PDB: 174 件ウェブページステータス検索Chemie searchBIRD

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5TT1	Crystal Structure of a Putative short-chain alcohol dehydrogenase from Burkholderia multivorans 分子名称: 1,2-ETHANEDIOL, NITRATE ION, Putative short-chain alcohol dehydrogenase, ... 著者 Seattle Structural Genomics Center for Infectious Disease (SSGCID) 登録日 2016-10-31 公開日 2016-11-09 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Crystal Structure of a Putative short-chain alcohol dehydrogenase from Burkholderia multivorans to be published
4YE5	The crystal structure of a peptidoglycan synthetase from Bifidobacterium adolescentis ATCC 15703 分子名称: ACETATE ION, GLYCEROL, Peptidoglycan synthetase penicillin-binding protein 3 著者 Cuff, M, Tan, K, Joachimiak, G, Clancy, S, Joachimiak, A, Midwest Center for Structural Genomics (MCSG) 登録日 2015-02-23 公開日 2015-03-18 最終更新日 2019-12-25 実験手法 X-RAY DIFFRACTION (2.052 Å) 主引用文献 The crystal structure of a peptidoglycan synthetase from Bifidobacterium adolescentis ATCC 15703 To Be Published
1VQQ	Structure of Penicillin binding protein 2a from methicillin resistant Staphylococcus aureus strain 27r at 1.80 A resolution. 分子名称: CADMIUM ION, CHLORIDE ION, penicillin-binding protein mecA, ... 著者 Lim, D, Strynadka, N.C.J. 登録日 2004-12-17 公開日 2004-12-28 最終更新日 2023-12-27 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Structural basis for the beta lactam resistance of PBP2a from methicillin-resistant Staphylococcus aureus. Nat.Struct.Biol., 9, 2002
1K25	PBP2x from a Highly Penicillin-resistant Streptococcus pneumoniae Clinical Isolate 分子名称: low-affinity PENICILLIN-BINDING PROTEIN 2X 著者 Dessen, A, Mouz, N, Hopkins, J, Dideberg, O. 登録日 2001-09-26 公開日 2001-10-31 最終更新日 2024-02-07 実験手法 X-RAY DIFFRACTION (3.2 Å) 主引用文献 Crystal structure of PBP2x from a highly penicillin-resistant Streptococcus pneumoniae clinical isolate: a mosaic framework containing 83 mutations. J.Biol.Chem., 276, 2001
7ZG8	Crystal structure of A. baumannii penicillin-binding protein 2 分子名称: Peptidoglycan D,D-transpeptidase MrdA, ZINC ION 著者 Micelli, C, Crow, A, Roper, D.I. 登録日 2022-04-02 公開日 2023-02-22 最終更新日 2024-02-07 実験手法 X-RAY DIFFRACTION (2.65 Å) 主引用文献 A conserved zinc-binding site in Acinetobacter baumannii PBP2 required for elongasome-directed bacterial cell shape. Proc.Natl.Acad.Sci.USA, 120, 2023
8TJ3	Structural basis of peptidoglycan synthesis by E. coli RodA-PBP2 complex 分子名称: Peptidoglycan D,D-transpeptidase MrdA, Peptidoglycan glycosyltransferase MrdB 著者 Nygaard, R, Mancia, F. 登録日 2023-07-20 公開日 2023-08-30 実験手法 ELECTRON MICROSCOPY (3.2 Å) 主引用文献 Structural basis of peptidoglycan synthesis by E. coli RodA-PBP2 complex Nat Commun, 14, 2023
8U55	Crystal structure of Enterococcus faecium EnGen25 Penicillin-binding protein 5 (PBP5) 分子名称: Penicillin-binding protein 5 著者 Pemberton, O.A, Shamoo, Y. 登録日 2023-09-12 公開日 2024-02-07 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Crystal structure of Enterococcus faecium EnGen25 Penicillin-binding protein 5 (PBP5) To Be Published
4FSF	Crystal structure of Pseudomonas aeruginosa PBP3 complexed with compound 14 分子名称: (4R,5S,8Z)-8-(2-amino-1,3-thiazol-4-yl)-1-[3-(1,5-dihydroxy-4-oxo-1,4-dihydropyridin-2-yl)-1,2-oxazol-5-yl]-5-formyl-11,11-dimethyl-1,7-dioxo-4-(sulfoamino)-10-oxa-2,6,9-triazadodec-8-en-12-oic acid, Penicillin-binding protein 3 著者 Han, S. 登録日 2012-06-27 公開日 2012-10-17 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Novel monobactams utilizing a siderophore uptake mechanism for the treatment of gram-negative infections. Bioorg.Med.Chem.Lett., 22, 2012
3EQU	Crystal structure of penicillin-binding protein 2 from Neisseria gonorrhoeae 分子名称: GLYCEROL, Penicillin-binding protein 2, SULFATE ION 著者 Powell, A.J, Deacon, A.M, Nicholas, R.A, Davies, C. 登録日 2008-10-01 公開日 2008-10-21 最終更新日 2023-12-27 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Crystal Structures of Penicillin-binding Protein 2 from Penicillin-susceptible and -resistant Strains of Neisseria gonorrhoeae Reveal an Unexpectedly Subtle Mechanism for Antibiotic Resistance. J.Biol.Chem., 284, 2009
3EQV	Crystal structure of penicillin-binding protein 2 from Neisseria gonorrhoeae containing four mutations associated with penicillin resistance 分子名称: GLYCEROL, Penicillin-binding protein 2, SULFATE ION 著者 Powell, A.J, Deacon, A.M, Nicholas, R.A, Davies, C. 登録日 2008-10-01 公開日 2008-10-21 最終更新日 2024-04-03 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Crystal Structures of Penicillin-binding Protein 2 from Penicillin-susceptible and -resistant Strains of Neisseria gonorrhoeae Reveal an Unexpectedly Subtle Mechanism for Antibiotic Resistance. J.Biol.Chem., 284, 2009
4KQQ	CRYSTAL STRUCTURE OF PENICILLIN-BINDING PROTEIN 3 FROM PSEUDOMONAS AERUGINOSA IN COMPLEX WITH (5S)-Penicilloic Acid 分子名称: (2S,4S)-2-[(R)-carboxy{[(2R)-2-{[(4-ethyl-2,3-dioxopiperazin-1-yl)carbonyl]amino}-2-phenylacetyl]amino}methyl]-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid, CHLORIDE ION, GLYCEROL, ... 著者 Nettleship, J.E, Stuart, D.I, Owens, R.J, Ren, J. 登録日 2013-05-15 公開日 2013-11-06 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Binding of (5S)-Penicilloic Acid to Penicillin Binding Protein 3. Acs Chem.Biol., 8, 2013
6XV5	Crystal structure of penicillin-binding protein 2 from Yersinia pestis in complex with ertapenem 分子名称: L(+)-TARTARIC ACID, Peptidoglycan D,D-transpeptidase MrdA 著者 Pankov, G, Hunter, W.N, Dawson, A. 登録日 2020-01-21 公開日 2021-02-03 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (2.673 Å) 主引用文献 The structure of penicillin-binding protein 2 from Yersinia pestis To Be Published
6Y6Z	Structure of Pseudomonas aeruginosa Penicillin-Binding Protein 3 (PBP3) in complex with Compound 1 分子名称: GLYCEROL, Peptidoglycan D,D-transpeptidase FtsI, ~{tert}-butyl ~{N}-[(2~{S})-2-methyl-4-oxidanyl-1-oxidanylidene-pent-4-en-2-yl]carbamate 著者 Newman, H, Bellini, D, Dowson, C.G. 登録日 2020-02-27 公開日 2020-06-24 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 Demonstration of the utility of DOS-derived fragment libraries for rapid hit derivatisation in a multidirectional fashion. Chem Sci, 11, 2020
4WEJ	Crystal structure of Pseudomonas aeruginosa PBP3 with a R4 substituted allyl monocarbam 分子名称: (3R,4S,7Z)-7-(2-amino-1,3-thiazol-4-yl)-4-formyl-1-[({3-[(5R)-5-hydroxy-4-oxo-4,5-dihydropyridin-2-yl]-4-[3-(methylsulfonyl)propyl]-5-oxo-4,5-dihydro-1H-1,2,4-triazol-1-yl}sulfonyl)amino]-10,10-dimethyl-1,6-dioxo-3-(prop-2-en-1-yl)-9-oxa-2,5,8-triazaundec-7-en-11-oic acid, Penicillin-binding protein 3 著者 Ferguson, A.D. 登録日 2014-09-10 公開日 2015-04-22 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (2.045 Å) 主引用文献 SAR and Structural Analysis of Siderophore-Conjugated Monocarbam Inhibitors of Pseudomonas aeruginosa PBP3. Acs Med.Chem.Lett., 6, 2015
4WEL	Crystal structure of Pseudomonas aeruginosa PBP3 with SMC-3176 分子名称: (3S,4S,7Z)-7-(2-amino-1,3-thiazol-4-yl)-4-formyl-1-[({3-(5-hydroxy-4-oxo-3,4-dihydropyridin-2-yl)-4-[3-(methylsulfonyl)propyl]-5-oxo-4,5-dihydro-1H-1,2,4-triazol-1-yl}sulfonyl)amino]-3,10,10-trimethyl-1,6-dioxo-9-oxa-2,5,8-triazaundec-7-en-11-oic acid, Penicillin-binding protein 3 著者 Ferguson, A.D. 登録日 2014-09-10 公開日 2015-04-22 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (1.99 Å) 主引用文献 SAR and Structural Analysis of Siderophore-Conjugated Monocarbam Inhibitors of Pseudomonas aeruginosa PBP3. Acs Med.Chem.Lett., 6, 2015
4WEK	Crystal structure of Pseudomonas aeruginosa PBP3 with a R4 substituted vinyl monocarbam 分子名称: (3S,4S,7Z)-7-(2-amino-1,3-thiazol-4-yl)-3-ethenyl-4-formyl-1-[({3-(5-hydroxy-4-oxo-3,4-dihydropyridin-2-yl)-4-[3-(methylsulfonyl)propyl]-5-oxo-4,5-dihydro-1H-1,2,4-triazol-1-yl}sulfonyl)amino]-10,10-dimethyl-1,6-dioxo-9-oxa-2,5,8-triazaundec-7-en-11-oic acid, Penicillin-binding protein 3 著者 Ferguson, A.D. 登録日 2014-09-10 公開日 2015-04-22 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (1.74 Å) 主引用文献 SAR and Structural Analysis of Siderophore-Conjugated Monocarbam Inhibitors of Pseudomonas aeruginosa PBP3. Acs Med.Chem.Lett., 6, 2015
6Y6U	Structure of Pseudomonas aeruginosa Penicillin-Binding Protein 3 (PBP3) in complex with Compound 6 分子名称: 2-(4-hydroxyphenyl)-~{N}-[(2~{S})-2-methyl-4-oxidanyl-1-oxidanylidene-pent-4-en-2-yl]ethanamide, GLYCEROL, Peptidoglycan D,D-transpeptidase FtsI 著者 Newman, H, Bellini, D, Dowson, C.G. 登録日 2020-02-27 公開日 2020-06-24 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (1.55 Å) 主引用文献 Demonstration of the utility of DOS-derived fragment libraries for rapid hit derivatisation in a multidirectional fashion Chem Sci, 11, 2020
6PL5	Structural coordination of polymerization and crosslinking by a peptidoglycan synthase complex 分子名称: Penicillin-binding protein 2/cell division protein FtsI, Peptidoglycan glycosyltransferase RodA, Unknown peptide 著者 Sjodt, M, Rohs, P.D.A, Erlandson, S.C, Zheng, S, Rudner, D.Z, Bernhardt, T.G, Kruse, A.C. 登録日 2019-06-30 公開日 2020-03-18 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (3.5 Å) 主引用文献 Structural coordination of polymerization and crosslinking by a SEDS-bPBP peptidoglycan synthase complex. Nat Microbiol, 5, 2020
6PL6	Structural coordination of polymerization and crosslinking by a peptidoglycan synthase complex 分子名称: (2R,4S)-2-[(1R)-1-{[(2R)-2-amino-2-phenylacetyl]amino}-2-oxoethyl]-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid, Penicillin-binding protein 2/cell division protein FtsI, Peptidoglycan glycosyltransferase RodA, ... 著者 Sjodt, M, Rohs, P.D.A, Erlandson, S.C, Zheng, S, Rudner, D.Z, Bernhardt, T.G, Kruse, A.C. 登録日 2019-06-30 公開日 2020-03-18 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (3.3 Å) 主引用文献 Structural coordination of polymerization and crosslinking by a SEDS-bPBP peptidoglycan synthase complex. Nat Microbiol, 5, 2020
6Q9N	Crystal structure of PBP2a from MRSA in complex with piperacillin and quinazolinone 分子名称: 3-[2-[(~{E})-2-(4-ethynylphenyl)ethenyl]-4-oxidanylidene-quinazolin-3-yl]benzoic acid, CADMIUM ION, CHLORIDE ION, ... 著者 Martinez-Caballero, S, Batuecas, M.T, Hermoso, J.A. 登録日 2018-12-18 公開日 2019-11-27 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 The Quinazolinone Allosteric Inhibitor of PBP 2a Synergizes with Piperacillin and Tazobactam against Methicillin-Resistant Staphylococcus aureus. Antimicrob.Agents Chemother., 63, 2019
6BSR	Crystal structure of penicillin-binding protein 4 (PBP4) from Enterococcus faecalis in the benzylpenicillin bound form. 分子名称: CHLORIDE ION, DI(HYDROXYETHYL)ETHER, GLYCEROL, ... 著者 Moon, T.M, D'Andrea, E.D, Peti, W, Page, R. 登録日 2017-12-04 公開日 2018-10-31 最終更新日 2024-03-13 実験手法 X-RAY DIFFRACTION (2.34 Å) 主引用文献 The structures of penicillin-binding protein 4 (PBP4) and PBP5 fromEnterococciprovide structural insights into beta-lactam resistance. J. Biol. Chem., 293, 2018
6C84	Crystal structure of PBP5 from Enterococcus faecium 分子名称: Penicillin-binding protein 著者 Shamoo, Y, Davlieva, M. 登録日 2018-01-24 公開日 2019-02-06 最終更新日 2022-03-23 実験手法 X-RAY DIFFRACTION (2.511 Å) 主引用文献 Crystal structure of PBP5 from Enterococcus faecium To Be Published
6BSQ	Enterococcus faecalis Penicillin Binding Protein 4 (PBP4) 分子名称: CHLORIDE ION, GLYCEROL, PBP4 protein 著者 Moon, T.M, D'Andrea, E.D, Peti, W, Page, R. 登録日 2017-12-04 公開日 2018-10-31 最終更新日 2024-04-03 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 The structures of penicillin-binding protein 4 (PBP4) and PBP5 fromEnterococciprovide structural insights into beta-lactam resistance. J. Biol. Chem., 293, 2018
4KQO	Crystal structure of penicillin-binding protein 3 from pseudomonas aeruginosa in complex with piperacillin 分子名称: CHLORIDE ION, GLYCEROL, IMIDAZOLE, ... 著者 Nettleship, J.E, Stuart, D.I, Owens, R.J, Ren, J. 登録日 2013-05-15 公開日 2013-11-06 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (2.31 Å) 主引用文献 Binding of (5S)-Penicilloic Acid to Penicillin Binding Protein 3. Acs Chem.Biol., 8, 2013
4KQR	CRYSTAL STRUCTURE OF PENICILLIN-BINDING PROTEIN 3 FROM PSEUDOMONAS AERUGINOSA IN COMPLEX WITH (5S)-Penicilloic Acid 分子名称: (2S,4S)-2-[(R)-carboxy{[(2R)-2-{[(4-ethyl-2,3-dioxopiperazin-1-yl)carbonyl]amino}-2-phenylacetyl]amino}methyl]-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid, CHLORIDE ION, GLYCEROL, ... 著者 Nettleship, J.E, Stuart, D.I, Owens, R.J, Ren, J. 登録日 2013-05-15 公開日 2013-11-06 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (2.01 Å) 主引用文献 Binding of (5S)-Penicilloic Acid to Penicillin Binding Protein 3. Acs Chem.Biol., 8, 2013

 

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