8OMM
 
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8OFL
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8BBV
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8AW7
 | | Structure of coproporphyrin III-LmCpfC R45L | | 分子名称: | Coproporphyrin III ferrochelatase, GLYCEROL, coproporphyrin III | | 著者 | Gabler, T, Hofbauer, S, Pfanzagl, V. | | 登録日 | 2022-08-29 | | 公開日 | 2022-12-28 | | 最終更新日 | 2024-01-31 | | 実験手法 | X-RAY DIFFRACTION (2.64 Å) | | 主引用文献 | Active site architecture of coproporphyrin ferrochelatase with its physiological substrate coproporphyrin III: Propionate interactions and porphyrin core deformation.
Protein Sci., 32, 2023
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8AT8
 | | Structure of coproporphyrin III-LmCpfC | | 分子名称: | 1,2-ETHANEDIOL, ACETATE ION, CALCIUM ION, ... | | 著者 | Gabler, T, Hofbauer, S. | | 登録日 | 2022-08-22 | | 公開日 | 2022-12-28 | | 最終更新日 | 2024-01-31 | | 実験手法 | X-RAY DIFFRACTION (1.51 Å) | | 主引用文献 | Active site architecture of coproporphyrin ferrochelatase with its physiological substrate coproporphyrin III: Propionate interactions and porphyrin core deformation.
Protein Sci., 32, 2023
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7L78
 | | H235C variant of Yeast Ferrochelatase | | 分子名称: | CHOLIC ACID, Ferrochelatase, mitochondrial | | 著者 | Lanzilotta, W.N, Medlock, A.E. | | 登録日 | 2020-12-27 | | 公開日 | 2021-11-24 | | 最終更新日 | 2023-10-18 | | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | | 主引用文献 | Mitochondrial contact site and cristae organizing system (MICOS) machinery supports heme biosynthesis by enabling optimal performance of ferrochelatase.
Redox Biol, 46, 2021
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7CTC
 | | FECH - inhibitor complex 1 | | 分子名称: | 2-(4-tert-butylphenyl)-5-[(quinolin-2-ylamino)methyl]-6H-[1,2,4]triazolo[1,5-a]pyrimidin-7-one, FE2/S2 (INORGANIC) CLUSTER, Ferrochelatase, ... | | 著者 | Lee, S.J, Park, J. | | 登録日 | 2020-08-18 | | 公開日 | 2021-08-18 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | FECH - inhibitor complex 1
to be published
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7CT7
 | | FECH - inhibitor complex 2 | | 分子名称: | 2-[[(4-chlorophenyl)amino]methyl]-5-propyl-6H-[1,2,4]triazolo[1,5-a]pyrimidin-7-one, FE2/S2 (INORGANIC) CLUSTER, Ferrochelatase, ... | | 著者 | Lee, S.J, Park, J. | | 登録日 | 2020-08-18 | | 公開日 | 2021-08-18 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | FECH - inhibitor complex 1
to be published
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6SV3
 | | Structure of coproheme-LmCpfC | | 分子名称: | 1,3,5,8-TETRAMETHYL-PORPHINE-2,4,6,7-TETRAPROPIONIC ACID FERROUS COMPLEX, Ferrochelatase, GLYCEROL | | 著者 | Hofbauer, S, Helm, J, Djinovic-Carugo, K, Furtmueller, P.G. | | 登録日 | 2019-09-17 | | 公開日 | 2019-12-18 | | 最終更新日 | 2024-02-07 | | 実験手法 | X-RAY DIFFRACTION (1.64000869 Å) | | 主引用文献 | Crystal structures and calorimetry reveal catalytically relevant binding mode of coproporphyrin and coproheme in coproporphyrin ferrochelatase.
Febs J., 287, 2020
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6RWV
 | | Structure of apo-LmCpfC | | 分子名称: | Ferrochelatase, GLYCEROL, PHOSPHATE ION, ... | | 著者 | Hofbauer, S, Helm, J, Djinovic-Carugo, K, Furtmueller, P.G. | | 登録日 | 2019-06-06 | | 公開日 | 2019-12-18 | | 最終更新日 | 2024-01-24 | | 実験手法 | X-RAY DIFFRACTION (1.6386379 Å) | | 主引用文献 | Crystal structures and calorimetry reveal catalytically relevant binding mode of coproporphyrin and coproheme in coproporphyrin ferrochelatase.
Febs J., 287, 2020
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4MK4
 | | S197C variant of human ferrochelatase. | | 分子名称: | CHOLIC ACID, FE2/S2 (INORGANIC) CLUSTER, Ferrochelatase, ... | | 著者 | Lanzilotta, W.N, Medlock, A.E, Dailey, T.E, Dailey, H.A. | | 登録日 | 2013-09-04 | | 公開日 | 2013-09-25 | | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | | 主引用文献 | S197C variant of human ferrochelatase.
To be Published
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4KMM
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4KLR
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4KLC
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4KLA
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4F4D
 | | F337R variant of human ferrochelatase | | 分子名称: | CHLORIDE ION, CHOLIC ACID, FE2/S2 (INORGANIC) CLUSTER, ... | | 著者 | Lanzilotta, W.N, Medlock, A.E, Dailey, T.E, Dailey, H.A. | | 登録日 | 2012-05-10 | | 公開日 | 2012-09-12 | | 最終更新日 | 2024-02-28 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | F337R Variant of Human Ferrochelatase
TO BE PUBLISHED
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3W1W
 | | Protein-drug complex | | 分子名称: | 1,2-ETHANEDIOL, 2-HYDROXYBENZOIC ACID, CHOLIC ACID, ... | | 著者 | Ishii, R, Gupta, V, Yamaguchi, Y, Handa, H, Nureki, O. | | 登録日 | 2012-11-21 | | 公開日 | 2013-10-09 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (2.006 Å) | | 主引用文献 | Salicylic Acid induces mitochondrial injury by inhibiting ferrochelatase heme biosynthesis activity
Mol.Pharmacol., 84, 2013
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3M4Z
 | | Crystal Structure of B. subtilis ferrochelatase with Cobalt bound at the active site | | 分子名称: | CHLORIDE ION, COBALT (II) ION, Ferrochelatase, ... | | 著者 | Soderberg, C.A.G, Hansson, M.D, Sreekanth, R, Al-Karadaghi, S, Hansson, M. | | 登録日 | 2010-03-12 | | 公開日 | 2010-11-10 | | 最終更新日 | 2023-11-01 | | 実験手法 | X-RAY DIFFRACTION (1.94 Å) | | 主引用文献 | Bacterial ferrochelatase goes human: Tyr13 determines the apparent metal specificity of Bacillus subtilis ferrochelatase
To be Published
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3HCR
 | | Human Ferrochelatase with deuteroporphyrin and Ni Bound | | 分子名称: | CHLORIDE ION, CHOLIC ACID, FE(III) DEUTEROPORPHYRIN IX, ... | | 著者 | Medlock, A.E, Dailey, H.A, Lanzilotta, W.N. | | 登録日 | 2009-05-06 | | 公開日 | 2009-11-10 | | 最終更新日 | 2024-02-21 | | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | | 主引用文献 | Product release rather than chelation determines metal specificity for ferrochelatase.
J.Mol.Biol., 393, 2009
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3HCP
 | | Human ferrochelatase with Mn and deuteroporphyrin bound | | 分子名称: | CHOLIC ACID, FE(III) DEUTEROPORPHYRIN IX, FE2/S2 (INORGANIC) CLUSTER, ... | | 著者 | Medlock, A.E, Dailey, H.A, Lanzilotta, W.N. | | 登録日 | 2009-05-06 | | 公開日 | 2009-11-10 | | 最終更新日 | 2024-02-21 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Product release rather than chelation determines metal specificity for ferrochelatase.
J.Mol.Biol., 393, 2009
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3HCO
 | | Human ferrochelatase with Cd and protoporphyrin IX bound | | 分子名称: | BICARBONATE ION, CHOLIC ACID, FE2/S2 (INORGANIC) CLUSTER, ... | | 著者 | Medlock, A.E, Dailey, H.A, Lanzilotta, W.N. | | 登録日 | 2009-05-06 | | 公開日 | 2009-11-10 | | 最終更新日 | 2024-02-21 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | Product release rather than chelation determines metal specificity for ferrochelatase.
J.Mol.Biol., 393, 2009
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3HCN
 | | Hg and protoporphyrin bound Human Ferrochelatase | | 分子名称: | BICARBONATE ION, CHOLIC ACID, FE2/S2 (INORGANIC) CLUSTER, ... | | 著者 | Medlock, A.E, Dailey, H.A, Lanzilotta, W.N. | | 登録日 | 2009-05-06 | | 公開日 | 2009-11-10 | | 最終更新日 | 2024-02-21 | | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | | 主引用文献 | Product release rather than chelation determines metal specificity for ferrochelatase.
J.Mol.Biol., 393, 2009
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3GOQ
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3AQI
 | | H240A variant of human ferrochelatase | | 分子名称: | CHOLIC ACID, FE2/S2 (INORGANIC) CLUSTER, Ferrochelatase, ... | | 著者 | Lanzilotta, W.N, Medlock, A.E, Dailey, T.A, Dailey, H.A. | | 登録日 | 2010-11-03 | | 公開日 | 2012-01-25 | | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | | 主引用文献 | H240A variant of human ferrochelatase
To be published
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2QD5
 | | Structure of wild type human ferrochelatase in complex with a lead-porphyrin compound | | 分子名称: | ACETIC ACID, CHOLIC ACID, FE2/S2 (INORGANIC) CLUSTER, ... | | 著者 | Meldock, A.E, Dailey, T.A, Ross, T.A, Dailey, H.A, Lanzilotta, W.N. | | 登録日 | 2007-06-20 | | 公開日 | 2007-10-30 | | 最終更新日 | 2024-02-21 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | A pi-Helix Switch Selective for Porphyrin Deprotonation and Product Release in Human Ferrochelatase.
J.Mol.Biol., 373, 2007
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