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4WF6
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BU of 4wf6 by Molmil
Anthrax toxin lethal factor with bound small molecule inhibitor MK-31
分子名称: 1,2-ETHANEDIOL, Lethal factor, N~2~-[(4-fluoro-3-methylphenyl)sulfonyl]-N-hydroxy-D-alaninamide, ...
著者Maize, K.M, De la Mora-Rey, T, Finzel, B.C.
登録日2014-09-12
公開日2015-09-09
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (2.6521 Å)
主引用文献Probing the S2' Subsite of the Anthrax Toxin Lethal Factor Using Novel N-Alkylated Hydroxamates.
J.Med.Chem., 58, 2015
6PSN
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BU of 6psn by Molmil
Anthrax toxin protective antigen channels bound to lethal factor
分子名称: CALCIUM ION, Lethal factor, Protective antigen
著者Hardenbrook, N.J, Liu, S, Zhou, K, Zhou, Z.H, Krantz, B.A.
登録日2019-07-12
公開日2020-03-04
最終更新日2024-03-20
実験手法ELECTRON MICROSCOPY (4.6 Å)
主引用文献Atomic structures of anthrax toxin protective antigen channels bound to partially unfolded lethal and edema factors.
Nat Commun, 11, 2020
6WJJ
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BU of 6wjj by Molmil
Anthrax octamer prechannel bound to full-length lethal factor
分子名称: CALCIUM ION, Lethal factor, Protective antigen, ...
著者Zhou, K, Hardenbrook, N.J, Liu, S, Cui, Y.X, Krantz, B.A, Zhou, Z.H.
登録日2020-04-13
公開日2020-12-16
最終更新日2024-03-06
実験手法ELECTRON MICROSCOPY (3.8 Å)
主引用文献Atomic Structures of Anthrax Prechannel Bound with Full-Length Lethal and Edema Factors.
Structure, 28, 2020
4DV8
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BU of 4dv8 by Molmil
Anthrax Lethal Factor metalloproteinase in complex with the Hydroxamic acid based small molecule PT8421
分子名称: (2S)-6-[(4-fluorobenzyl)amino]-2-[(2R)-2-(4-fluorophenyl)-2-methoxyethyl]-N-hydroxyhexanamide, Lethal factor, MALONATE ION, ...
著者Margosiak, S.A, Sankaran, B.
登録日2012-02-22
公開日2012-03-14
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (1.632 Å)
主引用文献Antidotes to anthrax lethal factor intoxication. Part 3: Evaluation of core structures and further modifications to the C2-side chain.
Bioorg.Med.Chem.Lett., 22, 2012
1YQY
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BU of 1yqy by Molmil
Structure of B. Anthrax Lethal factor in complex with a hydroxamate inhibitor
分子名称: (2R)-2-{[(4-FLUORO-3-METHYLPHENYL)SULFONYL]AMINO}-N-HYDROXY-2-TETRAHYDRO-2H-PYRAN-4-YLACETAMIDE, Lethal factor, ZINC ION
著者Shoop, W.L, Xiong, Y, Wiltsie, J, Woods, A, Guo, J, Pivnichny, J.V, Felcetto, T, Michael, B.F, Bansal, A.
登録日2005-02-02
公開日2005-05-31
最終更新日2023-08-23
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Anthrax lethal factor inhibition.
Proc.Natl.Acad.Sci.Usa, 102, 2005
1ZXV
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BU of 1zxv by Molmil
X-Ray Crystal Structure of the Anthrax Lethal Factor Bound to a Small Molecule Inhibitor, BI-MFM3, 3-{5-[5-(4-Chloro-phenyl)-furan-2-ylmethylene]-4-oxo-2-thioxo-thiazolidin-3-yl}-propionic acid.
分子名称: (E)-3-(5((5-(4-CHLOROPHENYL)FURAN-2-YL)METHYLENE)-4-OXO-2-THIOXOTHIAZOLIDIN-3-YL)PROPANOIC ACID, ZINC ION, lethal factor
著者Wong, T.Y, Liddington, R.C.
登録日2005-06-08
公開日2005-07-05
最終更新日2024-03-13
実験手法X-RAY DIFFRACTION (2.67 Å)
主引用文献Efficient synthetic inhibitors of anthrax lethal factor.
Proc.Natl.Acad.Sci.Usa, 102, 2005
1J7N
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BU of 1j7n by Molmil
Anthrax Toxin Lethal factor
分子名称: Lethal Factor precursor, SULFATE ION, ZINC ION
著者Pannifer, A.D, Wong, T.Y, Schwarzenbacher, R, Renatus, M, Petosa, C, Collier, R.J, Bienkowska, J, Lacy, D.B, Park, S, Leppla, S.H, Hanna, P, Liddington, R.C.
登録日2001-05-17
公開日2001-11-07
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Crystal structure of the anthrax lethal factor.
Nature, 414, 2001
1JKY
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BU of 1jky by Molmil
Crystal Structure of the Anthrax Lethal Factor (LF): Wild-type LF Complexed with the N-terminal Sequence of MAPKK2
分子名称: Lethal Factor, mitogen-activated protein kinase kinase 2
著者Pannifer, A.D, Wong, T.Y, Schwarzenbacher, R, Renatus, M, Petosa, C, Collier, R.J, Bienkowska, J, Lacy, D.B, Park, S, Leppla, S.H, Hanna, P, Liddington, R.C.
登録日2001-07-13
公開日2001-11-07
最終更新日2023-08-16
実験手法X-RAY DIFFRACTION (3.9 Å)
主引用文献Crystal structure of the anthrax lethal factor.
Nature, 414, 2001
4XM8
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BU of 4xm8 by Molmil
Anthrax toxin lethal factor with ligand-induced binding pocket
分子名称: Lethal factor, N-hydroxy-N~2~-{[3-(methoxymethyl)phenyl]sulfonyl}-N~2~-(2-methylpropyl)-D-valinamide, ZINC ION
著者Maize, K.M, Finzel, B.C.
登録日2015-01-14
公開日2015-11-11
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献Ligand-induced expansion of the S1' site in the anthrax toxin lethal factor.
Febs Lett., 589, 2015
4XM6
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BU of 4xm6 by Molmil
Anthrax toxin lethal factor with ligand-induced binding pocket
分子名称: 1,2-ETHANEDIOL, Lethal factor, N~2~-[(4-fluoro-3-methylphenyl)sulfonyl]-N-hydroxy-N~2~-(2-methylpropyl)-D-valinamide, ...
著者Maize, K.M, De la Mora-Rey, T, Finzel, B.C.
登録日2015-01-14
公開日2015-11-11
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (2.352 Å)
主引用文献Ligand-induced expansion of the S1' site in the anthrax toxin lethal factor.
Febs Lett., 589, 2015
4XM7
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BU of 4xm7 by Molmil
Anthrax toxin lethal factor with ligand-induced binding pocket
分子名称: 1,2-ETHANEDIOL, Lethal factor, N~2~-[(4-fluoro-3-methoxyphenyl)sulfonyl]-N-hydroxy-N~2~-(2-methylpropyl)-D-valinamide, ...
著者Maize, K.M, Finzel, B.C.
登録日2015-01-14
公開日2015-11-11
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献Ligand-induced expansion of the S1' site in the anthrax toxin lethal factor.
Febs Lett., 589, 2015
5D1T
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BU of 5d1t by Molmil
Anthrax toxin lethal factor with hydroxamic acid inhibitor
分子名称: Lethal factor, N~2~-[3-(aminomethyl)benzyl]-N~2~-[(4-fluoro-3-methylphenyl)sulfonyl]-N-hydroxy-D-alaninamide, ZINC ION
著者Maize, K.M, Finzel, B.C.
登録日2015-08-04
公開日2015-11-11
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Probing the S2' Subsite of the Anthrax Toxin Lethal Factor Using Novel N-Alkylated Hydroxamates.
J.Med.Chem., 58, 2015
5D1S
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BU of 5d1s by Molmil
Anthrax toxin lethal factor with hydroxamic acid inhibitor
分子名称: Lethal factor, N~2~-[(4-fluoro-3-methylphenyl)sulfonyl]-N-hydroxy-N~2~-methyl-D-alaninamide, ZINC ION
著者Maize, K.M, Finzel, B.C.
登録日2015-08-04
公開日2015-11-11
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Probing the S2' Subsite of the Anthrax Toxin Lethal Factor Using Novel N-Alkylated Hydroxamates.
J.Med.Chem., 58, 2015
5D1U
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BU of 5d1u by Molmil
Anthrax toxin lethal factor with hydroxamic acid inhibitor
分子名称: Lethal factor, N~2~-(6-aminohexyl)-N~2~-[(4-fluoro-3-methylphenyl)sulfonyl]-N-hydroxy-D-alaninamide, ZINC ION
著者Maize, K.M, Finzel, B.C.
登録日2015-08-04
公開日2015-11-11
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (2.8503 Å)
主引用文献Probing the S2' Subsite of the Anthrax Toxin Lethal Factor Using Novel N-Alkylated Hydroxamates.
J.Med.Chem., 58, 2015
6ZXK
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BU of 6zxk by Molmil
Fully-loaded anthrax lethal toxin in its heptameric pre-pore state and PA7LF(2+1B) arrangement
分子名称: Lethal factor, Protective antigen
著者Quentin, D, Antoni, C, Gatsogiannis, C, Raunser, S.
登録日2020-07-29
公開日2020-09-02
実験手法ELECTRON MICROSCOPY (3.8 Å)
主引用文献Cryo-EM structure of the fully-loaded asymmetric anthrax lethal toxin in its heptameric pre-pore state.
Plos Pathog., 16, 2020
6ZXL
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BU of 6zxl by Molmil
Fully-loaded anthrax lethal toxin in its heptameric pre-pore state and PA7LF(2+1A) arrangement
分子名称: Lethal factor, Protective antigen
著者Quentin, D, Antoni, C, Gatsogiannis, C, Raunser, S.
登録日2020-07-29
公開日2020-09-02
実験手法ELECTRON MICROSCOPY (4.2 Å)
主引用文献Cryo-EM structure of the fully-loaded asymmetric anthrax lethal toxin in its heptameric pre-pore state.
Plos Pathog., 16, 2020
6ZXJ
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BU of 6zxj by Molmil
Fully-loaded anthrax lethal toxin in its heptameric pre-pore state, in which the third lethal factor is masked out (PA7LF3-masked)
分子名称: Lethal factor, Protective antigen
著者Quentin, D, Antoni, C, Gatsogiannis, C, Raunser, S.
登録日2020-07-29
公開日2020-09-02
実験手法ELECTRON MICROSCOPY (3.5 Å)
主引用文献Cryo-EM structure of the fully-loaded asymmetric anthrax lethal toxin in its heptameric pre-pore state.
Plos Pathog., 16, 2020
1PWP
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BU of 1pwp by Molmil
Crystal Structure of the Anthrax Lethal Factor complexed with Small Molecule Inhibitor NSC 12155
分子名称: Lethal factor, N,N'-BIS(4-AMINO-2-METHYLQUINOLIN-6-YL)UREA, ZINC ION
著者Wong, T.Y, Schwarzenbacher, R, Liddington, R.C.
登録日2003-07-02
公開日2004-01-13
最終更新日2023-08-16
実験手法X-RAY DIFFRACTION (2.9 Å)
主引用文献Identification of small molecule inhibitors of anthrax lethal factor.
Nat.Struct.Mol.Biol., 11, 2004
1PWQ
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BU of 1pwq by Molmil
Crystal structure of Anthrax Lethal Factor complexed with Thioacetyl-Tyr-Pro-Met-Amide, a metal-chelating peptidyl small molecule inhibitor
分子名称: Lethal factor, N-(SULFANYLACETYL)TYROSYLPROLYLMETHIONINAMIDE, ZINC ION
著者Wong, T.Y, Schwarzenbacher, R, Liddington, R.C.
登録日2003-07-02
公開日2004-01-13
最終更新日2023-08-16
実験手法X-RAY DIFFRACTION (3.52 Å)
主引用文献The structural basis for substrate and inhibitor selectivity of the anthrax lethal factor.
Nat.Struct.Mol.Biol., 11, 2004
1PWW
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BU of 1pww by Molmil
Crystal structure of Anthrax Lethal Factor active site mutant protein complexed with an optimised peptide substrate in the presence of zinc.
分子名称: LF20, Lethal factor, ZINC ION
著者Wong, T.Y, Schwarzenbacher, R, Liddington, R.C.
登録日2003-07-02
公開日2004-01-27
最終更新日2023-08-16
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献The structural basis for substrate and inhibitor selectivity of the anthrax lethal factor.
Nat.Struct.Mol.Biol., 11, 2004
1PWV
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BU of 1pwv by Molmil
Crystal structure of Anthrax Lethal Factor wild-type protein complexed with an optimised peptide substrate.
分子名称: LF20, Lethal factor
著者Wong, T.Y, Schwarzenbacher, R, Liddington, R.C.
登録日2003-07-02
公開日2004-02-03
最終更新日2023-08-16
実験手法X-RAY DIFFRACTION (2.85 Å)
主引用文献The structural basis for substrate and inhibitor selectivity of the anthrax lethal factor.
Nat.Struct.Mol.Biol., 11, 2004
1PWU
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BU of 1pwu by Molmil
Crystal Structure of Anthrax Lethal Factor complexed with (3-(N-hydroxycarboxamido)-2-isobutylpropanoyl-Trp-methylamide), a known small molecule inhibitor of matrix metalloproteases.
分子名称: 3-(N-HYDROXYCARBOXAMIDO)-2-ISOBUTYLPROPANOYL-TRP-METHYLAMIDE, Lethal factor, ZINC ION
著者Wong, T.Y, Schwarzenbacher, R, Liddington, R.C.
登録日2003-07-02
公開日2004-02-03
最終更新日2023-08-16
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献The structural basis for substrate and inhibitor selectivity of the anthrax lethal factor.
Nat.Struct.Mol.Biol., 11, 2004
4PKS
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BU of 4pks by Molmil
Anthrax toxin lethal factor with bound small molecule inhibitor 11
分子名称: 1,2-ETHANEDIOL, GLYCEROL, Lethal factor, ...
著者Maize, K.M, De la Mora, T, Finzel, B.C.
登録日2014-05-15
公開日2014-11-12
最終更新日2023-12-27
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Anthrax toxin lethal factor domain 3 is highly mobile and responsive to ligand binding.
Acta Crystallogr.,Sect.D, 70, 2014
4PKR
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BU of 4pkr by Molmil
Anthrax toxin lethal factor with bound small molecule inhibitor 10
分子名称: CHLORIDE ION, GLYCEROL, Lethal factor, ...
著者Maize, K.M, De la Mora, T, Finzel, B.C.
登録日2014-05-15
公開日2014-11-12
最終更新日2023-12-27
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Anthrax toxin lethal factor domain 3 is highly mobile and responsive to ligand binding.
Acta Crystallogr.,Sect.D, 70, 2014
4PKU
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BU of 4pku by Molmil
Anthrax toxin lethal factor with bound small molecule inhibitor 15
分子名称: Lethal factor, N~2~-(3-aminobenzyl)-N~2~-[(4-fluoro-3-methylphenyl)sulfonyl]-N-hydroxy-D-alaninamide, ZINC ION
著者Maize, K.M, De la Mora, T, Finzel, B.C.
登録日2014-05-15
公開日2014-11-12
最終更新日2023-12-27
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Anthrax toxin lethal factor domain 3 is highly mobile and responsive to ligand binding.
Acta Crystallogr.,Sect.D, 70, 2014

 

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