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2P9R
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Human alpha2-macroglogulin is composed of multiple domains, as predicted by homology with complement component C3
分子名称: Alpha-2-macroglobulin
著者Doan, N.
登録日2007-03-26
公開日2007-08-21
最終更新日2024-02-21
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Human alpha2-macroglobulin is composed of multiple domains, as predicted by homology with complement component C3.
Biochem.J., 407, 2007
4LNV
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Crystal Structure of TEP1s
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Thioester-containing protein I
著者Le, B.V, Williams, M, Logarajah, S, Baxter, R.H.G.
登録日2013-07-12
公開日2013-07-24
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (3.7 Å)
主引用文献Molecular basis for genetic resistance of Anopheles gambiae to Plasmodium: structural analysis of TEP1 susceptible and resistant alleles.
Plos Pathog., 8, 2012
6TAV
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Crystal structure of endopeptidase-induced alpha2-macroglobulin
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Alpha-2-macroglobulin, ...
著者Gomis-Ruth, F.X, Duquerroy, S, Trapani, S, Marrero, A, Goulas, T, Guevara, T, Andersen, G.A, Sottrup-Jensen, L, Navaza, J.
登録日2019-10-30
公開日2021-05-12
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (4.2 Å)
主引用文献Cryo-EM structures shows the mechanistic basis of pan-peptidase inhibition by human alpha2-macroglobulin
Proc.Natl.Acad.Sci.USA, 2022
3T4A
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Structure of a truncated form of Staphylococcal Complement Inhibitor B bound to human C3c at 3.4 Angstrom resolution
分子名称: Complement C3 beta chain, Complement C3c alpha' chain fragment 1, Complement C3c alpha' chain fragment 2, ...
著者Garcia, B.L, Geisbrecht, B.V, Summers, B.J.
登録日2011-07-25
公開日2011-11-23
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (3.4 Å)
主引用文献Diversity in the C3b Convertase Contact Residues and Tertiary Structures of the Staphylococcal Complement Inhibitor (SCIN) Protein Family.
J.Biol.Chem., 287, 2012
6EHG
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complement component C3b in complex with a nanobody
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, Complement C3, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
著者Jensen, R.K, Andersen, K.R, Gadeberg, T.A.F, Laursen, N.S, Andersen, G.R.
登録日2017-09-13
公開日2018-02-14
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (2.65 Å)
主引用文献A potent complement factor C3-specific nanobody inhibiting multiple functions in the alternative pathway of human and murine complement.
J. Biol. Chem., 293, 2018
5O35
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Structure of complement proteins complex
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Complement C3, Complement factor H,Complement factor H
著者Xue, X, Wu, J, Forneris, F, Gros, P.
登録日2017-05-23
公開日2017-06-28
最終更新日2020-07-29
実験手法X-RAY DIFFRACTION (4.2 Å)
主引用文献Regulator-dependent mechanisms of C3b processing by factor I allow differentiation of immune responses.
Nat. Struct. Mol. Biol., 24, 2017
7ZGJ
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Trypanosoma brucei gambiense ISG65 in complex with human complement component C3
分子名称: 65 kDa invariant surface glycoprotein, putative, Complement C3, ...
著者Suelzen, H, Zoll, S.
登録日2022-04-03
公開日2023-04-05
最終更新日2024-03-27
実験手法ELECTRON MICROSCOPY (3.58 Å)
主引用文献Cryo-EM structures of Trypanosoma brucei gambiense ISG65 with human complement C3 and C3b and their roles in alternative pathway restriction.
Nat Commun, 14, 2023
7ZGK
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Trypanosoma brucei gambiense ISG65 in complex with human complement component C3b
分子名称: 65 kDa invariant surface glycoprotein, putative, Complement C3 beta chain, ...
著者Suelzen, H, Zoll, S.
登録日2022-04-03
公開日2023-04-05
最終更新日2024-03-27
実験手法ELECTRON MICROSCOPY (3.59 Å)
主引用文献Cryo-EM structures of Trypanosoma brucei gambiense ISG65 with human complement C3 and C3b and their roles in alternative pathway restriction.
Nat Commun, 14, 2023
5O32
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The structure of complement complex
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ...
著者Xue, X, Wu, J, Forneris, F, Gros, P.
登録日2017-05-23
公開日2017-06-28
最終更新日2020-07-29
実験手法X-RAY DIFFRACTION (4.206209 Å)
主引用文献Regulator-dependent mechanisms of C3b processing by factor I allow differentiation of immune responses.
Nat. Struct. Mol. Biol., 24, 2017
8ENU
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Structure of the C3bB proconvertase in complex with lufaxin
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, Complement C3 beta chain, Complement C3b alpha' chain, ...
著者Andersen, J.F, Lei, H.
登録日2022-09-30
公開日2023-08-09
最終更新日2024-02-21
実験手法ELECTRON MICROSCOPY (3.22 Å)
主引用文献A bispecific inhibitor of complement and coagulation blocks activation in complementopathy models via a novel mechanism.
Blood, 141, 2023
8EOK
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Structure of the C3bB proconvertase in complex with lufaxin and factor Xa
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, Activated factor Xa heavy chain, Complement C3 beta chain, ...
著者Andersen, J.F, Lei, H.
登録日2022-10-03
公開日2023-08-30
実験手法ELECTRON MICROSCOPY (3.53 Å)
主引用文献A bispecific inhibitor of complement and coagulation blocks activation in complementopathy models via a novel mechanism.
Blood, 141, 2023
6H03
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OPEN CONFORMATION OF THE MEMBRANE ATTACK COMPLEX
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Complement C5,Complement C5, ...
著者Menny, A, Serna, M, Boyd, C.M, Gardner, S, Joseph, A.P, Topf, M, Bubeck, D.
登録日2018-07-06
公開日2018-12-19
最終更新日2020-07-29
実験手法ELECTRON MICROSCOPY (5.6 Å)
主引用文献CryoEM reveals how the complement membrane attack complex ruptures lipid bilayers.
Nat Commun, 9, 2018
6H04
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Closed conformation of the Membrane Attack Complex
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Complement C5,Complement C5, ...
著者Menny, A, Serna, M, Boyd, C.M, Gardner, S, Joseph, A.P, Topf, M, Bubeck, D.
登録日2018-07-06
公開日2018-12-19
最終更新日2020-07-29
実験手法ELECTRON MICROSCOPY (5.6 Å)
主引用文献CryoEM reveals how the complement membrane attack complex ruptures lipid bilayers.
Nat Commun, 9, 2018
2A74
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Human Complement Component C3c
分子名称: 2-acetamido-2-deoxy-alpha-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-alpha-D-glucopyranose, Complement Component C3c, GLYCEROL, ...
著者Janssen, B.J.C, Huizinga, E.G, Raaijmakers, H.C.A, Roos, A, Daha, M.R, Nilsson-Ekdahl, K, Nilsson, B, Gros, P.
登録日2005-07-04
公開日2005-09-27
最終更新日2020-07-29
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Structures of complement component C3 provide insights into the function and evolution of immunity.
Nature, 437, 2005
2A73
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Human Complement Component C3
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Complement C3, alpha-D-mannopyranose-(1-3)-[beta-D-mannopyranose-(1-6)]alpha-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose
著者Janssen, B.J.C, Huizinga, E.G, Raaijmakers, H.C.A, Roos, A, Daha, M.R, Nilsson-Ekdahl, K, Nilsson, B, Gros, P.
登録日2005-07-04
公開日2005-09-27
最終更新日2023-08-23
実験手法X-RAY DIFFRACTION (3.3 Å)
主引用文献Structures of complement component C3 provide insights into the function and evolution of immunity.
Nature, 437, 2005
7VOO
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BU of 7voo by Molmil
Induced alpha-2-macroglobulin monomer
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Alpha-2-macroglobulin, ...
著者Huang, X, Wang, Y, Ping, Z.
登録日2021-10-14
公開日2022-10-19
最終更新日2022-12-07
実験手法ELECTRON MICROSCOPY (3.9 Å)
主引用文献Cryo-EM structures reveal the dynamic transformation of human alpha-2-macroglobulin working as a protease inhibitor.
Sci China Life Sci, 65, 2022
7VON
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Native alpha-2-macroglobulin monomer
分子名称: Alpha-2-macroglobulin
著者Huang, X, Wang, Y.
登録日2021-10-14
公開日2022-11-16
最終更新日2022-12-07
実験手法ELECTRON MICROSCOPY (5.2 Å)
主引用文献Cryo-EM structures reveal the dynamic transformation of human alpha-2-macroglobulin working as a protease inhibitor.
Sci China Life Sci, 65, 2022
4ZIQ
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BU of 4ziq by Molmil
Crystal structure of trypsin activated alpha-2-macroglobulin from Escherichia coli.
分子名称: CHLORIDE ION, GLYCEROL, Uncharacterized lipoprotein YfhM
著者Garcia-Ferrer, I, Arede, P, Gomez-Blanco, J, Luque, D, Duquerroy, S, Caston, J.R, Goulas, T, Gomis-Ruth, X.F.
登録日2015-04-28
公開日2015-06-10
最終更新日2015-07-15
実験手法X-RAY DIFFRACTION (2.55 Å)
主引用文献Structural and functional insights into Escherichia coli alpha 2-macroglobulin endopeptidase snap-trap inhibition.
Proc.Natl.Acad.Sci.USA, 112, 2015
6YO6
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Structure of iC3b1
分子名称: hC3Nb1, iC3b1 alpha chain, iC3b1 beta chain
著者Jensen, R.K, Andersen, G.R.
登録日2020-04-14
公開日2021-02-24
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (6 Å)
主引用文献Complement Receptor 3 Forms a Compact High-Affinity Complex with iC3b.
J Immunol., 206, 2021
8OQ3
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Structure of methylamine treated human complement C3
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, Complement C3, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
著者Gadeberg, T.A.F, Andersen, G.R.
登録日2023-04-11
公開日2024-02-21
実験手法ELECTRON MICROSCOPY (2.9 Å)
主引用文献Structure of methylamine treated human complement C3
To Be Published
8OVB
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Human Complement C3b in complex with Trypanosoma brucei ISG65.
分子名称: Complement C3, Complement C3f fragment, ISG65 G
著者Cook, A.D, Higgins, M.K.
登録日2023-04-25
公開日2024-02-14
実験手法ELECTRON MICROSCOPY (3.4 Å)
主引用文献Molecular mechanism of complement factor C3b inhibition by the trypanosome ISG65 receptor.
To be published
3CU7
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Human Complement Component 5
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CADMIUM ION, ...
著者Fredslund, F, Andersen, G.R.
登録日2008-04-16
公開日2008-06-10
最終更新日2023-11-01
実験手法X-RAY DIFFRACTION (3.105 Å)
主引用文献Structure of and influence of a tick complement inhibitor on human complement component 5
Nat.Immunol., 9, 2008
6YSQ
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The hC4Nb8 complement inhibitory nanobody in complex with C4b
分子名称: Complement C4 beta chain, Complement C4 gamma chain, Complement C4-A alpha chain, ...
著者Zarantonello, A, Laursen, N.S, Andersen, G.R.
登録日2020-04-23
公開日2020-06-24
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (3.3 Å)
主引用文献An Ultrahigh-Affinity Complement C4b-Specific Nanobody Inhibits In Vivo Assembly of the Classical Pathway Proconvertase.
J Immunol., 205, 2020
5A42
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Cryo-EM single particle 3D reconstruction of the native conformation of E. coli alpha-2-macroglobulin (ECAM)
分子名称: UNCHARACTERIZED LIPOPROTEIN YFHM
著者Garcia-Ferrer, I, Arede, P, Gomez-Blanco, J, Luque, D, Duquerroy, S, Caston, J.R, Goulas, T, Gomis-Ruth, F.X.
登録日2015-06-04
公開日2015-07-29
最終更新日2017-08-23
実験手法ELECTRON MICROSCOPY (16 Å)
主引用文献Structural and Functional Insights Into Escherichia Coli Alpha2- Macroglobulin Endopeptidase Snap-Trap Inhibition.
Proc.Natl.Acad.Sci.USA, 112, 2015
3FRP
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Crystal Structure of Cobra Venom Factor, a Co-factor for C3- and C5 convertase CVFBb
分子名称: CALCIUM ION, Cobra venom factor alpha chain, Cobra venom factor beta chain, ...
著者Krishnan, V, Narayana, S.V.L.
登録日2009-01-08
公開日2009-04-28
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (2.61 Å)
主引用文献The Crystal Structure of Cobra Venom Factor, a Cofactor for C3- and C5-Convertase CVFBb.
Structure, 17, 2009

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