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5AXI
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BU of 5axi by Molmil
Crystal structure of Cbl-b TKB domain in complex with Cblin
分子名称: CALCIUM ION, CHLORIDE ION, Cblin, ...
著者Ohno, A, Maita, N, Ochi, A, Nakao, R, Nikawa, T.
登録日2015-07-29
公開日2016-03-02
最終更新日2023-11-15
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Structural analysis of the TKB domain of ubiquitin ligase Cbl-b complexed with its small inhibitory peptide, Cblin
Arch.Biochem.Biophys., 594, 2016
1B47
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BU of 1b47 by Molmil
STRUCTURE OF THE N-TERMINAL DOMAIN OF CBL IN COMPLEX WITH ITS BINDING SITE IN ZAP-70
分子名称: CALCIUM ION, CBL
著者Meng, W, Sawasdikosol, S, Burakoff, S.J, Eck, M.J.
登録日1999-01-06
公開日1999-04-27
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Structure of the amino-terminal domain of Cbl complexed to its binding site on ZAP-70 kinase.
Nature, 398, 1999
6XAR
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BU of 6xar by Molmil
Structure of CBL tyrosine kinase binding domain (TKBD) with C-terminal tail of Src-like kinase protein 2 (SLAP2)
分子名称: CALCIUM ION, E3 ubiquitin-protein ligase CBL, Src-like-adapter 2
著者Wybenga-Groot, L.E, McGlade, C.J.
登録日2020-06-04
公開日2021-03-03
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (2.501 Å)
主引用文献SLAP2 Adaptor Binding Disrupts c-CBL Autoinhibition to Activate Ubiquitin Ligase Function.
J.Mol.Biol., 433, 2021
4GPL
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BU of 4gpl by Molmil
Structure of Cbl(TKB) bound to a phosphorylated pentapeptide
分子名称: ACE-PTR-THR-PRO-GLU-PRO, PEPTIDE INHIBITOR, E3 ubiquitin-protein ligase CBL
著者Borgstahl, G, Natarajan, A.
登録日2012-08-21
公開日2013-09-18
最終更新日2023-12-06
実験手法X-RAY DIFFRACTION (3 Å)
主引用文献The paradox of conformational constraint in the design of Cbl(TKB)-binding peptides.
Sci Rep, 3, 2013
7SIY
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BU of 7siy by Molmil
cCBL TKB domain in complex with pZAP70 peptide
分子名称: E3 ubiquitin-protein ligase CBL, MAGNESIUM ION, Peptide from Tyrosine-protein kinase ZAP-70
著者Murray, J.M, Yu, C.
登録日2021-10-15
公開日2022-11-09
最終更新日2023-11-15
実験手法X-RAY DIFFRACTION (1.48 Å)
主引用文献cCBL TKB domain in complex with pZAP70 peptide
To Be Published
6BK5
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BU of 6bk5 by Molmil
Inactive choanoflagellate E3 ubiquitin ligase Cbl TKB
分子名称: CALCIUM ION, Ubiquitin Ligase Cbl
著者Amacher, J.F, Kuriyan, J.
登録日2017-11-07
公開日2018-03-14
最終更新日2024-03-13
実験手法X-RAY DIFFRACTION (2.401 Å)
主引用文献Phosphorylation control of the ubiquitin ligase Cbl is conserved in choanoflagellates.
Protein Sci., 27, 2018
1YVH
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BU of 1yvh by Molmil
Crystal Structure of the c-Cbl TKB Domain in Complex with the APS pTyr-618 Phosphopeptide
分子名称: 13-mer fragment of SH2 and PH domain-containing adapter protein APS, CBL E3 ubiquitin protein ligase, MAGNESIUM ION
著者Hu, J, Hubbard, S.R.
登録日2005-02-15
公開日2005-03-08
最終更新日2023-11-15
実験手法X-RAY DIFFRACTION (2.05 Å)
主引用文献Structural Characterization of a Novel Cbl Phosphotyrosine Recognition Motif in the APS Family of Adapter Proteins
J.Biol.Chem., 280, 2005
2CBL
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BU of 2cbl by Molmil
N-TERMINAL DOMAIN OF CBL IN COMPLEX WITH ITS BINDING SITE ON ZAP-70
分子名称: CALCIUM ION, PROTO-ONCOGENE CBL, ZAP-70
著者Meng, W, Sawasdikosol, S, Burakoff, S.J, Eck, M.J.
登録日1998-08-28
公開日1999-05-18
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Structure of the amino-terminal domain of Cbl complexed to its binding site on ZAP-70 kinase.
Nature, 398, 1999
6O02
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BU of 6o02 by Molmil
Monobody (MC3) bound to tyrosine kinase binding domain of E3 ubiquitin ligase CBL
分子名称: E3 ubiquitin-protein ligase CBL, Monobody (MC3)
著者Kukenshoner, T, Pojer, F, Hantschel, O.
登録日2019-02-15
公開日2020-08-19
最終更新日2024-03-13
実験手法X-RAY DIFFRACTION (2.953 Å)
主引用文献Monobody (MC3) bound to tyrosine kinase binding domain of E3 ubiquitin ligase CBL
To Be Published
6O03
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BU of 6o03 by Molmil
Monobody (MC17) bound to tyrosine kinase binding domain of E3 ubiquitin ligase CBL
分子名称: E3 ubiquitin-protein ligase CBL, Monobody (MC17)
著者Kukenshoner, T, Pojer, F, Hantschel, O.
登録日2019-02-15
公開日2020-08-19
最終更新日2024-03-13
実験手法X-RAY DIFFRACTION (3.3 Å)
主引用文献Monobody (MC17) bound to tyrosine kinase binding domain of E3 ligase CBL
To Be Published
3BUN
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BU of 3bun by Molmil
Crystal structure of c-Cbl-TKB domain complexed with its binding motif in Sprouty4
分子名称: 13-meric peptide from Protein sprouty homolog 4, E3 ubiquitin-protein ligase CBL
著者Ng, C, Jackson, R.A, Buschdorf, J.P, Sun, Q, Guy, G.R, Sivaraman, J.
登録日2008-01-03
公開日2008-02-26
最終更新日2023-11-15
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Structural basis for a novel intrapeptidyl H-bond and reverse binding of c-Cbl-TKB domain substrates
Embo J., 27, 2008
3BUX
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BU of 3bux by Molmil
Crystal structure of c-Cbl-TKB domain complexed with its binding motif in c-Met
分子名称: 13-meric peptide from Hepatocyte growth factor receptor, E3 ubiquitin-protein ligase CBL
著者Ng, C, Jackson, R.A, Buschdorf, J.P, Sun, Q, Guy, G.R, Sivaraman, J.
登録日2008-01-03
公開日2008-02-26
最終更新日2023-11-15
実験手法X-RAY DIFFRACTION (1.35 Å)
主引用文献Structural basis for a novel intrapeptidyl H-bond and reverse binding of c-Cbl-TKB domain substrates
Embo J., 27, 2008
3BUM
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BU of 3bum by Molmil
Crystal structure of c-Cbl-TKB domain complexed with its binding motif in Sprouty2
分子名称: E3 ubiquitin-protein ligase CBL, Protein sprouty homolog 2
著者Ng, C, Jackson, A.R, Buschdorf, P.J, Sun, Q, Guy, R.G, Sivaraman, J.
登録日2008-01-03
公開日2008-02-26
最終更新日2023-11-15
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Structural basis for a novel intrapeptidyl H-bond and reverse binding of c-Cbl-TKB domain substrates
Embo J., 27, 2008
3BUW
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BU of 3buw by Molmil
Crystal structure of c-Cbl-TKB domain complexed with its binding motif in Syk
分子名称: 13-meric peptide from Tyrosine-protein kinase SYK, E3 ubiquitin-protein ligase CBL
著者Ng, C, Jackson, R.A, Buschdorf, J.P, Sun, Q, Guy, G.R, Sivaraman, J.
登録日2008-01-03
公開日2008-02-26
最終更新日2023-11-15
実験手法X-RAY DIFFRACTION (1.45 Å)
主引用文献Structural basis for a novel intrapeptidyl H-bond and reverse binding of c-Cbl-TKB domain substrates
Embo J., 27, 2008
3BUO
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BU of 3buo by Molmil
Crystal structure of c-Cbl-TKB domain complexed with its binding motif in EGF receptor'
分子名称: 13-meric peptide from Epidermal growth factor receptor, E3 ubiquitin-protein ligase CBL
著者Ng, C, Jackson, R.A, Buschdorf, J.P, Sun, Q, Guy, G.R, Sivaraman, J.
登録日2008-01-03
公開日2008-02-26
最終更新日2023-11-15
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献Structural basis for a novel intrapeptidyl H-bond and reverse binding of c-Cbl-TKB domain substrates
Embo J., 27, 2008
3OB1
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BU of 3ob1 by Molmil
Crystal structure of c-Cbl TKB domain in complex with double phosphorylated Spry2 peptide
分子名称: 12-meric peptide from Protein sprouty homolog 2, E3 ubiquitin-protein ligase CBL
著者Sun, Q, Sivaraman, J.
登録日2010-08-06
公開日2010-08-18
最終更新日2023-12-06
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Additional serine/threonine phosphorylation reduces binding affinity but preserves interface topography of substrate proteins to the c-Cbl TKB domain
Plos One, 5, 2010
3OB2
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BU of 3ob2 by Molmil
Crystal structure of c-Cbl TKB domain in complex with double phosphorylated EGFR peptide
分子名称: 12-meric peptide from Epidermal growth factor receptor, E3 ubiquitin-protein ligase CBL
著者Sun, Q, Sivaraman, J.
登録日2010-08-06
公開日2010-08-18
最終更新日2023-12-06
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Additional serine/threonine phosphorylation reduces binding affinity but preserves interface topography of substrate proteins to the c-Cbl TKB domain
Plos One, 5, 2010
3OP0
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BU of 3op0 by Molmil
Crystal structure of Cbl-c (Cbl-3) TKB domain in complex with EGFR pY1069 peptide
分子名称: Epidermal growth factor receptor, NICKEL (II) ION, SODIUM ION, ...
著者Chaikuad, A, Guo, K, Cooper, C.D.O, Ayinampudi, V, Krojer, T, Ugochukwu, E, Muniz, J.R.C, Vollmar, M, Canning, P, von Delft, F, Arrowsmith, C.H, Weigelt, J, Edwards, A.M, Bountra, C, Bullock, A, Structural Genomics Consortium (SGC)
登録日2010-08-31
公開日2010-10-20
最終更新日2023-12-06
実験手法X-RAY DIFFRACTION (2.52 Å)
主引用文献Crystal structure of Cbl-c (Cbl-3) TKB domain in complex with EGFR pY1069 peptide
To be Published
3PFV
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BU of 3pfv by Molmil
Crystal structure of Cbl-b TKB domain in complex with EGFR pY1069 peptide
分子名称: 1,2-ETHANEDIOL, 11-meric peptide from Epidermal growth factor receptor, CHLORIDE ION, ...
著者Chaikuad, A, Guo, K, Cooper, C.D.O, Ayinampudi, V, Krojer, T, Muniz, J.R.C, Vollmar, M, Canning, P, Gileadi, O, von Delft, F, Arrowsmith, C.H, Weigelt, J, Edwards, A.M, Bountra, C, Bullock, A, Structural Genomics Consortium (SGC)
登録日2010-10-29
公開日2010-12-08
最終更新日2023-12-06
実験手法X-RAY DIFFRACTION (2.27 Å)
主引用文献Crystal structure of Cbl-b TKB domain in complex with EGFR pY1069 peptide
To be Published
3PLF
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BU of 3plf by Molmil
Reverse Binding Mode of MetRD peptide complexed with c-Cbl TKB domain
分子名称: CALCIUM ION, CHLORIDE ION, E3 ubiquitin-protein ligase CBL, ...
著者Sun, Q, Sivaraman, J.
登録日2010-11-15
公開日2010-12-01
最終更新日2023-12-06
実験手法X-RAY DIFFRACTION (1.92 Å)
主引用文献An adjacent arginine, and the phosphorylated tyrosine in the c-Met receptor target sequence, dictates the orientation of c-Cbl binding
Febs Lett., 585, 2011
5HKW
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BU of 5hkw by Molmil
Crystal Structure of Apo c-Cbl TKBD Refined to 2.25 A Resolution
分子名称: E3 ubiquitin-protein ligase CBL, SODIUM ION
著者Lovell, S, Battaile, K.P, Mehzabeen, N, Zhang, N, Cooper, A, Gao, P, Perez, R.P.
登録日2016-01-14
公開日2017-01-18
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (2.25 Å)
主引用文献Crystal Structure of Apo c-Cbl TKBD Refined to 2.25 A Resolution
To be published
5HKY
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BU of 5hky by Molmil
Crystal structure of c-Cbl TKBD domain in complex with SPRY2 peptide (36-60, pY55) Refined to 1.8A Resolution (P6 form)
分子名称: CHLORIDE ION, E3 ubiquitin-protein ligase CBL, PENTAETHYLENE GLYCOL, ...
著者Lovell, S, Battaile, K.P, Mehzabeen, N, Zhang, N, Cooper, A, Gao, P, Perez, R.P.
登録日2016-01-14
公開日2017-01-18
最終更新日2023-11-15
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Crystal structure of c-Cbl TKBD domain in complex with SPRY2 peptide (36-60, pY55) Refined to 1.8A Resolution (P6 form)
To be published
5HKZ
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BU of 5hkz by Molmil
Crystal Structure of c-Cbl TKBD in complex with SPRY2 peptide (36-60, pY55) Refined to 1.8 A Resolution (P21 form)
分子名称: E3 ubiquitin-protein ligase CBL, Protein sprouty homolog 2, SODIUM ION
著者Lovell, S, Battaile, K.P, Mehzabeen, N, Zhang, N, Cooper, A, Gao, P, Perez, R.P.
登録日2016-01-14
公開日2017-01-18
最終更新日2023-11-15
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Crystal Structure of c-Cbl TKBD in complex with SPRY2 peptide (36-60, pY55) Refined to 1.8 A Resolution (P21 form)
To be published
5HL0
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BU of 5hl0 by Molmil
Crystal Structure of c-Cbl TKBD in complex with SPRY2 peptide (54-60, pY55) Refined to 2.2A Resolution
分子名称: E3 ubiquitin-protein ligase CBL, SODIUM ION, Sprouty 2 (SPRY2)
著者Lovell, S, Battaile, K.P, Mehzabeen, N, Zhang, N, Cooper, A, Gao, P, Perez, R.P.
登録日2016-01-14
公開日2017-01-18
最終更新日2023-11-15
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Crystal Structure of c-Cbl TKBD in complex with SPRY2 peptide (54-60, pY55) Refined to 2.2A Resolution
To Be Published
3VRP
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BU of 3vrp by Molmil
Crystal structure of the tyrosine kinase binding domain of Cbl-c in complex with phospho-EGFR peptide
分子名称: CALCIUM ION, Epidermal growth factor receptor, Signal transduction protein CBL-C
著者Takeshita, K, Tezuka, T, Isozaki, Y, Yamashita, E, Suzuki, M, Yamanashi, Y, Yamamoto, T, Nakagawa, A.
登録日2012-04-13
公開日2013-03-06
実験手法X-RAY DIFFRACTION (1.52 Å)
主引用文献Structural flexibility regulates phosphopeptide-binding activity of the tyrosine kinase binding domain of Cbl-c.
J.Biochem., 152, 2012

 

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