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1NDW
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Crystal Structure of Adenosine Deaminase Complexed with FR221647
Descriptor: 1-((1R)-1-(HYDROXYMETHYL)-3-PHENYLPROPYL)-1H-IMIDAZOLE-4-CARBOXAMIDE, Adenosine Deaminase, ZINC ION
Authors:Kinoshita, T.
Deposit date:2002-12-09
Release date:2003-12-09
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:A highly potent non-nucleoside adenosine deaminase inhibitor: efficient drug discovery by intentional lead hybridization
J.Am.Chem.Soc., 126, 2004
1NDZ
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BU of 1ndz by Molmil
Crystal Structure of Adenosine Deaminase Complexed with FR235999
Descriptor: 1-((1R)-1-(HYDROXYMETHYL)-3-(6-((3-(1-METHYL-1H-BENZIMIDAZOL-2-YL)PROPANOYL)AMINO)-1H-INDOL-1-YL)PROPYL)-1H-IMIDAZOLE-4-CARBOXAMIDE, Adenosine Deaminase, ZINC ION
Authors:Kinoshita, T.
Deposit date:2002-12-09
Release date:2003-12-09
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:A highly potent non-nucleoside adenosine deaminase inhibitor: efficient drug discovery by intentional lead hybridization
J.Am.Chem.Soc., 126, 2004
3MVT
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BU of 3mvt by Molmil
Crystal structure of apo mADA at 2.2A resolution
Descriptor: Adenosine deaminase, CHLORIDE ION, GLYCEROL
Authors:Niu, W, Shu, Q, Chen, Z, Mathews, S, Di Cera, E, Frieden, C.
Deposit date:2010-05-04
Release date:2010-10-13
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:The role of Zn2+ on the structure and stability of murine adenosine deaminase.
J.Phys.Chem.B, 114, 2010
1O5R
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BU of 1o5r by Molmil
Crystal structure of adenosine deaminase complexed with a potent inhibitor
Descriptor: 1-[(1R)-3-(6-{[(BENZYLAMINO)CARBONYL]AMINO}-1H-INDOL-1-YL)-1-(HYDROXYMETHYL)PROPYL]-1H-IMIDAZOLE-4-CARBOXAMIDE, Adenosine deaminase, ZINC ION
Authors:Kinoshita, T.
Deposit date:2003-10-05
Release date:2004-09-21
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:Structure-based design, synthesis, and structure-activity relationship studies of novel non-nucleoside adenosine deaminase inhibitors
J.Med.Chem., 47, 2004
3MVI
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BU of 3mvi by Molmil
Crystal structure of holo mADA at 1.6 A resolution
Descriptor: Adenosine deaminase, GLYCEROL, ZINC ION
Authors:Niu, W, Shu, Q, Chen, Z, Mathews, S, Di Cera, E, Frieden, C.
Deposit date:2010-05-04
Release date:2010-11-03
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:The role of Zn2+ on the structure and stability of murine adenosine deaminase.
J.Phys.Chem.B, 114, 2010
3OU8
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BU of 3ou8 by Molmil
The crystal structure of adenosine deaminase from Pseudomonas aeruginosa
Descriptor: Adenosine deaminase, ZINC ION
Authors:Zhang, Z, Burley, S.K, Swaminathan, S, New York SGX Research Center for Structural Genomics (NYSGXRC)
Deposit date:2010-09-14
Release date:2010-10-13
Last modified:2021-02-10
Method:X-RAY DIFFRACTION (2.51 Å)
Cite:The crystal structure of adenosine deaminase from Pseudomonas aeruginosa
To be Published
3PAN
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BU of 3pan by Molmil
The crystal structure of adenosine deaminase with hypoxanthine bound from Pseudomonas aeruginosa
Descriptor: Adenosine deaminase, HYPOXANTHINE, ZINC ION
Authors:Zhang, Z, Burley, S.K, Swaminathan, S, New York SGX Research Center for Structural Genomics (NYSGXRC)
Deposit date:2010-10-19
Release date:2010-12-22
Last modified:2023-12-06
Method:X-RAY DIFFRACTION (2.627 Å)
Cite:The crystal structure of adenosine deaminase with hypoxanthine bound from Pseudomonas aeruginosa
TO BE PUBLISHED
3PAO
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BU of 3pao by Molmil
The crystal structure of adenosine deaminase with adenine bound from Pseudomonas aeruginosa
Descriptor: ADENINE, Adenosine deaminase, ZINC ION
Authors:Zhang, Z, Burley, S.K, Swaminathan, S, New York SGX Research Center for Structural Genomics (NYSGXRC)
Deposit date:2010-10-19
Release date:2010-12-22
Last modified:2023-12-06
Method:X-RAY DIFFRACTION (2.493 Å)
Cite:The crystal structure of adenosine deaminase with adenine bound from Pseudomonas aeruginosa
To be Published
1QXL
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BU of 1qxl by Molmil
Crystal structure of Adenosine deaminase complexed with FR235380
Descriptor: 1-((1R)-1-(HYDROXYMETHYL)-3-{6-[(5-PHENYLPENTANOYL)AMINO]-1H-INDOL-1-YL}PROPYL)-1H-IMIDAZOLE-4-CARBOXAMIDE, Adenosine deaminase, ZINC ION
Authors:Kinoshita, T.
Deposit date:2003-09-08
Release date:2004-09-21
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Structure-based design, synthesis, and structure-activity relationship studies of novel non-nucleoside adenosine deaminase inhibitors
J.Med.Chem., 47, 2004
3PBM
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BU of 3pbm by Molmil
The crystal structure of adenosine deaminase in complex with chloropurine from Pseudomonas aeruginosa
Descriptor: 6-chloro-9H-purine, Adenosine deaminase, ZINC ION
Authors:Zhang, Z, Burley, S.K, Swaminathan, S, New York SGX Research Center for Structural Genomics (NYSGXRC)
Deposit date:2010-10-20
Release date:2010-12-22
Last modified:2023-12-06
Method:X-RAY DIFFRACTION (2.591 Å)
Cite:The crystal structure of adenosine deaminase in complex with chloropurine from Pseudomonas aeruginosa
To be Published
6IJP
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BU of 6ijp by Molmil
The structure of the ADAL-IMP complex
Descriptor: Adenosine/AMP deaminase family protein, INOSINIC ACID, ZINC ION
Authors:Xie, W, Jia, Q.
Deposit date:2018-10-11
Release date:2019-02-06
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Alternative conformation induced by substrate binding for Arabidopsis thalianaN6-methyl-AMP deaminase.
Nucleic Acids Res., 47, 2019
6IV5
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BU of 6iv5 by Molmil
Crystal structure of arabidopsis N6-mAMP deaminase MAPDA
Descriptor: Adenosine/AMP deaminase family protein, PHOSPHATE ION, ZINC ION
Authors:Wu, B.X, Zhang, D, Nie, H.B, Shen, S.L, Li, S.S, Patel, D.J.
Deposit date:2018-12-02
Release date:2019-02-27
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (1.749 Å)
Cite:Structure ofArabidopsis thaliana N6-methyl-AMP deaminase ADAL with bound GMP and IMP and implications forN6-methyl-AMP recognition and processing.
Rna Biol., 16, 2019
6II7
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BU of 6ii7 by Molmil
Crystal structure of Plasmodium falciparum adenosine deaminase C27Q+L227I mutant co-complexed with Zn ion, hypoxanthine and inosine
Descriptor: Adenosine deaminase, HYPOXANTHINE, INOSINE, ...
Authors:Chitnumsub, P, Jaruwat, A.
Deposit date:2018-10-03
Release date:2019-05-01
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (2.48 Å)
Cite:Crystal structure of Plasmodium falciparum adenosine deaminase reveals a novel binding pocket for inosine.
Arch. Biochem. Biophys., 667, 2019
6IJN
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BU of 6ijn by Molmil
The D295N mutant of the N6-methyl-AMP deaminase from Arabidopsis thaliana complexed with N6m-AMP
Descriptor: Adenosine/AMP deaminase family protein, N6-METHYLADENOSINE-5'-MONOPHOSPHATE
Authors:Xie, W, Jia, Q.
Deposit date:2018-10-10
Release date:2019-02-06
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (1.66 Å)
Cite:Alternative conformation induced by substrate binding for Arabidopsis thalianaN6-methyl-AMP deaminase.
Nucleic Acids Res., 47, 2019
6IJM
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BU of 6ijm by Molmil
Apo structure of the N6-methyl-AMP Deaminase from Arabidopsis thaliana
Descriptor: Adenosine/AMP deaminase family protein, ZINC ION
Authors:Xie, W, Jia, Q.
Deposit date:2018-10-10
Release date:2019-02-06
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (2.016 Å)
Cite:Alternative conformation induced by substrate binding for Arabidopsis thalianaN6-methyl-AMP deaminase.
Nucleic Acids Res., 47, 2019
6J23
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BU of 6j23 by Molmil
Crystal structure of arabidopsis ADAL complexed with GMP
Descriptor: Adenosine/AMP deaminase family protein, GUANOSINE-5'-MONOPHOSPHATE, ZINC ION
Authors:Wu, B.X, Zhang, D, Nie, H.B, Shen, S.L, Li, S.S, Patel, D.J.
Deposit date:2018-12-30
Release date:2019-02-27
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structure ofArabidopsis thaliana N6-methyl-AMP deaminase ADAL with bound GMP and IMP and implications forN6-methyl-AMP recognition and processing.
Rna Biol., 16, 2019
6J4T
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BU of 6j4t by Molmil
Crystal structure of arabidopsis ADAL complexed with IMP
Descriptor: Adenosine/AMP deaminase family protein, INOSINIC ACID, ZINC ION
Authors:Wu, B.X, Zhang, D, Nie, H.B, Shen, S.L, Li, S.S, Patel, D.J.
Deposit date:2019-01-10
Release date:2019-07-31
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (1.82 Å)
Cite:Structure ofArabidopsis thaliana N6-methyl-AMP deaminase ADAL with bound GMP and IMP and implications forN6-methyl-AMP recognition and processing.
Rna Biol., 16, 2019
1V7A
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BU of 1v7a by Molmil
Crystal structures of adenosine deaminase complexed with potent inhibitors
Descriptor: 1-{(1R,2S)-2-HYDROXY-1-[2-(2-NAPHTHYLOXY)ETHYL]PROPYL}-1H-IMIDAZONE-4-CARBOXAMIDE, ZINC ION, adenosine deaminase
Authors:Kinoshita, T.
Deposit date:2003-12-14
Release date:2004-12-21
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structure-based design and synthesis of non-nucleoside, potent, and orally bioavailable adenosine deaminase inhibitors
J.Med.Chem., 47, 2004
1UML
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BU of 1uml by Molmil
Crystal structure of adenosine deaminase complexed with a potent inhibitor FR233624
Descriptor: 1-((1R)-1-(HYDROXYMETHYL)-3-{6-[(3-PHENYLPROPANOYL)AMINO]-1H-INDOL-1-YL}PROPYL)-1H-IMIDAZOLE-4-CARBOXAMIDE, Adenosine deaminase, ZINC ION
Authors:Kinoshita, T.
Deposit date:2003-10-03
Release date:2004-09-21
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structure-based design, synthesis, and structure-activity relationship studies of novel non-nucleoside adenosine deaminase inhibitors
J.Med.Chem., 47, 2004
1V79
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BU of 1v79 by Molmil
Crystal structures of adenosine deaminase complexed with potent inhibitors
Descriptor: 1-{(1R,2S)-1-[2-(2,3,-DICHLOROPHENYL)ETHYL]-2-HYDROXYPROPYL}-1H-IMIDAZOLE-4-CARBOXAMIDE, Adenosine deaminase, ZINC ION
Authors:Kinoshita, T.
Deposit date:2003-12-14
Release date:2004-12-21
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structure-based design and synthesis of non-nucleoside, potent, and orally bioavailable adenosine deaminase inhibitors
J.Med.Chem., 47, 2004
1UIP
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BU of 1uip by Molmil
ADENOSINE DEAMINASE (HIS 238 GLU MUTANT)
Descriptor: ADENOSINE DEAMINASE, PURINE RIBOSIDE, ZINC ION
Authors:Wilson, D.K, Quiocho, F.A.
Deposit date:1996-08-30
Release date:1997-06-24
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Site-directed mutagenesis of histidine 238 in mouse adenosine deaminase: substitution of histidine 238 does not impede hydroxylate formation.
Biochemistry, 35, 1996
1UIO
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BU of 1uio by Molmil
ADENOSINE DEAMINASE (HIS 238 ALA MUTANT)
Descriptor: 6-HYDROXY-7,8-DIHYDRO PURINE NUCLEOSIDE, ADENOSINE DEAMINASE, ZINC ION
Authors:Wilson, D.K, Quiocho, F.A.
Deposit date:1996-08-30
Release date:1997-06-24
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Site-directed mutagenesis of histidine 238 in mouse adenosine deaminase: substitution of histidine 238 does not impede hydroxylate formation.
Biochemistry, 35, 1996
1VFL
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BU of 1vfl by Molmil
Adenosine deaminase
Descriptor: Adenosine deaminase, ZINC ION
Authors:Kinoshita, T.
Deposit date:2004-04-16
Release date:2005-08-16
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structural Basis of Compound Recognition by Adenosine Deaminase
Biochemistry, 44, 2005
1WXY
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BU of 1wxy by Molmil
Crystal structure of adenosine deaminase ligated with a potent inhibitor
Descriptor: Adenosine deaminase, N-[4,5-BIS(4-HYDROXYPHENYL)-1,3-THIAZOL-2-YL]HEXANAMIDE, ZINC ION
Authors:Kinoshita, T.
Deposit date:2005-02-02
Release date:2005-08-16
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structural Basis of Compound Recognition by Adenosine Deaminase
Biochemistry, 44, 2005
1WXZ
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BU of 1wxz by Molmil
Crystal structure of adenosine deaminase ligated with a potent inhibitor
Descriptor: 1-((1R,2S)-1-{2-[2-(4-CHLOROPHENYL)-1,3-BENZOXAZOL-7-YL]ETHYL}-2-HYDROXYPROPYL)-1H-IMIDAZOLE-4-CARBOXAMIDE, Adenosine deaminase, ZINC ION
Authors:Kinoshita, T.
Deposit date:2005-02-02
Release date:2005-08-16
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Rational design of non-nucleoside, potent, and orally bioavailable adenosine deaminase inhibitors: predicting enzyme conformational change and metabolism
J.Med.Chem., 48, 2005

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