4XWK
| P-glycoprotein co-crystallized with BDE-100 | 分子名称: | 2,4-dibromophenyl 2,4,6-tribromophenyl ether, Multidrug resistance protein 1A | 著者 | McGrath, A.P, Rees, S.D, Chang, G. | 登録日 | 2015-01-28 | 公開日 | 2016-04-27 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (3.5 Å) | 主引用文献 | Global marine pollutants inhibit P-glycoprotein: Environmental levels, inhibitory effects, and cocrystal structure. Sci Adv, 2, 2016
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2ONJ
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2HYD
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3QF4
| Crystal structure of a heterodimeric ABC transporter in its inward-facing conformation | 分子名称: | ABC transporter, ATP-binding protein, MAGNESIUM ION, ... | 著者 | Hohl, M, Briand, C, Gruetter, M.G, Seeger, M.A. | 登録日 | 2011-01-21 | 公開日 | 2012-03-28 | 最終更新日 | 2024-03-20 | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | 主引用文献 | Crystal structure of a heterodimeric ABC transporter in its inward-facing conformation Nat.Struct.Mol.Biol., 19, 2012
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6VQU
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6VQT
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3G60
| Structure of P-glycoprotein Reveals a Molecular Basis for Poly-Specific Drug Binding | 分子名称: | (4R,11R,18R)-4,11,18-tri(propan-2-yl)-6,13,20-triselena-3,10,17,22,23,24-hexaazatetracyclo[17.2.1.1~5,8~.1~12,15~]tetracosa-1(21),5(24),7,12(23),14,19(22)-hexaene-2,9,16-trione, Multidrug resistance protein 1a | 著者 | Aller, S.G, Yu, J, Ward, A, Weng, Y, Chittaboina, S, Zhuo, R, Harrell, P.M, Trinh, Y.T, Zhang, Q, Urbatsch, I.L, Chang, G. | 登録日 | 2009-02-05 | 公開日 | 2009-03-24 | 最終更新日 | 2024-02-21 | 実験手法 | X-RAY DIFFRACTION (4.4 Å) | 主引用文献 | Structure of P-glycoprotein reveals a molecular basis for poly-specific drug binding. Science, 323, 2009
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5OFR
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3G5U
| Structure of P-glycoprotein Reveals a Molecular Basis for Poly-Specific Drug Binding | 分子名称: | MERCURY (II) ION, Multidrug resistance protein 1a | 著者 | Aller, S.G, Yu, J, Ward, A, Weng, Y, Chittaboina, S, Zhuo, R, Harrell, P.M, Trinh, Y.T, Zhang, Q, Urbatsch, I.L, Chang, G. | 登録日 | 2009-02-05 | 公開日 | 2009-03-24 | 最終更新日 | 2024-02-21 | 実験手法 | X-RAY DIFFRACTION (3.8 Å) | 主引用文献 | Structure of P-glycoprotein reveals a molecular basis for poly-specific drug binding. Science, 323, 2009
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5OCH
| The crystal structure of human ABCB8 in an outward-facing state | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, ATP-binding cassette sub-family B member 8, mitochondrial, ... | 著者 | Faust, B, Pike, A.C.W, Shintre, C.A, Quiqley, A.M, Chu, A, Barr, A, Shrestha, L, Mukhopadhyay, S, Borkowska, O, Chalk, R, Burgess-Brown, N.A, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Carpenter, E.P, Structural Genomics Consortium (SGC) | 登録日 | 2017-06-30 | 公開日 | 2018-07-25 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (3.4 Å) | 主引用文献 | The crystal structure of human ABCB8 in an outward-facing state To Be Published
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5OFP
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3G61
| Structure of P-glycoprotein Reveals a Molecular Basis for Poly-Specific Drug Binding | 分子名称: | (4S,11S,18S)-4,11,18-tri(propan-2-yl)-6,13,20-triselena-3,10,17,22,23,24-hexaazatetracyclo[17.2.1.1~5,8~.1~12,15~]tetracosa-1(21),5(24),7,12(23),14,19(22)-hexaene-2,9,16-trione, Multidrug resistance protein 1a | 著者 | Aller, S.G, Yu, J, Ward, A, Weng, Y, Chittaboina, S, Zhuo, R, Harrell, P.M, Trinh, Y.T, Zhang, Q, Urbatsch, I.L, Chang, G. | 登録日 | 2009-02-05 | 公開日 | 2009-03-24 | 最終更新日 | 2024-02-21 | 実験手法 | X-RAY DIFFRACTION (4.35 Å) | 主引用文献 | Structure of P-glycoprotein reveals a molecular basis for poly-specific drug binding. Science, 323, 2009
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3WMG
| Crystal structure of an inward-facing eukaryotic ABC multidrug transporter G277V/A278V/A279V mutant in complex with an cyclic peptide inhibitor, aCAP | 分子名称: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, ATP-binding cassette, sub-family B, ... | 著者 | Kodan, A, Yamaguchi, T, Nakatsu, T, Sakiyama, K, Hipolito, C.J, Fujioka, A, Hirokane, R, Ikeguchi, K, Watanabe, B, Hirtake, J, Kimura, Y, Suga, H, Ueda, K, Kato, H. | 登録日 | 2013-11-18 | 公開日 | 2014-04-30 | 最終更新日 | 2017-11-22 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Structural basis for gating mechanisms of a eukaryotic P-glycoprotein homolog. Proc.Natl.Acad.Sci.USA, 111, 2014
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3WME
| Crystal structure of an inward-facing eukaryotic ABC multidrug transporter | 分子名称: | ATP-binding cassette, sub-family B, member 1, ... | 著者 | Kodan, A, Yamaguchi, T, Nakatsu, T, Kato, H. | 登録日 | 2013-11-18 | 公開日 | 2014-03-19 | 最終更新日 | 2024-03-20 | 実験手法 | X-RAY DIFFRACTION (2.751 Å) | 主引用文献 | Structural basis for gating mechanisms of a eukaryotic P-glycoprotein homolog. Proc.Natl.Acad.Sci.USA, 111, 2014
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3WMF
| Crystal structure of an inward-facing eukaryotic ABC multitrug transporter G277V/A278V/A279V mutant | 分子名称: | ATP-binding cassette, sub-family B, member 1, ... | 著者 | Kodan, A, Yamaguchi, T, Nakatsu, T, Kato, H. | 登録日 | 2013-11-18 | 公開日 | 2014-03-19 | 最終更新日 | 2022-08-24 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | Structural basis for gating mechanisms of a eukaryotic P-glycoprotein homolog. Proc.Natl.Acad.Sci.USA, 111, 2014
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4F4C
| The Crystal Structure of the Multi-Drug Transporter | 分子名称: | Multidrug resistance protein pgp-1, alpha-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, undecyl 4-O-alpha-D-glucopyranosyl-1-thio-beta-D-glucopyranoside | 著者 | Jin, M.S, Oldham, M.L, Zhang, Q, Chen, J. | 登録日 | 2012-05-10 | 公開日 | 2012-09-26 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (3.4 Å) | 主引用文献 | Crystal structure of the multidrug transporter P-glycoprotein from Caenorhabditis elegans. Nature, 490, 2012
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5C76
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5C73
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5C78
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5EG1
| Antibacterial peptide ABC transporter McjD with a resolved lipid | 分子名称: | (2S)-3-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-2-[(6E)-HEXADEC-6-ENOYLOXY]PROPYL (8E)-OCTADEC-8-ENOATE, MAGNESIUM ION, Microcin-J25 export ATP-binding/permease protein McjD, ... | 著者 | Choudhury, H.G, Beis, K. | 登録日 | 2015-10-26 | 公開日 | 2016-08-31 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (3.42 Å) | 主引用文献 | Structural and Functional Basis for Lipid Synergy on the Activity of the Antibacterial Peptide ABC Transporter McjD. J.Biol.Chem., 291, 2016
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4KSD
| Structures of P-glycoprotein reveal its conformational flexibility and an epitope on the nucleotide-binding domain | 分子名称: | Multidrug resistance protein 1A, R2 protein | 著者 | Ward, A, Szewczyk, P, Grimard, V, Lee, C.-W, Martinez, L, Doshi, R, Caya, A, Villaluz, M, Pardon, E, Cregger, C, Swartz, D.J, Falson, P, Urbatsch, I, Govaerts, C, Steyaert, J, Chang, G. | 登録日 | 2013-05-17 | 公開日 | 2013-07-31 | 最終更新日 | 2019-07-17 | 実験手法 | X-RAY DIFFRACTION (4.1001 Å) | 主引用文献 | Structures of P-glycoprotein reveal its conformational flexibility and an epitope on the nucleotide-binding domain. Proc.Natl.Acad.Sci.USA, 110, 2013
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4KSC
| Structures of P-glycoprotein reveal its conformational flexibility and an epitope on the nucleotide-binding domain | 分子名称: | Multidrug resistance protein 1A | 著者 | Ward, A, Szewczyk, P, Grimard, V, Lee, C.-W, Martinez, L, Doshi, R, Caya, A, Villaluz, M, Pardon, E, Cregger, C, Swartz, D.J, Falson, P, Urbatsch, I, Govaerts, C, Steyaert, J, Chang, G. | 登録日 | 2013-05-17 | 公開日 | 2013-07-31 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (4 Å) | 主引用文献 | Structures of P-glycoprotein reveal its conformational flexibility and an epitope on the nucleotide-binding domain. Proc.Natl.Acad.Sci.USA, 110, 2013
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4KSB
| Structures of P-glycoprotein reveal its conformational flexibility and an epitope on the nucleotide-binding domain | 分子名称: | Multidrug resistance protein 1A | 著者 | Ward, A, Szewczyk, P, Grimard, V, Lee, C.-W, Martinez, L, Doshi, R, Caya, A, Villaluz, M, Pardon, E, Cregger, C, Swartz, D.J, Falson, P, Urbatsch, I, Govaerts, C, Steyaert, J, Chang, G. | 登録日 | 2013-05-17 | 公開日 | 2013-07-31 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (3.8001 Å) | 主引用文献 | Structures of P-glycoprotein reveal its conformational flexibility and an epitope on the nucleotide-binding domain. Proc.Natl.Acad.Sci.USA, 110, 2013
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6C0V
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6C3P
| Cryo-EM structure of human KATP bound to ATP and ADP in propeller form | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, ATP-binding cassette sub-family C member 8, ... | 著者 | Lee, K.P.K, Chen, J, MacKinnon, R. | 登録日 | 2018-01-10 | 公開日 | 2018-01-24 | 実験手法 | ELECTRON MICROSCOPY (5.6 Å) | 主引用文献 | Molecular structure of human KATP in complex with ATP and ADP. Elife, 6, 2017
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