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1AX8
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Human obesity protein, leptin
分子名称: OBESITY PROTEIN
著者Zhang, F, Beals, J.M, Briggs, S.L, Clawson, D.K, Wery, J.-P, Schevitz, R.W.
登録日1997-10-31
公開日1998-11-25
最終更新日2012-05-09
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Crystal structure of the obese protein leptin-E100.
Nature, 387, 1997
8K6Z
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NMR structure of human leptin
分子名称: Leptin
著者Fan, X, Qin, R, Yuan, W, Fan, J, Huang, W, Lin, Z.
登録日2023-07-26
公開日2024-02-07
実験手法SOLUTION NMR
主引用文献The solution structure of human leptin reveals a conformational plasticity important for receptor recognition.
Structure, 32, 2024
7Z3Q
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Crystal structure of the human leptin:LepR-CRH2 encounter complex to 3.6 A resolution.
分子名称: Leptin, Leptin receptor
著者Verstraete, K, Verschueren, K, Alexandra, T, Savvides, S.N.
登録日2022-03-02
公開日2023-03-22
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (3.617 Å)
主引用文献Mechanism of receptor assembly via the pleiotropic adipokine Leptin.
Nat.Struct.Mol.Biol., 30, 2023
7Z3R
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Crystal structure of the mouse leptin:LepR-IgCRH2 complex to 2.95 A resolution.
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, Leptin, Leptin receptor
著者Verstraete, K, Verschueren, K, Savvides, S.N, Tsirigotaki, A.
登録日2022-03-02
公開日2023-03-22
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (2.951 Å)
主引用文献Mechanism of receptor assembly via the pleiotropic adipokine Leptin.
Nat.Struct.Mol.Biol., 30, 2023
7Z3P
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BU of 7z3p by Molmil
Crystal structure of the mouse leptin:LepR-CRH2 encounter complex to 1.95 A resolution.
分子名称: CALCIUM ION, DI(HYDROXYETHYL)ETHER, Leptin, ...
著者Tsirigotaki, A, Verschueren, K, Savvides, S.N, Verstraete, K.
登録日2022-03-02
公開日2023-03-22
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (1.943 Å)
主引用文献Mechanism of receptor assembly via the pleiotropic adipokine Leptin.
Nat.Struct.Mol.Biol., 30, 2023
8AVE
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BU of 8ave by Molmil
Human leptin in complex with the human LEP-R ectodomain fused to a C-terminal trimeric isoleucine GCN4 zipper (2:2 model)
分子名称: Leptin, Leptin receptor
著者Verstraete, K, Savvides, S.N, Verschueren, K.G, Tsirigotaki, A.
登録日2022-08-26
公開日2023-04-05
最終更新日2023-04-26
実験手法ELECTRON MICROSCOPY (5.62 Å)
主引用文献Mechanism of receptor assembly via the pleiotropic adipokine Leptin.
Nat.Struct.Mol.Biol., 30, 2023
8AVO
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BU of 8avo by Molmil
Human leptin in complex with the human LEP-R ectodomain fused to a C-terminal trimeric isoleucine GCN4 zipper (open 3:3 model).
分子名称: Leptin, Leptin receptor
著者Verstraete, K, Savvides, S.N, Verschueren, K.G, Tsirigotaki, A.
登録日2022-08-26
公開日2023-04-05
最終更新日2023-04-26
実験手法ELECTRON MICROSCOPY (6.84 Å)
主引用文献Mechanism of receptor assembly via the pleiotropic adipokine Leptin.
Nat.Struct.Mol.Biol., 30, 2023
8B7Q
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Cryo-EM structure for the mouse LEPR-CRH2:Leptin:LEPR-Ig complex following symmetry expansion in combination with local refinement
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, Leptin, Leptin receptor
著者Verstraete, K, Savvides, S.N, Verschueren, K.G, Tsirigotaki, A.
登録日2022-09-30
公開日2023-04-05
最終更新日2023-04-26
実験手法ELECTRON MICROSCOPY (4.02 Å)
主引用文献Mechanism of receptor assembly via the pleiotropic adipokine Leptin.
Nat.Struct.Mol.Biol., 30, 2023
8AVC
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BU of 8avc by Molmil
Mouse leptin:LEP-R complex cryoEM structure (3:3 model)
分子名称: Leptin, Leptin receptor, NICKEL (II) ION
著者Verstraete, K, Savvides, S.N, Verschueren, K.G, Tsirigotaki, A.
登録日2022-08-26
公開日2023-04-05
最終更新日2023-04-26
実験手法ELECTRON MICROSCOPY (4.6 Å)
主引用文献Mechanism of receptor assembly via the pleiotropic adipokine Leptin.
Nat.Struct.Mol.Biol., 30, 2023
8AVF
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BU of 8avf by Molmil
Human leptin in complex with the human LEP-R ectodomain fused to a C-terminal trimeric isoleucine GCN4 zipper (closed 3:3 model)
分子名称: Leptin, Leptin receptor
著者Verstraete, K, Savvides, S.N, Verschueren, K.G, Tsirigotaki, A.
登録日2022-08-26
公開日2023-04-05
最終更新日2023-04-26
実験手法ELECTRON MICROSCOPY (6.45 Å)
主引用文献Mechanism of receptor assembly via the pleiotropic adipokine Leptin.
Nat.Struct.Mol.Biol., 30, 2023
8AVD
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BU of 8avd by Molmil
Cryo-EM structure for a 3:3 complex between mouse leptin and the mouse LEP-R ectodomain (local refinement)
分子名称: Leptin, Leptin receptor, NICKEL (II) ION
著者Verstraete, K, Savvides, S.N, Verschueren, K.G, Tsirigotaki, A.
登録日2022-08-26
公開日2023-04-05
最終更新日2023-04-26
実験手法ELECTRON MICROSCOPY (4.42 Å)
主引用文献Mechanism of receptor assembly via the pleiotropic adipokine Leptin.
Nat.Struct.Mol.Biol., 30, 2023
8AVB
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BU of 8avb by Molmil
Cryo-EM structure for mouse leptin in complex with the mouse LEP-R ectodomain (1:2 mLEP:mLEPR model).
分子名称: Leptin, Leptin receptor
著者Verstraete, K, Savvides, S.N, Verschueren, K.G, Tsirigotaki, A.
登録日2022-08-26
公開日2023-04-05
最終更新日2023-07-26
実験手法ELECTRON MICROSCOPY (4.43 Å)
主引用文献Mechanism of receptor assembly via the pleiotropic adipokine Leptin.
Nat.Struct.Mol.Biol., 30, 2023
8DH9
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BU of 8dh9 by Molmil
Leptin-bound leptin receptor complex-D3-D7
分子名称: Leptin, Leptin receptor
著者Saxton, R.A, Caveney, N.A, Garcia, K.C.
登録日2022-06-25
公開日2023-04-19
実験手法ELECTRON MICROSCOPY (4.5 Å)
主引用文献Structural insights into the mechanism of leptin receptor activation.
Nat Commun, 14, 2023
8DH8
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BU of 8dh8 by Molmil
Leptin-bound leptin receptor complex-full ECD
分子名称: Leptin, Leptin receptor
著者Saxton, R.A, Caveney, N.A, Garcia, K.C.
登録日2022-06-25
公開日2023-04-19
実験手法ELECTRON MICROSCOPY (5.9 Å)
主引用文献Structural insights into the mechanism of leptin receptor activation.
Nat Commun, 14, 2023
8DHA
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BU of 8dha by Molmil
Leptin-bound leptin receptor complex- focused interaction
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, Leptin, Leptin receptor
著者Saxton, R.A, Caveney, N.A, Garcia, K.C.
登録日2022-06-25
公開日2023-04-19
実験手法ELECTRON MICROSCOPY (3.8 Å)
主引用文献Structural insights into the mechanism of leptin receptor activation.
Nat Commun, 14, 2023

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件を2024-04-24に公開中

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