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1IWC
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BU of 1iwc by Molmil
TFE-induded structure of the N-terminal domain of pig gastric H/K-ATPase
分子名称: gastric H/K-ATPase
著者Fujitani, N, Kanagawa, M, Aizawa, T, Ohkubo, T, Kaya, S, Demura, M, Kawano, K, Taniguchi, K, Nitta, K.
登録日2002-05-02
公開日2002-11-27
最終更新日2023-12-27
実験手法SOLUTION NMR
主引用文献Structure determination and conformational change induced by tyrosine phosphorylation of the N-terminal domain of the alpha-chain of pig gastric H+/K+-ATPase
Biochem.Biophys.Res.Commun., 300, 2003
1IWF
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BU of 1iwf by Molmil
Solution structure of the N-terminal domain of pig gastric H/K-ATPase
分子名称: gastric H/K-ATPase
著者Fujitani, N, Kanagawa, M, Aizawa, T, Ohkubo, T, Kaya, S, Demura, M, Kawano, K, Taniguchi, K, Nitta, K.
登録日2002-05-06
公開日2002-11-27
最終更新日2023-12-27
実験手法SOLUTION NMR
主引用文献Structure determination and conformational change induced by tyrosine phosphorylation of the N-terminal domain of the alpha-chain of pig gastric H+/K+-ATPase
Biochem.Biophys.Res.Commun., 300, 2003
4UX1
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BU of 4ux1 by Molmil
Cryo-EM structure of antagonist-bound E2P gastric H,K-ATPase (SCH.E2. AlF)
分子名称: POTASSIUM-TRANSPORTING ATPASE ALPHA CHAIN 1, POTASSIUM-TRANSPORTING ATPASE SUBUNIT BETA
著者Abe, K, Tani, K, Fujiyoshi, Y.
登録日2014-08-18
公開日2014-09-17
最終更新日2014-11-12
実験手法ELECTRON CRYSTALLOGRAPHY (8 Å)
主引用文献Systematic Comparison of Molecular Conformations of H+,K+-ATPase Reveals an Important Contribution of the A-M2 Linker for the Luminal Gating.
J.Biol.Chem., 289, 2014
8WA5
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BU of 8wa5 by Molmil
Cryo-EM structure of the gastric proton pump Y799W/E936Q mutant in K+-occluded (K+)E2-AlF state
分子名称: 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 2-acetamido-2-deoxy-beta-D-glucopyranose, CHOLESTEROL, ...
著者Abe, K.
登録日2023-09-07
公開日2023-11-29
最終更新日2024-01-31
実験手法ELECTRON MICROSCOPY (2.51 Å)
主引用文献Specific protonation of acidic residues confers K + selectivity to the gastric proton pump.
J.Biol.Chem., 300, 2023
3IXZ
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BU of 3ixz by Molmil
Pig gastric H+/K+-ATPase complexed with aluminium fluoride
分子名称: Potassium-transporting ATPase alpha, Potassium-transporting ATPase subunit beta
著者Abe, K, Tani, K, Nishizawa, T, Fujiyoshi, Y.
登録日2009-03-09
公開日2009-06-23
最終更新日2024-02-21
実験手法ELECTRON CRYSTALLOGRAPHY (6.5 Å)
主引用文献Inter-subunit interaction of gastric H+,K+-ATPase prevents reverse reaction of the transport cycle
Embo J., 28, 2009
4UX2
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BU of 4ux2 by Molmil
Cryo-EM structure of antagonist-bound E2P gastric H,K-ATPase (SCH.E2. MgF)
分子名称: POTASSIUM-TRANSPORTING ATPASE ALPHA CHAIN 1, POTASSIUM-TRANSPORTING ATPASE SUBUNIT BETA
著者Abe, K, Tani, K, Fujiyoshi, Y.
登録日2014-08-18
公開日2014-09-17
最終更新日2014-11-12
実験手法ELECTRON CRYSTALLOGRAPHY (7 Å)
主引用文献Systematic Comparison of Molecular Conformations of H+,K+-ATPase Reveals an Important Contribution of the A-M2 Linker for the Luminal Gating.
J.Biol.Chem., 289, 2014
2XZB
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BU of 2xzb by Molmil
Pig Gastric H,K-ATPase with bound BeF and SCH28080
分子名称: POTASSIUM-TRANSPORTING ATPASE ALPHA CHAIN 1, POTASSIUM-TRANSPORTING ATPASE SUBUNIT BETA
著者Abe, K, Tani, K, Fujiyoshi, Y.
登録日2010-11-24
公開日2011-01-26
最終更新日2020-09-16
実験手法ELECTRON CRYSTALLOGRAPHY (7 Å)
主引用文献Conformational Rearrangement of Gastric H(+),K(+)- ATPase Induced by an Acid Suppressant.
Nat.Commun., 2, 2011
2YN9
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BU of 2yn9 by Molmil
Cryo-EM structure of gastric H+,K+-ATPase with bound rubidium
分子名称: POTASSIUM-TRANSPORTING ATPASE ALPHA CHAIN 1, POTASSIUM-TRANSPORTING ATPASE SUBUNIT BETA
著者Abe, K, Tani, K, Friedrich, T, Fujiyoshi, Y.
登録日2012-10-13
公開日2012-11-07
最終更新日2014-07-16
実験手法ELECTRON CRYSTALLOGRAPHY (8 Å)
主引用文献Cryo-Em Structure of Gastric H+,K+-ATPase with a Single Occupied Cation-Binding Site.
Proc.Natl.Acad.Sci.USA, 109, 2012
5YLV
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BU of 5ylv by Molmil
Crystal structure of the gastric proton pump complexed with SCH28080
分子名称: 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 2-(2-methyl-8-phenylmethoxy-imidazo[1,2-a]pyridin-3-yl)ethanenitrile, 2-acetamido-2-deoxy-beta-D-glucopyranose, ...
著者Abe, K, Irie, K, Nakanishi, H, Fujiyoshi, Y.
登録日2017-10-19
公開日2018-04-11
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (2.79977775 Å)
主引用文献Crystal structures of the gastric proton pump
Nature, 556, 2018
5Y0B
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BU of 5y0b by Molmil
PIG GASTRIC H+,K+ - ATPASE IN COMPLEX with BYK99
分子名称: Potassium-transporting ATPase alpha chain 1, Potassium-transporting ATPase subunit beta
著者Abe, K, Shimokawa, J, Natio, M, Munson, K, Vagin, O, Sachs, G, Suzuki, H, Tani, K, Fujiyoshi, Y.
登録日2017-07-16
公開日2017-08-09
実験手法ELECTRON CRYSTALLOGRAPHY (6.7 Å)
主引用文献The cryo-EM structure of gastric H(+),K(+)-ATPase with bound BYK99, a high-affinity member of K(+)-competitive, imidazo[1,2-a]pyridine inhibitors
Sci Rep, 7, 2017
5YLU
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BU of 5ylu by Molmil
Crystal structure of the gastric proton pump complexed with vonoprazan
分子名称: 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 1-[5-(2-fluorophenyl)-1-pyridin-3-ylsulfonyl-pyrrol-3-yl]-~{N}-methyl-methanamine, 2-acetamido-2-deoxy-beta-D-glucopyranose, ...
著者Abe, K, Irie, K, Nakanishi, H, Fujiyoshi, Y.
登録日2017-10-19
公開日2018-04-11
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (2.79988956 Å)
主引用文献Crystal structures of the gastric proton pump
Nature, 556, 2018
7W49
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BU of 7w49 by Molmil
Crystal structure of the gastric proton pump complexed with soraprazan
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, MAGNESIUM ION, Potassium-transporting ATPase alpha chain 1, ...
著者Abe, K, Tanaka, S.
登録日2021-11-26
公開日2022-01-05
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (3.1 Å)
主引用文献Structural Basis for Binding of Potassium-Competitive Acid Blockers to the Gastric Proton Pump.
J.Med.Chem., 65, 2022
7W48
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BU of 7w48 by Molmil
Crystal structure of the gastric proton pump complexed with PF-03716556
分子名称: 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 2-acetamido-2-deoxy-beta-D-glucopyranose, MAGNESIUM ION, ...
著者Abe, K, Tanaka, S.
登録日2021-11-26
公開日2022-01-05
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (3.5 Å)
主引用文献Structural Basis for Binding of Potassium-Competitive Acid Blockers to the Gastric Proton Pump.
J.Med.Chem., 65, 2022
7W47
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BU of 7w47 by Molmil
Crystal structure of the gastric proton pump complexed with tegoprazan
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, MAGNESIUM ION, Potassium-transporting ATPase alpha chain 1, ...
著者Abe, K, Tanaka, S, Morita, M, Yamagishi, T.
登録日2021-11-26
公開日2022-01-05
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (3 Å)
主引用文献Structural Basis for Binding of Potassium-Competitive Acid Blockers to the Gastric Proton Pump.
J.Med.Chem., 65, 2022
7W4A
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BU of 7w4a by Molmil
Cryo-EM structure of the gastric proton pump complexed with revaprazan
分子名称: 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 2-acetamido-2-deoxy-beta-D-glucopyranose, MAGNESIUM ION, ...
著者Abe, K, Tanaka, S, Morita, M, Yamagishi, T.
登録日2021-11-26
公開日2022-03-02
最終更新日2022-07-20
実験手法ELECTRON MICROSCOPY (2.76 Å)
主引用文献Structural Basis for Binding of Potassium-Competitive Acid Blockers to the Gastric Proton Pump.
J.Med.Chem., 65, 2022
8IJX
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BU of 8ijx by Molmil
Cryo-EM structure of the gastric proton pump with bound DQ-18
分子名称: 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 1-[4-[(5-chloranyl-2-phenylmethoxy-phenyl)methoxy]phenyl]-N-methyl-methanamine, 2-acetamido-2-deoxy-beta-D-glucopyranose, ...
著者Abe, K, Yokoshima, S, Yoshimori, A.
登録日2023-02-28
公開日2023-08-30
最終更新日2023-10-04
実験手法ELECTRON MICROSCOPY (2.08 Å)
主引用文献Deep learning driven de novo drug design based on gastric proton pump structures.
Commun Biol, 6, 2023
8IJV
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BU of 8ijv by Molmil
Cryo-EM structure of the gastric proton pump with bound DQ-02
分子名称: 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 2-acetamido-2-deoxy-beta-D-glucopyranose, 4-[[5-chloranyl-2-(4-chlorophenyl)phenyl]methoxy]-N-methyl-but-2-yn-1-amine, ...
著者Abe, K, Yokoshima, S, Yoshimori, A.
登録日2023-02-28
公開日2023-08-30
最終更新日2023-10-04
実験手法ELECTRON MICROSCOPY (2.1 Å)
主引用文献Deep learning driven de novo drug design based on gastric proton pump structures.
Commun Biol, 6, 2023
8JMN
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BU of 8jmn by Molmil
Cryo-EM structure of the gastric proton pump with bound DQ-21
分子名称: 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 1-[4-[[2-[(4-chlorophenyl)methoxy]phenyl]methoxy]phenyl]-N-methyl-methanamine, 2-acetamido-2-deoxy-beta-D-glucopyranose, ...
著者Abe, K, Yokoshima, S, Yoshimori, A.
登録日2023-06-05
公開日2023-08-30
最終更新日2023-10-04
実験手法ELECTRON MICROSCOPY (2.26 Å)
主引用文献Deep learning driven de novo drug design based on gastric proton pump structures.
Commun Biol, 6, 2023
8IJW
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BU of 8ijw by Molmil
Cryo-EM structure of the gastric proton pump with bound DQ-06
分子名称: 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 2-acetamido-2-deoxy-beta-D-glucopyranose, CHOLESTEROL, ...
著者Abe, K, Yokoshima, S, Yoshimori, A.
登録日2023-02-28
公開日2023-08-30
最終更新日2023-10-04
実験手法ELECTRON MICROSCOPY (2.19 Å)
主引用文献Deep learning driven de novo drug design based on gastric proton pump structures.
Commun Biol, 6, 2023

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件を2024-03-27に公開中

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