1IFG
| CRYSTAL STRUCTURE OF A MONOMERIC FORM OF GENERAL PROTEASE INHIBITOR, ECOTIN IN ABSENCE OF A PROTEASE | 分子名称: | ECOTIN | 著者 | Eggers, C.T, Wang, S.X, Fletterick, R.J, Craik, C.S. | 登録日 | 2001-04-12 | 公開日 | 2001-05-18 | 最終更新日 | 2023-08-16 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | The role of ecotin dimerization in protease inhibition. J.Mol.Biol., 308, 2001
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1ECY
| PROTEASE INHIBITOR ECOTIN | 分子名称: | ECOTIN, alpha-D-glucopyranose, alpha-D-glucopyranose-(1-1)-alpha-D-glucopyranose, ... | 著者 | Shin, D.H, Suh, S.W. | 登録日 | 1996-08-06 | 公開日 | 1997-02-12 | 最終更新日 | 2024-04-03 | 実験手法 | X-RAY DIFFRACTION (2.19 Å) | 主引用文献 | Crystal structure analyses of uncomplexed ecotin in two crystal forms: implications for its function and stability. Protein Sci., 5, 1996
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1ECZ
| PROTEASE INHIBITOR ECOTIN | 分子名称: | ECOTIN, octyl beta-D-glucopyranoside | 著者 | Shin, D.H, Suh, S.W. | 登録日 | 1996-08-06 | 公開日 | 1997-02-12 | 最終更新日 | 2024-04-03 | 実験手法 | X-RAY DIFFRACTION (2.68 Å) | 主引用文献 | Crystal structure analyses of uncomplexed ecotin in two crystal forms: implications for its function and stability. Protein Sci., 5, 1996
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1AZZ
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7CBK
| Structure of Human Neutrophil Elastase Ecotin complex | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, Ecotin, ... | 著者 | Jobichen, C, Sivaraman, J. | 登録日 | 2020-06-12 | 公開日 | 2020-08-12 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | 主引用文献 | Structural Basis for the Inhibition Mechanism of Ecotin against Neutrophil Elastase by Targeting the Active Site and Secondary Binding Site. Biochemistry, 59, 2020
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4NIY
| Crystal structure of trypsiligase (K60E/N143H/Y151H/D189K trypsin) complexed to YRH-ecotin (M84Y/M85R/A86H ecotin) | 分子名称: | CALCIUM ION, Cationic trypsin, Ecotin, ... | 著者 | Schoepfel, M, Parthier, C, Stubbs, M.T. | 登録日 | 2013-11-08 | 公開日 | 2014-02-19 | 最終更新日 | 2014-03-19 | 実験手法 | X-RAY DIFFRACTION (2.84 Å) | 主引用文献 | N-terminal protein modification by substrate-activated reverse proteolysis. Angew.Chem.Int.Ed.Engl., 53, 2014
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2Y6T
| Molecular Recognition of Chymotrypsin by the Serine Protease Inhibitor Ecotin from Yersinia pestis | 分子名称: | CHYMOTRYPSINOGEN A, ECOTIN, SULFATE ION | 著者 | Clark, E.A, Walker, N, Ford, D.C, Cooper, I.A, Oyston, P.C.F, Acharya, K.R. | 登録日 | 2011-01-26 | 公開日 | 2011-04-20 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (2.74 Å) | 主引用文献 | Molecular Recognition of Chymotrypsin by the Serine Protease Inhibitor Ecotin from Yersinia Pestis. J.Biol.Chem., 286, 2011
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4IW4
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7PQN
| Catalytic fragment of MASP-2 in complex with ecotin | 分子名称: | Ecotin, GLYCEROL, Mannan-binding lectin serine protease 2 A chain, ... | 著者 | Harmat, V, Fodor, K, Heja, D. | 登録日 | 2021-09-17 | 公開日 | 2022-05-18 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (2.400015 Å) | 主引用文献 | Synergy of protease-binding sites within the ecotin homodimer is crucial for inhibition of MASP enzymes and for blocking lectin pathway activation. J.Biol.Chem., 298, 2022
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7PQO
| Catalytic fragment of MASP-1 in complex with P1 site mutant ecotin | 分子名称: | Ecotin, GLYCEROL, Mannan-binding lectin serine protease 1, ... | 著者 | Harmat, V, Fodor, K, Heja, D. | 登録日 | 2021-09-17 | 公開日 | 2022-05-18 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (3.39 Å) | 主引用文献 | Synergy of protease-binding sites within the ecotin homodimer is crucial for inhibition of MASP enzymes and for blocking lectin pathway activation. J.Biol.Chem., 298, 2022
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1ID5
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1SLV
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1XXD
| Crystal Structure of the FXIa Catalytic Domain in Complex with mutated Ecotin | 分子名称: | Coagulation factor XI, Ecotin | 著者 | Jin, L, Pandey, P, Babine, R.E, Gorga, J.C, Seidl, K.J, Gelfand, E, Weaver, D.T, Abdel-Meguid, S.S, Strickler, J.E. | 登録日 | 2004-11-04 | 公開日 | 2004-11-16 | 最終更新日 | 2023-08-23 | 実験手法 | X-RAY DIFFRACTION (2.91 Å) | 主引用文献 | Crystal Structures of the FXIa Catalytic Domain in Complex with Ecotin Mutants Reveal Substrate-like Interactions J.Biol.Chem., 280, 2005
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1XX9
| Crystal Structure of the FXIa Catalytic Domain in Complex with EcotinM84R | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Coagulation factor XI, Ecotin | 著者 | Jin, L, Pandey, P, Babine, R.E, Gorga, J.C, Seidl, K.J, Gelfand, E, Weaver, D.T, Abdel-Meguid, S.S, Strickler, J.E. | 登録日 | 2004-11-04 | 公開日 | 2004-11-16 | 最終更新日 | 2023-08-23 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Crystal Structures of the FXIa Catalytic Domain in Complex with Ecotin Mutants Reveal Substrate-like Interactions J.Biol.Chem., 280, 2005
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1XXF
| Crystal Structure of the FXIa Catalytic Domain in Complex with Ecotin Mutant (EcotinP) | 分子名称: | Coagulation factor XI, Ecotin, SODIUM ION | 著者 | Jin, L, Pandey, P, Babine, R.E, Gorga, J.C, Seidl, K.J, Gelfand, E, Weaver, D.T, Abdel-Meguid, S.S, Strickler, J.E. | 登録日 | 2004-11-04 | 公開日 | 2004-11-16 | 最終更新日 | 2023-08-23 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | Crystal Structures of the FXIa Catalytic Domain in Complex with Ecotin Mutants Reveal Substrate-like Interactions J.Biol.Chem., 280, 2005
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1N8O
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1P0S
| Crystal Structure of Blood Coagulation Factor Xa in Complex with Ecotin M84R | 分子名称: | Coagulation factor X precursor, Ecotin precursor, MAGNESIUM ION, ... | 著者 | Wang, S.X, Hur, E, Sousa, C.A, Brinen, L, Slivka, E.J, Fletterick, R.J. | 登録日 | 2003-04-10 | 公開日 | 2003-08-26 | 最終更新日 | 2021-10-27 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | The Extended Interactions and Gla Domain of Blood Coagulation Factor Xa Biochemistry, 42, 2003
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1EZU
| ECOTIN Y69F, D70P BOUND TO D102N TRYPSIN | 分子名称: | CALCIUM ION, ECOTIN, TRYPSIN II, ... | 著者 | Gillmor, S.A, Takeuchi, T, Yang, S.Q, Craik, C.S, Fletterick, R.J. | 登録日 | 2000-05-11 | 公開日 | 2000-06-23 | 最終更新日 | 2021-11-03 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Compromise and accommodation in ecotin, a dimeric macromolecular inhibitor of serine proteases. J.Mol.Biol., 299, 2000
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1EZS
| CRYSTAL STRUCTURE OF ECOTIN MUTANT M84R, W67A, G68A, Y69A, D70A BOUND TO RAT ANIONIC TRYPSIN II | 分子名称: | CALCIUM ION, ECOTIN, TRYPSIN II, ... | 著者 | Gillmor, S.A, Takeuchi, T, Yang, S.Q, Craik, C.S, Fletterick, R.J. | 登録日 | 2000-05-11 | 公開日 | 2000-06-23 | 最終更新日 | 2021-11-03 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Compromise and accommodation in ecotin, a dimeric macromolecular inhibitor of serine proteases. J.Mol.Biol., 299, 2000
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1FI8
| RAT GRANZYME B [N66Q] COMPLEXED TO ECOTIN [81-84 IEPD] | 分子名称: | ECOTIN, NATURAL KILLER CELL PROTEASE 1 | 著者 | Waugh, S.M, Harris, J.L, Fletterick, R.J, Craik, C.S. | 登録日 | 2000-08-03 | 公開日 | 2000-09-13 | 最終更新日 | 2021-11-03 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | The structure of the pro-apoptotic protease granzyme B reveals the molecular determinants of its specificity Nat.Struct.Biol., 7, 2000
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1SLW
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1SLX
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1SLU
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