PDB: 47 件ウェブページステータス検索Chemie searchBIRD

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6XAR	Structure of CBL tyrosine kinase binding domain (TKBD) with C-terminal tail of Src-like kinase protein 2 (SLAP2) 分子名称: CALCIUM ION, E3 ubiquitin-protein ligase CBL, Src-like-adapter 2 著者 Wybenga-Groot, L.E, McGlade, C.J. 登録日 2020-06-04 公開日 2021-03-03 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (2.501 Å) 主引用文献 SLAP2 Adaptor Binding Disrupts c-CBL Autoinhibition to Activate Ubiquitin Ligase Function. J.Mol.Biol., 433, 2021
4GPL	Structure of Cbl(TKB) bound to a phosphorylated pentapeptide 分子名称: ACE-PTR-THR-PRO-GLU-PRO, PEPTIDE INHIBITOR, E3 ubiquitin-protein ligase CBL 著者 Borgstahl, G, Natarajan, A. 登録日 2012-08-21 公開日 2013-09-18 最終更新日 2023-12-06 実験手法 X-RAY DIFFRACTION (3 Å) 主引用文献 The paradox of conformational constraint in the design of Cbl(TKB)-binding peptides. Sci Rep, 3, 2013
7SIY	cCBL TKB domain in complex with pZAP70 peptide 分子名称: E3 ubiquitin-protein ligase CBL, MAGNESIUM ION, Peptide from Tyrosine-protein kinase ZAP-70 著者 Murray, J.M, Yu, C. 登録日 2021-10-15 公開日 2022-11-09 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (1.48 Å) 主引用文献 cCBL TKB domain in complex with pZAP70 peptide To Be Published
1FBV	STRUCTURE OF A CBL-UBCH7 COMPLEX: RING DOMAIN FUNCTION IN UBIQUITIN-PROTEIN LIGASES 分子名称: SIGNAL TRANSDUCTION PROTEIN CBL, SULFATE ION, UBIQUITIN-CONJUGATING ENZYME E12-18 KDA UBCH7, ... 著者 Zheng, N, Wang, P, Jeffrey, P.D, Pavletich, N.P. 登録日 2000-07-17 公開日 2000-08-30 最終更新日 2017-10-04 実験手法 X-RAY DIFFRACTION (2.9 Å) 主引用文献 Structure of a c-Cbl-UbcH7 complex: RING domain function in ubiquitin-protein ligases. Cell(Cambridge,Mass.), 102, 2000
1B47	STRUCTURE OF THE N-TERMINAL DOMAIN OF CBL IN COMPLEX WITH ITS BINDING SITE IN ZAP-70 分子名称: CALCIUM ION, CBL 著者 Meng, W, Sawasdikosol, S, Burakoff, S.J, Eck, M.J. 登録日 1999-01-06 公開日 1999-04-27 最終更新日 2024-02-07 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Structure of the amino-terminal domain of Cbl complexed to its binding site on ZAP-70 kinase. Nature, 398, 1999
8GCY	Co-crystal structure of CBL-B in complex with N-Aryl isoindolin-1-one inhibitor 分子名称: 1,2-ETHANEDIOL, 2-{3-[(1s,3R)-3-methyl-1-(4-methyl-4H-1,2,4-triazol-3-yl)cyclobutyl]phenyl}-6-{[(3S)-3-methylpiperidin-1-yl]methyl}-4-(trifluoromethyl)-2,3-dihydro-1H-isoindol-1-one, E3 ubiquitin-protein ligase CBL-B, ... 著者 Kimani, S, Zeng, H, Dong, A, Li, Y, Santhakumar, V, Arrowsmith, C.H, Edwards, A.M, Halabelian, L, Structural Genomics Consortium (SGC) 登録日 2023-03-03 公開日 2023-03-22 最終更新日 2024-04-03 実験手法 X-RAY DIFFRACTION (1.81 Å) 主引用文献 The co-crystal structure of Cbl-b and a small-molecule inhibitor reveals the mechanism of Cbl-b inhibition. Commun Biol, 6, 2023
6BK5	Inactive choanoflagellate E3 ubiquitin ligase Cbl TKB 分子名称: CALCIUM ION, Ubiquitin Ligase Cbl 著者 Amacher, J.F, Kuriyan, J. 登録日 2017-11-07 公開日 2018-03-14 最終更新日 2024-03-13 実験手法 X-RAY DIFFRACTION (2.401 Å) 主引用文献 Phosphorylation control of the ubiquitin ligase Cbl is conserved in choanoflagellates. Protein Sci., 27, 2018
5O76	Structure of phosphoY371 c-CBL in complex with ZAP70-peptide and UbV.pCBL ubiquitin variant 分子名称: CALCIUM ION, E3 ubiquitin-protein ligase CBL, Tyrosine protein kinase ZAP70 peptide, ... 著者 Gabrielsen, M, Buetow, L, Huang, D.T. 登録日 2017-06-08 公開日 2017-11-01 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (2.473 Å) 主引用文献 A General Strategy for Discovery of Inhibitors and Activators of RING and U-box E3 Ligases with Ubiquitin Variants. Mol. Cell, 68, 2017
5AXI	Crystal structure of Cbl-b TKB domain in complex with Cblin 分子名称: CALCIUM ION, CHLORIDE ION, Cblin, ... 著者 Ohno, A, Maita, N, Ochi, A, Nakao, R, Nikawa, T. 登録日 2015-07-29 公開日 2016-03-02 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Structural analysis of the TKB domain of ubiquitin ligase Cbl-b complexed with its small inhibitory peptide, Cblin Arch.Biochem.Biophys., 594, 2016
2CBL	N-TERMINAL DOMAIN OF CBL IN COMPLEX WITH ITS BINDING SITE ON ZAP-70 分子名称: CALCIUM ION, PROTO-ONCOGENE CBL, ZAP-70 著者 Meng, W, Sawasdikosol, S, Burakoff, S.J, Eck, M.J. 登録日 1998-08-28 公開日 1999-05-18 最終更新日 2024-04-03 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Structure of the amino-terminal domain of Cbl complexed to its binding site on ZAP-70 kinase. Nature, 398, 1999
5HKW	Crystal Structure of Apo c-Cbl TKBD Refined to 2.25 A Resolution 分子名称: E3 ubiquitin-protein ligase CBL, SODIUM ION 著者 Lovell, S, Battaile, K.P, Mehzabeen, N, Zhang, N, Cooper, A, Gao, P, Perez, R.P. 登録日 2016-01-14 公開日 2017-01-18 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (2.25 Å) 主引用文献 Crystal Structure of Apo c-Cbl TKBD Refined to 2.25 A Resolution To be published
1YVH	Crystal Structure of the c-Cbl TKB Domain in Complex with the APS pTyr-618 Phosphopeptide 分子名称: 13-mer fragment of SH2 and PH domain-containing adapter protein APS, CBL E3 ubiquitin protein ligase, MAGNESIUM ION 著者 Hu, J, Hubbard, S.R. 登録日 2005-02-15 公開日 2005-03-08 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (2.05 Å) 主引用文献 Structural Characterization of a Novel Cbl Phosphotyrosine Recognition Motif in the APS Family of Adapter Proteins J.Biol.Chem., 280, 2005
4A4B	Structure of modified phosphoTyr371-c-Cbl-UbcH5B-ZAP-70 complex 分子名称: CALCIUM ION, E3 UBIQUITIN-PROTEIN LIGASE CBL, TYROSINE-PROTEIN KINASE ZAP-70, ... 著者 Dou, H, Buetow, L, Hock, A, Sibbet, G.J, Vousden, K.H, Huang, D.T. 登録日 2011-10-08 公開日 2012-01-25 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (2.789 Å) 主引用文献 Structural Basis for Autoinhibition and Phosphorylation-Dependent Activation of C-Cbl Nat.Struct.Mol.Biol., 19, 2012
4A4C	Structure of phosphoTyr371-c-Cbl-UbcH5B-ZAP-70 complex 分子名称: CALCIUM ION, E3 UBIQUITIN-PROTEIN LIGASE CBL, TYROSINE-PROTEIN KINASE ZAP-70, ... 著者 Dou, H, Buetow, L, Hock, A, Sibbet, G.J, Vousden, K.H, Huang, D.T. 登録日 2011-10-08 公開日 2012-01-25 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (2.704 Å) 主引用文献 Structural Basis for Autoinhibition and Phosphorylation-Dependent Activation of C-Cbl Nat.Struct.Mol.Biol., 19, 2012
6O02	Monobody (MC3) bound to tyrosine kinase binding domain of E3 ubiquitin ligase CBL 分子名称: E3 ubiquitin-protein ligase CBL, Monobody (MC3) 著者 Kukenshoner, T, Pojer, F, Hantschel, O. 登録日 2019-02-15 公開日 2020-08-19 最終更新日 2024-03-13 実験手法 X-RAY DIFFRACTION (2.953 Å) 主引用文献 Monobody (MC3) bound to tyrosine kinase binding domain of E3 ubiquitin ligase CBL To Be Published
6O03	Monobody (MC17) bound to tyrosine kinase binding domain of E3 ubiquitin ligase CBL 分子名称: E3 ubiquitin-protein ligase CBL, Monobody (MC17) 著者 Kukenshoner, T, Pojer, F, Hantschel, O. 登録日 2019-02-15 公開日 2020-08-19 最終更新日 2024-03-13 実験手法 X-RAY DIFFRACTION (3.3 Å) 主引用文献 Monobody (MC17) bound to tyrosine kinase binding domain of E3 ligase CBL To Be Published
2Y1N	Structure of c-Cbl-ZAP-70 peptide complex 分子名称: CALCIUM ION, E3 UBIQUITIN-PROTEIN LIGASE, TYROSINE-PROTEIN KINASE ZAP-70 ZAP-70,70 KDA ZETA-ASSOCIATED PROTEIN, ... 著者 Dou, H, Sibbet, G.J, Huang, D.T. 登録日 2010-12-08 公開日 2012-01-18 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (1.999 Å) 主引用文献 Structural Basis for Autoinhibition and Phosphorylation-Dependent Activation of C-Cbl. Nat.Struct.Mol.Biol., 19, 2012
2Y1M	Structure of native c-Cbl 分子名称: CALCIUM ION, E3 UBIQUITIN-PROTEIN LIGASE, ZINC ION 著者 Dou, H, Sibbet, G.J, Huang, D.T. 登録日 2010-12-08 公開日 2012-01-18 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (2.67 Å) 主引用文献 Structural Basis for Autoinhibition and Phosphorylation-Dependent Activation of C-Cbl. Nat.Struct.Mol.Biol., 19, 2012
5HKY	Crystal structure of c-Cbl TKBD domain in complex with SPRY2 peptide (36-60, pY55) Refined to 1.8A Resolution (P6 form) 分子名称: CHLORIDE ION, E3 ubiquitin-protein ligase CBL, PENTAETHYLENE GLYCOL, ... 著者 Lovell, S, Battaile, K.P, Mehzabeen, N, Zhang, N, Cooper, A, Gao, P, Perez, R.P. 登録日 2016-01-14 公開日 2017-01-18 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Crystal structure of c-Cbl TKBD domain in complex with SPRY2 peptide (36-60, pY55) Refined to 1.8A Resolution (P6 form) To be published
5HKZ	Crystal Structure of c-Cbl TKBD in complex with SPRY2 peptide (36-60, pY55) Refined to 1.8 A Resolution (P21 form) 分子名称: E3 ubiquitin-protein ligase CBL, Protein sprouty homolog 2, SODIUM ION 著者 Lovell, S, Battaile, K.P, Mehzabeen, N, Zhang, N, Cooper, A, Gao, P, Perez, R.P. 登録日 2016-01-14 公開日 2017-01-18 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Crystal Structure of c-Cbl TKBD in complex with SPRY2 peptide (36-60, pY55) Refined to 1.8 A Resolution (P21 form) To be published
3BUN	Crystal structure of c-Cbl-TKB domain complexed with its binding motif in Sprouty4 分子名称: 13-meric peptide from Protein sprouty homolog 4, E3 ubiquitin-protein ligase CBL 著者 Ng, C, Jackson, R.A, Buschdorf, J.P, Sun, Q, Guy, G.R, Sivaraman, J. 登録日 2008-01-03 公開日 2008-02-26 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Structural basis for a novel intrapeptidyl H-bond and reverse binding of c-Cbl-TKB domain substrates Embo J., 27, 2008
5HL0	Crystal Structure of c-Cbl TKBD in complex with SPRY2 peptide (54-60, pY55) Refined to 2.2A Resolution 分子名称: E3 ubiquitin-protein ligase CBL, SODIUM ION, Sprouty 2 (SPRY2) 著者 Lovell, S, Battaile, K.P, Mehzabeen, N, Zhang, N, Cooper, A, Gao, P, Perez, R.P. 登録日 2016-01-14 公開日 2017-01-18 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Crystal Structure of c-Cbl TKBD in complex with SPRY2 peptide (54-60, pY55) Refined to 2.2A Resolution To Be Published
5HKX	Crystal Structure of c-Cbl TKBD-RING domains (Y371E mutant) Refined to 1.85 A Resolution 分子名称: 1,2-ETHANEDIOL, E3 ubiquitin-protein ligase CBL, SODIUM ION, ... 著者 Lovell, S, Battaile, K.P, Mehzabeen, N, Zhang, N, Cooper, A, Gao, P, Perez, R.P. 登録日 2016-01-14 公開日 2017-01-18 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (1.85 Å) 主引用文献 Crystal Structure of c-Cbl TKBD-RING domains (Y371E mutant) Refined to 1.85 A Resolution To be published
3BUX	Crystal structure of c-Cbl-TKB domain complexed with its binding motif in c-Met 分子名称: 13-meric peptide from Hepatocyte growth factor receptor, E3 ubiquitin-protein ligase CBL 著者 Ng, C, Jackson, R.A, Buschdorf, J.P, Sun, Q, Guy, G.R, Sivaraman, J. 登録日 2008-01-03 公開日 2008-02-26 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (1.35 Å) 主引用文献 Structural basis for a novel intrapeptidyl H-bond and reverse binding of c-Cbl-TKB domain substrates Embo J., 27, 2008
3BUM	Crystal structure of c-Cbl-TKB domain complexed with its binding motif in Sprouty2 分子名称: E3 ubiquitin-protein ligase CBL, Protein sprouty homolog 2 著者 Ng, C, Jackson, A.R, Buschdorf, P.J, Sun, Q, Guy, R.G, Sivaraman, J. 登録日 2008-01-03 公開日 2008-02-26 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Structural basis for a novel intrapeptidyl H-bond and reverse binding of c-Cbl-TKB domain substrates Embo J., 27, 2008

 

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