7LF6
 
 | | Structure of lysosomal membrane protein | | 分子名称: | Endosomal/lysosomal potassium channel TMEM175 | | 著者 | Shen, C, Fu, T.M, Wang, L.F, Rawson, S, Wu, H. | | 登録日 | 2021-01-15 | | 公開日 | 2022-01-26 | | 最終更新日 | 2023-08-09 | | 実験手法 | ELECTRON MICROSCOPY (3.5 Å) | | 主引用文献 | pH regulates potassium conductance and drives a constitutive proton current in human TMEM175.
Sci Adv, 8, 2022
|
|
5VRE
 | |
8DHM
 | | Human TMEM175 in complex with 4-aminopyridine | | 分子名称: | 4-AMINOPYRIDINE, Endosomal/lysosomal potassium channel TMEM175, POTASSIUM ION | | 著者 | Oh, S, Hite, R.K. | | 登録日 | 2022-06-27 | | 公開日 | 2022-11-23 | | 実験手法 | ELECTRON MICROSCOPY (2.73 Å) | | 主引用文献 | Mechanism of 4-aminopyridine inhibition of the lysosomal channel TMEM175.
Proc.Natl.Acad.Sci.USA, 119, 2022
|
|
7UNL
 | | Human TMEM175 in an open state | | 分子名称: | Endosomal/lysosomal potassium channel TMEM175, POTASSIUM ION | | 著者 | Oh, S, Hite, R.K. | | 登録日 | 2022-04-11 | | 公開日 | 2022-06-01 | | 最終更新日 | 2024-02-14 | | 実験手法 | ELECTRON MICROSCOPY (2.45 Å) | | 主引用文献 | Differential ion dehydration energetics explains selectivity in the non-canonical lysosomal K + channel TMEM175.
Elife, 11, 2022
|
|
7UNM
 | | Human TMEM175 in an closed state | | 分子名称: | Endosomal/lysosomal potassium channel TMEM175, POTASSIUM ION | | 著者 | Oh, S, Hite, R.K. | | 登録日 | 2022-04-11 | | 公開日 | 2022-06-29 | | 最終更新日 | 2024-02-14 | | 実験手法 | ELECTRON MICROSCOPY (2.61 Å) | | 主引用文献 | Differential ion dehydration energetics explains selectivity in the non-canonical lysosomal K + channel TMEM175.
Elife, 11, 2022
|
|
6W8N
 | |
6W8P
 | | Structure of membrane protein with ions | | 分子名称: | Endosomal/lysosomal potassium channel TMEM175, POTASSIUM ION | | 著者 | Shen, C, Fu, T.M, Wang, L.F, Rawson, S, Wu, H. | | 登録日 | 2020-03-21 | | 公開日 | 2021-08-04 | | 実験手法 | ELECTRON MICROSCOPY (3.6 Å) | | 主引用文献 | Structure of membrane protein with ions
To Be Published
|
|
6W8O
 | |
6WCA
 | | Human closed state TMEM175 in KCl | | 分子名称: | Endosomal/lysosomal potassium channel TMEM175, POTASSIUM ION | | 著者 | Oh, S, Paknejad, N, Hite, R.K. | | 登録日 | 2020-03-30 | | 公開日 | 2020-04-15 | | 最終更新日 | 2024-03-06 | | 実験手法 | ELECTRON MICROSCOPY (3.03 Å) | | 主引用文献 | Gating and selectivity mechanisms for the lysosomal K + channel TMEM175.
Elife, 9, 2020
|
|
6WC9
 | | Human open state TMEM175 in KCl | | 分子名称: | Endosomal/lysosomal potassium channel TMEM175, POTASSIUM ION | | 著者 | Oh, S, Paknejad, N, Hite, R.K. | | 登録日 | 2020-03-30 | | 公開日 | 2020-04-15 | | 最終更新日 | 2024-03-06 | | 実験手法 | ELECTRON MICROSCOPY (2.64 Å) | | 主引用文献 | Gating and selectivity mechanisms for the lysosomal K + channel TMEM175.
Elife, 9, 2020
|
|
6WCB
 | | Human open state TMEM175 in CsCl | | 分子名称: | CESIUM ION, Endosomal/lysosomal potassium channel TMEM175 | | 著者 | Oh, S, Paknejad, N, Hite, R.K. | | 登録日 | 2020-03-30 | | 公開日 | 2020-04-15 | | 最終更新日 | 2024-03-06 | | 実験手法 | ELECTRON MICROSCOPY (3.17 Å) | | 主引用文献 | Gating and selectivity mechanisms for the lysosomal K + channel TMEM175.
Elife, 9, 2020
|
|
6WCC
 | |
6SWR
 | | Crystal structure of the lysosomal potassium channel MtTMEM175 T38A mutant soaked with zinc | | 分子名称: | DODECYL-BETA-D-MALTOSIDE, Nanobody, Maltose/maltodextrin-binding periplasmic protein,Maltodextrin-binding protein,Maltose/maltodextrin-binding periplasmic protein, ... | | 著者 | Brunner, J.D, Jakob, R.P, Schulze, T, Neldner, Y, Moroni, A, Thiel, G, Maier, T, Schenck, S. | | 登録日 | 2019-09-23 | | 公開日 | 2020-04-15 | | 最終更新日 | 2024-01-24 | | 実験手法 | X-RAY DIFFRACTION (3.2 Å) | | 主引用文献 | Structural basis for ion selectivity in TMEM175 K + channels.
Elife, 9, 2020
|
|
8FYF
 | | Human TMEM175-LAMP1 transmembrane domain only complex | | 分子名称: | Endosomal/lysosomal potassium channel TMEM175, Lysosome-associated membrane glycoprotein 1 | | 著者 | Zhang, J.Y, Zeng, W.Z, Han, Y, Jiang, Y.X. | | 登録日 | 2023-01-26 | | 公開日 | 2023-06-28 | | 最終更新日 | 2023-08-02 | | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | | 主引用文献 | Lysosomal LAMP proteins regulate lysosomal pH by direct inhibition of the TMEM175 channel.
Mol.Cell, 83, 2023
|
|
8FY5
 | | Human TMEM175-LAMP1 full-length complex | | 分子名称: | Endosomal/lysosomal potassium channel TMEM175, Lysosome-associated membrane glycoprotein 1 | | 著者 | Zhang, J.Y, Zeng, W.Z, Han, Y, Jiang, Y.X. | | 登録日 | 2023-01-25 | | 公開日 | 2023-06-28 | | 最終更新日 | 2023-08-02 | | 実験手法 | ELECTRON MICROSCOPY (3.5 Å) | | 主引用文献 | Lysosomal LAMP proteins regulate lysosomal pH by direct inhibition of the TMEM175 channel.
Mol.Cell, 83, 2023
|
|
6HD8
 | | Crystal structure of the potassium channel MtTMEM175 in complex with a Nanobody-MBP fusion protein | | 分子名称: | DODECYL-BETA-D-MALTOSIDE, Nanobody,Maltose/maltodextrin-binding periplasmic protein, POTASSIUM ION, ... | | 著者 | Brunner, J.D, Jakob, R.P, Schulze, T, Neldner, Y, Moroni, A, Thiel, G, Maier, T, Schenck, S. | | 登録日 | 2018-08-17 | | 公開日 | 2019-08-28 | | 最終更新日 | 2024-01-17 | | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | | 主引用文献 | Structural basis for ion selectivity in TMEM175 K+channels.
Elife, 9, 2020
|
|
6HDB
 | | Crystal structure of the potassium channel MtTMEM175 with zinc | | 分子名称: | DODECYL-BETA-D-MALTOSIDE, Nanobody,Maltose/maltodextrin-binding periplasmic protein, POTASSIUM ION, ... | | 著者 | Brunner, J.D, Jakob, R.P, Schulze, T, Neldner, Y, Moroni, A, Thiel, G, Maier, T, Schenck, S. | | 登録日 | 2018-08-17 | | 公開日 | 2019-08-28 | | 最終更新日 | 2024-01-17 | | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | | 主引用文献 | Structural basis for ion selectivity in TMEM175 K+channels.
Elife, 9, 2020
|
|
6HDC
 | | Crystal structure of the potassium channel MtTMEM175 T38A variant in complex with a Nanobody-MBP fusion protein | | 分子名称: | DODECYL-BETA-D-MALTOSIDE, Nanobody,Maltose/maltodextrin-binding periplasmic protein,Maltose/maltodextrin-binding periplasmic protein, POTASSIUM ION, ... | | 著者 | Brunner, J.D, Jakob, R.P, Schulze, T, Neldner, Y, Moroni, A, Thiel, G, Maier, T, Schenck, S. | | 登録日 | 2018-08-17 | | 公開日 | 2019-08-28 | | 最終更新日 | 2024-01-17 | | 実験手法 | X-RAY DIFFRACTION (3.4 Å) | | 主引用文献 | Structural basis for ion selectivity in TMEM175 K+channels.
Elife, 9, 2020
|
|
6HD9
 | | Crystal structure of the potassium channel MtTMEM175 with rubidium | | 分子名称: | DODECYL-BETA-D-MALTOSIDE, Nanobody,Maltose/maltodextrin-binding periplasmic protein, RUBIDIUM ION, ... | | 著者 | Brunner, J.D, Jakob, R.P, Schulze, T, Neldner, Y, Moroni, A, Thiel, G, Maier, T, Schenck, S. | | 登録日 | 2018-08-17 | | 公開日 | 2019-08-28 | | 最終更新日 | 2024-01-17 | | 実験手法 | X-RAY DIFFRACTION (3.5 Å) | | 主引用文献 | Structural basis for ion selectivity in TMEM175 K+channels.
Elife, 9, 2020
|
|
6HDA
 | | Crystal structure of the potassium channel MtTMEM175 with cesium | | 分子名称: | CESIUM ION, DODECYL-BETA-D-MALTOSIDE, Nanobody,Maltose/maltodextrin-binding periplasmic protein, ... | | 著者 | Brunner, J.D, Jakob, R.P, Schulze, T, Neldner, Y, Moroni, A, Thiel, G, Maier, T, Schenck, S. | | 登録日 | 2018-08-17 | | 公開日 | 2019-08-28 | | 最終更新日 | 2024-01-17 | | 実験手法 | X-RAY DIFFRACTION (3.8 Å) | | 主引用文献 | Structural basis for ion selectivity in TMEM175 K+channels.
Elife, 9, 2020
|
|
