PDB: 56 件ウェブページステータス検索Chemie searchBIRD

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4WF2	Structure of E. coli BirA G142A bound to biotinol-5'-AMP 分子名称: ((2R,3S,4R,5R)-5-(6-AMINO-9H-PURIN-9-YL)-3,4-DIHYDROXY-TETRAHYDROFURAN-2-YL)METHYL 5-((3AS,4S,6AR)-2-OXO-HEXAHYDRO-1H-THIENO[3,4-D]IMIDAZOL-4-YL)PENTYL HYDROGEN PHOSPHATE, Bifunctional ligase/repressor BirA 著者 Eginton, C, Beckett, D, Wade, H. 登録日 2014-09-11 公開日 2014-10-22 最終更新日 2023-12-27 実験手法 X-RAY DIFFRACTION (2.31 Å) 主引用文献 Allosteric Coupling via Distant Disorder-to-Order Transitions. J.Mol.Biol., 427, 2015
4OP0	Crystal structure of biotin protein ligase (RV3279C) of Mycobacterium tuberculosis, complexed with biotinyl-5'-AMP 分子名称: BIOTINYL-5-AMP, BirA bifunctional protein, SULFATE ION 著者 Ma, Q, Wilmanns, M, Akhter, Y. 登録日 2014-02-04 公開日 2014-04-30 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 Active site conformational changes upon reaction intermediate biotinyl-5'-AMP binding in biotin protein ligase from Mycobacterium tuberculosis. Protein Sci., 23, 2014
2ZGW	Crystal Structure Of Biotin Protein Ligase From Pyrococcus Horikoshii Complexed with Adenosine and Biotin, Mutations R48A and K111A 分子名称: ADENOSINE, BIOTIN, biotin--[acetyl-CoA-carboxylase] ligase 著者 Bagautdinov, B, Matsuura, Y, Bagautdinova, S, Kunishima, N, RIKEN Structural Genomics/Proteomics Initiative (RSGI) 登録日 2008-01-28 公開日 2008-02-05 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (1.5 Å) 主引用文献 Protein biotinylation visualized by a complex structure of biotin protein ligase with a substrate J.Biol.Chem., 283, 2008
1HXD	CRYSTAL STRUCTURE OF E. COLI BIOTIN REPRESSOR WITH BOUND BIOTIN 分子名称: BIOTIN, BIRA BIFUNCTIONAL PROTEIN 著者 Kwon, K, Streaker, E.D, Ruparelia, S, Beckett, D. 登録日 2001-01-12 公開日 2001-05-30 最終更新日 2023-08-09 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Corepressor-induced organization and assembly of the biotin repressor: a model for allosteric activation of a transcriptional regulator. Proc.Natl.Acad.Sci.USA, 98, 2001
3RUX	Crystal structure of biotin-protein ligase BirA from Mycobacterium tuberculosis in complex with an acylsulfamide bisubstrate inhibitor 分子名称: 5'-deoxy-5'-[({5-[(3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl]pentanoyl}sulfamoyl)amino]adenosine, BirA bifunctional protein 著者 Geders, T.W, Finzel, B.C. 登録日 2011-05-05 公開日 2011-12-14 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 Bisubstrate Adenylation Inhibitors of Biotin Protein Ligase from Mycobacterium tuberculosis. Chem.Biol., 18, 2011
6NDL	Crystal structure of Staphylococcus aureus biotin protein ligase in complex with a sulfonamide inhibitor 分子名称: 1-[4-(6-aminopurin-9-yl)butylsulfamoyl]-3-[4-[(4~{S})-2-oxidanylidene-1,3,3~{a},4,6,6~{a}-hexahydrothieno[3,4-d]imidazol-4-yl]butyl]urea, Biotin Protein Ligase, GLYCEROL 著者 Marshall, A.C, Polyak, S.W, Bruning, J.B, Lee, K. 登録日 2018-12-13 公開日 2019-12-18 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Sulfonamide-Based Inhibitors of Biotin Protein Ligase as New Antibiotic Leads. Acs Chem.Biol., 14, 2019
2FYK	Crystal Structure Of Biotin Protein Ligase From Pyrococcus Horikoshii OT3 in complex with ADP and Biotin 分子名称: ADENOSINE-5'-DIPHOSPHATE, BIOTIN, biotin--protein ligase 著者 Bagautdinov, B, Kunishima, N, RIKEN Structural Genomics/Proteomics Initiative (RSGI) 登録日 2006-02-08 公開日 2006-08-08 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (1.6 Å) 主引用文献 Ligand Structures Of Biotin Protein Ligase From Pyrococcus Horikoshii Ot3 To be Published
6ORU	Crystal structure of Bira from S. aureus in complex with a acylsulfamide analogue of biotinyl-5'-AMP 分子名称: Bifunctional ligase/repressor BirA, N-{[4-(6-amino-9H-purin-9-yl)butyl]sulfamoyl}-5-[(3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl]pentanamide 著者 Wilce, M.C.J, Cini, D. 登録日 2019-05-01 公開日 2020-07-01 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (2.392 Å) 主引用文献 Enhancing the stability of the sulfonamide linker of BPL inhibitors To Be Published
2HNI	Crystal Structure Of Biotin Protein Ligase From Pyrococcus Horikoshii OT3, K111A mutation 分子名称: 235aa long hypothetical biotin-[acetyl-CoA-carboxylase] ligase, ACETIC ACID 著者 Bagautdinov, B, Kunishima, N, RIKEN Structural Genomics/Proteomics Initiative (RSGI) 登録日 2006-07-13 公開日 2007-01-13 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Ligand Structures Of Biotin Protein Ligase From Pyrococcus Horikoshii OT3 To be Published
1BIB	THE E. COLI BIOTIN HOLOENZYME SYNTHETASE(SLASH)BIO REPRESSOR CRYSTAL STRUCTURE DELINEATES THE BIOTIN AND DNA-BINDING DOMAINS 分子名称: BIOTIN, BIR A 著者 Wilson, K.P, Shewchuk, L.M, Matthews, B.W. 登録日 1992-07-06 公開日 1993-10-31 最終更新日 2024-02-07 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 Escherichia coli biotin holoenzyme synthetase/bio repressor crystal structure delineates the biotin- and DNA-binding domains. Proc.Natl.Acad.Sci.USA, 89, 1992
1BIA	THE E. COLI BIOTIN HOLOENZYME SYNTHETASE(SLASH)BIO REPRESSOR CRYSTAL STRUCTURE DELINEATES THE BIOTIN AND DNA-BINDING DOMAINS 分子名称: BirA BIFUNCTIONAL PROTEIN 著者 Wilson, K.P, Shewchuk, L.M, Matthews, B.W. 登録日 1992-07-06 公開日 1993-10-31 最終更新日 2024-02-07 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Escherichia coli biotin holoenzyme synthetase/bio repressor crystal structure delineates the biotin- and DNA-binding domains. Proc.Natl.Acad.Sci.USA, 89, 1992
3L1A	Structural ordering of disordered ligand binding loops of biotin protein ligase into active conformations as a consequence of dehydration 分子名称: BirA bifunctional protein 著者 Gupta, V. 登録日 2009-12-11 公開日 2010-03-09 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (2.69 Å) 主引用文献 Structural ordering of disordered ligand-binding loops of biotin protein ligase into active conformations as a consequence of dehydration. Plos One, 5, 2010
3L2Z	Crystal structure of hydrated Biotin Protein Ligase from M. tuberculosis 分子名称: BirA bifunctional protein 著者 Gupta, V, Gupta, R.K, Khare, G, Salunke, D.M, Tyagi, A.K. 登録日 2009-12-16 公開日 2010-03-09 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 Structural ordering of disordered ligand-binding loops of biotin protein ligase into active conformations as a consequence of dehydration. Plos One, 5, 2010
8ENI	Crystal structure of Staphylococcus aureus biotin protein ligase in complex with inhibitor 分子名称: 3-[4-(5-fluoro-4-{5-[(3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl]pentyl}-1H-1,2,3-triazol-1-yl)butyl]-5-methyl-1,3-benzoxazol-2(3H)-one, Bifunctional ligase/repressor BirA 著者 Wilce, M.C.J, Cini, D.A. 登録日 2022-09-30 公開日 2022-11-30 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Halogenation of Biotin Protein Ligase Inhibitors Improves Whole Cell Activity against Staphylococcus aureus. ACS Infect Dis, 4, 2018
8F8U	Bifunctional ligase/repressor BirA from Klebsiella pneumoniae (Domain Swapped Dimer) 分子名称: Bifunctional ligase/repressor BirA, IMIDAZOLE 著者 Seattle Structural Genomics Center for Infectious Disease, Seattle Structural Genomics Center for Infectious Disease (SSGCID) 登録日 2022-11-22 公開日 2022-11-30 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (2.85 Å) 主引用文献 Bifunctional ligase/repressor BirA from Klebsiella pneumoniae (Domain Swapped Dimer) To be published
8FI3	Bifunctional ligase/repressor BirA from Klebsiella pneumoniae complexed with biotin (Domain Swapped Dimer) 分子名称: BIOTIN, Bifunctional ligase/repressor BirA 著者 Seattle Structural Genomics Center for Infectious Disease, Seattle Structural Genomics Center for Infectious Disease (SSGCID) 登録日 2022-12-15 公開日 2022-12-28 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (2.9 Å) 主引用文献 Bifunctional ligase/repressor BirA from Klebsiella pneumoniae complexed with biotin (Domain Swapped Dimer) To be published
3EFR	Biotin protein ligase R40G mutant from Aquifex aeolicus in complex with biotin 分子名称: BIOTIN, Biotin [acetyl-CoA-carboxylase] ligase, SULFATE ION 著者 Tron, C.M, McNae, I.W, Walkinshaw, M.D, Baxter, R.L, Campopiano, D.J. 登録日 2008-09-10 公開日 2009-06-09 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (2.55 Å) 主引用文献 Structural and functional studies of the biotin protein ligase from Aquifex aeolicus reveal a critical role for a conserved residue in target specificity. J.Mol.Biol., 387, 2009
3EFS	Biotin protein ligase from Aquifex aeolicus in complex with biotin and ATP 分子名称: ADENOSINE-5'-TRIPHOSPHATE, BIOTIN, Biotin [acetyl-CoA-carboxylase] ligase, ... 著者 Tron, C.M, McNae, I.W, Walkinshaw, M.D, Baxter, R.L, Campopiano, D.J. 登録日 2008-09-10 公開日 2009-06-09 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Structural and functional studies of the biotin protein ligase from Aquifex aeolicus reveal a critical role for a conserved residue in target specificity. J.Mol.Biol., 387, 2009
3FJP	Apo structure of Biotin protein ligase from Aquifex aeolicus 分子名称: Biotin [acetyl-CoA-carboxylase] ligase, SULFATE ION 著者 McNae, I.W, Tron, C.M, Baxter, R.L, Walkinshaw, M.D, Campopiano, D.J. 登録日 2008-12-15 公開日 2009-06-09 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Structural and functional studies of the biotin protein ligase from Aquifex aeolicus reveal a critical role for a conserved residue in target specificity. J.Mol.Biol., 387, 2009
1WNL	Crystal Structure Of Biotin-(Acetyl-CoA-Carboxylase) ligase From Pyrococcus Horikoshii Ot3 in complex with ADP 分子名称: ADENOSINE-5'-DIPHOSPHATE, GLYCEROL, biotin--[acetyl-CoA-carboxylase] ligase 著者 Bagautdinov, B, Kunishima, N, RIKEN Structural Genomics/Proteomics Initiative (RSGI) 登録日 2004-08-05 公開日 2005-08-16 最終更新日 2024-04-03 実験手法 X-RAY DIFFRACTION (1.6 Å) 主引用文献 Crystal Structures of Biotin Protein Ligase from Pyrococcus horikoshii OT3 and its Complexes: Structural Basis of Biotin Activation J.Mol.Biol., 353, 2005
1WQW	Crystal Structure Of Biotin Protein Ligase From Pyrococcus Horikoshii Ot3 in complex with Biotinyl-5-AMP 分子名称: BIOTINYL-5-AMP, biotin--[acetyl-CoA-carboxylase] ligase 著者 Bagautdinov, B, Kunishima, N, RIKEN Structural Genomics/Proteomics Initiative (RSGI) 登録日 2004-10-04 公開日 2005-10-04 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (1.45 Å) 主引用文献 Crystal Structures of Biotin Protein Ligase from Pyrococcus horikoshii OT3 and its Complexes: Structural Basis of Biotin Activation J.Mol.Biol., 353, 2005
1WQ7	Crystal Structure Of Biotin-(Acetyl-CoA-Carboxylase) ligase From Pyrococcus Horikoshii Ot3 分子名称: biotin--[acetyl-CoA-carboxylase] ligase 著者 Bagautdinov, B, Kunishima, N, RIKEN Structural Genomics/Proteomics Initiative (RSGI) 登録日 2004-09-23 公開日 2005-10-04 最終更新日 2024-03-13 実験手法 X-RAY DIFFRACTION (1.6 Å) 主引用文献 Crystal Structures of Biotin Protein Ligase from Pyrococcus horikoshii OT3 and its Complexes: Structural Basis of Biotin Activation J.Mol.Biol., 353, 2005
1X01	Crystal Structure Of Biotin Protein Ligase From Pyrococcus Horikoshii Ot3 in complex with ATP 分子名称: ACETIC ACID, ADENOSINE-5'-TRIPHOSPHATE, PHOSPHATE ION, ... 著者 Bagautdinov, B, Kunishima, N, RIKEN Structural Genomics/Proteomics Initiative (RSGI) 登録日 2005-03-11 公開日 2006-05-23 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Protein biotinylation visualized by a complex structure of biotin protein ligase with a substrate J.Biol.Chem., 283, 2008
1WPY	Crystal Structure Of Biotin-(Acetyl-CoA-Carboxylase) ligase From Pyrococcus Horikoshii Ot3 in complex with biotin 分子名称: BIOTIN, biotin--[acetyl-CoA-carboxylase] ligase 著者 Bagautdinov, B, Kunishima, N, RIKEN Structural Genomics/Proteomics Initiative (RSGI) 登録日 2004-09-17 公開日 2005-10-04 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (1.6 Å) 主引用文献 Crystal Structures of Biotin Protein Ligase from Pyrococcus horikoshii OT3 and its Complexes: Structural Basis of Biotin Activation J.Mol.Biol., 353, 2005
4XTX	Mycobacterium tuberculosis biotin ligase complexed with bisubstrate inhibitor 57 with azide in place of ribose 2'OH 分子名称: 1,2-ETHANEDIOL, 9-[2-azido-2-deoxy-5-O-({5-[(3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl]pentanoyl}sulfamoyl)-beta-D-arabinofuranosyl]-9H-purin-6-amine, Bifunctional ligase/repressor BirA 著者 De la Mora-Rey, T, Finzel, B.C. 登録日 2015-01-24 公開日 2015-09-02 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (2.30010319 Å) 主引用文献 Targeting Mycobacterium tuberculosis Biotin Protein Ligase (MtBPL) with Nucleoside-Based Bisubstrate Adenylation Inhibitors. J.Med.Chem., 58, 2015

 

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