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8TDW
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ssRNA bound SAMHD1 T open
分子名称: Deoxynucleoside triphosphate triphosphohydrolase SAMHD1, FE (III) ION, RNA (5'-R(P*CP*CP*GP*AP*CP*C)-3'), ...
著者Sung, M, Huynh, K, Han, S.
登録日2023-07-05
公開日2023-11-22
最終更新日2023-12-20
実験手法ELECTRON MICROSCOPY (3.04 Å)
主引用文献Guanine-containing ssDNA and RNA induce dimeric and tetrameric structural forms of SAMHD1.
Nucleic Acids Res., 51, 2023
8TDV
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ssRNA bound SAMHD1 T closed
分子名称: Deoxynucleoside triphosphate triphosphohydrolase SAMHD1, FE (III) ION, RNA (5'-R(P*CP*CP*GP*AP*CP*CP*C)-3'), ...
著者Sung, M, Huynh, K, Han, S.
登録日2023-07-05
公開日2023-12-20
実験手法ELECTRON MICROSCOPY (3.44 Å)
主引用文献Guanine-containing ssDNA and RNA induce dimeric and tetrameric structural forms of SAMHD1.
Nucleic Acids Res., 51, 2023
8P2M
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C. elegans TIR-1 protein.
分子名称: NAD(+) hydrolase tir-1
著者Isupov, M.N, Opatowsky, Y.
登録日2023-05-16
公開日2023-09-06
実験手法ELECTRON MICROSCOPY (3.82 Å)
主引用文献Structure-function analysis of ceTIR-1/hSARM1 explains the lack of Wallerian axonal degeneration in C. elegans.
Cell Rep, 42, 2023
8P2L
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A CHIMERA construct containing human SARM1 ARM and SAM domains and C. elegans TIR domain.
分子名称: NAD(+) hydrolase SARM1,NAD(+) hydrolase tir-1, NICOTINAMIDE-ADENINE-DINUCLEOTIDE
著者Isupov, M.N, Opatowsky, Y.
登録日2023-05-16
公開日2023-09-06
実験手法ELECTRON MICROSCOPY (2.68 Å)
主引用文献Structure-function analysis of ceTIR-1/hSARM1 explains the lack of Wallerian axonal degeneration in C. elegans.
Cell Rep, 42, 2023
8GQ5
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Human SARM1 bounded with NMN and Nanobody-C6, double-layer structure
分子名称: NAD(+) hydrolase SARM1, Nanobody C6
著者Cai, Y, Zhang, H.
登録日2022-08-29
公開日2023-01-18
実験手法ELECTRON MICROSCOPY (2.7 Å)
主引用文献A conformation-specific nanobody targeting the nicotinamide mononucleotide-activated state of SARM1.
Nat Commun, 13, 2022
8GNJ
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Human SARM1 bounded with NMN and Nanobody-C6, Conformation 2
分子名称: BETA-NICOTINAMIDE RIBOSE MONOPHOSPHATE, NAD(+) hydrolase SARM1, Nanobody-C6
著者Cai, Y, Zhang, H.
登録日2022-08-24
公開日2023-01-18
実験手法ELECTRON MICROSCOPY (3.78 Å)
主引用文献A conformation-specific nanobody targeting the nicotinamide mononucleotide-activated state of SARM1.
Nat Commun, 13, 2022
8GNI
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Human SARM1 bounded with NMN and Nanobody-C6, Conformation 1
分子名称: BETA-NICOTINAMIDE RIBOSE MONOPHOSPHATE, NAD(+) hydrolase SARM1, Nanobody C6
著者Cai, Y, Zhang, H.
登録日2022-08-24
公開日2023-01-18
実験手法ELECTRON MICROSCOPY (3.74 Å)
主引用文献A conformation-specific nanobody targeting the nicotinamide mononucleotide-activated state of SARM1.
Nat Commun, 13, 2022
8D9J
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SAMHD1-DNA complex
分子名称: CALCIUM ION, DNA (5'-D(*CP*AP*AP*TP*G)-3'), Deoxynucleoside triphosphate triphosphohydrolase SAMHD1, ...
著者Hollis, T.J, Batalis, S.M.
登録日2022-06-10
公開日2023-07-05
最終更新日2023-10-25
実験手法X-RAY DIFFRACTION (2.82 Å)
主引用文献SAMHD1-DNA complex
To Be Published
8D94
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SAMHD1-DNA complex
分子名称: CALCIUM ION, DNA (5'-D(P*TP*GP*T)-3'), Deoxynucleoside triphosphate triphosphohydrolase SAMHD1, ...
著者Hollis, T.J, Batalis, S.M.
登録日2022-06-09
公開日2023-07-05
最終更新日2023-10-25
実験手法X-RAY DIFFRACTION (2.44 Å)
主引用文献SAMHD1-DNA complex
To Be Published
8BW9
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Cryo-EM structure of the RAF activating complex KSR-MEK-CNK-HYP
分子名称: Connector enhancer of KSR protein CNK, Dual specificity mitogen-activated protein kinase kinase dSOR1, KSR, ...
著者Maisonneuve, P, Fronzes, R, Sicheri, F.
登録日2022-12-06
公開日2024-02-21
最終更新日2024-03-06
実験手法ELECTRON MICROSCOPY (3.32 Å)
主引用文献The CNK-HYP scaffolding complex promotes RAF activation by enhancing KSR-MEK interaction.
Nat.Struct.Mol.Biol., 2024
8BW8
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Crystal structure of the dCNK-SAM-CRIC-PDZ/dHYP-SAM complex
分子名称: Connector enhancer of KSR protein CNK, GLYCEROL, Protein aveugle
著者Maisonneuve, P, Kurinov, I, Sicheri, F.
登録日2022-12-06
公開日2024-02-21
最終更新日2024-03-06
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献The CNK-HYP scaffolding complex promotes RAF activation by enhancing KSR-MEK interaction.
Nat.Struct.Mol.Biol., 2024
8ALY
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BU of 8aly by Molmil
Cryo-EM structure of human tankyrase 2 SAM-PARP filament (G1032W mutant)
分子名称: Poly [ADP-ribose] polymerase tankyrase-2, ZINC ION
著者Mariotti, L, Inian, O, Desfosses, A, Beuron, F, Morris, E.P, Guettler, S.
登録日2022-08-01
公開日2022-11-16
最終更新日2022-12-14
実験手法ELECTRON MICROSCOPY (2.98 Å)
主引用文献Structural basis of tankyrase activation by polymerization.
Nature, 612, 2022
7Z72
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Crystal structure of p63 SAM in complex with darpin A5
分子名称: DI(HYDROXYETHYL)ETHER, Darpin A5, Isoform 9 of Tumor protein 63
著者Chaikuad, A, Strubel, A, Doetsch, V, Knapp, S, Structural Genomics Consortium (SGC)
登録日2022-03-14
公開日2022-07-06
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Designed Ankyrin Repeat Proteins as a tool box for analyzing p63.
Cell Death Differ., 29, 2022
7UJN
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Structure of Human SAMHD1 with Non-Hydrolysable dGTP Analog
分子名称: 2'-deoxyguanosine-5'-O-(1-thiotriphosphate), Deoxynucleoside triphosphate triphosphohydrolase SAMHD1
著者Huynh, K.W, Ammirati, M, Han, S.
登録日2022-03-31
公開日2022-07-20
最終更新日2024-02-14
実験手法ELECTRON MICROSCOPY (2.89 Å)
主引用文献Phosphorylation of SAMHD1 Thr592 increases C-terminal domain dynamics, tetramer dissociation and ssDNA binding kinetics.
Nucleic Acids Res., 50, 2022
7QG0
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Inhibitor-induced hSARM1 duplex
分子名称: NAD(+) hydrolase SARM1
著者Zalk, R, Kahzma, T, Guez-Haddad, J.
登録日2021-12-07
公開日2022-12-21
最終更新日2023-01-11
実験手法ELECTRON MICROSCOPY (4.02 Å)
主引用文献A duplex structure of SARM1 octamers stabilized by a new inhibitor.
Cell.Mol.Life Sci., 80, 2022
7NAL
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Cryo-EM structure of activated human SARM1 in complex with NMN and 1AD (ARM and SAM domains)
分子名称: BETA-NICOTINAMIDE RIBOSE MONOPHOSPHATE, NAD(+) hydrolase SARM1
著者Kerry, P.S, Nanson, J.D, Adams, S, Cunnea, K, Bosanac, T, Kobe, B, Hughes, R.O, Ve, T.
登録日2021-06-21
公開日2022-03-23
最終更新日2022-05-18
実験手法ELECTRON MICROSCOPY (3 Å)
主引用文献Structural basis of SARM1 activation, substrate recognition, and inhibition by small molecules.
Mol.Cell, 82, 2022
7NAK
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BU of 7nak by Molmil
Cryo-EM structure of activated human SARM1 in complex with NMN and 1AD (TIR:1AD)
分子名称: NAD(+) hydrolase SARM1, [[(2~{R},3~{S},4~{R},5~{R})-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-oxidanyl-phosphoryl] [(2~{R},3~{S},4~{R},5~{R})-5-(5-iodanylisoquinolin-2-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methyl hydrogen phosphate
著者Kerry, P.S, Nanson, J.D, Adams, S, Cunnea, K, Bosanac, T, Kobe, B, Hughes, R.O, Ve, T.
登録日2021-06-21
公開日2022-03-23
最終更新日2022-05-18
実験手法ELECTRON MICROSCOPY (2.9 Å)
主引用文献Structural basis of SARM1 activation, substrate recognition, and inhibition by small molecules.
Mol.Cell, 82, 2022
7LD0
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BU of 7ld0 by Molmil
Cryo-EM structure of ligand-free Human SARM1
分子名称: NAD(+) hydrolase SARM1
著者Nanson, J.D, Gu, W, Luo, Z, Jia, X, Landsberg, M.J, Kobe, B, Ve, T.
登録日2021-01-12
公開日2021-03-10
最終更新日2024-03-06
実験手法ELECTRON MICROSCOPY (3.1 Å)
主引用文献SARM1 is a metabolic sensor activated by an increased NMN/NAD + ratio to trigger axon degeneration.
Neuron, 109, 2021
7KNQ
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SARM1 Octamer
分子名称: NAD(+) hydrolase SARM1
著者Shen, C, Wu, H.
登録日2020-11-05
公開日2021-11-17
最終更新日2022-06-15
実験手法ELECTRON MICROSCOPY (3.4 Å)
主引用文献Multiple domain interfaces mediate SARM1 autoinhibition.
Proc.Natl.Acad.Sci.USA, 118, 2021
7DJT
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Human SARM1 inhibitory state bounded with inhibitor dHNN
分子名称: NAD(+) hydrolase SARM1, O3-methyl O5-(2-methylpropyl) 2,6-dimethyl-4-[2-(oxidanylamino)phenyl]pyridine-3,5-dicarboxylate
著者Cai, Y, Zhang, H.
登録日2020-11-21
公開日2021-05-19
最終更新日2023-11-15
実験手法ELECTRON MICROSCOPY (2.8 Å)
主引用文献Permeant fluorescent probes visualize the activation of SARM1 and uncover an anti-neurodegenerative drug candidate.
Elife, 10, 2021
7CM7
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BU of 7cm7 by Molmil
NAD+-bound Sarm1 E642A in the self-inhibited state
分子名称: NAD(+) hydrolase SARM1, NICOTINAMIDE-ADENINE-DINUCLEOTIDE
著者Zhang, Z, Jiang, Y.
登録日2020-07-25
公開日2020-10-21
最終更新日2024-03-27
実験手法ELECTRON MICROSCOPY (2.6 Å)
主引用文献The NAD + -mediated self-inhibition mechanism of pro-neurodegenerative SARM1.
Nature, 588, 2020
7CM6
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NAD+-bound Sarm1 in the self-inhibited state
分子名称: NAD(+) hydrolase SARM1, NICOTINAMIDE-ADENINE-DINUCLEOTIDE
著者Zhang, Z, Jiang, Y.
登録日2020-07-25
公開日2020-10-21
最終更新日2024-03-27
実験手法ELECTRON MICROSCOPY (3 Å)
主引用文献The NAD + -mediated self-inhibition mechanism of pro-neurodegenerative SARM1.
Nature, 588, 2020
7CM5
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Full-length Sarm1 in a self-inhibited state
分子名称: NAD(+) hydrolase SARM1
著者Zhang, Z, Jiang, Y.
登録日2020-07-24
公開日2020-10-21
最終更新日2024-03-27
実験手法ELECTRON MICROSCOPY (2.6 Å)
主引用文献The NAD + -mediated self-inhibition mechanism of pro-neurodegenerative SARM1.
Nature, 588, 2020
7ANW
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hSARM1 NAD+ complex
分子名称: NAD(+) hydrolase SARM1, NICOTINAMIDE-ADENINE-DINUCLEOTIDE
著者Sporny, M, Guez-Haddad, J, Khazma, T, Yaron, A, Mim, C, Isupov, M.N, Zalk, R, Dessau, M, Hons, M, Opatowsky, Y.
登録日2020-10-13
公開日2020-11-11
最終更新日2020-12-09
実験手法ELECTRON MICROSCOPY (2.68 Å)
主引用文献Structural basis for SARM1 inhibition and activation under energetic stress.
Elife, 9, 2020
6ZG1
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SARM1 SAM1-2 domains
分子名称: 1,2-ETHANEDIOL, BETA-MERCAPTOETHANOL, DI(HYDROXYETHYL)ETHER, ...
著者Sporny, M, Guez-Haddad, J, Khazma, T, Yaron, A, Dessau, M, Mim, C, Isupov, M.N, Zalk, R, Hons, M, Opatowsky, Y.
登録日2020-06-18
公開日2020-11-11
最終更新日2020-12-09
実験手法ELECTRON MICROSCOPY (3.77 Å)
主引用文献Structural basis for SARM1 inhibition and activation under energetic stress.
Elife, 9, 2020

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件を2024-03-27に公開中

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