PDB: 364 件ウェブページステータス検索Chemie searchBIRD

---

8WF7	The Crystal Structure of integrase from Biortus 分子名称: ACETATE ION, Integrase, SULFATE ION 著者 Wang, F, Cheng, W, Yuan, Z, Qi, J, Li, J. 登録日 2023-09-19 公開日 2023-10-04 実験手法 X-RAY DIFFRACTION (1.55 Å) 主引用文献 The Crystal Structure of integrase from Biortus To Be Published
7D83	Crystal structure of HIV-1 integrase catalytic core domain in complex with 2-(tert-butoxy)-2-(2-(3-cyclohexylureido)-3,6-dimethyl-5-(5-methylchroman-6-yl)pyridin-4-yl)acetic acid 分子名称: (2S)-2-[2-(cyclohexylcarbamoylamino)-3,6-dimethyl-5-(5-methyl-3,4-dihydro-2H-chromen-6-yl)pyridin-4-yl]-2-[(2-methylpropan-2-yl)oxy]ethanoic acid, Integrase, SULFATE ION 著者 Sugiyama, S, Sekiguchi, Y. 登録日 2020-10-07 公開日 2021-01-13 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (2.43 Å) 主引用文献 Discovery of novel HIV-1 integrase-LEDGF/p75 allosteric inhibitors based on a pyridine scaffold forming an intramolecular hydrogen bond. Bioorg.Med.Chem.Lett., 33, 2020
8S9Q	HIV-1 Integrase Catalytic Core Domain (CCD) F185H Mutant Complexed with STP03-0404 分子名称: (2S)-tert-butoxy{4-(4-chlorophenyl)-2,3,6-trimethyl-1-[(1-methyl-1H-pyrazol-4-yl)methyl]-1H-pyrrolo[2,3-b]pyridin-5-yl}acetic acid, Integrase 著者 Dinh, T, Kvaratskhelia, M. 登録日 2023-03-29 公開日 2024-02-07 最終更新日 2024-02-14 実験手法 X-RAY DIFFRACTION (2.26 Å) 主引用文献 HIV-1 Integrase Catalytic Core Domain Complexed with STP-0404 To Be Published
1QS4	Core domain of HIV-1 integrase complexed with Mg++ and 1-(5-chloroindol-3-yl)-3-hydroxy-3-(2H-tetrazol-5-yl)-propenone 分子名称: 1-(5-CHLOROINDOL-3-YL)-3-HYDROXY-3-(2H-TETRAZOL-5-YL)-PROPENONE, MAGNESIUM ION, PROTEIN (HIV-1 INTEGRASE (E.C.2.7.7.49)) 著者 Goldgur, Y, Craigie, R, Fujiwara, T, Yoshinaga, T, Davies, D.R. 登録日 1999-06-25 公開日 1999-11-17 最終更新日 2024-02-14 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Structure of the HIV-1 integrase catalytic domain complexed with an inhibitor: a platform for antiviral drug design. Proc.Natl.Acad.Sci.USA, 96, 1999
2ITG	CATALYTIC DOMAIN OF HIV-1 INTEGRASE: ORDERED ACTIVE SITE IN THE F185H CONSTRUCT 分子名称: HUMAN IMMUNODEFICIENCY VIRUS-1 INTEGRASE 著者 Bujacz, G, Alexandratos, J, Wlodawer, A, Zhou-Liu, Q, Clement-Mella, C. 登録日 1996-09-13 公開日 1997-03-12 最終更新日 2023-08-09 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 The catalytic domain of human immunodeficiency virus integrase: ordered active site in the F185H mutant. FEBS Lett., 398, 1996
4PA1	Crystal Structure of Catalytic Core domain of FIV Integrase 分子名称: Integrase 著者 Galilee, M, Alian, A. 登録日 2014-04-07 公開日 2014-09-17 最終更新日 2024-03-27 実験手法 X-RAY DIFFRACTION (1.84 Å) 主引用文献 Identification of phe187 as a crucial dimerization determinant facilitates crystallization of a monomeric retroviral integrase core domain. Structure, 22, 2014
4TSX	HIV-1 Integrase Catalytic Core Domain Mutant Complexed with Allosteric Inhibitor 分子名称: (2S)-tert-butoxy[4-(3,4-dihydro-2H-chromen-6-yl)-2-methylquinolin-3-yl]ethanoic acid, Integrase, SULFATE ION 著者 Feng, L, Kvaratskhelia, M. 登録日 2014-06-19 公開日 2014-12-17 最終更新日 2023-12-27 実験手法 X-RAY DIFFRACTION (1.94 Å) 主引用文献 The mechanism of H171T resistance reveals the importance of N -protonated His171 for the binding of allosteric inhibitor BI-D to HIV-1 integrase. Retrovirology, 11, 2014
6EB1	HIV-1 Integrase Catalytic Core Domain Complexed with Allosteric Inhibitor (2S)-tert-butoxy[3-(3,4-dihydro-2H-1-benzopyran-6-yl)-1-phenylisoquinolin-4-yl]acetic acid 分子名称: (2S)-tert-butoxy[3-(3,4-dihydro-2H-1-benzopyran-6-yl)-1-phenylisoquinolin-4-yl]acetic acid, Integrase 著者 Lindenberger, J.J, Kobe, M, Kvaratskhelia, M. 登録日 2018-08-03 公開日 2019-03-06 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 An Isoquinoline Scaffold as a Novel Class of Allosteric HIV-1 Integrase Inhibitors. ACS Med Chem Lett, 10, 2019
6EB2	HIV-1 Integrase Catalytic Core Domain Complexed with Allosteric Inhibitor (2S)-[1-(1-benzyl-1H-pyrazol-4-yl)-3-(3,4-dihydro-2H-1-benzopyran-6-yl)isoquinolin-4-yl](tert-butoxy)acetic acid 分子名称: (2S)-[1-(1-benzyl-1H-pyrazol-4-yl)-3-(3,4-dihydro-2H-1-benzopyran-6-yl)isoquinolin-4-yl](tert-butoxy)acetic acid, Integrase 著者 Lindenberger, J.J, Kobe, M, Kvaratskhelia, M. 登録日 2018-08-03 公開日 2019-03-06 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (2.493 Å) 主引用文献 An Isoquinoline Scaffold as a Novel Class of Allosteric HIV-1 Integrase Inhibitors. ACS Med Chem Lett, 10, 2019
6EX9	Crystal Structure of HIV-1 Integrase Catalytic Core Domain with Inhibitor Peptide 分子名称: Inhibitor Peptide, Integrase 著者 Galilee, M, Alian, A. 登録日 2017-11-07 公開日 2018-06-06 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (2.014 Å) 主引用文献 Multimerization of HIV-1 integrase hinges on conserved SH3-docking platforms Biorxiv, 2018
7RQ0	HIV Integrase CORE domain in complex with 2-{2-[2-(3-{[4-(2-{[(3-{2-[3-(carboxymethyl)-5-methyl-1-benzofuran-2-yl]ethynyl}phenyl)methyl]amino}ethyl)piperazin-1-yl]methyl}phenyl)ethynyl]-5-methyl-1-benzofuran-3-yl}acetic acid 分子名称: IODIDE ION, Integrase, SULFATE ION, ... 著者 Gorman, M.A, Parker, M.W. 登録日 2021-08-05 公開日 2022-08-10 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (1.95 Å) 主引用文献 HIV integrase-LEDGF interaction screening by fragment linking using off-rate screening To Be Published
5T3A	Maedi-Visna virus (MVV) integrase CCD-CTD (residues 60-275) 分子名称: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, ACETATE ION, integrase 著者 Cook, N.J, Pye, V.E, Cherepanov, P. 登録日 2016-08-25 公開日 2017-01-18 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (2.501 Å) 主引用文献 A supramolecular assembly mediates lentiviral DNA integration. Science, 355, 2017
4Y1C	Cyclic hexapeptide cyc[NdPopPKID] in complex with HIV-1 integrase core domain 分子名称: CADMIUM ION, Cyclic hexapeptide cyc[NdPopPKID], Integrase, ... 著者 Wielens, J, Chalmers, D.K. 登録日 2015-02-07 公開日 2015-02-25 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 HEXAPEPTIDE MIMETICS OF LEDGF IN COMPLEX WITH HIV-1 INTEGRASE To Be Published
4Y1D	Cyclic hexapeptide cyc[NdPopPKID] in complex with HIV-1 integrase core domain 分子名称: CADMIUM ION, CHLORIDE ION, Cyclic hexapeptide cyc[NdPopPKID], ... 著者 Wielens, J, Chalmers, D.K. 登録日 2015-02-07 公開日 2015-05-13 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (1.93 Å) 主引用文献 HEXAPEPTIDE MIMETICS OF LEDGF IN COMPLEX WITH HIV-1 INTEGRASE To Be Published
1HYV	HIV INTEGRASE CORE DOMAIN COMPLEXED WITH TETRAPHENYL ARSONIUM 分子名称: CHLORIDE ION, INTEGRASE, SULFATE ION, ... 著者 Molteni, V, Greenwald, J, Rhodes, D, Hwang, Y, Kwiatkowski, W, Bushman, F.D, Siegel, J.S, Choe, S. 登録日 2001-01-22 公開日 2001-04-04 最終更新日 2021-10-27 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 Identification of a small-molecule binding site at the dimer interface of the HIV integrase catalytic domain. Acta Crystallogr.,Sect.D, 57, 2001
1HYZ	HIV INTEGRASE CORE DOMAIN COMPLEXED WITH A DERIVATIVE OF TETRAPHENYL ARSONIUM. 分子名称: (3,4-DIHYDROXY-PHENYL)-TRIPHENYL-ARSONIUM, CHLORIDE ION, INTEGRASE, ... 著者 Molteni, V, Greenwald, J, Rhodes, D, Hwang, Y, Kwiatkowski, W, Bushman, F.D, Siegel, J.S, Choe, S. 登録日 2001-01-22 公開日 2001-04-04 最終更新日 2021-10-27 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Identification of a small-molecule binding site at the dimer interface of the HIV integrase catalytic domain. Acta Crystallogr.,Sect.D, 57, 2001
2X74	Human foamy virus integrase - catalytic core. 分子名称: INTEGRASE 著者 Rety, S, Delelis, O, Rezabkova, L, Dubanchet, B, Legrand, P, Silhan, J, Lewit-Bentley, A. 登録日 2010-02-23 公開日 2010-08-11 最終更新日 2012-04-18 実験手法 X-RAY DIFFRACTION (2.34 Å) 主引用文献 Structural Studies of the Catalytic Core of the Primate Foamy Virus (Pfv-1) Integrase Acta Crystallogr.,Sect.F, 66, 2010
1ITG	CRYSTAL STRUCTURE OF THE CATALYTIC DOMAIN OF HIV-1 INTEGRASE: SIMILARITY TO OTHER POLYNUCLEOTIDYL TRANSFERASES 分子名称: CACODYLATE ION, HIV-1 INTEGRASE 著者 Dyda, F, Hickman, A.B, Jenkins, T.M, Engelman, A, Craigie, R, Davies, D.R. 登録日 1994-11-21 公開日 1995-05-08 最終更新日 2024-02-07 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Crystal structure of the catalytic domain of HIV-1 integrase: similarity to other polynucleotidyl transferases. Science, 266, 1994
2X6S	Human foamy virus integrase - catalytic core. Magnesium-bound structure. 分子名称: INTEGRASE, MAGNESIUM ION 著者 Rety, S, Delelis, O, Rezabkova, L, Dubanchet, B, Silhan, J, Lewit-Bentley, A. 登録日 2010-02-19 公開日 2010-08-11 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (2.29 Å) 主引用文献 Structural Studies of the Catalytic Core of the Primate Foamy Virus (Pfv-1) Integrase Acta Crystallogr.,Sect.F, 66, 2010
2X6N	Human foamy virus integrase - catalytic core. Manganese-bound structure. 分子名称: INTEGRASE, MANGANESE (II) ION 著者 Rety, S, Delelis, O, Rezabkova, L, Dubanchet, B, Silhan, J, Lewit-Bentley, A. 登録日 2010-02-18 公開日 2010-08-11 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (2.06 Å) 主引用文献 Structural Studies of the Catalytic Core of the Primate Foamy Virus (Pfv-1) Integrase Acta Crystallogr.,Sect.F, 66, 2010
2X78	Human foamy virus integrase - catalytic core. 分子名称: INTEGRASE 著者 Rety, S, Delelis, O, Rezabkova, L, Dubanchet, B, Legrand, P, Silhan, J, Lewit-Bentley, A. 登録日 2010-02-24 公開日 2010-08-11 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Structural Studies of the Catalytic Core of the Primate Foamy Virus (Pfv-1) Integrase Acta Crystallogr.,Sect.F, 66, 2010
7LQP	Rapid development of potent inhibitors of the HIV integrase-LEDGF interaction by fragment-linking using off-rate screening 分子名称: 2-[2-[2-[3-[2-[2-[2-[[3-[2-[3-(2-hydroxy-2-oxoethyl)-5-methyl-1-benzofuran-2-yl]ethynyl]phenyl]carbonylamino]ethoxy]ethoxy]ethylcarbamoyl]phenyl]ethynyl]-5-methyl-1-benzofuran-3-yl]ethanoic acid, IODIDE ION, Integrase, ... 著者 Gorman, M.A, Parker, M.W. 登録日 2021-02-15 公開日 2022-02-23 実験手法 X-RAY DIFFRACTION (2.07 Å) 主引用文献 Rapid development of potent inhibitors of the HIV integrase-LEDGF interaction by fragment-linking using off-rate screening To Be Published
5OI8	Dissociation of biochemical and antiretroviral activities of Integrase-LEDGF Allosteric Inhibitors revealed by resistance of A125 polymorphic HIV-1 分子名称: (2~{S})-2-[4-(4,4-dimethylcyclohexen-1-yl)-2-methyl-5-pyridin-4-yl-thiophen-3-yl]-2-[(2-methylpropan-2-yl)oxy]ethanoic acid, MAGNESIUM ION, Pol protein, ... 著者 Ruff, M, Benarous, R. 登録日 2017-07-18 公開日 2018-03-07 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (2.35 Å) 主引用文献 Structure-function analyses unravel distinct effects of allosteric inhibitors of HIV-1 integrase on viral maturation and integration. J. Biol. Chem., 293, 2018
5OI3	Dissociation of biochemical and antiretroviral activities of Integrase-LEDGF Allosteric Inhibitors revealed by resistance of A125 polymorphic HIV-1 分子名称: Integrase, MAGNESIUM ION 著者 Ruff, M, Benarous, R. 登録日 2017-07-18 公開日 2018-03-07 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Structure-function analyses unravel distinct effects of allosteric inhibitors of HIV-1 integrase on viral maturation and integration. J. Biol. Chem., 293, 2018
5OIA	Dissociation of biochemical and antiretroviral activities of Integrase-LEDGF Allosteric Inhibitors revealed by resistance of A125 polymorphic HIV-1 分子名称: (2~{S})-2-[4-(4,4-dimethylcyclohexen-1-yl)-2-methyl-5-pyridin-2-yl-thiophen-3-yl]-2-[(2-methylpropan-2-yl)oxy]ethanoic acid, MAGNESIUM ION, Pol protein, ... 著者 Ruff, M, Benarous, R. 登録日 2017-07-18 公開日 2018-03-07 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Structure-function analyses unravel distinct effects of allosteric inhibitors of HIV-1 integrase on viral maturation and integration. J. Biol. Chem., 293, 2018

 

123456789101112131415>