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5DM3
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Crystal Structure of Glutamine Synthetase from Chromohalobacter salexigens DSM 3043(Csal_0679, TARGET EFI-550015) with bound ADP
Descriptor: ADENOSINE-5'-DIPHOSPHATE, L-glutamine synthetase
Authors:Yadava, U, Vetting, M.W, Al Obaidi, N.F, Toro, R, Morisco, L.L, Benach, J, Koss, J, Wasserman, S.R, Attonito, J.D, Scott Glenn, A, Chamala, S, Chowdhury, S, Lafleur, J, Love, J, Seidel, R.D, Whalen, K.L, Gerlt, J.A, Almo, S.C, Enzyme Function Initiative (EFI)
Deposit date:2015-09-07
Release date:2015-09-16
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Crystal Structure of Glutamine Synthetase from Chromohalobacter salexigens DSM 3043(Csal_0679, TARGET EFI-550015) with bound ADP
To be published
2J9I
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Lengsin is a survivor of an ancient family of class I glutamine synthetases in eukaryotes that has undergone evolutionary re- engineering for a tissue-specific role in the vertebrate eye lens.
Descriptor: GLUTAMATE-AMMONIA LIGASE DOMAIN-CONTAINING PROTEIN 1
Authors:Wyatt, K, White, H.E, Wang, L, Bateman, O.A, Slingsby, C, Orlova, E.V, Wistow, G.
Deposit date:2006-11-09
Release date:2006-12-13
Last modified:2019-10-23
Method:ELECTRON MICROSCOPY (17 Å)
Cite:Lengsin is a Survivor of an Ancient Family of Class I Glutamine Synthetases Re-Engineered by Evolution for a Role in the Vertebrate Lens.
Structure, 14, 2006
7CQX
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GmaS/ADP complex-Conformation 2
Descriptor: ADENOSINE-5'-DIPHOSPHATE, Type III glutamate--ammonia ligase
Authors:Li, C.Y, Zhang, Y.Z.
Deposit date:2020-08-11
Release date:2020-11-18
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (2.301 Å)
Cite:Crystal structures of gamma-glutamylmethylamide synthetase provide insight into bacterial metabolism of oceanic monomethylamine.
J.Biol.Chem., 296, 2020
7CQW
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GmaS/ADP complex-Conformation 1
Descriptor: ADENOSINE-5'-DIPHOSPHATE, Type III glutamate--ammonia ligase
Authors:Li, C.Y, Zhang, Y.Z.
Deposit date:2020-08-11
Release date:2020-11-18
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (2.297 Å)
Cite:Crystal structures of gamma-glutamylmethylamide synthetase provide insight into bacterial metabolism of oceanic monomethylamine.
J.Biol.Chem., 296, 2020
7CPR
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glutamine synthetase from Drosophila
Descriptor: ADENOSINE-5'-DIPHOSPHATE, Glutamine synthetase 2 cytoplasmic
Authors:Yin, H.S, Chen, W.T.
Deposit date:2020-08-07
Release date:2021-08-11
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (2.12 Å)
Cite:Structural Insight into the Contributions of the N-Terminus and Key Active-Site Residues to the Catalytic Efficiency of Glutamine Synthetase 2.
Biomolecules, 10, 2020
7CQQ
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GmaS in complex with AMPPNP and MetSox
Descriptor: (2S)-2-AMINO-4-(METHYLSULFONIMIDOYL)BUTANOIC ACID, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ...
Authors:Li, C.Y, Zhang, Y.Z.
Deposit date:2020-08-11
Release date:2020-11-18
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (2.295 Å)
Cite:Crystal structures of gamma-glutamylmethylamide synthetase provide insight into bacterial metabolism of oceanic monomethylamine.
J.Biol.Chem., 296, 2020
7CQL
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Apo GmaS without ligand
Descriptor: Type III glutamate--ammonia ligase
Authors:Li, C.Y, Zhang, Y.Z.
Deposit date:2020-08-11
Release date:2020-11-18
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (2.801 Å)
Cite:Crystal structures of gamma-glutamylmethylamide synthetase provide insight into bacterial metabolism of oceanic monomethylamine.
J.Biol.Chem., 296, 2020
7CQN
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BU of 7cqn by Molmil
GmaS in complex with AMPPCP
Descriptor: PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER, Type III glutamate--ammonia ligase
Authors:Li, C.Y, Zhang, Y.Z.
Deposit date:2020-08-11
Release date:2020-11-18
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (1.962 Å)
Cite:Crystal structures of gamma-glutamylmethylamide synthetase provide insight into bacterial metabolism of oceanic monomethylamine.
J.Biol.Chem., 296, 2020
7CQU
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BU of 7cqu by Molmil
GmaS/ADP/MetSox-P complex
Descriptor: ADENOSINE-5'-DIPHOSPHATE, L-METHIONINE-S-SULFOXIMINE PHOSPHATE, MAGNESIUM ION, ...
Authors:Li, C.Y, Zhang, Y.Z.
Deposit date:2020-08-11
Release date:2020-11-18
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (2.06 Å)
Cite:Crystal structures of gamma-glutamylmethylamide synthetase provide insight into bacterial metabolism of oceanic monomethylamine.
J.Biol.Chem., 296, 2020
8WWU
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BU of 8wwu by Molmil
1-naphthylamine GS in complex with AMP PNP
Descriptor: Glutamine synthetase, MAGNESIUM ION, MANGANESE (II) ION, ...
Authors:Zhang, S.T, Zhou, N.Y.
Deposit date:2023-10-26
Release date:2024-01-03
Method:X-RAY DIFFRACTION (2 Å)
Cite:Discovery of the 1-naphthylamine biodegradation pathway reveals a glutamine synthetase-like protein that catalyzes 1-naphthylamine glutamylation
To Be Published
8WWV
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1-naphthylamine GS in complex with ADP and MetSox-P
Descriptor: ADENOSINE-5'-DIPHOSPHATE, Glutamine synthetase, L-METHIONINE-S-SULFOXIMINE PHOSPHATE, ...
Authors:Zhang, S.T, Zhou, N.Y.
Deposit date:2023-10-26
Release date:2024-01-03
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Discovery of the 1-naphthylamine biodegradation pathway reveals a glutamine synthetase-like protein that catalyzes 1-naphthylamine glutamylation
To Be Published
7V4H
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BU of 7v4h by Molmil
Cryo-EM Structure of Glycine max glutamine synthetase GmGS Beta2
Descriptor: Glutamine synthetase
Authors:Xu, W, Chen, Y, Xing, Q, Huang, C.
Deposit date:2021-08-13
Release date:2022-05-18
Method:ELECTRON MICROSCOPY (2.9 Å)
Cite:Assembly status transition offers an avenue for activity modulation of a supramolecular enzyme.
Elife, 10, 2021
6PEW
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BU of 6pew by Molmil
CryoEM Plasmodium falciparum glutamine synthetase
Descriptor: Glutamine synthetase
Authors:Ho, C.M, Lai, M, Zhou, Z.H.
Deposit date:2019-06-21
Release date:2019-12-11
Last modified:2024-03-20
Method:ELECTRON MICROSCOPY (3.2 Å)
Cite:Bottom-up structural proteomics: cryoEM of protein complexes enriched from the cellular milieu.
Nat.Methods, 17, 2020
4XYC
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BU of 4xyc by Molmil
NANOMOLAR INHIBITORS OF MYCOBACTERIUM TUBERCULOSIS GLUTAMINE SYNTHETASE 1: SYNTHESIS, BIOLOGICAL EVALUATION AND X-RAY CRYSTALLOGRAPHIC STUDIES
Descriptor: 9-phenyl-4H-imidazo[1,2-a]indeno[1,2-e]pyrazin-4-one, Glutamine synthetase 1
Authors:Couturier, C, Silve, S, Morales, R, Ppessegue, B, Llopart, S, Nair, A, Bauer, A, Scheiper, B, poeverlein, c, Ganzhorn, A, Lagrange, S, Bacque, E.
Deposit date:2015-02-02
Release date:2015-03-25
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (3.3 Å)
Cite:Nanomolar inhibitors of Mycobacterium tuberculosis glutamine synthetase 1: Synthesis, biological evaluation and X-ray crystallographic studies.
Bioorg.Med.Chem.Lett., 25, 2015
5LDF
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BU of 5ldf by Molmil
Maltose binding protein genetically fused to dodecameric glutamine synthetase
Descriptor: Glutamine synthetase, Maltose-binding periplasmic protein, alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose
Authors:Coscia, F, Petosa, C, Schoehn, G.
Deposit date:2016-06-25
Release date:2016-08-10
Last modified:2020-07-29
Method:ELECTRON MICROSCOPY (6.2 Å)
Cite:Fusion to a homo-oligomeric scaffold allows cryo-EM analysis of a small protein.
Sci Rep, 6, 2016
8DNU
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BU of 8dnu by Molmil
Human Brain Glutamine Synthetase
Descriptor: Glutamine synthetase, MANGANESE (II) ION
Authors:Tringides, M.L.
Deposit date:2022-07-11
Release date:2022-11-16
Last modified:2023-05-31
Method:ELECTRON MICROSCOPY (2.73 Å)
Cite:A cryo-electron microscopic approach to elucidate protein structures from human brain microsomes.
Life Sci Alliance, 6, 2023
3FKY
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BU of 3fky by Molmil
Crystal structure of the glutamine synthetase Gln1deltaN18 from the yeast Saccharomyces cerevisiae
Descriptor: CITRATE ANION, Glutamine synthetase
Authors:He, Y.X, Gui, L, Liu, Y.Z, Du, Y, Zhou, Y.Y, Li, P, Zhou, C.Z.
Deposit date:2008-12-18
Release date:2009-10-06
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (2.95 Å)
Cite:Crystal structure of Saccharomyces cerevisiae glutamine synthetase Gln1 suggests a nanotube-like supramolecular assembly
Proteins, 76, 2009
8ECY
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BU of 8ecy by Molmil
cryoEM structure of bovine bestrophin-2 and glutamine synthetase complex
Descriptor: Bestrophin, CALCIUM ION, CHLORIDE ION, ...
Authors:Owji, A.P, Kittredge, A.K, Yang, T.
Deposit date:2022-09-02
Release date:2022-11-02
Last modified:2022-11-16
Method:ELECTRON MICROSCOPY (2 Å)
Cite:Bestrophin-2 and glutamine synthetase form a complex for glutamate release.
Nature, 611, 2022
4S0R
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BU of 4s0r by Molmil
Structure of GS-TnrA complex
Descriptor: GLUTAMINE, Glutamine synthetase, MAGNESIUM ION, ...
Authors:Schumacher, M.A, Chinnam, N.G, Cuthbert, B, Tonthat, N.K.
Deposit date:2015-01-04
Release date:2015-03-04
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (3.5 Å)
Cite:Structures of regulatory machinery reveal novel molecular mechanisms controlling B. subtilis nitrogen homeostasis.
Genes Dev., 29, 2015
3NG0
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BU of 3ng0 by Molmil
Crystal Structure of Glutamine Synthetase from Synechocystis sp. PCC 6803
Descriptor: Glutamine synthetase, MANGANESE (II) ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER
Authors:Saelices, L, Cascio, D, Florencio, F.J, Muro-Pastor, M.I.
Deposit date:2010-06-10
Release date:2011-06-15
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Crystal Structure of Glutamine Synthetase from Synechocystis sp. PCC 6803
To be Published
4S17
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BU of 4s17 by Molmil
The crystal structure of glutamine synthetase from Bifidobacterium adolescentis ATCC 15703
Descriptor: ACETATE ION, Glutamine synthetase, MAGNESIUM ION
Authors:Cuff, M, Tan, K, Mack, J, Clancy, S, Joachimiak, A, Midwest Center for Structural Genomics (MCSG)
Deposit date:2015-01-08
Release date:2015-01-28
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:The crystal structure of glutamine synthetase from Bifidobacterium adolescentis ATCC 15703
To be Published
8FBP
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BU of 8fbp by Molmil
Glutamine synthetase from Pseudomonas aeruginosa, filament double-unit in compressed conformation
Descriptor: Glutamine synthetase
Authors:Phan, I.Q, Staker, B, Shek, R, Moser, T.H, Evans, J.E, van Voorhis, W.C, Myler, P.J, Seattle Structural Genomics Center for Infectious Disease (SSGCID)
Deposit date:2022-11-29
Release date:2024-02-14
Method:ELECTRON MICROSCOPY (2.8 Å)
Cite:Glutamine synthetase from Pseudomonas aeruginosa, filament double-unit in compressed conformation
To Be Published
2OJW
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BU of 2ojw by Molmil
Crystal structure of human glutamine synthetase in complex with ADP and phosphate
Descriptor: ADENOSINE-5'-DIPHOSPHATE, CHLORIDE ION, GLYCEROL, ...
Authors:Karlberg, T, Uppenberg, J, Arrowsmith, C, Berglund, H, Busam, R.D, Collins, R, Edwards, A, Flodin, S, Flores, A, Graslund, S, Hallberg, B.M, Hammarstrom, M, Hogbom, M, Johansson, I, Kotenyova, T, Moche, M, Nilsson, M.E, Nordlund, P, Nyman, T, Ogg, D, Persson, C, Sagemark, J, Stenmark, P, Sundstrom, M, Thorsell, A.G, Van Den Berg, S, Wallden, K, Weigelt, J, Holmberg-Schiavone, L, Structural Genomics Consortium (SGC)
Deposit date:2007-01-15
Release date:2007-03-13
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Crystal structures of mammalian glutamine synthetases illustrate substrate-induced conformational changes and provide opportunities for drug and herbicide design.
J.Mol.Biol., 375, 2008
5ZLP
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BU of 5zlp by Molmil
Crystal structure of glutamine synthetase from helicobacter pylori
Descriptor: (2S)-2-AMINO-4-[METHYL(PHOSPHONOOXY)PHOSPHORYL]BUTANOIC ACID, ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, ...
Authors:Joo, H.K, Lee, J.Y.
Deposit date:2018-03-29
Release date:2018-08-29
Last modified:2024-03-27
Method:X-RAY DIFFRACTION (2.93 Å)
Cite:Structural Analysis of Glutamine Synthetase from Helicobacter pylori.
Sci Rep, 8, 2018
3O6X
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BU of 3o6x by Molmil
Crystal Structure of the type III Glutamine Synthetase from Bacteroides fragilis
Descriptor: ADENOSINE-5'-DIPHOSPHATE, CHLORIDE ION, Glutamine synthetase, ...
Authors:van Rooyen, J.M, Belrhali, H, Abratt, V.R, Sewell, B.T.
Deposit date:2010-07-29
Release date:2011-03-09
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (3.5 Å)
Cite:Crystal Structure of Type III Glutamine Synthetase: Surprising Reversal of the Inter-Ring Interface.
Structure, 19, 2011

 

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