PDB: 2399 件ウェブページステータス検索Chemie searchBIRD

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1AGW	CRYSTAL STRUCTURE OF THE TYROSINE KINASE DOMAIN OF FIBROBLAST GROWTH FACTOR RECEPTOR 1 IN COMPLEX WITH SU4984 INHIBITOR 分子名称: 3-[4-(1-FORMYLPIPERAZIN-4-YL)-BENZYLIDENYL]-2-INDOLINONE, FGF RECEPTOR 1 著者 Mohammadi, M, Schlessinger, J, Hubbard, S.R. 登録日 1997-03-25 公開日 1998-03-25 最終更新日 2024-02-07 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Structures of the tyrosine kinase domain of fibroblast growth factor receptor in complex with inhibitors. Science, 276, 1997
1BYG	KINASE DOMAIN OF HUMAN C-TERMINAL SRC KINASE (CSK) IN COMPLEX WITH INHIBITOR STAUROSPORINE 分子名称: PROTEIN (C-TERMINAL SRC KINASE), STAUROSPORINE 著者 Antson, A.A, Lamers, M.B.A.C, Scott, R.K, Williams, D.H, Hubbard, R.E. 登録日 1998-10-14 公開日 1999-10-14 最終更新日 2023-08-09 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Structure of the protein tyrosine kinase domain of C-terminal Src kinase (CSK) in complex with staurosporine. J.Mol.Biol., 285, 1999
1FPU	CRYSTAL STRUCTURE OF ABL KINASE DOMAIN IN COMPLEX WITH A SMALL MOLECULE INHIBITOR 分子名称: N-[4-METHYL-3-[[4-(3-PYRIDINYL)-2-PYRIMIDINYL]AMINO]PHENYL]-3-PYRIDINECARBOXAMIDE, PROTO-ONCOGENE TYROSINE-PROTEIN KINASE ABL 著者 Schindler, T, Bornmann, W, Pellicena, P, Miller, W.T, Clarkson, B, Kuriyan, J. 登録日 2000-08-31 公開日 2000-09-20 最終更新日 2024-03-13 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Structural mechanism for STI-571 inhibition of abelson tyrosine kinase. Science, 289, 2000
1FGK	CRYSTAL STRUCTURE OF THE TYROSINE KINASE DOMAIN OF FIBROBLAST GROWTH FACTOR RECEPTOR 1 分子名称: FGF RECEPTOR 1 著者 Mohammadi, M, Schlessinger, J, Hubbard, S.R. 登録日 1997-02-08 公開日 1997-07-23 最終更新日 2024-02-07 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Structure of the FGF receptor tyrosine kinase domain reveals a novel autoinhibitory mechanism. Cell(Cambridge,Mass.), 86, 1996
1FGI	CRYSTAL STRUCTURE OF THE TYROSINE KINASE DOMAIN OF FIBROBLAST GROWTH FACTOR RECEPTOR 1 IN COMPLEX WITH SU5402 INHIBITOR 分子名称: 3-[(3-(2-CARBOXYETHYL)-4-METHYLPYRROL-2-YL)METHYLENE]-2-INDOLINONE, FGF RECEPTOR 1 著者 Mohammadi, M, Schlessinger, J, Hubbard, S.R. 登録日 1997-03-22 公開日 1998-04-08 最終更新日 2024-02-07 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Structures of the tyrosine kinase domain of fibroblast growth factor receptor in complex with inhibitors. Science, 276, 1997
1GAG	CRYSTAL STRUCTURE OF THE INSULIN RECEPTOR KINASE IN COMPLEX WITH A BISUBSTRATE INHIBITOR 分子名称: BISUBSTRATE PEPTIDE INHIBITOR, INSULIN RECEPTOR, TYROSINE KINASE DOMAIN, ... 著者 Parang, K, Till, J.H, Ablooglu, A.J, Kohanski, R.A, Hubbard, S.R, Cole, P.A. 登録日 2000-11-29 公開日 2001-01-17 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (2.7 Å) 主引用文献 Mechanism-based design of a protein kinase inhibitor. Nat.Struct.Biol., 8, 2001
1FVR	TIE2 KINASE DOMAIN 分子名称: TYROSINE-PROTEIN KINASE TIE-2 著者 Shewchuk, L.M, Hassell, A.M, Ellis, B, Holmes, W.D, Davis, R, Horne, E.L, Kadwell, S.H, McKee, D.D, Moore, J.T. 登録日 2000-09-20 公開日 2001-09-20 最終更新日 2024-02-07 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Structure of the Tie2 RTK domain: self-inhibition by the nucleotide binding loop, activation loop, and C-terminal tail. Structure Fold.Des., 8, 2000
1GJO	The FGFr2 tyrosine kinase domain 分子名称: FIBROBLAST GROWTH FACTOR RECEPTOR 2, SULFATE ION 著者 Ceska, T.A, Owens, R, Doyle, C, Hamlyn, P, Crabbe, T, Moffat, D, Davis, J, Martin, R, Perry, M.J. 登録日 2001-07-31 公開日 2003-08-15 最終更新日 2023-12-13 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 The Fgfr2 Tyrosine Kinase Domain To be Published
1I44	CRYSTALLOGRAPHIC STUDIES OF AN ACTIVATION LOOP MUTANT OF THE INSULIN RECEPTOR TYROSINE KINASE 分子名称: INSULIN RECEPTOR, MAGNESIUM ION, PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER 著者 Till, J.H, Ablooglu, A.J, Frankel, M, Kohanski, R.A, Hubbard, S.R. 登録日 2001-02-19 公開日 2001-03-07 最終更新日 2023-08-09 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Crystallographic and solution studies of an activation loop mutant of the insulin receptor tyrosine kinase: insights into kinase mechanism. J.Biol.Chem., 276, 2001
1IEP	CRYSTAL STRUCTURE OF THE C-ABL KINASE DOMAIN IN COMPLEX WITH STI-571. 分子名称: 4-(4-METHYL-PIPERAZIN-1-YLMETHYL)-N-[4-METHYL-3-(4-PYRIDIN-3-YL-PYRIMIDIN-2-YLAMINO)-PHENYL]-BENZAMIDE, CHLORIDE ION, PROTO-ONCOGENE TYROSINE-PROTEIN KINASE ABL 著者 Nagar, B, Bornmann, W, Schindler, T, Clarkson, B, Kuriyan, J. 登録日 2001-04-10 公開日 2001-04-18 最終更新日 2023-08-09 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Crystal structures of the kinase domain of c-Abl in complex with the small molecule inhibitors PD173955 and imatinib (STI-571) Cancer Res., 62, 2002
1IR3	PHOSPHORYLATED INSULIN RECEPTOR TYROSINE KINASE IN COMPLEX WITH PEPTIDE SUBSTRATE AND ATP ANALOG 分子名称: INSULIN RECEPTOR, MAGNESIUM ION, PEPTIDE SUBSTRATE, ... 著者 Hubbard, S.R. 登録日 1997-09-22 公開日 1998-01-07 最終更新日 2023-08-09 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Crystal structure of the activated insulin receptor tyrosine kinase in complex with peptide substrate and ATP analog. EMBO J., 16, 1997
1IRK	CRYSTAL STRUCTURE OF THE TYROSINE KINASE DOMAIN OF THE HUMAN INSULIN RECEPTOR 分子名称: ETHYL MERCURY ION, INSULIN RECEPTOR TYROSINE KINASE DOMAIN 著者 Hubbard, S.R, Wei, L, Ellis, L, Hendrickson, W.A. 登録日 1995-01-02 公開日 1995-02-27 最終更新日 2024-02-07 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Crystal structure of the tyrosine kinase domain of the human insulin receptor. Nature, 372, 1994
1K2P	Crystal structure of Bruton's tyrosine kinase domain 分子名称: Tyrosine-protein kinase BTK 著者 Mao, C, Zhou, M, Uckun, F.M. 登録日 2001-09-28 公開日 2002-06-26 最終更新日 2024-02-07 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Crystal structure of Bruton's tyrosine kinase domain suggests a novel pathway for activation and provides insights into the molecular basis of X-linked agammaglobulinemia. J.Biol.Chem., 276, 2001
1JQH	IGF-1 receptor kinase domain 分子名称: IGF-1 receptor kinase, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ... 著者 Pautsch, A, Zoephel, A, Ahorn, H, Spevak, W, Hauptmann, R, Nar, H. 登録日 2001-08-07 公開日 2002-04-19 最終更新日 2021-11-10 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Crystal structure of bisphosphorylated IGF-1 receptor kinase: insight into domain movements upon kinase activation. Structure, 9, 2001
1K3A	Structure of the Insulin-like Growth Factor 1 Receptor Kinase 分子名称: PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER, insulin receptor substrate 1, insulin-like growth factor 1 receptor 著者 Favelyukis, S, Till, J.H, Hubbard, S.R, Miller, W.T. 登録日 2001-10-02 公開日 2001-11-28 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Structure and autoregulation of the insulin-like growth factor 1 receptor kinase. Nat.Struct.Biol., 8, 2001
1LUF	Crystal Structure of the MuSK Tyrosine Kinase: Insights into Receptor Autoregulation 分子名称: muscle-specific tyrosine kinase receptor musk 著者 Till, J.H, Becerra, M, Watty, A, Lu, Y, Ma, Y, Neubert, T.A, Burden, S.J, Hubbard, S.R. 登録日 2002-05-22 公開日 2002-09-11 最終更新日 2024-02-14 実験手法 X-RAY DIFFRACTION (2.05 Å) 主引用文献 Crystal structure of the MuSK tyrosine kinase: insights into receptor autoregulation. Structure, 10, 2002
1M7N	Crystal Structure of Unactivated APO Insulin-like Growth Factor-1 Receptor Kinase Domain 分子名称: Insulin-like growth factor I receptor 著者 Munshi, S, Kuo, L. 登録日 2002-07-22 公開日 2003-01-07 最終更新日 2024-02-14 実験手法 X-RAY DIFFRACTION (2.7 Å) 主引用文献 Crystal structure of the Apo, unactivated insulin-like growth factor-1 receptor kinase. Implication for inhibitor specificity. J.Biol.Chem., 277, 2002
1M17	Epidermal Growth Factor Receptor tyrosine kinase domain with 4-anilinoquinazoline inhibitor erlotinib 分子名称: [6,7-BIS(2-METHOXY-ETHOXY)QUINAZOLINE-4-YL]-(3-ETHYNYLPHENYL)AMINE, epidermal growth factor receptor 著者 Stamos, J, Sliwkowski, M.X, Eigenbrot, C. 登録日 2002-06-17 公開日 2002-09-04 最終更新日 2024-02-14 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 Structure of the epidermal growth factor receptor kinase domain alone and in complex with a 4-anilinoquinazoline inhibitor. J.Biol.Chem., 277, 2002
1M14	Tyrosine Kinase Domain from Epidermal Growth Factor Receptor 分子名称: Epidermal growth factor receptor 著者 Stamos, J, Sliwkowski, M.X, Eigenbrot, C. 登録日 2002-06-17 公開日 2002-09-04 最終更新日 2024-02-14 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 Structure of the epidermal growth factor receptor kinase domain alone and in complex with a 4-anilinoquinazoline inhibitor. J.Biol.Chem., 277, 2002
1MP8	Crystal structure of Focal Adhesion Kinase (FAK) 分子名称: ADENOSINE-5'-DIPHOSPHATE, focal adhesion kinase 1 著者 Nowakowski, J, Cronin, C.N, McRee, D.E, Knuth, M.W, Nelson, C.G, Pavletich, N.P, Rodgers, J, Sang, B.-C, Scheibe, D.N, Swanson, R.V, Thompson, D.A. 登録日 2002-09-11 公開日 2003-09-16 最終更新日 2011-07-13 実験手法 X-RAY DIFFRACTION (1.6 Å) 主引用文献 Structures of the cancer-related Aurora-A, FAK, and EphA2 protein kinases from nanovolume crystallography Structure, 10, 2002
1M52	Crystal Structure of the c-Abl Kinase domain in complex with PD173955 分子名称: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 6-(2,6-DICHLORO-PHENYL)-8-METHYL-2-(3-METHYLSULFANYL-PHENYLAMINO)-8H-PYRIDO[2,3-D]PYRIMIDIN-7-ONE, PROTO-ONCOGENE TYROSINE-PROTEIN KINASE ABL1 著者 Nagar, B, Bornmann, W, Pellicena, P, Schindler, T, Veach, D, Miller, W.T, Clarkson, B, Kuriyan, J. 登録日 2002-07-08 公開日 2002-09-18 最終更新日 2024-02-14 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 Crystal Structures of the Kinase Domain of c-Abl in Complex with the Small Molecule Inhibitors PD173955 and Imatinib (STI-571) Cancer Res., 62, 2002
1MQB	Crystal Structure of Ephrin A2 (ephA2) Receptor Protein Kinase 分子名称: Ephrin type-A receptor 2, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER 著者 Nowakowski, J, Cronin, C.N, McRee, D.E, Knuth, M.W, Nelson, C, Pavletich, N, Rogers, J, Sang, B.C, Scheibe, D.N, Swanson, R.V, Thompson, D.A. 登録日 2002-09-16 公開日 2003-09-16 最終更新日 2024-02-14 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Structures of the Cancer Related Aurora-A, FAK and EphA2 Protein Kinases from Nanovolume Crystallography Structure, 10, 2003
1U4D	Structure of the ACK1 Kinase Domain bound to Debromohymenialdisine 分子名称: Activated CDC42 kinase 1, CHLORIDE ION, DEBROMOHYMENIALDISINE 著者 Lougheed, J.C, Chen, R.H, Mak, P, Stout, T.J. 登録日 2004-07-23 公開日 2004-08-31 最終更新日 2023-08-23 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Crystal Structures of the Phosphorylated and Unphosphorylated Kinase Domains of the Cdc42-associated Tyrosine Kinase ACK1. J.Biol.Chem., 279, 2004
1U46	Crystal Structure of the Unphosphorylated Kinase Domain of the Tyrosine Kinase ACK1 分子名称: Activated CDC42 kinase 1, CHLORIDE ION 著者 Lougheed, J.C, Chen, R.H, Mak, P, Stout, T.J. 登録日 2004-07-23 公開日 2004-08-31 最終更新日 2024-02-14 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Crystal Structures of the Phosphorylated and Unphosphorylated Kinase Domains of the Cdc42-associated Tyrosine Kinase ACK1. J.Biol.Chem., 279, 2004
1U59	Crystal Structure of the ZAP-70 Kinase Domain in Complex with Staurosporine 分子名称: STAUROSPORINE, Tyrosine-protein kinase ZAP-70 著者 Jin, L, Pluskey, S, Petrella, E.C, Cantin, S.M, Gorga, J.C, Rynkiewicz, M.J, Pandey, P, Strickler, J.E, Babine, R.E, Weaver, D.T, Seidl, K.J. 登録日 2004-07-27 公開日 2004-08-17 最終更新日 2023-08-23 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 The Three-dimensional Structure of the ZAP-70 Kinase Domain in Complex with Staurosporine: IMPLICATIONS FOR THE DESIGN OF SELECTIVE INHIBITORS J.Biol.Chem., 279, 2004

 

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