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8FW6
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BU of 8fw6 by Molmil
Human Lactate Dehydrogenase A in Complex with Inhibitor CHK-336
Descriptor: (2P)-2-{5-(cyclopropylmethyl)-3-(4-fluorophenyl)-4-[(3-fluoro-4-sulfamoylphenyl)methyl]-1H-pyrazol-1-yl}-1,3-thiazole-4-carboxylic acid, 1,2-ETHANEDIOL, 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE, ...
Authors:Lowther, W.T, Gumpena, R.
Deposit date:2023-01-20
Release date:2024-01-24
Method:X-RAY DIFFRACTION (2.34 Å)
Cite:Human Lactate Dehydrogenase A in complex with inhibitor CHK-336
To Be Published
6Y91
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BU of 6y91 by Molmil
Crystal structure of malate dehydrogenase from Plasmodium Falciparum in complex with NADH
Descriptor: Malate dehydrogenase, NICOTINAMIDE-ADENINE-DINUCLEOTIDE
Authors:Romero, A.R, Calderone, V, Gentili, M, Lunev, S, Groves, M, Popowicz, G, Domling, A, Sattler, M.
Deposit date:2020-03-06
Release date:2021-03-31
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:A fragment-based approach identifies an allosteric pocket that impacts malate dehydrogenase activity.
Commun Biol, 4, 2021
5ES3
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BU of 5es3 by Molmil
Co-crystal structure of LDH liganded with oxamate
Descriptor: L-lactate dehydrogenase A chain, OXAMIC ACID
Authors:Nowicki, M.W, Wear, M.A, McNae, I.W, Blackburn, E.A.
Deposit date:2015-11-16
Release date:2016-01-13
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.29 Å)
Cite:A Streamlined, Automated Protocol for the Production of Milligram Quantities of Untagged Recombinant Rat Lactate Dehydrogenase A Using AKTAxpressTM.
Plos One, 10, 2015
5NUF
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BU of 5nuf by Molmil
Cytosolic Malate Dehydrogenase 1
Descriptor: 1,2-ETHANEDIOL, ACETATE ION, DI(HYDROXYETHYL)ETHER, ...
Authors:Young, D, Messens, J, Huang, J, Reichheld, J.-P.
Deposit date:2017-04-29
Release date:2018-01-10
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Self-protection of cytosolic malate dehydrogenase against oxidative stress in Arabidopsis.
J. Exp. Bot., 69, 2018
2LDX
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BU of 2ldx by Molmil
CHARACTERIZATION OF THE ANTIGENIC SITES ON THE REFINED 3-ANGSTROMS RESOLUTION STRUCTURE OF MOUSE TESTICULAR LACTATE DEHYDROGENASE C4
Descriptor: APO-LACTATE DEHYDROGENASE
Authors:Griffith, J.P, Rossmann, M.G.
Deposit date:1987-11-25
Release date:1989-04-19
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (2.96 Å)
Cite:Characterization of the antigenic sites on the refined 3-A resolution structure of mouse testicular lactate dehydrogenase C4.
J.Biol.Chem., 262, 1987
5NUE
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BU of 5nue by Molmil
Cytosolic Malate Dehydrogenase 1 (peroxide-treated)
Descriptor: 1,2-ETHANEDIOL, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, 2-ETHOXYETHANOL, ...
Authors:Young, D, Messens, J, Huang, J, Reichheld, J.-P.
Deposit date:2017-04-29
Release date:2018-02-28
Last modified:2018-07-04
Method:X-RAY DIFFRACTION (1.35000277 Å)
Cite:Self-protection of cytosolic malate dehydrogenase against oxidative stress in Arabidopsis.
J. Exp. Bot., 69, 2018
9LDB
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BU of 9ldb by Molmil
DESIGN AND SYNTHESIS OF NEW ENZYMES BASED ON THE LACTATE DEHYDROGENASE FRAMEWORK
Descriptor: LACTATE DEHYDROGENASE, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, OXAMIC ACID, ...
Authors:Dunn, C.R, Holbrook, J.J, Muirhead, H.
Deposit date:1991-11-26
Release date:1993-10-31
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Design and synthesis of new enzymes based on the lactate dehydrogenase framework.
Philos.Trans.R.Soc.London,Ser.B, 332, 1991
9LDT
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BU of 9ldt by Molmil
DESIGN AND SYNTHESIS OF NEW ENZYMES BASED ON THE LACTATE DEHYDROGENASE FRAMEWORK
Descriptor: LACTATE DEHYDROGENASE, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, OXAMIC ACID, ...
Authors:Dunn, C.R, Holbrook, J.J, Muirhead, H.
Deposit date:1991-11-26
Release date:1993-10-31
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2 Å)
Cite:Design and synthesis of new enzymes based on the lactate dehydrogenase framework.
Philos.Trans.R.Soc.London,Ser.B, 332, 1991
8AB3
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BU of 8ab3 by Molmil
Crystal Structure of the Lactate Dehydrogenase of Cyanobacterium Aponinum in complex with oxamate, NADH and FBP.
Descriptor: 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE, 1,6-di-O-phosphono-beta-D-fructofuranose, L-lactate dehydrogenase, ...
Authors:Robin, A.Y, Girard, E, Madern, D.
Deposit date:2022-07-04
Release date:2022-07-27
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2.616 Å)
Cite:Deciphering Evolutionary Trajectories of Lactate Dehydrogenases Provides New Insights into Allostery.
Mol.Biol.Evol., 40, 2023
8AB2
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BU of 8ab2 by Molmil
Crystal Structure of the Lactate Dehydrogenase of Cyanobacterium Aponinum in its apo form.
Descriptor: 1,2-ETHANEDIOL, L-lactate dehydrogenase, TERBIUM(III) ION, ...
Authors:Robin, A.Y, Girard, E, Madern, D.
Deposit date:2022-07-04
Release date:2022-08-03
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Deciphering Evolutionary Trajectories of Lactate Dehydrogenases Provides New Insights into Allostery.
Mol.Biol.Evol., 40, 2023
6CEP
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BU of 6cep by Molmil
Sus scrofa heart L-lactate dehydrogenase ternary complex with NADH and oxamate
Descriptor: L-lactate dehydrogenase B chain, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, OXAMIC ACID
Authors:Hoffer, E.D, Andrews, B, Dunham, C.M, Dyer, R.B.
Deposit date:2018-02-12
Release date:2018-06-27
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (2 Å)
Cite:Small molecule cores demonstrate non-competitive inhibition of lactate dehydrogenase.
Medchemcomm, 9, 2018
7RM9
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BU of 7rm9 by Molmil
Human Malate Dehydrogenase I (MDHI)
Descriptor: MALONATE ION, Malate dehydrogenase, cytoplasmic
Authors:McCue, W, Finzel, B.C.
Deposit date:2021-07-27
Release date:2022-01-05
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Structural Characterization of the Human Cytosolic Malate Dehydrogenase I.
Acs Omega, 7, 2022
7RRL
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BU of 7rrl by Molmil
Alternate Crystal Form of Human Malate Dehydrogenase I
Descriptor: Malate dehydrogenase, cytoplasmic
Authors:McCue, W, Finzel, B.C.
Deposit date:2021-08-09
Release date:2022-02-16
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Structural Studies to Enable Drug Discovery
Ph.D.Thesis,University of Minnesota, 2021
6CT6
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BU of 6ct6 by Molmil
Crystal structure of lactate dehydrogenase from Eimeria maxima with NADH and oxamate
Descriptor: 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE, Lactate dehydrogenase, OXAMIC ACID, ...
Authors:Wirth, J.D, Xu, C, Theobald, D.L.
Deposit date:2018-03-22
Release date:2019-03-27
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (1.705 Å)
Cite:The Mechanistic, Structural, and Evolutionary Origin of Lactate Dehydrogenase Substrate Specificity in Apicomplexa
To Be Published
7X1L
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BU of 7x1l by Molmil
Malate dehydrogenase from Geobacillus stearothermophilus (gs-MDH) delta E311 mutant complexed with Nicotinamide Adenine Dinucleotide (NAD+)
Descriptor: Malate dehydrogenase, NICOTINAMIDE-ADENINE-DINUCLEOTIDE
Authors:Shimozawa, Y, Himiyama, T, Nakamura, T, Nishiya, Y.
Deposit date:2022-02-24
Release date:2022-10-19
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (2.28 Å)
Cite:Reducing substrate inhibition of malate dehydrogenase from Geobacillus stearothermophilus by C-terminal truncation.
Protein Eng.Des.Sel., 35, 2022
7XQN
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BU of 7xqn by Molmil
InDel-mutant malate dehydrogenase from E. coli
Descriptor: Malate dehydrogenase
Authors:Toledo-Patino, S, Laurino, P.
Deposit date:2022-05-08
Release date:2022-12-07
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (1.98 Å)
Cite:Insertions and deletions mediated functional divergence of Rossmann fold enzymes.
Proc.Natl.Acad.Sci.USA, 119, 2022
2PWZ
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BU of 2pwz by Molmil
Crystal structure of the apo form of E.Coli malate dehydrogenase
Descriptor: Malate dehydrogenase
Authors:Soderberg, C.A.G, Clarke, T.A, Richardson, D.J, Hemmings, A.M.
Deposit date:2007-05-14
Release date:2007-05-29
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:The X-ray crystal structure of the apo form of E.Coli malate dehydrogenase in space group C2
To be Published
6SBU
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BU of 6sbu by Molmil
X-ray Structure of Human LDHA with an Allosteric Inhibitor (Compound 3)
Descriptor: 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE, 4-[[4-[(5-chloranylthiophen-2-yl)carbonylamino]-1,3-bis(oxidanylidene)isoindol-2-yl]methyl]benzoic acid, L-lactate dehydrogenase A chain
Authors:Friberg, A, Puetter, V, Nguyen, D, Rehwinkel, H.
Deposit date:2019-07-22
Release date:2020-06-10
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (2.91 Å)
Cite:Structural Evidence for Isoform-Selective Allosteric Inhibition of Lactate Dehydrogenase A.
Acs Omega, 5, 2020
1B8P
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BU of 1b8p by Molmil
MALATE DEHYDROGENASE FROM AQUASPIRILLUM ARCTICUM
Descriptor: PROTEIN (MALATE DEHYDROGENASE)
Authors:Kim, S.Y, Hwang, K.Y, Kim, S.-H, Han, Y.S, Cho, Y.
Deposit date:1999-02-02
Release date:1999-07-09
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structural basis for cold adaptation. Sequence, biochemical properties, and crystal structure of malate dehydrogenase from a psychrophile Aquaspirillium arcticum.
J.Biol.Chem., 274, 1999
6SBV
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BU of 6sbv by Molmil
X-ray Structure of Human LDH-A with an Allosteric Inhibitor (Compound 7)
Descriptor: L-lactate dehydrogenase A chain, ~{N}-[3-[(7-nitrodibenzofuran-2-yl)sulfonylamino]phenyl]-1-oxidanyl-cyclopropane-1-carboxamide
Authors:Friberg, A, Puetter, V, Nguyen, D, Rehwinkel, H.
Deposit date:2019-07-22
Release date:2020-06-10
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Structural Evidence for Isoform-Selective Allosteric Inhibition of Lactate Dehydrogenase A.
Acs Omega, 5, 2020
1BDM
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BU of 1bdm by Molmil
THE STRUCTURE AT 1.8 ANGSTROMS RESOLUTION OF A SINGLE SITE MUTANT (T189I) OF MALATE DEHYDROGENASE FROM THERMUS FLAVUS WITH INCREASED ENZYMATIC ACTIVITY
Descriptor: BETA-6-HYDROXY-1,4,5,6-TETRHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE, MALATE DEHYDROGENASE
Authors:Kelly, C.A, Birktoft, J.J.
Deposit date:1993-02-16
Release date:1994-12-20
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Determinants of protein thermostability observed in the 1.9-A crystal structure of malate dehydrogenase from the thermophilic bacterium Thermus flavus.
Biochemistry, 32, 1993
1A5Z
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BU of 1a5z by Molmil
LACTATE DEHYDROGENASE FROM THERMOTOGA MARITIMA (TMLDH)
Descriptor: 1,6-di-O-phosphono-beta-D-fructofuranose, CADMIUM ION, L-LACTATE DEHYDROGENASE, ...
Authors:Auerbach, G, Ostendorp, R, Prade, L, Korndoerfer, I, Dams, T, Huber, R, Jaenicke, R.
Deposit date:1998-02-18
Release date:1999-03-23
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Lactate dehydrogenase from the hyperthermophilic bacterium thermotoga maritima: the crystal structure at 2.1 A resolution reveals strategies for intrinsic protein stabilization.
Structure, 6, 1998
1BMD
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BU of 1bmd by Molmil
DETERMINANTS OF PROTEIN THERMOSTABILITY OBSERVED IN THE 1.9 ANGSTROMS CRYSTAL STRUCTURE OF MALATE DEHYDROGENASE FROM THE THERMOPHILIC BACTERIUM THERMUS FLAVUS
Descriptor: MALATE DEHYDROGENASE, NICOTINAMIDE-ADENINE-DINUCLEOTIDE
Authors:Kelly, C.A, Birktoft, J.J.
Deposit date:1992-11-10
Release date:1994-07-31
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Determinants of protein thermostability observed in the 1.9-A crystal structure of malate dehydrogenase from the thermophilic bacterium Thermus flavus.
Biochemistry, 32, 1993
1B8U
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BU of 1b8u by Molmil
MALATE DEHYDROGENASE FROM AQUASPIRILLUM ARCTICUM
Descriptor: NICOTINAMIDE-ADENINE-DINUCLEOTIDE, OXALOACETATE ION, PROTEIN (MALATE DEHYDROGENASE)
Authors:Kim, S.Y, Hwang, K.Y, Kim, S.-H, Han, Y.S, Cho, Y.
Deposit date:1999-02-02
Release date:1999-07-09
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structural basis for cold adaptation. Sequence, biochemical properties, and crystal structure of malate dehydrogenase from a psychrophile Aquaspirillium arcticum.
J.Biol.Chem., 274, 1999
1B8V
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BU of 1b8v by Molmil
Malate dehydrogenase from Aquaspirillum arcticum
Descriptor: NICOTINAMIDE-ADENINE-DINUCLEOTIDE, PROTEIN (MALATE DEHYDROGENASE)
Authors:Kim, S.Y, Hwang, K.Y, Kim, S.H, Han, Y.S, Cho, Y.
Deposit date:1999-02-02
Release date:1999-07-09
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structural basis for cold adaptation. Sequence, biochemical properties, and crystal structure of malate dehydrogenase from a psychrophile Aquaspirillium arcticum.
J.Biol.Chem., 274, 1999

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