Loading
PDBj
English日本語简体中文繁體中文한국어
✖
ﾒﾆｭｰPDBj@FacebookPDBj@TwitterPDBj@YouTubewwPDB FoundationwwPDB
RCSB PDBPDBeBMRBAdv. SearchSearch help
7FGQ
DownloadVisualize
BU of 7fgq by Molmil
Crystal structure of Thymidylate kinase with TMP and its low-resolution (SAXS) solution structure from Brugia malayi
分子名称: THYMIDINE-5'-PHOSPHATE, dTMP kinase
著者Ramachandran, R, Vishwakarma, J, Sharma, V.K.
登録日2021-07-27
公開日2022-07-27
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (1.91 Å)
主引用文献Crystal structure of Thymidylate kinase with TMP and its low-resolution (SAXS) solution structure from Brugia malayi
To Be Published
3N2I
DownloadVisualize
BU of 3n2i by Molmil
2.25 Angstrom resolution crystal structure of a thymidylate kinase (tmk) from Vibrio cholerae O1 biovar eltor str. N16961 in complex with thymidine
分子名称: CHLORIDE ION, THYMIDINE, Thymidylate kinase
著者Halavaty, A.S, Minasov, G, Shuvalova, L, Winsor, J, Dubrovska, I, Peterson, S, Anderson, W.F, Center for Structural Genomics of Infectious Diseases (CSGID)
登録日2010-05-18
公開日2010-06-02
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (2.25 Å)
主引用文献2.25 Angstrom resolution crystal structure of a thymidylate kinase (tmk) from Vibrio cholerae O1 biovar eltor str. N16961 in complex with thymidine
To be Published
4XWA
DownloadVisualize
BU of 4xwa by Molmil
TMK from S.aureus in complex with the Piperidinyl Thymine class inhibitor with a C5 ethyl-amine
分子名称: 2-(3-chlorophenoxy)-6-(ethylamino)-4-[(R)-[(3S)-3-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)piperidin-1-yl](phenyl)methyl]benzoic acid, Thymidylate kinase
著者Olivier, N.B.
登録日2015-01-28
公開日2015-02-11
実験手法X-RAY DIFFRACTION (1.89 Å)
主引用文献A highly potent antibacterial inhibitor of Gram-positive bacterial thymidylate kinase (TMK): SAR of piperidinyl thymines at position C5 and L1
Bioorg Med Chem Lett, 2015
6YT1
DownloadVisualize
BU of 6yt1 by Molmil
Mtb TMK crystal structure in complex with compound 26
分子名称: 2-ethyl-~{N}-[[4-[4-[5-methyl-2,4-bis(oxidanylidene)pyrimidin-1-yl]piperidin-1-yl]phenyl]methyl]-1,2,3,5,6,7,8,8~{a}-octahydroimidazo[1,2-a]pyridine-3-carboxamide, CITRIC ACID, Thymidylate kinase
著者Merceron, R, De Munck, S, Jian, Y, Munier-Lehmann, H, Van Calenbergh, S, Savvides, S.N.
登録日2020-04-23
公開日2020-09-02
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Endeavors towards transformation of M. tuberculosis thymidylate kinase (MtbTMPK) inhibitors into potential antimycobacterial agents.
Eur.J.Med.Chem., 206, 2020
5ZB4
DownloadVisualize
BU of 5zb4 by Molmil
Crystal structure of thymidylate kinase in complex with ADP and TMP from thermus thermophilus HB8
分子名称: ADENOSINE-5'-DIPHOSPHATE, CALCIUM ION, CHLORIDE ION, ...
著者Chaudhary, S.K, Jeyakanthan, J, Sekar, K.
登録日2018-02-09
公開日2018-12-19
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (1.92 Å)
主引用文献Insights into product release dynamics through structural analyses of thymidylate kinase.
Int. J. Biol. Macromol., 123, 2018
1TMK
DownloadVisualize
BU of 1tmk by Molmil
YEAST THYMIDYLATE KINASE COMPLEXED WITH THYMIDINE MONOPHOSPHATE (DTMP)
分子名称: SULFATE ION, THYMIDINE-5'-PHOSPHATE, THYMIDYLATE KINASE
著者Lavie, A, Schlichting, I.
登録日1997-06-12
公開日1998-06-17
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Structure of thymidylate kinase reveals the cause behind the limiting step in AZT activation.
Nat.Struct.Biol., 4, 1997
3HJN
DownloadVisualize
BU of 3hjn by Molmil
Crystal structure of thymidylate kinase in complex with dTDP and ADP from Thermotoga maritima
分子名称: ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, THYMIDINE-5'-DIPHOSPHATE, ...
著者Yoshikawa, S, Nakagawa, N, Shirouzu, M, Yokoyama, S, Kuramitsu, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI)
登録日2009-05-22
公開日2009-06-02
最終更新日2023-11-01
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Crystal structure of thymidylate kinase in complex with dTDP and ADP from Thermotoga maritima
To be Published
5ZB0
DownloadVisualize
BU of 5zb0 by Molmil
Crystal structure of thymidylate kinase in complex with ADP and TDP from thermus thermophilus HB8
分子名称: ADENOSINE-5'-DIPHOSPHATE, CHLORIDE ION, MAGNESIUM ION, ...
著者Chaudhary, S.K, Jeyakanthan, J, Sekar, K.
登録日2018-02-09
公開日2018-12-19
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (1.19 Å)
主引用文献Insights into product release dynamics through structural analyses of thymidylate kinase.
Int. J. Biol. Macromol., 123, 2018
5ZAX
DownloadVisualize
BU of 5zax by Molmil
Crystal structure of thymidylate kinase in complex with ADP, TDP and TMP from thermus thermophilus HB8
分子名称: ADENOSINE-5'-DIPHOSPHATE, CHLORIDE ION, MAGNESIUM ION, ...
著者Chaudhary, S.K, Jeyakanthan, J, Sekar, K.
登録日2018-02-09
公開日2018-12-19
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (2.36 Å)
主引用文献Insights into product release dynamics through structural analyses of thymidylate kinase.
Int. J. Biol. Macromol., 123, 2018
1W2H
DownloadVisualize
BU of 1w2h by Molmil
Crystal Structure Of Mycobacterium Tuberculosis Thymidylate Kinase Complexed With Azidothymidine Monophosphate (AZT-MP) (2.0 A Resolution)
分子名称: 3'-AZIDO-3'-DEOXYTHYMIDINE-5'-MONOPHOSPHATE, ACETATE ION, THYMIDYLATE KINASE TMK
著者Fioravanti, E, Adam, V, Munier-Lehmann, H, Bourgeois, D.
登録日2004-07-06
公開日2005-01-12
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献The crystal structure of Mycobacterium tuberculosis thymidylate kinase in complex with 3'-azidodeoxythymidine monophosphate suggests a mechanism for competitive inhibition.
Biochemistry, 44, 2005
1W2G
DownloadVisualize
BU of 1w2g by Molmil
Crystal Structure Of Mycobacterium Tuberculosis Thymidylate Kinase Complexed With Deoxythymidine (dT) (2.1 A Resolution)
分子名称: ACETATE ION, THYMIDINE, THYMIDYLATE KINASE TMK
著者Fioravanti, E, Adam, V, Munier-Lehmann, H, Bourgeois, D.
登録日2004-07-06
公開日2005-01-12
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献The Crystal Structure of Mycobacterium Tuberculosis Thymidylate Kinase in Complex with 3'-Azidodeoxythymidine Monophosphate Suggests a Mechanism for Competitive Inhibition
Biochemistry, 44, 2005
2CCK
DownloadVisualize
BU of 2cck by Molmil
CRYSTAL STRUCTURE OF UNLIGANDED S. AUREUS THYMIDYLATE KINASE
分子名称: 1,2-ETHANEDIOL, CHLORIDE ION, THYMIDYLATE KINASE
著者Kotaka, M, Dhaliwal, B, Ren, J, Nichols, C.E, Angell, R, Lockyer, M, Hawkins, A.R, Stammers, D.K.
登録日2006-01-16
公開日2006-03-08
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (2.21 Å)
主引用文献Structures of S. Aureus Thymidylate Kinase Reveal an Atypical Active Site Configuration and an Intermediate Conformational State Upon Substrate Binding
Protein Sci., 15, 2006
2CCG
DownloadVisualize
BU of 2ccg by Molmil
Crystal structure of His-tagged S. aureus thymidylate kinase complexed with thymidine monophosphate (TMP)
分子名称: THYMIDINE-5'-PHOSPHATE, THYMIDYLATE KINASE
著者Kotaka, M, Dhaliwal, B, Ren, J, Nichols, C.E, Angell, R, Lockyer, M, Hawkins, A.R, Stammers, D.K.
登録日2006-01-16
公開日2006-03-08
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Structures of S. Aureus Thymidylate Kinase Reveal an Atypical Active Site Configuration and an Intermediate Conformational State Upon Substrate Binding
Protein Sci., 15, 2006
2CCJ
DownloadVisualize
BU of 2ccj by Molmil
Crystal structure of S. aureus thymidylate kinase complexed with thymidine monophosphate
分子名称: 1,2-ETHANEDIOL, CHLORIDE ION, THYMIDINE-5'-PHOSPHATE, ...
著者Kotaka, M, Dhaliwal, B, Ren, J, Nichols, C.E, Angell, R, Lockyer, M, Hawkins, A.R, Stammers, D.K.
登録日2006-01-16
公開日2006-03-08
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献Structures of S. Aureus Thymidylate Kinase Reveal an Atypical Active Site Configuration and an Intermediate Conformational State Upon Substrate Binding
Protein Sci., 15, 2006
3LD9
DownloadVisualize
BU of 3ld9 by Molmil
Crystal structure of thymidylate kinase from Ehrlichia chaffeensis at 2.15A resolution
分子名称: 1,2-ETHANEDIOL, SULFATE ION, Thymidylate kinase
著者Seattle Structural Genomics Center for Infectious Disease (SSGCID)
登録日2010-01-12
公開日2010-02-16
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (2.15 Å)
主引用文献Structure of thymidylate kinase from Ehrlichia chaffeensis.
Acta Crystallogr.,Sect.F, 67, 2011
3LV8
DownloadVisualize
BU of 3lv8 by Molmil
1.8 Angstrom resolution crystal structure of a thymidylate kinase (tmk) from Vibrio cholerae O1 biovar eltor str. N16961 in complex with TMP, thymidine-5'-diphosphate and ADP
分子名称: ADENOSINE-5'-DIPHOSPHATE, CALCIUM ION, CHLORIDE ION, ...
著者Halavaty, A.S, Minasov, G, Dubrovska, I, Winsor, J, Shuvalova, L, Kwon, K, Anderson, W.F, Center for Structural Genomics of Infectious Diseases (CSGID)
登録日2010-02-19
公開日2010-03-02
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献1.8 Angstrom resolution crystal structure of a thymidylate kinase (tmk) from Vibrio cholerae O1 biovar eltor str. N16961 in complex with TMP, thymidine-5'-diphosphate and ADP
To be Published
2PBR
DownloadVisualize
BU of 2pbr by Molmil
Crystal structure of thymidylate kinase (aq_969) from Aquifex Aeolicus VF5
分子名称: SULFATE ION, Thymidylate kinase
著者Jeyakanthan, J, Kanaujia, S.P, Vasuki Ranjani, C, Sekar, K, Nakagawa, N, Ebihara, A, Kuramitsu, S, Shinkai, A, Shiro, Y, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI)
登録日2007-03-29
公開日2007-10-02
最終更新日2023-10-25
実験手法X-RAY DIFFRACTION (1.96 Å)
主引用文献Crystal structure of thymidylate kinase (aq_969) from Aquifex Aeolicus VF5
To be Published
5NR7
DownloadVisualize
BU of 5nr7 by Molmil
Mtb TMK crystal structure in complex with compound 43
分子名称: 1-[1-[[4-(3-chloranylphenoxy)quinolin-2-yl]methyl]piperidin-4-yl]-5-methyl-pyrimidine-2,4-dione, CHLORIDE ION, Thymidylate kinase
著者Merceron, R, Song, L, Munier-Lehmann, H, Van Calenbergh, S, Savvides, S.
登録日2017-04-22
公開日2018-03-21
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (2.35 Å)
主引用文献Structure Guided Lead Generation toward Nonchiral M. tuberculosis Thymidylate Kinase Inhibitors.
J. Med. Chem., 61, 2018
5NQ5
DownloadVisualize
BU of 5nq5 by Molmil
Mtb TMK crystal structure in complex with compound 1
分子名称: 5-methyl-1-[(3~{S})-1-[(3-phenoxyphenyl)methyl]piperidin-3-yl]pyrimidine-2,4-dione, Thymidylate kinase
著者Merceron, R, Song, L, Munier-Lehmann, H, Van Calenbergh, S, Savvides, S.
登録日2017-04-19
公開日2018-03-21
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (2.85 Å)
主引用文献Structure Guided Lead Generation toward Nonchiral M. tuberculosis Thymidylate Kinase Inhibitors.
J. Med. Chem., 61, 2018
5NRQ
DownloadVisualize
BU of 5nrq by Molmil
Mtb TMK crystal structure in complex with compound 33
分子名称: 1-[1-[[5-(3-chloranylphenoxy)pyridin-3-yl]methyl]piperidin-4-yl]-5-methyl-pyrimidine-2,4-dione, CHLORIDE ION, Thymidylate kinase
著者Merceron, R, Song, L, Munier-Lehmann, H, Van Calenbergh, S, Savvides, S.
登録日2017-04-25
公開日2018-08-08
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Mtb TMK crystal structure in complex with compound LS3112
To Be Published
2PLR
DownloadVisualize
BU of 2plr by Molmil
Crystal structure of dTMP kinase (st1543) from Sulfolobus Tokodaii Strain7
分子名称: 1,2-ETHANEDIOL, 2,3-DIHYDROXY-1,4-DITHIOBUTANE, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, ...
著者Kanaujia, S.P, Jeyakanthan, J, Rafi, Z.A, Sekar, K, Nakagawa, N, Ebihara, A, Kuramitsu, S, Shinkai, A, Shiro, Y, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI)
登録日2007-04-20
公開日2008-04-22
最終更新日2023-11-15
実験手法X-RAY DIFFRACTION (1.6 Å)
主引用文献Crystal structure of dTMP kinase (st1543) from Sulfolobus Tokodaii Strain7
To be Published
5NRN
DownloadVisualize
BU of 5nrn by Molmil
Mtb TMK crystal structure in complex with compound 3
分子名称: 5-methyl-1-[1-[(6-phenoxypyridin-2-yl)methyl]piperidin-4-yl]pyrimidine-2,4-dione, CHLORIDE ION, Thymidylate kinase
著者Merceron, R, Song, L, Munier-Lehmann, H, Van Calenbergh, S, Savvides, S.
登録日2017-04-25
公開日2018-08-08
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Mtb TMK crystal structure in complex with compound LS3080
To Be Published
5H5B
DownloadVisualize
BU of 5h5b by Molmil
Citrate ion bound crystal structure of thymidylate kinase (aq_969) from Aquifex Aeolicus VF5
分子名称: CITRATE ANION, Thymidylate kinase
著者Biswas, A, Jeyakanthan, J, Sekar, K.
登録日2016-11-05
公開日2017-06-28
最終更新日2023-11-08
実験手法X-RAY DIFFRACTION (2.05 Å)
主引用文献Structural studies of a hyperthermophilic thymidylate kinase enzyme reveal conformational substates along the reaction coordinate
FEBS J., 284, 2017
5H56
DownloadVisualize
BU of 5h56 by Molmil
ADP and dTDP bound Crystal structure of thymidylate kinase (aq_969) from Aquifex Aeolicus VF5
分子名称: (4S)-2-METHYL-2,4-PENTANEDIOL, ADENOSINE-5'-DIPHOSPHATE, CALCIUM ION, ...
著者Biswas, A, Jeyakanthan, J, Sekar, K, Kuramitsu, S, Yokoyama, S.
登録日2016-11-04
公開日2017-06-28
最終更新日2023-11-08
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献Structural studies of a hyperthermophilic thymidylate kinase enzyme reveal conformational substates along the reaction coordinate
FEBS J., 284, 2017
5H5K
DownloadVisualize
BU of 5h5k by Molmil
ATP and CMP bound Crystal structure of thymidylate kinase (aq_969) from Aquifex Aeolicus VF5
分子名称: 1,2-ETHANEDIOL, ADENOSINE-5'-TRIPHOSPHATE, CYTIDINE-5'-MONOPHOSPHATE, ...
著者Biswas, A, Jeyakanthan, J, Sekar, K.
登録日2016-11-06
公開日2017-06-28
最終更新日2023-11-08
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Structural studies of a hyperthermophilic thymidylate kinase enzyme reveal conformational substates along the reaction coordinate
FEBS J., 284, 2017

218500

件を2024-04-17に公開中

PDB statisticsPDBj update infoContact PDBjnumon