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6ER3
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BU of 6er3 by Molmil
Ruminococcus gnavus IT-sialidase CBM40 bound to alpha2,3 sialyllactose
分子名称: BNR/Asp-box repeat protein, GLYCEROL, N-acetyl-alpha-neuraminic acid-(2-3)-beta-D-galactopyranose
著者Owen, C.D, Tailford, L.E, Taylor, G.L, Juge, N.
登録日2017-10-16
公開日2018-05-02
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (1.37 Å)
主引用文献Unravelling the specificity and mechanism of sialic acid recognition by the gut symbiont Ruminococcus gnavus.
Nat Commun, 8, 2017
6ER4
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BU of 6er4 by Molmil
Ruminococcus gnavus IT-sialidase CBM40 bound to alpha2,6 sialyllactose
分子名称: BNR/Asp-box repeat protein, GLYCEROL, N-acetyl-alpha-neuraminic acid-(2-6)-beta-D-galactopyranose-(1-4)-beta-D-glucopyranose, ...
著者Owen, C.D, Tailford, L.E, Taylor, G.L, Juge, N.
登録日2017-10-16
公開日2018-05-02
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (1.3 Å)
主引用文献Unravelling the specificity and mechanism of sialic acid recognition by the gut symbiont Ruminococcus gnavus.
Nat Commun, 8, 2017
6ER2
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BU of 6er2 by Molmil
Ruminococcus gnavus IT-sialidase CBM40
分子名称: BNR/Asp-box repeat protein
著者Owen, C.D, Tailford, L.E, Taylor, G.L, Juge, N.
登録日2017-10-16
公開日2018-05-02
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (1.73 Å)
主引用文献Unravelling the specificity and mechanism of sialic acid recognition by the gut symbiont Ruminococcus gnavus.
Nat Commun, 8, 2017
5FRA
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BU of 5fra by Molmil
CBM40_CPF0721-6'SL
分子名称: ACETATE ION, N-acetyl-alpha-neuraminic acid, N-acetyl-alpha-neuraminic acid-(2-6)-beta-D-galactopyranose, ...
著者Ribeiro, J.P, Pau, W, Pifferi, C, Renaudet, O, Varrot, A, Mahal, L.K, Imberty, A.
登録日2015-12-16
公開日2016-07-20
最終更新日2024-01-10
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Characterization of a High-Affinity Sialic Acid-Specific Cbm40 from Clostridium Perfringens and Engineering of a Divalent Form.
Biochem.J., 473, 2016
5FRE
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BU of 5fre by Molmil
Characterization of a novel CBM from Clostridium perfringens
分子名称: 2-(2-{2-[2-(2-METHOXY-ETHOXY)-ETHOXY]-ETHOXY}-ETHOXY)-ETHANOL, ACETATE ION, CALCIUM ION, ...
著者Ribeiro, J, Pau, W, Pifferi, C, Renaudet, O, Varrot, A, Mahal, L.K, Imberty, A.
登録日2015-12-17
公開日2016-07-20
最終更新日2024-01-10
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Characterization of a High-Affinity Sialic Acid-Specific Cbm40 from Clostridium Perfringens and Engineering of a Divalent Form.
Biochem.J., 473, 2016
2V73
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BU of 2v73 by Molmil
The structure of the family 40 CBM from C. perfringens NanJ in complex with a sialic acid containing molecule
分子名称: CALCIUM ION, N-acetyl-alpha-neuraminic acid, PUTATIVE EXO-ALPHA-SIALIDASE
著者Boraston, A.B, Ficko-Blean, E, Healey, M.
登録日2007-07-25
公開日2007-08-21
最終更新日2020-07-29
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Carbohydrate Recognition by a Large Sialidase Toxin from Clostridium Perfringens.
Biochemistry, 46, 2007
4C1X
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BU of 4c1x by Molmil
Carbohydrate binding domain from Streptococcus pneumoniae NanA sialidase complexed with 6'-sialyllactose
分子名称: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, N-acetyl-alpha-neuraminic acid-(2-6)-beta-D-galactopyranose-(1-4)-beta-D-glucopyranose, SIALIDASE A
著者Yang, L, Connaris, H, Potter, J.A, Taylor, G.L.
登録日2013-08-14
公開日2014-09-10
最終更新日2020-07-29
実験手法X-RAY DIFFRACTION (1.84 Å)
主引用文献Structural Characterization of the Carbohydrate-Binding Module of Nana Sialidase, a Pneumococcal Virulence Factor.
Bmc Struct.Biol., 15, 2015
4C1W
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Carbohydrate binding domain from Streptococcus pneumoniae NanA sialidase complexed with 3'-sialyllactose
分子名称: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, N-acetyl-alpha-neuraminic acid-(2-3)-beta-D-galactopyranose-(1-4)-alpha-D-glucopyranose, NEURAMINIDASE
著者Yang, L, Connaris, H, Potter, J.A, Taylor, G.L.
登録日2013-08-14
公開日2014-08-27
最終更新日2020-07-29
実験手法X-RAY DIFFRACTION (1.84 Å)
主引用文献Prevention of Influenza by Targeting Host Receptors Using Engineered Proteins.
Proc.Natl.Acad.Sci.USA, 111, 2014
4ZXK
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BU of 4zxk by Molmil
Carbohydrate binding domain from Streptococcus pneumoniae NanA sialidase
分子名称: Sialidase A
著者Yang, L, Connaris, H, Potter, J.A, Taylor, G.L.
登録日2015-05-20
公開日2015-05-27
最終更新日2024-01-10
実験手法X-RAY DIFFRACTION (1.84 Å)
主引用文献Carbohydrate binding domain from Streptococcus pneumoniae NanA sialidase
To Be Published
3SLI
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BU of 3sli by Molmil
LEECH INTRAMOLECULAR TRANS-SIALIDASE COMPLEXED WITH 2,7-ANHYDRO-NEU5AC PREPARED BY SOAKING WITH 3'-SIALYLLACTOSE
分子名称: 2-ACETYLAMINO-7-(1,2-DIHYDROXY-ETHYL)-3-HYDROXY-6,8-DIOXA-BICYCLO[3.2.1]OCTANE-5-CARBOXYLIC ACID, INTRAMOLECULAR TRANS-SIALIDASE
著者Luo, Y, Li, S.C, Li, Y.T, Luo, M.
登録日1998-10-03
公開日1999-04-27
最終更新日2024-04-03
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献The 1.8 A structures of leech intramolecular trans-sialidase complexes: evidence of its enzymatic mechanism.
J.Mol.Biol., 285, 1999
4SLI
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BU of 4sli by Molmil
LEECH INTRAMOLECULAR TRANS-SIALIDASE COMPLEXED WITH 2-PROPENYL-NEU5AC, AN INACTIVE SUBSTRATE ANALOGUE
分子名称: 2-propenyl-N-acetyl-neuraminic acid, INTRAMOLECULAR TRANS-SIALIDASE
著者Luo, Y, Li, S.C, Li, Y.T, Luo, M.
登録日1998-10-04
公開日1999-05-25
最終更新日2024-04-03
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献The 1.8 A structures of leech intramolecular trans-sialidase complexes: evidence of its enzymatic mechanism.
J.Mol.Biol., 285, 1999
1SLL
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BU of 1sll by Molmil
SIALIDASE L FROM LEECH MACROBDELLA DECORA
分子名称: SIALIDASE L
著者Luo, Y, Li, S.C, Chou, M.Y, Li, Y.T, Luo, M.
登録日1997-10-14
公開日1998-12-16
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献The crystal structure of an intramolecular trans-sialidase with a NeuAc alpha2-->3Gal specificity.
Structure, 6, 1998
1SLI
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BU of 1sli by Molmil
LEECH INTRAMOLECULAR TRANS-SIALIDASE COMPLEXED WITH DANA
分子名称: 2-DEOXY-2,3-DEHYDRO-N-ACETYL-NEURAMINIC ACID, INTRAMOLECULAR TRANS-SIALIDASE
著者Luo, Y, Li, S.C, Chou, M.Y, Li, Y.T, Luo, M.
登録日1998-03-28
公開日1999-04-20
最終更新日2024-04-03
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献The crystal structure of an intramolecular trans-sialidase with a NeuAc alpha2-->3Gal specificity.
Structure, 6, 1998
2SLI
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BU of 2sli by Molmil
LEECH INTRAMOLECULAR TRANS-SIALIDASE COMPLEXED WITH 2,7-ANHYDRO-NEU5AC, THE REACTION PRODUCT
分子名称: 2-ACETYLAMINO-7-(1,2-DIHYDROXY-ETHYL)-3-HYDROXY-6,8-DIOXA-BICYCLO[3.2.1]OCTANE-5-CARBOXYLIC ACID, INTRAMOLECULAR TRANS-SIALIDASE
著者Luo, Y, Li, S.C, Li, Y.T, Luo, M.
登録日1998-10-03
公開日1999-04-27
最終更新日2024-04-03
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献The 1.8 A structures of leech intramolecular trans-sialidase complexes: evidence of its enzymatic mechanism.
J.Mol.Biol., 285, 1999
2VW0
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BU of 2vw0 by Molmil
Crystal structure of the NanB sialidase from Streptococcus pneumoniae
分子名称: GLYCEROL, SIALIDASE B
著者Xu, G, Potter, J.A, Russell, R.J.M, Oggioni, M.R, Andrew, P.W, Taylor, G.L.
登録日2008-06-13
公開日2008-06-24
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Crystal Structure of the Nanb Sialidase from Streptococcus Pneumoniae
J.Mol.Biol., 384, 2008
2JKB
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BU of 2jkb by Molmil
Crystal structure of Streptococcus pneumoniae NanB in complex with 2, 7-anhydro-Neu5Ac
分子名称: 1,2-ETHANEDIOL, 2-ACETYLAMINO-7-(1,2-DIHYDROXY-ETHYL)-3-HYDROXY-6,8-DIOXA-BICYCLO[3.2.1]OCTANE-5-CARBOXYLIC ACID, SIALIDASE B
著者Gut, H, King, S.J, Walsh, M.A.
登録日2008-08-26
公開日2008-09-16
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (1.54 Å)
主引用文献Structural and Functional Studies of Streptococcus Pneumoniae Neuraminidase B: An Intramolecular Trans-Sialidase.
FEBS Lett., 582, 2008
5F9T
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BU of 5f9t by Molmil
Crystal Structure of Streptococcus pneumoniae NanC, covalent complex with a fluorinated Neu5Ac derivative
分子名称: (2R,3R,4R,5R,6R)-5-acetamido-2,3-difluoro-4-hydroxy-6-[(1R,2R)-1,2,3-trihydroxypropyl]tetrahydro-2H-pyran-2-carboxylic acid, 5-acetamido-3,5-dideoxy-3-fluoro-D-erythro-alpha-L-manno-non-2-ulopyranosonic acid, GLYCEROL, ...
著者Owen, C.D, Lukacik, P, Potter, J.A, Walsh, M, Taylor, G.L.
登録日2015-12-10
公開日2015-12-23
最終更新日2024-01-10
実験手法X-RAY DIFFRACTION (2.05 Å)
主引用文献Streptococcus pneumoniae NanC: STRUCTURAL INSIGHTS INTO THE SPECIFICITY AND MECHANISM OF A SIALIDASE THAT PRODUCES A SIALIDASE INHIBITOR.
J.Biol.Chem., 290, 2015
4XJ8
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BU of 4xj8 by Molmil
Crystal structure of apo NanB sialidase from streptococcus pneumoniae at pH 5.0 in 50mM sodium Acetate with DMSO
分子名称: Sialidase B
著者Brear, P.
登録日2015-01-08
公開日2016-01-20
最終更新日2024-01-10
実験手法X-RAY DIFFRACTION (2.749 Å)
主引用文献`The Hunt for Serendipitous Allosteric Sites: Discovery of a novel allosteric inhibitor of the bacterial sialidase NanB
To be published
4XE9
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BU of 4xe9 by Molmil
Crystal structure of the NanB sialidase from Streptococcus pneumoniae in complex with Optactin
分子名称: (1s,3R,4S)-1-[(cyclohexylamino)methyl]-3,4-dihydroxycyclopentanesulfonic acid, DIMETHYL SULFOXIDE, Sialidase B
著者Brear, P.
登録日2014-12-23
公開日2016-01-13
最終更新日2024-01-10
実験手法X-RAY DIFFRACTION (1.84 Å)
主引用文献The Hunt for Serendipitous Allosteric Sites: Discovery of a novel allosteric inhibitor of the bacterial sialidase NanB
To be published
4XHB
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Crystal structure of the NanB sialidase from streptococcus pneumoniae in complex with pentanediol and CHES
分子名称: (1R,2S)-cyclopentane-1,2-diol, 2-[N-CYCLOHEXYLAMINO]ETHANE SULFONIC ACID, Sialidase B
著者Brear, P.
登録日2015-01-05
公開日2016-01-27
最終更新日2024-01-10
実験手法X-RAY DIFFRACTION (1.88 Å)
主引用文献The Hunt for Serendipitous Allosteric Sites: Discovery of a novel allosteric inhibitor of the bacterial sialidase NanB
To be published
4XJW
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BU of 4xjw by Molmil
Crystal structure of the NanB sialidase from streptococcus pneumoniae in complex with Optactin at pH 7.4 in PBS with DMSO as the cryoprotectant
分子名称: (1s,3R,4S)-1-[(cyclohexylamino)methyl]-3,4-dihydroxycyclopentanesulfonic acid, DIMETHYL SULFOXIDE, PHOSPHATE ION, ...
著者Brear, P.
登録日2015-01-09
公開日2016-01-13
最終更新日2024-01-10
実験手法X-RAY DIFFRACTION (1.53 Å)
主引用文献`The Hunt for Serendipitous Allosteric Sites: Discovery of a novel allosteric inhibitor of the bacterial sialidase NanB
To be published
2VW1
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BU of 2vw1 by Molmil
Crystal structure of the NanB sialidase from Streptococcus pneumoniae
分子名称: 2-DEOXY-2,3-DEHYDRO-N-ACETYL-NEURAMINIC ACID, GLYCEROL, SIALIDASE B
著者Xu, G, Potter, J.A, Russell, R.J.M, Oggioni, M.R, Andrew, P.W, Taylor, G.L.
登録日2008-06-13
公開日2008-06-24
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (2.39 Å)
主引用文献Crystal Structure of the Nanb Sialidase from Streptococcus Pneumoniae
J.Mol.Biol., 384, 2008
2VW2
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Crystal structure of the NanB sialidase from Streptococcus pneumoniae
分子名称: 2-[N-CYCLOHEXYLAMINO]ETHANE SULFONIC ACID, GLYCEROL, SIALIDASE B
著者Xu, G, Potter, J.A, Russell, R.J.M, Oggioni, M.R, Andrew, P.W, Taylor, G.L.
登録日2008-06-13
公開日2008-06-24
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献Crystal Structure of the Nanb Sialidase from Streptococcus Pneumoniae
J.Mol.Biol., 384, 2008
4FPO
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Crystal structure of the NanB sialidase from streptococcus pneumoniae in complex with 2-[(3-chloro-4-methoxybenzyl)ammonio]ethanesulfonate
分子名称: 2-[(3-chloro-4-methoxybenzyl)amino]ethanesulfonic acid, DIMETHYL SULFOXIDE, Sialidase B
著者Brear, P.
登録日2012-06-22
公開日2012-10-31
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (2.591 Å)
主引用文献Synthesis and structural characterisation of selective non-carbohydrate-based inhibitors of bacterial sialidases.
Chembiochem, 13, 2012
4FP2
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Crystal structure of the NanB sialidase from streptococcus pneumoniae in complex with 2[(Cyclohexylmethyl)ammonio]sulfonate
分子名称: 2-[(cyclohexylmethyl)amino]ethanesulfonic acid, Sialidase B
著者Brear, P.
登録日2012-06-21
公開日2012-10-31
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (2.05 Å)
主引用文献Synthesis and structural characterisation of selective non-carbohydrate-based inhibitors of bacterial sialidases.
Chembiochem, 13, 2012

 

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