PDB: 336 件ウェブページステータス検索Chemie searchBIRD

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2GH6	Crystal structure of a HDAC-like protein with 9,9,9-trifluoro-8-oxo-N-phenylnonan amide bound 分子名称: 9,9,9-TRIFLUORO-8-OXO-N-PHENYLNONANAMIDE, Histone deacetylase-like amidohydrolase, POTASSIUM ION, ... 著者 Nielsen, T.K, Hildmann, C, Riester, D, Wegener, D, Schwienhorst, A, Ficner, R. 登録日 2006-03-26 公開日 2007-03-20 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (2.203 Å) 主引用文献 Complex structure of a bacterial class 2 histone deacetylase homologue with a trifluoromethylketone inhibitor. Acta Crystallogr.,Sect.F, 63, 2007
5LI3	Crystal structure of HDAC-like protein from P. aeruginosa in complex with a photo-switchable inhibitor. 分子名称: (2E)-N-hydroxy-3-{4-[(E)-(1,3,5-trimethyl-1H-pyrazol-4-yl)diazenyl]phenyl}prop-2-enamide, Acetoin utilization protein, POTASSIUM ION, ... 著者 Kraemer, A, Meyer-Almes, F.J, Yildiz, O. 登録日 2016-07-14 公開日 2016-11-23 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Toward Photopharmacological Antimicrobial Chemotherapy Using Photoswitchable Amidohydrolase Inhibitors. ACS Infect Dis, 3, 2017
1C3P	CRYSTAL STRUCTURE OF AN HDAC HOMOLOG FROM AQUIFEX AEOLICUS 分子名称: PROTEIN (HDLP (HISTONE DEACETYLASE-LIKE PROTEIN)) 著者 Finnin, M.S, Donigian, J.R, Pavletich, N.P. 登録日 1999-07-28 公開日 1999-09-15 最終更新日 2024-02-07 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Structures of a histone deacetylase homologue bound to the TSA and SAHA inhibitors. Nature, 401, 1999
1C3S	CRYSTAL STRUCTURE OF AN HDAC HOMOLOG COMPLEXED WITH SAHA 分子名称: HDLP (HISTONE DEACETYLASE-LIKE PROTEIN), OCTANEDIOIC ACID HYDROXYAMIDE PHENYLAMIDE, ZINC ION 著者 Finnin, M.S, Donigian, J.R, Pavletich, N.P. 登録日 1999-07-28 公開日 1999-09-15 最終更新日 2024-02-07 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Structures of a histone deacetylase homologue bound to the TSA and SAHA inhibitors. Nature, 401, 1999
1C3R	CRYSTAL STRUCTURE OF AN HDAC HOMOLOG COMPLEXED WITH TRICHOSTATIN A 分子名称: HDLP (HISTONE DEACETYLASE-LIKE PROTEIN), TRICHOSTATIN A, ZINC ION 著者 Finnin, M.S, Donigian, J.R, Pavletich, N.P. 登録日 1999-07-28 公開日 1999-09-15 最終更新日 2024-02-07 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Structures of a histone deacetylase homologue bound to the TSA and SAHA inhibitors. Nature, 401, 1999
1ZZ0	Crystal structure of a HDAC-like protein with acetate bound 分子名称: ACETATE ION, Histone deacetylase-like amidohydrolase, POTASSIUM ION, ... 著者 Nielsen, T.K, Hildmann, C, Dickmanns, A, Schwienhorst, A, Ficner, R. 登録日 2005-06-13 公開日 2005-11-29 最終更新日 2024-03-13 実験手法 X-RAY DIFFRACTION (1.6 Å) 主引用文献 Crystal structure of a bacterial class 2 histone deacetylase homologue J.Mol.Biol., 354, 2005
1ZZ3	Crystal structure of a HDAC-like protein with CypX bound 分子名称: 3-CYCLOPENTYL-N-HYDROXYPROPANAMIDE, Histone deacetylase-like amidohydrolase, POTASSIUM ION, ... 著者 Nielsen, T.K, Hildmann, C, Dickmanns, A, Schwienhorst, A, Ficner, R. 登録日 2005-06-13 公開日 2005-11-29 最終更新日 2024-03-13 実験手法 X-RAY DIFFRACTION (1.76 Å) 主引用文献 Crystal structure of a bacterial class 2 histone deacetylase homologue J.Mol.Biol., 354, 2005
4LY1	Structure of Human HDAC2 in complex with inhibitor 4-(acetylamino)-N-[2-amino-5-(thiophen-2-yl)phenyl]benzamide 分子名称: 2-[N-CYCLOHEXYLAMINO]ETHANE SULFONIC ACID, 4-(acetylamino)-N-[2-amino-5-(thiophen-2-yl)phenyl]benzamide, CALCIUM ION, ... 著者 Fong, R, Lupardus, P.J. 登録日 2013-07-30 公開日 2013-08-21 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (1.57 Å) 主引用文献 Histone Deacetylase (HDAC) Inhibitor Kinetic Rate Constants Correlate with Cellular Histone Acetylation but Not Transcription and Cell Viability. J.Biol.Chem., 288, 2013
1ZZ1	Crystal structure of a HDAC-like protein with SAHA bound 分子名称: Histone deacetylase-like amidohydrolase, OCTANEDIOIC ACID HYDROXYAMIDE PHENYLAMIDE, POTASSIUM ION, ... 著者 Nielsen, T.K, Hildmann, C, Dickmanns, A, Schwienhorst, A, Ficner, R. 登録日 2005-06-13 公開日 2005-11-29 最終更新日 2024-03-13 実験手法 X-RAY DIFFRACTION (1.57 Å) 主引用文献 Crystal structure of a bacterial class 2 histone deacetylase homologue J.Mol.Biol., 354, 2005
4LXZ	Structure of Human HDAC2 in complex with SAHA (vorinostat) 分子名称: 2-[N-CYCLOHEXYLAMINO]ETHANE SULFONIC ACID, CALCIUM ION, Histone deacetylase 2, ... 著者 Fong, R, Lupardus, P.J. 登録日 2013-07-30 公開日 2013-08-21 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (1.85 Å) 主引用文献 Histone Deacetylase (HDAC) Inhibitor Kinetic Rate Constants Correlate with Cellular Histone Acetylation but Not Transcription and Cell Viability. J.Biol.Chem., 288, 2013
4QA5	Crystal structure of A188T/Y306F HDAC8 in complex with a tetrapeptide substrate 分子名称: 7-AMINO-4-METHYL-CHROMEN-2-ONE, GLYCEROL, Histone deacetylase 8, ... 著者 Decroos, C, Bowman, C.B, Moser, J.-A.S, Christianson, K.E, Deardorff, M.A, Christianson, D.W. 登録日 2014-05-02 公開日 2014-08-06 最終更新日 2023-12-06 実験手法 X-RAY DIFFRACTION (1.76 Å) 主引用文献 Compromised Structure and Function of HDAC8 Mutants Identified in Cornelia de Lange Syndrome Spectrum Disorders. Acs Chem.Biol., 9, 2014
8SZT	Structure of Kdac1 from Acinetobacter baumannii 分子名称: CHLORIDE ION, Histone deacetylase domain-containing protein, POTASSIUM ION, ... 著者 Watson, P.R, Christianson, D.W. 登録日 2023-05-30 公開日 2023-09-06 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Structure and Function of Kdac1, a Class II Deacetylase from the Multidrug-Resistant Pathogen Acinetobacter baumannii . Biochemistry, 62, 2023
8SZU	Structure of Kdac1-Citarinostat complex from Acinetobacter baumannii 分子名称: Citarinostat, Histone deacetylase domain-containing protein, POTASSIUM ION, ... 著者 Watson, P.R, Christianson, D.W. 登録日 2023-05-30 公開日 2023-09-06 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (1.75 Å) 主引用文献 Structure and Function of Kdac1, a Class II Deacetylase from the Multidrug-Resistant Pathogen Acinetobacter baumannii . Biochemistry, 62, 2023
8TQ0	Crystal structure of Danio rerio histone deacetylase 6 catalytic domain 2 complexed with (R)-Lipoic Acid 分子名称: DIHYDROLIPOIC ACID, Hdac6 protein, POTASSIUM ION, ... 著者 Watson, P.R, Christianson, D.W. 登録日 2023-08-06 公開日 2023-09-20 最終更新日 2024-04-03 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Crystal structure of histone deacetylase 6 complexed with (R)-lipoic acid, an essential cofactor in central carbon metabolism. J.Biol.Chem., 299, 2023
7Q1C	Crystal structure of Trypanosoma cruzi histone deacetylase DAC2 complexed with a hydroxamate inhibitor 分子名称: (E)-3-dibenzofuran-4-yl-N-oxidanyl-prop-2-enamide, Histone deacetylase DAC2, POTASSIUM ION, ... 著者 Ramos-Morales, E, Marek, M, Romier, C. 登録日 2021-10-18 公開日 2021-12-15 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Species-selective targeting of pathogens revealed by the atypical structure and active site of Trypanosoma cruzi histone deacetylase DAC2. Cell Rep, 37, 2021
7Q1B	Crystal structure of Trypanosoma cruzi histone deacetylase DAC2 complexed with Quisinostat 分子名称: 2-[4-[[(1-methylindol-3-yl)methylamino]methyl]piperidin-1-yl]-~{N}-oxidanyl-pyrimidine-5-carboxamide, GLYCEROL, Histone deacetylase DAC2, ... 著者 Marek, M, Ramos-Morales, E, Romier, C. 登録日 2021-10-18 公開日 2021-12-15 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (1.75 Å) 主引用文献 Species-selective targeting of pathogens revealed by the atypical structure and active site of Trypanosoma cruzi histone deacetylase DAC2. Cell Rep, 37, 2021
6R0K	X-ray structure of Danio rerio histone deacetylase 6 (HDAC6) CD2 in complex with a inhibitor SS208 分子名称: 5-[2-[(3,4-dichlorophenyl)carbonylamino]ethyl]-~{N}-oxidanyl-1,2-oxazole-3-carboxamide, Histone deacetylase 6, POTASSIUM ION, ... 著者 Barinka, C, Ustinova, K, Motlova, L, Pavlicek, J. 登録日 2019-03-13 公開日 2019-10-09 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (1.15 Å) 主引用文献 Discovery of a New Isoxazole-3-hydroxamate-Based Histone Deacetylase 6 Inhibitor SS-208 with Antitumor Activity in Syngeneic Melanoma Mouse Models. J.Med.Chem., 62, 2019
7POZ	Crystal structure of Schistosoma mansoni HDAC8 with DMSO bound in the active site 分子名称: DIMETHYL SULFOXIDE, GLYCEROL, Histone deacetylase 8, ... 著者 Saccoccia, F, Ruberti, G. 登録日 2021-09-10 公開日 2022-08-31 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Crystal structures of Schistosoma mansoni histone deacetylase 8 reveal a novel binding site for allosteric inhibitors. J.Biol.Chem., 298, 2022
7QNO	Crystal structure of ligand-free Danio rerio HDAC6 CD1 CD2 分子名称: GLYCEROL, Histone deacetylase 6, POTASSIUM ION, ... 著者 Kempf, G, Langousis, G, Sanchez, J, Matthias, P. 登録日 2021-12-21 公開日 2022-02-09 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (2.38 Å) 主引用文献 Expression and Crystallization of HDAC6 Tandem Catalytic Domains. Methods Mol.Biol., 2589, 2023
6TCY	X-ray structure of Danio rerio histone deacetylase 6 (HDAC6) CD2 in complex with a inhibitor SS555 分子名称: 1,2-ETHANEDIOL, 2-METHOXYETHANOL, 2-[2-(2-METHOXY-ETHOXY)-ETHOXY]-ETHOXYL, ... 著者 Stransky, J, Barinka, C. 登録日 2019-11-06 公開日 2020-11-04 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (1.6 Å) 主引用文献 Rational Design of Suprastat: A Novel Selective Histone Deacetylase 6 Inhibitor with the Ability to Potentiate Immunotherapy in Melanoma Models. J.Med.Chem., 63, 2020
6THV	X-ray structure of the Danio rerio histone deacetylase 6 (HDAC6; catalytic domain 2) in complex with Tubastatin A 分子名称: 1,2-ETHANEDIOL, 4-[(2-methyl-3,4-dihydro-1~{H}-pyrido[4,3-b]indol-5-yl)methyl]-~{N}-oxidanyl-benzamide, DI(HYDROXYETHYL)ETHER, ... 著者 Barinka, C, Motlova, L, Svoboda, M. 登録日 2019-11-21 公開日 2020-07-15 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (1.1 Å) 主引用文献 Structural and in Vivo Characterization of Tubastatin A, a Widely Used Histone Deacetylase 6 Inhibitor. Acs Med.Chem.Lett., 11, 2020
6TLD	Crystal structure of Schistosoma mansoni HDAC8 complexed with a triazole hydroxamate inhibitor 2 分子名称: DIMETHYLFORMAMIDE, GLYCEROL, Histone deacetylase, ... 著者 Shaik, T.B, Romier, C. 登録日 2019-12-02 公開日 2019-12-18 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (1.61 Å) 主引用文献 Structure-Based Design, Synthesis, and Biological Evaluation of Triazole-Based smHDAC8 Inhibitors. Chemmedchem, 15, 2020
3RQD	Ideal Thiolate-Zinc Coordination Geometry in Depsipeptide Binding to Histone Deacetylase 8 分子名称: Histone deacetylase 8, Largazole, POTASSIUM ION, ... 著者 Cole, K.E, Dowling, D.P, Christianson, D.W. 登録日 2011-04-28 公開日 2011-08-24 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (2.143 Å) 主引用文献 Structural basis of the antiproliferative activity of largazole, a depsipeptide inhibitor of the histone deacetylases. J.Am.Chem.Soc., 133, 2011
1T69	Crystal Structure of human HDAC8 complexed with SAHA 分子名称: Histone deacetylase 8, OCTANEDIOIC ACID HYDROXYAMIDE PHENYLAMIDE, ZINC ION 著者 Somoza, J.R, Skene, R.J, Katz, B.A, Mol, C, Ho, J.D, Jennings, A.J, Luong, C, Arvai, A, Buggy, J.J, Chi, E, Tang, J, Sang, B.-C, Verner, E, Wynands, R, Leahy, E.M, Dougan, D.R, Snell, G, Navre, M, Knuth, M.W, Swanson, R.V, McRee, D.E, Tari, L.W. 登録日 2004-05-05 公開日 2004-07-27 最終更新日 2023-08-23 実験手法 X-RAY DIFFRACTION (2.91 Å) 主引用文献 Structural Snapshots of Human HDAC8 Provide Insights into the Class I Histone Deacetylases Structure, 12, 2004
1T67	Crystal Structure of Human HDAC8 complexed with MS-344 分子名称: 4-(dimethylamino)-N-[7-(hydroxyamino)-7-oxoheptyl]benzamide, Histone deacetylase 8, SODIUM ION, ... 著者 Somoza, J.R, Skene, R.J, Katz, B.A, Mol, C, Ho, J.D, Jennings, A.J, Luong, C, Arvai, A, Buggy, J.J, Chi, E, Tang, J, Sang, B.-C, Verner, E, Wynands, R, Leahy, E.M, Dougan, D.R, Snell, G, Navre, M, Knuth, M.W, Swanson, R.V, McRee, D.E, Tari, L.W. 登録日 2004-05-05 公開日 2004-07-27 最終更新日 2023-08-23 実験手法 X-RAY DIFFRACTION (2.31 Å) 主引用文献 Structural Snapshots of Human HDAC8 Provide Insights into the Class I Histone Deacetylases Structure, 12, 2004

 

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