6EHA
 
 | | Heme oxygenase 1 in complex with inhibitor | | 分子名称: | 1-(3-imidazol-1-ylpropyl)-5-(2-methylpropyl)-4-phenyl-imidazole, Heme oxygenase 1, PROTOPORPHYRIN IX CONTAINING FE | | 著者 | Grudnik, P, Mieczkowski, M. | | 登録日 | 2017-09-12 | | 公開日 | 2018-10-10 | | 最終更新日 | 2019-10-23 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Development and characterization of a new inhibitor of heme oxygenase activity for cancer treatment.
Arch.Biochem.Biophys., 671, 2019
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7EQH
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4MEC
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4WMH
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3CZY
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7CKA
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4WD4
 | | Crystal structure of human HO1 H25R | | 分子名称: | 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, Heme oxygenase 1, PROTOPORPHYRIN IX CONTAINING FE | | 著者 | Caaveiro, J.M.M, Morante, K, Sigala, P, Tsumoto, K. | | 登録日 | 2014-09-06 | | 公開日 | 2015-09-09 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (2.95 Å) | | 主引用文献 | In-Cell Enzymology To Probe His-Heme Ligation in Heme Oxygenase Catalysis
Biochemistry, 55, 2016
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5BTQ
 | | Crystal structure of human heme oxygenase 1 H25R with biliverdin bound | | 分子名称: | BILIVERDINE IX ALPHA, Heme oxygenase 1, SULFATE ION | | 著者 | Caaveiro, J.M.M, Morante, K, Sigala, P, Tsumoto, K. | | 登録日 | 2015-06-03 | | 公開日 | 2016-06-08 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (2.08 Å) | | 主引用文献 | In-Cell Enzymology To Probe His-Heme Ligation in Heme Oxygenase Catalysis
Biochemistry, 55, 2016
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5KZL
 | | Structure of Heme Oxygenase from Leptospira interrogans | | 分子名称: | Heme oxygenase, PROTOPORPHYRIN IX CONTAINING FE | | 著者 | Klinke, S, Soldano, A, Otero, L.H, Rivera, M, Catalano-Dupuy, D.L, Ceccarelli, E.A. | | 登録日 | 2016-07-25 | | 公開日 | 2017-07-26 | | 最終更新日 | 2023-10-04 | | 実験手法 | X-RAY DIFFRACTION (1.73 Å) | | 主引用文献 | Structural and mutational analyses of the Leptospira interrogans virulence-related heme oxygenase provide insights into its catalytic mechanism.
PLoS ONE, 12, 2017
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1DVE
 | | CRYSTAL STRUCTURE OF RAT HEME OXYGENASE-1 IN COMPLEX WITH HEME | | 分子名称: | HEME OXYGENASE-1, PROTOPORPHYRIN IX CONTAINING FE | | 著者 | Sugishima, M, Omata, Y, Kakuta, Y, Sakamoto, H, Noguchi, M, Fukuyama, K. | | 登録日 | 2000-01-20 | | 公開日 | 2000-04-12 | | 最終更新日 | 2024-02-07 | | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | | 主引用文献 | Crystal structure of rat heme oxygenase-1 in complex with heme.
FEBS Lett., 471, 2000
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1DVG
 | | CRYSTAL STRUCTURE OF RAT HEME OXYGENASE-1 IN COMPLEX WITH HEME; SELELENO-METHIONINE DERIVATIVE, MUTATED AT M51T,M93L,M155L,M191L. | | 分子名称: | HEME OXYGENASE-1, PROTOPORPHYRIN IX CONTAINING FE | | 著者 | Sugishima, M, Omata, Y, Kakuta, Y, Sakamoto, H, Noguchi, M, Fukuyama, K. | | 登録日 | 2000-01-20 | | 公開日 | 2000-04-12 | | 最終更新日 | 2021-11-03 | | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | | 主引用文献 | Crystal structure of rat heme oxygenase-1 in complex with heme.
FEBS Lett., 471, 2000
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3TGM
 | | X-Ray Crystal Structure of Human Heme Oxygenase-1 in Complex with 1-(1H-imidazol-1-yl)-4,4-diphenyl-2 butanone | | 分子名称: | 1-(1H-imidazol-1-yl)-4,4-diphenylbutan-2-one, HEXANE-1,6-DIOL, Heme oxygenase 1, ... | | 著者 | Rahman, M.N, Jia, Z. | | 登録日 | 2011-08-17 | | 公開日 | 2012-02-01 | | 最終更新日 | 2023-09-13 | | 実験手法 | X-RAY DIFFRACTION (2.85 Å) | | 主引用文献 | A novel, "double-clamp" binding mode for human heme oxygenase-1 inhibition.
Plos One, 7, 2012
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2Z68
 | | Crystal Structure Of An Artificial Metalloprotein: Cr[N-salicylidene-4-amino-3-hydroxyhydrocinnamic acid]/Wild Type Heme oxygenase | | 分子名称: | Heme oxygenase, SODIUM ION, SULFATE ION, ... | | 著者 | Yokoi, N, Unno, M, Ueno, T, Ikeda-Saito, M, Watanabe, Y. | | 登録日 | 2007-07-24 | | 公開日 | 2007-08-28 | | 最終更新日 | 2023-11-01 | | 実験手法 | X-RAY DIFFRACTION (1.58 Å) | | 主引用文献 | Ligand design for improvement of thermal stabilityof metal complex/protein hybrids
To be Published
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2ZVU
 | | Crystal structure of rat heme oxygenase-1 in complex with ferrous verdoheme | | 分子名称: | 5-OXA-PROTOPORPHYRIN IX CONTAINING FE, FORMIC ACID, Heme oxygenase 1 | | 著者 | Sato, H, Sugishima, M, Fukuyama, K, Noguchi, M. | | 登録日 | 2008-11-21 | | 公開日 | 2009-02-03 | | 最終更新日 | 2023-11-01 | | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | | 主引用文献 | Crystal structure of rat haem oxygenase-1 in complex with ferrous verdohaem: presence of a hydrogen-bond network on the distal side
Biochem.J., 419, 2009
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2DY5
 | | Crystal structure of rat heme oxygenase-1 in complex with heme and 2-[2-(4-chlorophenyl)ethyl]-2-[(1H-imidazol-1-yl)methyl]-1,3-dioxolane | | 分子名称: | 1-({2-[2-(4-CHLOROPHENYL)ETHYL]-1,3-DIOXOLAN-2-YL}METHYL)-1H-IMIDAZOLE, CHLORIDE ION, Heme oxygenase 1, ... | | 著者 | Sugishima, M, Takahashi, H, Fukuyama, K. | | 登録日 | 2006-09-06 | | 公開日 | 2007-05-22 | | 最終更新日 | 2023-10-25 | | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | | 主引用文献 | X-ray crystallographic and biochemical characterization of the inhibitory action of an imidazole-dioxolane compound on heme oxygenase
Biochemistry, 46, 2007
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2E7E
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5UC8
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5UC9
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5UCA
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2Q32
 | | Crystal structure of human heme oxygenase-2 C127A (HO-2) | | 分子名称: | Heme oxygenase 2, OXTOXYNOL-10 | | 著者 | Bianchetti, C.M, Bingman, C.A, Bitto, E, Wesenberg, G.E, Phillips Jr, G.N, Center for Eukaryotic Structural Genomics (CESG) | | 登録日 | 2007-05-29 | | 公開日 | 2007-06-05 | | 最終更新日 | 2023-08-30 | | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | | 主引用文献 | Comparison of Apo- and Heme-bound Crystal Structures of a Truncated Human Heme Oxygenase-2.
J.Biol.Chem., 282, 2007
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2QPP
 | | Crystal structure of human heme oxygenase-2 C127A (HO-2) with bound heme | | 分子名称: | Heme oxygenase 2, PROTOPORPHYRIN IX CONTAINING FE | | 著者 | Bianchetti, C.M, Bingman, C.A, Bitto, E, Wesenberg, G.E, Phillips Jr, G.N, Center for Eukaryotic Structural Genomics (CESG) | | 登録日 | 2007-07-24 | | 公開日 | 2007-08-07 | | 最終更新日 | 2023-08-30 | | 実験手法 | X-RAY DIFFRACTION (2.61 Å) | | 主引用文献 | Comparison of Apo- and Heme-bound Crystal Structures of a Truncated Human Heme Oxygenase-2.
J.Biol.Chem., 282, 2007
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2RGZ
 | | Ensemble refinement of the protein crystal structure of human heme oxygenase-2 C127A (HO-2) with bound heme | | 分子名称: | Heme oxygenase 2, PROTOPORPHYRIN IX CONTAINING FE | | 著者 | Bianchetti, C.M, Bingman, C.A, Bitto, E, Wesenberg, G.E, Phillips Jr, G.N, Center for Eukaryotic Structural Genomics (CESG) | | 登録日 | 2007-10-05 | | 公開日 | 2007-10-23 | | 最終更新日 | 2023-08-30 | | 実験手法 | X-RAY DIFFRACTION (2.61 Å) | | 主引用文献 | Comparison of Apo- and Heme-bound Crystal Structures of a Truncated Human Heme Oxygenase-2.
J.Biol.Chem., 282, 2007
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3HOK
 | | X-ray Crystal Structure of Human Heme Oxygenase-1 with (2R, 4S)-2-[2-(4-Chlorophenyl)ethyl]-2-[(1H-imidazol-1-yl)methyl]-4[((5-trifluoromethylpyridin-2-yl)thio)methyl]-1,3-dioxolane: A Novel, Inducible Binding Mode | | 分子名称: | 2-({[(2R,4S)-2-[2-(4-chlorophenyl)ethyl]-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methyl}sulfanyl)-5-(trifluoromethyl)pyridine, Heme oxygenase 1, PROTOPORPHYRIN IX CONTAINING FE | | 著者 | Rahman, M.N, Jia, Z. | | 登録日 | 2009-06-02 | | 公開日 | 2009-07-28 | | 最終更新日 | 2023-09-06 | | 実験手法 | X-RAY DIFFRACTION (2.19 Å) | | 主引用文献 | X-ray crystal structure of human heme oxygenase-1 with (2R,4S)-2-[2-(4-chlorophenyl)ethyl]-2-[(1H-imidazol-1-yl)methyl]-4[((5-trifluoromethylpyridin-2-yl)thio)methyl]-1,3-dioxolane: a novel, inducible binding mode.
J.Med.Chem., 52, 2009
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3I9T
 | | Crystal structure of the rat heme oxygenase (HO-1) in complex with heme binding dithiothreitol (DTT) | | 分子名称: | (2S,3S)-1,4-DIMERCAPTOBUTANE-2,3-DIOL, Heme oxygenase 1, PROTOPORPHYRIN IX CONTAINING FE | | 著者 | Matsui, T, Unno, M, Ikeda-Saito, M. | | 登録日 | 2009-07-13 | | 公開日 | 2010-05-19 | | 最終更新日 | 2023-11-01 | | 実験手法 | X-RAY DIFFRACTION (2.15 Å) | | 主引用文献 | Dioxygen activation for the self-degradation of heme: reaction mechanism and regulation of heme oxygenase.
Inorg.Chem., 49, 2010
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3I9U
 | | Crystal structure of the rat heme oxygenase (HO-1) in complex with heme binding dithioerythritol (DTE) | | 分子名称: | (2R,3S)-1,4-DIMERCAPTOBUTANE-2,3-DIOL, Heme oxygenase 1, PROTOPORPHYRIN IX CONTAINING FE | | 著者 | Matsui, T, Unno, M, Ikeda-Saito, M. | | 登録日 | 2009-07-13 | | 公開日 | 2010-05-19 | | 最終更新日 | 2023-11-01 | | 実験手法 | X-RAY DIFFRACTION (2.25 Å) | | 主引用文献 | Dioxygen activation for the self-degradation of heme: reaction mechanism and regulation of heme oxygenase.
Inorg.Chem., 49, 2010
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