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4JKV
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Structure of the human smoothened 7TM receptor in complex with an antitumor agent
分子名称: (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, 4-fluoro-N-methyl-N-{1-[4-(1-methyl-1H-pyrazol-5-yl)phthalazin-1-yl]piperidin-4-yl}-2-(trifluoromethyl)benzamide, DI(HYDROXYETHYL)ETHER, ...
著者Wang, C, Wu, H, Katritch, V, Han, G.W, Huang, X, Liu, W, Siu, F.Y, Roth, B.L, Cherezov, V, Stevens, R.C, GPCR Network (GPCR)
登録日2013-03-11
公開日2013-04-24
最終更新日2017-11-15
実験手法X-RAY DIFFRACTION (2.45 Å)
主引用文献Structure of the human smoothened receptor bound to an antitumour agent.
Nature, 497, 2013
4QIM
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Structure of the human smoothened receptor in complex with ANTA XV
分子名称: 2-{6-[4-(4-benzylphthalazin-1-yl)piperazin-1-yl]pyridin-3-yl}propan-2-ol, Smoothened homolog/Soluble cytochrome b562 chimeric protein, ZINC ION
著者Wang, C, Wu, H, Evron, T, Vardy, E, Han, G.W, Huang, X.-P, Hufeisen, S.J, Mangano, T.J, Urban, D.J, Katritch, V, Cherezov, V, Caron, M.G, Roth, B.L, Stevens, R.C, GPCR Network (GPCR)
登録日2014-05-31
公開日2014-07-23
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (2.61 Å)
主引用文献Structural basis for Smoothened receptor modulation and chemoresistance to anticancer drugs.
Nat Commun, 5, 2014
4QIN
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BU of 4qin by Molmil
Structure of the human smoothened receptor in complex with SAG1.5
分子名称: 3-chloro-4,7-difluoro-N-[trans-4-(methylamino)cyclohexyl]-N-[3-(pyridin-4-yl)benzyl]-1-benzothiophene-2-carboxamide, Smoothened homolog/Soluble cytochrome b562 chimeric protein
著者Wang, C, Wu, H, Evron, T, Vardy, E, Han, G.W, Huang, X.-P, Hufeisen, S.J, Mangano, T.J, Urban, D.J, Katritch, V, Cherezov, V, Caron, M.G, Roth, B.L, Stevens, R.C, GPCR Network (GPCR)
登録日2014-05-31
公開日2014-07-23
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献Structural basis for Smoothened receptor modulation and chemoresistance to anticancer drugs.
Nat Commun, 5, 2014
4N4W
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BU of 4n4w by Molmil
Structure of the human smoothened receptor in complex with SANT-1.
分子名称: (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, (E)-N-(4-benzylpiperazin-1-yl)-1-(3,5-dimethyl-1-phenyl-1H-pyrazol-4-yl)methanimine, Cytochrome b(562),Smoothened homolog, ...
著者Wang, C, Wu, H, Han, G.W, Cherezov, V, Stevens, R.C, GPCR Network (GPCR)
登録日2013-10-08
公開日2014-01-22
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Structural basis for Smoothened receptor modulation and chemoresistance to anticancer drugs.
Nat Commun, 5, 2014
4O9R
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BU of 4o9r by Molmil
Human Smoothened Receptor structure in complex with cyclopamine
分子名称: Cyclopamine, Smoothened homolog/Soluble cytochrome b562 chimeric protein
著者Wang, C, Weierstall, U, James, D, White, T.A, Wang, D, Liu, W, Spence, J.C.H, Doak, R.B, Nelson, G, Fromme, P, Fromme, R, Grotjohann, I, Kupitz, C, Zatsepin, N.A, Liu, H, Basu, S, Wacker, D, Han, G.W, Katritch, V, Boutet, S, Messerschmidt, M, Willams, G.J, Koglin, J.E, Seibert, M.M, Klinker, M, Gati, C, Shoeman, R.L, Barty, A, Chapman, H.N, Kirian, R.A, Beyerlein, K.R, Stevens, R.C, Li, D, Shah, S.T.A, Howe, N, Caffrey, M, Cherezov, V, GPCR Network (GPCR)
登録日2014-01-02
公開日2014-03-05
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (3.204 Å)
主引用文献Lipidic cubic phase injector facilitates membrane protein serial femtosecond crystallography.
Nat Commun, 5, 2014
8CXO
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Cryo-EM structure of the unliganded mSMO-PGS2 in a lipidic environment
分子名称: CHOLESTEROL, Smoothened homolog, GlgA glycogen synthase chimera
著者Zhang, K, Wu, H, Hoppe, N, Manglik, A, Cheng, Y.
登録日2022-05-22
公開日2022-08-03
実験手法ELECTRON MICROSCOPY (3.7 Å)
主引用文献Fusion protein strategies for cryo-EM study of G protein-coupled receptors.
Nat Commun, 13, 2022
7EVW
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Fzd7 -Gs complex
分子名称: Frizzled-7, Ggamma, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ...
著者Chen, B, Xu, L, Xu, F.
登録日2021-05-23
公開日2021-08-04
最終更新日2022-02-16
実験手法ELECTRON MICROSCOPY (3.22 Å)
主引用文献Cryo-EM structure of constitutively active human Frizzled 7 in complex with heterotrimeric G s .
Cell Res., 31, 2021
6BD4
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BU of 6bd4 by Molmil
Crystal structure of human apo-Frizzled4 receptor
分子名称: (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, Frizzled-4/Rubredoxin chimeric protein, OLEIC ACID, ...
著者Yang, S, Wu, Y, Pu, M, Chen, Y, Dong, S, Guo, Y, Han, G.Y, Stevens, R.C, Zhao, S, Xu, F.
登録日2017-10-21
公開日2018-08-22
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Crystal structure of the Frizzled 4 receptor in a ligand-free state.
Nature, 560, 2018
7ZI0
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Structure of human Smoothened in complex with cholesterol and SAG
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 3-chloro-N-[trans-4-(methylamino)cyclohexyl]-N-{[3-(pyridin-4-yl)phenyl]methyl}-1-benzothiophene-2-carboxamide, CHOLESTEROL, ...
著者Byrne, E.F.X, Woolley, R.E, Ansell, B, Sansom, M.S.P, Newstead, S, Siebold, C.
登録日2022-04-07
公開日2022-06-15
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (3 Å)
主引用文献Patched 1 regulates Smoothened by controlling sterol binding to its extracellular cysteine-rich domain.
Sci Adv, 8, 2022
5L7I
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BU of 5l7i by Molmil
Structure of human Smoothened in complex with Vismodegib
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-chloranyl-~{N}-(4-chloranyl-3-pyridin-2-yl-phenyl)-4-methylsulfonyl-benzamide, SODIUM ION, ...
著者Byrne, E.X.B, Sircar, R, Miller, P.S, Hedger, G, Luchetti, G, Nachtergaele, S, Tully, M.D, Mydock-McGrane, L, Covey, D.F, Rambo, R.F, Sansom, M.S.P, Newstead, S, Rohatgi, R, Siebold, C.
登録日2016-06-03
公開日2016-07-20
最終更新日2024-01-10
実験手法X-RAY DIFFRACTION (3.3 Å)
主引用文献Structural basis of Smoothened regulation by its extracellular domains.
Nature, 535, 2016
5L7D
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Structure of human Smoothened in complex with cholesterol
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, CHOLESTEROL, SODIUM ION, ...
著者Byrne, E.F.X, Sircar, R, Miller, P.S, Hedger, G, Luchetti, G, Nachtergaele, S, Tully, M.D, Mydock-McGrane, L, Covey, D.F, Rambo, R.P, Sansom, M.S.P, Newstead, S, Rohatgi, R, Siebold, C.
登録日2016-06-03
公開日2016-07-20
最終更新日2024-01-10
実験手法X-RAY DIFFRACTION (3.2 Å)
主引用文献Structural basis of Smoothened regulation by its extracellular domains.
Nature, 535, 2016
5V57
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3.0A SYN structure of the multi-domain human smoothened receptor in complex with TC114
分子名称: (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, FLAVIN MONONUCLEOTIDE, N-methyl-N-[1-[4-(2-methylpyrazol-3-yl)phthalazin-1-yl]piperidin-4-yl]-4-nitro-2-(trifluoromethyl)benzamide, ...
著者Zhang, X, Zhao, F, Wu, Y, Yang, J, Han, G.W, Zhao, S, Ishchenko, A, Ye, L, Lin, X, Ding, K, Dharmarajan, V, Griffin, P.R, Gati, C, Nelson, G, Hunter, M.S, Hanson, M.A, Cherezov, V, Stevens, R.C, Tan, W, Tao, H, Xu, F.
登録日2017-03-13
公開日2017-05-24
最終更新日2023-11-08
実験手法X-RAY DIFFRACTION (3 Å)
主引用文献Crystal structure of a multi-domain human smoothened receptor in complex with a super stabilizing ligand.
Nat Commun, 8, 2017
5V56
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2.9A XFEL structure of the multi-domain human smoothened receptor (with E194M mutation) in complex with TC114
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, FLAVIN MONONUCLEOTIDE, N-methyl-N-[1-[4-(2-methylpyrazol-3-yl)phthalazin-1-yl]piperidin-4-yl]-4-nitro-2-(trifluoromethyl)benzamide, ...
著者Zhang, X, Zhao, F, Wu, Y, Yang, J, Han, G.W, Zhao, S, Ishchenko, A, Ye, L, Lin, X, Ding, K, Dharmarajan, V, Griffin, P.R, Gati, C, Nelson, G, Hunter, M.S, Hanson, M.A, Cherezov, V, Stevens, R.C, Tan, W, Tao, H, Xu, F.
登録日2017-03-13
公開日2017-05-24
最終更新日2023-11-08
実験手法X-RAY DIFFRACTION (2.9 Å)
主引用文献Crystal structure of a multi-domain human smoothened receptor in complex with a super stabilizing ligand.
Nat Commun, 8, 2017
6O3C
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BU of 6o3c by Molmil
Crystal structure of active Smoothened bound to SAG21k, cholesterol, and NbSmo8
分子名称: (2S)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, 2-acetamido-2-deoxy-beta-D-glucopyranose, 3-chloro-4,7-difluoro-N-{[2-methoxy-5-(pyridin-4-yl)phenyl]methyl}-N-[trans-4-(methylamino)cyclohexyl]-1-benzothiophene-2-carboxamide, ...
著者Deshpande, I.S, Liang, J, Hedeen, D, Roberts, K.J, Zhang, Y, Ha, B, Latorraca, N.R, Faust, B, Dror, R.O, Beachy, P.A, Myers, B.R, Manglik, A.
登録日2019-02-26
公開日2019-07-03
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Smoothened stimulation by membrane sterols drives Hedgehog pathway activity.
Nature, 571, 2019
6OT0
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BU of 6ot0 by Molmil
Structure of human Smoothened-Gi complex
分子名称: 17-[3-(3,3-DIMETHYL-OXIRANYL)-1-METHYL-PROPYL]-10,13-DIMETHYL-2,3,4,7,8,9,10,11,12,13,14,15,16,17-TETRADECAHYDRO-1H-CYCLOPENTA[A]PHENANTHREN-3-OL, Fab heavy chain, Fab light chain, ...
著者Qi, X, Li, X.
登録日2019-05-02
公開日2019-06-12
最終更新日2019-12-18
実験手法ELECTRON MICROSCOPY (3.9 Å)
主引用文献Cryo-EM structure of oxysterol-bound human Smoothened coupled to a heterotrimeric Gi.
Nature, 571, 2019
6WW2
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Structure of human Frizzled5 by fiducial-assisted cryo-EM
分子名称: Frizzled-5,Soluble cytochrome b562, anti-BRIL Fab Heavy chain, anti-BRIL Fab Light chain, ...
著者Tsutsumi, N, Jude, K.M, Gati, C, Garcia, K.C.
登録日2020-05-07
公開日2020-08-19
実験手法ELECTRON MICROSCOPY (3.7 Å)
主引用文献Structure of human Frizzled5 by fiducial-assisted cryo-EM supports a heterodimeric mechanism of canonical Wnt signaling.
Elife, 9, 2020
6XBM
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BU of 6xbm by Molmil
Structure of human SMO-Gi complex with 24(S),25-EC
分子名称: 17-[3-(3,3-DIMETHYL-OXIRANYL)-1-METHYL-PROPYL]-10,13-DIMETHYL-2,3,4,7,8,9,10,11,12,13,14,15,16,17-TETRADECAHYDRO-1H-CYC LOPENTA[A]PHENANTHREN-3-OL, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ...
著者Qi, X, Long, T, Li, X.
登録日2020-06-06
公開日2020-09-30
最終更新日2020-11-25
実験手法ELECTRON MICROSCOPY (3.15 Å)
主引用文献Sterols in an intramolecular channel of Smoothened mediate Hedgehog signaling.
Nat.Chem.Biol., 16, 2020
6XBL
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Structure of human SMO-Gi complex with SAG
分子名称: 3-chloro-N-[trans-4-(methylamino)cyclohexyl]-N-{[3-(pyridin-4-yl)phenyl]methyl}-1-benzothiophene-2-carboxamide, CHOLESTEROL, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ...
著者Qi, X, Li, X.
登録日2020-06-06
公開日2020-09-30
最終更新日2020-11-25
実験手法ELECTRON MICROSCOPY (3.9 Å)
主引用文献Sterols in an intramolecular channel of Smoothened mediate Hedgehog signaling.
Nat.Chem.Biol., 16, 2020
6XBK
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BU of 6xbk by Molmil
Structure of human SMO-G111C/I496C complex with Gi
分子名称: CHOLESTEROL, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ...
著者Qi, X, Long, T, Li, X.
登録日2020-06-06
公開日2020-09-30
最終更新日2020-11-25
実験手法ELECTRON MICROSCOPY (3.24 Å)
主引用文献Sterols in an intramolecular channel of Smoothened mediate Hedgehog signaling.
Nat.Chem.Biol., 16, 2020
6XBJ
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BU of 6xbj by Molmil
Structure of human SMO-D384R complex with Gi
分子名称: CHOLESTEROL, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ...
著者Qi, X, Long, T, Li, X.
登録日2020-06-06
公開日2020-09-30
最終更新日2020-11-25
実験手法ELECTRON MICROSCOPY (3.88 Å)
主引用文献Sterols in an intramolecular channel of Smoothened mediate Hedgehog signaling.
Nat.Chem.Biol., 16, 2020
8JHB
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BU of 8jhb by Molmil
FZD6 Gs complex
分子名称: Frizzled-6, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ...
著者Xu, F, Zhang, Z.
登録日2023-05-23
公開日2024-01-17
実験手法ELECTRON MICROSCOPY (3.3 Å)
主引用文献A framework for Frizzled-G protein coupling and implications to the PCP signaling pathways.
Cell Discov, 10, 2024
8J9O
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Cryo-EM structure of inactive FZD1
分子名称: Frizzled-1,Soluble cytochrome b562, anti-BRIL Fab Heavy Chain, anti-BRIL Fab Light Chain, ...
著者Lin, X, Xu, F.
登録日2023-05-04
公開日2024-01-17
実験手法ELECTRON MICROSCOPY (3.4 Å)
主引用文献A framework for Frizzled-G protein coupling and implications to the PCP signaling pathways.
Cell Discov, 10, 2024
8JH7
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BU of 8jh7 by Molmil
FZD6 in inactive state
分子名称: Frizzled-6,Soluble cytochrome b562, anti-BRIL Fab Heavy chain, anti-BRIL Fab Light chain, ...
著者Xu, F, Zhang, Z.
登録日2023-05-22
公開日2024-01-17
実験手法ELECTRON MICROSCOPY (3.2 Å)
主引用文献A framework for Frizzled-G protein coupling and implications to the PCP signaling pathways.
Cell Discov, 10, 2024
8JHC
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BU of 8jhc by Molmil
FZD3 in inactive state
分子名称: Frizzled-3,Soluble cytochrome b562, anti-BRIL Fab Heavy chain, anti-BRIL Fab Light chain, ...
著者Xu, F, Zhang, Z.
登録日2023-05-23
公開日2024-01-17
実験手法ELECTRON MICROSCOPY (3.3 Å)
主引用文献A framework for Frizzled-G protein coupling and implications to the PCP signaling pathways.
Cell Discov, 10, 2024
8JHI
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BU of 8jhi by Molmil
FZD3-Gs complex
分子名称: Frizzled-3, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ...
著者Xu, F, Zhang, Z.
登録日2023-05-23
公開日2024-01-17
実験手法ELECTRON MICROSCOPY (3.2 Å)
主引用文献A framework for Frizzled-G protein coupling and implications to the PCP signaling pathways.
Cell Discov, 10, 2024

 

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