7F27
 
 | | Crystal structure of polyketide ketosynthase | | 分子名称: | 3-oxoacyl-(Acyl-carrier-protein) synthase | | 著者 | Kim, Y, Lee, W.C. | | 登録日 | 2021-06-10 | | 公開日 | 2022-06-15 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (1.806 Å) | | 主引用文献 | Structural basis of the complementary activity of two ketosynthases in aryl polyene biosynthesis.
Sci Rep, 11, 2021
|
|
1DD8
 | | CRYSTAL STRUCTURE OF BETA-KETOACYL-[ACYL CARRIER PROTEIN] SYNTHASE I FROM ESCHERICHIA COLI | | 分子名称: | BETA-KETOACYL [ACYL CARRIER PROTEIN] SYNTHASE I | | 著者 | Olsen, J.G, Kadziola, A, von Wettstein-Knowles, P, Siggaard-Andersen, M, Lindquist, Y, Larsen, S. | | 登録日 | 1999-11-09 | | 公開日 | 1999-11-18 | | 最終更新日 | 2024-02-07 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | The X-ray crystal structure of beta-ketoacyl [acyl carrier protein] synthase I.
FEBS Lett., 460, 1999
|
|
1B3N
 | | BETA-KETOACYL CARRIER PROTEIN SYNTHASE AS A DRUG TARGET, IMPLICATIONS FROM THE CRYSTAL STRUCTURE OF A COMPLEX WITH THE INHIBITOR CERULENIN. | | 分子名称: | (2S, 3R)-3-HYDROXY-4-OXO-7,10-TRANS,TRANS-DODECADIENAMIDE, PROTEIN (KETOACYL ACYL CARRIER PROTEIN SYNTHASE 2) | | 著者 | Moche, M, Schneider, G, Edwards, P, Dehesh, K, Lindqvist, Y. | | 登録日 | 1998-12-14 | | 公開日 | 1999-04-06 | | 最終更新日 | 2023-12-27 | | 実験手法 | X-RAY DIFFRACTION (2.65 Å) | | 主引用文献 | Structure of the complex between the antibiotic cerulenin and its target, beta-ketoacyl-acyl carrier protein synthase.
J.Biol.Chem., 274, 1999
|
|
1W0I
 | | Arabidopsis thaliana Mitochondrial KAS | | 分子名称: | 3-OXOACYL CARRIER PROTEIN SYNTHASE, POTASSIUM ION, SULFATE ION | | 著者 | Olsen, J.G, Rasmussen, A.V, von Wettstein-Knowles, P, Henriksen, A. | | 登録日 | 2004-06-04 | | 公開日 | 2004-11-10 | | 最終更新日 | 2023-12-13 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | Structure of the mitochondrial beta-ketoacyl-[acyl carrier protein] synthase from Arabidopsis and its role in fatty acid synthesis.
FEBS Lett., 577, 2004
|
|
5KOF
 | | Crosslinked Crystal Structure of Type II Fatty Acid Synthase Ketosynthase, FabB, and Acyl Carrier Protein, AcpP | | 分子名称: | 3-oxoacyl-[acyl-carrier-protein] synthase 1, Acyl carrier protein, [(3~{S})-2,2-dimethyl-3-oxidanyl-4-oxidanylidene-4-[[3-oxidanylidene-3-[2-(prop-2-enoylamino)ethylamino]propyl]amino]butyl] dihydrogen phosphate | | 著者 | Milligan, J.C, Jackson, D.R, Barajas, J.F, Tsai, S.C. | | 登録日 | 2016-06-30 | | 公開日 | 2018-01-24 | | 最終更新日 | 2023-10-04 | | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | | 主引用文献 | Molecular basis for interactions between an acyl carrier protein and a ketosynthase.
Nat.Chem.Biol., 15, 2019
|
|
6C9U
 | | Crystal structure of [KS3][AT3] didomain from module 3 of 6-deoxyerthronolide B synthase in complex with antibody fragment (Fab) | | 分子名称: | 6-deoxyerythronolide-B synthase EryA2, modules 3 and 4, Heavy chain of Fab 1B2, ... | | 著者 | Deis, L.N, Li, X, Mathews, I.I, Khosla, C. | | 登録日 | 2018-01-28 | | 公開日 | 2018-05-23 | | 最終更新日 | 2023-10-04 | | 実験手法 | X-RAY DIFFRACTION (2.09 Å) | | 主引用文献 | Structure-Function Analysis of the Extended Conformation of a Polyketide Synthase Module.
J. Am. Chem. Soc., 140, 2018
|
|
4R8E
 | | Crystal structure of beta-ketoacyl-ACP synthase II (FabF) from Yersinia pestis | | 分子名称: | 3-oxoacyl-[acyl-carrier-protein] synthase 2 | | 著者 | Himiari, Z, Nanson, J.D, Swarbrick, C.M.D, Forwood, J.K. | | 登録日 | 2014-09-02 | | 公開日 | 2014-12-17 | | 最終更新日 | 2024-02-28 | | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | | 主引用文献 | Structural Characterisation of the Beta-Ketoacyl-Acyl Carrier Protein Synthases, FabF and FabH, of Yersinia pestis.
Sci Rep, 5, 2015
|
|
4V8L
 | |
1J3N
 | | Crystal Structure of 3-oxoacyl-(acyl-carrier protein) Synthase II from Thermus thermophilus HB8 | | 分子名称: | 3-oxoacyl-(acyl-carrier protein) synthase II, CITRIC ACID, MAGNESIUM ION | | 著者 | Bagautdinov, B, Miyano, M, Tahirov, T.H, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | | 登録日 | 2003-02-10 | | 公開日 | 2003-03-11 | | 最終更新日 | 2023-10-25 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Structure of 3-oxoacyl-(acyl-carrier protein) synthase II from Thermus thermophilus HB8.
Acta Crystallogr.,Sect.F, 64, 2008
|
|
6Y2I
 | |
3O04
 | | Crystal structure of the beta-keto-acyl carrier protein synthase II (lmo2201) from Listeria monocytogenes | | 分子名称: | beta-keto-acyl carrier protein synthase II | | 著者 | Anderson, S.M, Wawrzak, Z, Onopriyenko, O, Anderson, W.F, Savchenko, A, Center for Structural Genomics of Infectious Diseases (CSGID) | | 登録日 | 2010-07-19 | | 公開日 | 2010-08-04 | | 最終更新日 | 2021-10-06 | | 実験手法 | X-RAY DIFFRACTION (1.85 Å) | | 主引用文献 | Crystal structure of the beta-keto-acyl carrier protein synthase II (lmo2201) from Listeria monocytogenes
To be Published
|
|
4WKY
 | | Streptomcyes albus JA3453 oxazolomycin ketosynthase domain OzmN KS2 | | 分子名称: | 1,2-ETHANEDIOL, Beta-ketoacyl synthase, GLYCEROL, ... | | 著者 | Cuff, M.E, Mack, J.C, Endres, M, Babnigg, G, Bingman, C.A, Yennamalli, R, Lohman, J.R, Ma, M, Shen, B, Phillips Jr, G.N, Joachimiak, A, Midwest Center for Structural Genomics (MCSG), Enzyme Discovery for Natural Product Biosynthesis (NatPro) | | 登録日 | 2014-10-03 | | 公開日 | 2014-10-29 | | 最終更新日 | 2023-12-27 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Structural and evolutionary relationships of "AT-less" type I polyketide synthase ketosynthases.
Proc.Natl.Acad.Sci.USA, 112, 2015
|
|
6Y2J
 | | Crystal structure of M. tuberculosis KasA in complex with 4,4,4-trifluoro-N-(isoquinolin-6-yl)butane-1-sulfonamide | | 分子名称: | 3-oxoacyl-[acyl-carrier-protein] synthase 1, 4,4,4-tris(fluoranyl)-~{N}-isoquinolin-6-yl-butane-1-sulfonamide, SODIUM ION, ... | | 著者 | Chung, C. | | 登録日 | 2020-02-16 | | 公開日 | 2020-04-08 | | 最終更新日 | 2020-05-20 | | 実験手法 | X-RAY DIFFRACTION (2.886 Å) | | 主引用文献 | Exploring the SAR of the beta-Ketoacyl-ACP Synthase Inhibitor GSK3011724A and Optimization around a Genotoxic Metabolite.
Acs Infect Dis., 6, 2020
|
|
4TKT
 | | Streptomyces platensis isomigrastatin ketosynthase domain MgsF KS6 | | 分子名称: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, AT-less polyketide synthase, CHLORIDE ION, ... | | 著者 | Chang, C, Li, H, Endres, M, Bingman, C.A, Yennamalli, R, Lohman, J.R, Ma, M, Shen, B, Phillips Jr, G.N, Joachimiak, A, Midwest Center for Structural Genomics (MCSG), Enzyme Discovery for Natural Product Biosynthesis (NatPro) | | 登録日 | 2014-05-27 | | 公開日 | 2014-06-11 | | 最終更新日 | 2023-03-22 | | 実験手法 | X-RAY DIFFRACTION (2.4289 Å) | | 主引用文献 | Structural and evolutionary relationships of "AT-less" type I polyketide synthase ketosynthases.
Proc.Natl.Acad.Sci.USA, 112, 2015
|
|
7PPS
 | | apo FabB from Pseudomonas aeruginosa with single point mutation C161A | | 分子名称: | 1,2-ETHANEDIOL, 3-oxoacyl-[acyl-carrier-protein] synthase 1, CHLORIDE ION, ... | | 著者 | Georgiou, C, Brenk, R, Yadrykhinsky, V. | | 登録日 | 2021-09-15 | | 公開日 | 2021-10-13 | | 最終更新日 | 2024-01-31 | | 実験手法 | X-RAY DIFFRACTION (1.3 Å) | | 主引用文献 | Crystal structure of Pseudomonas aeruginosa FabB C161A, a template for structure-based design for new antibiotics.
F1000Res, 10, 2021
|
|
3U0F
 | |
6FIJ
 | | Structure of the loading/condensing region (SAT-KS-MAT) of the cercosporin fungal non-reducing polyketide synthase (NR-PKS) CTB1 | | 分子名称: | 1,2-ETHANEDIOL, 2,3-DIHYDROXY-1,4-DITHIOBUTANE, GLYCEROL, ... | | 著者 | Herbst, D.A, Jakob, R.P, Townsend, C.A, Maier, T. | | 登録日 | 2018-01-18 | | 公開日 | 2018-03-21 | | 最終更新日 | 2024-01-17 | | 実験手法 | X-RAY DIFFRACTION (2.77 Å) | | 主引用文献 | The structural organization of substrate loading in iterative polyketide synthases.
Nat. Chem. Biol., 14, 2018
|
|
7Q5S
 | | Protein community member fatty acid synthase complex from C. thermophilum | | 分子名称: | 3-hydroxyacyl-[acyl-carrier-protein] dehydratase, 3-oxoacyl-[acyl-carrier-protein] reductase | | 著者 | Chojnowski, G, Skalidis, I, Kyrilis, F.L, Tueting, C, Hamdi, F, Kastritis, P.L. | | 登録日 | 2021-11-04 | | 公開日 | 2022-02-02 | | 最終更新日 | 2023-12-13 | | 実験手法 | ELECTRON MICROSCOPY (4.47 Å) | | 主引用文献 | Cryo-EM and artificial intelligence visualize endogenous protein community members.
Structure, 30, 2022
|
|
3U0E
 | |
6FIK
 | | ACP2 crosslinked to the KS of the loading/condensing region of the CTB1 PKS | | 分子名称: | Polyketide synthase | | 著者 | Herbst, D.A, Huitt-Roehl, C.R, Jakob, R.P, Townsend, C.A, Maier, T. | | 登録日 | 2018-01-18 | | 公開日 | 2018-03-21 | | 最終更新日 | 2019-12-11 | | 実験手法 | ELECTRON MICROSCOPY (7.1 Å) | | 主引用文献 | The structural organization of substrate loading in iterative polyketide synthases.
Nat. Chem. Biol., 14, 2018
|
|
3OYT
 | | 1.84 Angstrom resolution crystal structure of 3-oxoacyl-(acyl carrier protein) synthase I (fabB) from Yersinia pestis CO92 | | 分子名称: | 1,2-ETHANEDIOL, 3-oxoacyl-[acyl-carrier-protein] synthase I, DI(HYDROXYETHYL)ETHER, ... | | 著者 | Halavaty, A.S, Wawrzak, Z, Onopriyenko, O, Peterson, S, Savchenko, A, Anderson, W.F, Center for Structural Genomics of Infectious Diseases (CSGID) | | 登録日 | 2010-09-23 | | 公開日 | 2011-01-12 | | 最終更新日 | 2024-04-03 | | 実験手法 | X-RAY DIFFRACTION (1.84 Å) | | 主引用文献 | 1.84 Angstrom resolution crystal structure of 3-oxoacyl-(acyl carrier protein) synthase I (fabB) from Yersinia pestis CO92
To be Published
|
|
1KAS
 | | BETA-KETOACYL-ACP SYNTHASE II FROM ESCHERICHIA COLI | | 分子名称: | BETA-KETOACYL ACP SYNTHASE II | | 著者 | Huang, W, Jia, J, Edwards, P, Dehesh, K, Schneider, G, Lindqvist, Y. | | 登録日 | 1997-12-22 | | 公開日 | 1999-03-02 | | 最終更新日 | 2024-02-07 | | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | | 主引用文献 | Crystal structure of beta-ketoacyl-acyl carrier protein synthase II from E.coli reveals the molecular architecture of condensing enzymes.
EMBO J., 17, 1998
|
|
5LD8
 | |
1OXH
 | |
8EE0
 | | KS-AT didomain from module 2 of the 6-deoxyerythronolide B synthase in complex with antibody fragment 1B2 | | 分子名称: | 1B2 antibody heavy chain, 1B2 antibody light chain, 6-deoxyerythronolide B synthase | | 著者 | Cogan, D.P, Brodsky, K.L, Guzman, K.M, Mathews, I.I, Khosla, C. | | 登録日 | 2022-09-06 | | 公開日 | 2023-05-31 | | 最終更新日 | 2023-10-25 | | 実験手法 | X-RAY DIFFRACTION (2.65 Å) | | 主引用文献 | Discovery and Characterization of Antibody Probes of Module 2 of the 6-Deoxyerythronolide B Synthase.
Biochemistry, 62, 2023
|
|
