulos, P, von Delft, F, Arrowsmith, C.H, Wikstrom, M, Edwards, A.M, Bountra, C, Oppermann, U, Structural Genomics Consortium (SGC)
Deposit date:2008-04-25
Release date:2008-08-12
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2 Å)
Cite:The structure of human GPX8
To be Published
2HE3
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BU of 2he3 by Molmil
Crystal structure of the selenocysteine to cysteine mutant of human glutathionine peroxidase 2 (GPX2)
Descriptor: CHLORIDE ION, Glutathione peroxidase 2
Authors:Johansson, C, Kavanagh, K.L, Rojkova, A, Gileadi, O, von Delft, F, Arrowsmith, C, Weigelt, J, Sundstrom, M, Edwards, A, Oppermann, U, Structural Genomics Consortium (SGC)
Deposit date:2006-06-21
Release date:2006-07-25
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Crystal structure of the selenocysteine to cysteine mutant of human glutathionine peroxidase 2 (GPX2)
To be Published
3CMI
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BU of 3cmi by Molmil
Crystal structure of glutathione-dependent phospholipid peroxidase Hyr1 from the yeast Saccharomyces cerevisiae
Descriptor: Peroxiredoxin HYR1
Authors:Zhang, W.J.Z, He, Y.X, Yu, J, Zhou, C.Z.
Deposit date:2008-03-21
Release date:2008-09-16
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (2.02 Å)
Cite:Crystal structure of glutathione-dependent phospholipid peroxidase Hyr1 from the yeast Saccharomyces cerevisiae
Proteins, 73, 2008
2I3Y
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BU of 2i3y by Molmil
Crystal structure of human glutathione peroxidase 5
Descriptor: 1,2-ETHANEDIOL, Epididymal secretory glutathione peroxidase
Authors:Kavanagh, K.L, Johansson, C, Rojkova, A, Umeano, C, Bunkoczi, G, Gileadi, O, von Delft, F, Weigelt, J, Arrowsmith, C, Sundstrom, M, Edwards, A, Oppermann, U, Structural Genomics Consortium (SGC)
Deposit date:2006-08-21
Release date:2006-09-12
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal structure of human glutathione peroxidase 5
To be published
3E0U
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BU of 3e0u by Molmil
Crystal structure of T. cruzi GPX1
Descriptor: AMMONIUM ION, GLYCEROL, Glutathione peroxidase
Authors:Patel, S.H, Hussain, S, Harris, R, Driscoll, P, Djordjevic, S.
Deposit date:2008-08-01
Release date:2009-08-04
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structural insights into the catalytic mechanism of Trypanosoma cruzi GPXI (glutathione peroxidase-like enzyme I).
Biochem.J., 425, 2010
3DWV
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BU of 3dwv by Molmil
Glutathione peroxidase-type tryparedoxin peroxidase, oxidized form
Descriptor: Glutathione peroxidase-like protein
Authors:Tews, I, Sinning, I, Krauth-Siegel, L.
Deposit date:2008-07-23
Release date:2008-08-05
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (1.41 Å)
Cite:Structural basis for a distinct catalytic mechanism in Trypanosoma brucei tryparedoxin peroxidase.
J.Biol.Chem., 283, 2008
7L8L
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BU of 7l8l by Molmil
Crystal structure of human R152H GPX4-U46C
Descriptor: Phospholipid hydroperoxide glutathione peroxidase, THIOCYANATE ION
Authors:Forouhar, F, Liu, H, Seibt, T, Saneto, R, Wigby, K, Friedman, J, Xia, X, Shchepinov, M.S, Ramesh, S, Conrad, M, Stockwell, B.R.
Deposit date:2020-12-31
Release date:2021-12-29
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (1.61 Å)
Cite:Patient-derived variant of GPX4 reveals the structural basis for its catalytic activity and degradation mechanism
Nat.Chem.Biol., 2021
7L8Q
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Crystal structure of human GPX4-U46C with oxidized Cys-46
Descriptor: ACETATE ION, Phospholipid hydroperoxide glutathione peroxidase
Authors:Forouhar, F, Liu, H, Seibt, T, Saneto, R, Wigby, K, Friedman, J, Xia, X, Shchepinov, M.S, Ramesh, S, Conrad, M, Stockwell, B.R.
Deposit date:2020-12-31
Release date:2021-12-29
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (1.48 Å)
Cite:Patient-derived variant of GPX4 reveals the structural basis for its catalytic activity and degradation mechanism
Nat.Chem.Biol., 2021
7L8M
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Crystal structure of human GPX4-U46C mutant K48L
Descriptor: Phospholipid hydroperoxide glutathione peroxidase
Authors:Forouhar, F, Liu, H, Seibt, T, Saneto, R, Friedman, J, Xia, X, Shchepinov, M.S, Ramesh, S, Conrad, M, Stockwell, B.R.
Deposit date:2020-12-31
Release date:2021-12-29
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.07 Å)
Cite:Patient-derived variant of GPX4 reveals the structural basis for its catalytic activity and degradation mechanism
Nat.Chem.Biol., 2021

 

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