PDB: 85 件ウェブページステータス検索Chemie searchBIRD

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8TXY	X-ray crystal structure of JRD-SIK1/2i-3 bound to a MARK2-SIK2 chimera 分子名称: DI(HYDROXYETHYL)ETHER, N-[(5P,8R)-5-(2-cyano-5-{[(3R)-1-methylpyrrolidin-3-yl]methoxy}pyridin-4-yl)pyrazolo[1,5-a]pyridin-2-yl]cyclopropanecarboxamide, SULFATE ION, ... 著者 Raymond, D.D, Lemke, C.T, Shaffer, P.L, Collins, B, Steele, R, Seierstad, M. 登録日 2023-08-24 公開日 2024-01-10 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Identification of highly selective SIK1/2 inhibitors that modulate innate immune activation and suppress intestinal inflammation. Proc.Natl.Acad.Sci.USA, 121, 2024
8XFL	The Crystal Structure of MARK4 from Biortus. 分子名称: MAP/microtubule affinity-regulating kinase 4 著者 Wang, F, Cheng, W, Yuan, Z, Qi, J, Li, J. 登録日 2023-12-14 公開日 2023-12-27 実験手法 X-RAY DIFFRACTION (3 Å) 主引用文献 The Crystal Structure of MARK4 from Biortus. To Be Published
8EBS	Initial DNA-lesion (Cy5) binding by XPC and TFIIH 分子名称: CALCIUM ION, Centrin-2, DNA, ... 著者 Kim, J, Yang, W. 登録日 2022-08-31 公開日 2023-04-19 最終更新日 2023-05-17 実験手法 ELECTRON MICROSCOPY (4 Å) 主引用文献 Lesion recognition by XPC, TFIIH and XPA in DNA excision repair. Nature, 617, 2023
8EBW	Initial DNA-lesion (AP) binding by XPC and TFIIH complex2 分子名称: CALCIUM ION, Centrin-2, DNA, ... 著者 Kim, J, Yang, W. 登録日 2022-08-31 公開日 2023-04-19 最終更新日 2023-05-17 実験手法 ELECTRON MICROSCOPY (5.6 Å) 主引用文献 Lesion recognition by XPC, TFIIH and XPA in DNA excision repair. Nature, 617, 2023
8EBV	Initial DNA-lesion (AP) binding by XPC and TFIIH complex 1 分子名称: CALCIUM ION, Centrin-2, DNA, ... 著者 Kim, J, Yang, W. 登録日 2022-08-31 公開日 2023-04-19 最終更新日 2023-05-17 実験手法 ELECTRON MICROSCOPY (7.1 Å) 主引用文献 Lesion recognition by XPC, TFIIH and XPA in DNA excision repair. Nature, 617, 2023
7TGP	E176T/Y188G variant of the internal UBA Domain of HHR23A 分子名称: UV excision repair protein RAD23 homolog A 著者 Rothfuss, M, Bowler, B.E, McClelland, L.J, Sprang, S.R. 登録日 2022-01-08 公開日 2023-04-12 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (1.4 Å) 主引用文献 High-Accuracy Prediction of Stabilizing Surface Mutations to the Three-Helix Bundle, UBA(1), with EmCAST. J.Am.Chem.Soc., 145, 2023
7F7X	Protein complex between phosphorylated ubiquitin and Ubqln2 UBA 分子名称: Polyubiquitin-B, Ubiquilin-2 著者 Qin, L.Y, Dong, X, Tang, C. 登録日 2021-06-30 公開日 2022-05-18 実験手法 SOLUTION NMR 主引用文献 Kinetic Constraints in the Specific Interaction between Phosphorylated Ubiquitin and Proteasomal Shuttle Factors. Biomolecules, 11, 2021
7OJX	E2 UBE2K covalently linked to donor Ub, acceptor di-Ub, and RING E3 primed for K48-linked Ub chain synthesis 分子名称: 1,1'-ethane-1,2-diylbis(1H-pyrrole-2,5-dione), E3 ubiquitin-protein ligase RNF38, Polyubiquitin-B, ... 著者 Majorek, K.A, Nakasone, M.A, Huang, D.T. 登録日 2021-05-17 公開日 2022-01-12 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Structure of UBE2K-Ub/E3/polyUb reveals mechanisms of K48-linked Ub chain extension. Nat.Chem.Biol., 18, 2022
6XQJ	Structure of HIV-1 Vpr in complex with the human nucleotide excision repair protein hHR23A 分子名称: Protein Vpr,UV excision repair protein RAD23 homolog A, ZINC ION 著者 Byeon, I.-J.L, Calero, G, Wu, Y, Byeon, C.H, Gronenborn, A.M. 登録日 2020-07-09 公開日 2021-11-17 最終更新日 2021-12-08 実験手法 SOLUTION NMR 主引用文献 Structure of HIV-1 Vpr in complex with the human nucleotide excision repair protein hHR23A. Nat Commun, 12, 2021
7MYH	Ubiquitin variant UbV.k.2 in complex with Ube2k 分子名称: GLYCEROL, Ubiquitin variant UbV.k.2, Ubiquitin-conjugating enzyme E2 K 著者 Middleton, A.J, Day, C.L, Teyra, J, Sidhu, S.S. 登録日 2021-05-21 公開日 2021-08-25 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (2.394 Å) 主引用文献 Identification of Ubiquitin Variants That Inhibit the E2 Ubiquitin Conjugating Enzyme, Ube2k. Acs Chem.Biol., 16, 2021
7MYF	Ubiquitin variant UbV.k.1 in complex with Ube2k 分子名称: Ubiquitin, Ubiquitin variant UbV.k.1, Ubiquitin-conjugating enzyme E2 K 著者 Middleton, A.J, Day, C.L, Teyra, J, Sidhu, S.S. 登録日 2021-05-21 公開日 2021-08-25 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (3 Å) 主引用文献 Identification of Ubiquitin Variants That Inhibit the E2 Ubiquitin Conjugating Enzyme, Ube2k. Acs Chem.Biol., 16, 2021
6XQI	Structure of HIV-1 Vpr in complex with the human nucleotide excision repair protein hHR23A 分子名称: ASN-PRO-LEU-GLU-PHE-LEU, Protein Vpr, UV excision repair protein RAD23 homolog A, ... 著者 Calero, G.C, Wu, Y, Weiss, S.C. 登録日 2020-07-09 公開日 2021-08-11 最終更新日 2021-12-08 実験手法 X-RAY DIFFRACTION (2.34 Å) 主引用文献 Structure of HIV-1 Vpr in complex with the human nucleotide excision repair protein hHR23A. Nat Commun, 12, 2021
7MWD	HUWE1 in map with focus on HECT 分子名称: E3 ubiquitin-protein ligase HUWE1 著者 Hunkeler, M, Fischer, E.S. 登録日 2021-05-16 公開日 2021-07-28 最終更新日 2021-09-15 実験手法 ELECTRON MICROSCOPY (3.7 Å) 主引用文献 Solenoid architecture of HUWE1 contributes to ligase activity and substrate recognition. Mol.Cell, 81, 2021
7MWF	HUWE1 in map with focus on interface 分子名称: E3 ubiquitin-protein ligase HUWE1 著者 Hunkeler, M, Fischer, E.S. 登録日 2021-05-16 公開日 2021-07-28 最終更新日 2021-09-15 実験手法 ELECTRON MICROSCOPY (3.3 Å) 主引用文献 Solenoid architecture of HUWE1 contributes to ligase activity and substrate recognition. Mol.Cell, 81, 2021
7MWE	HUWE1 in map with focus on WWE 分子名称: E3 ubiquitin-protein ligase HUWE1 著者 Hunkeler, M, Fischer, E.S. 登録日 2021-05-16 公開日 2021-07-28 最終更新日 2021-09-15 実験手法 ELECTRON MICROSCOPY (3.4 Å) 主引用文献 Solenoid architecture of HUWE1 contributes to ligase activity and substrate recognition. Mol.Cell, 81, 2021
7MOP	Cryo-EM structure of human HUWE1 in complex with DDIT4 分子名称: DNA damage-inducible transcript 4 protein, E3 ubiquitin-protein ligase HUWE1 著者 Hunkeler, M, Fischer, E.S. 登録日 2021-05-03 公開日 2021-07-28 最終更新日 2021-09-15 実験手法 ELECTRON MICROSCOPY (3.3 Å) 主引用文献 Solenoid architecture of HUWE1 contributes to ligase activity and substrate recognition. Mol.Cell, 81, 2021
7JQ9	Cryo-EM structure of human HUWE1 分子名称: E3 ubiquitin-protein ligase HUWE1 著者 Hunkeler, M, Fischer, E.S. 登録日 2020-08-10 公開日 2021-07-28 最終更新日 2021-09-15 実験手法 ELECTRON MICROSCOPY (3.1 Å) 主引用文献 Solenoid architecture of HUWE1 contributes to ligase activity and substrate recognition. Mol.Cell, 81, 2021
7P1L	The MARK3 Kinase Domain Bound To AA-CS-1-008 分子名称: 1,2-ETHANEDIOL, 5-Bromo-4-N-[2-(1H-imidazol-5-yl)ethyl]-2-N-[3-(morpholin-4-ylmethyl)phenyl]pyrimidine-2,4-diamine, MAP/microtubule affinity-regulating kinase 3 著者 Dederer, V, Preuss, F, Chatterjee, D, Vlassova, A, Mathea, S, Axtman, A, Knapp, S. 登録日 2021-07-01 公開日 2021-07-14 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (1.95 Å) 主引用文献 Identification of Pyrimidine-Based Lead Compounds for Understudied Kinases Implicated in Driving Neurodegeneration. J.Med.Chem., 65, 2022
6W2G	Crystal Structure of Y188G Variant of the Internal UBA Domain of HHR23A in Monoclinic Unit Cell 分子名称: 1,2-ETHANEDIOL, UV excision repair protein RAD23 homolog A 著者 Bowler, B.E, Zeng, B, Becht, D.C, Rothfuss, M, Sprang, S.R, Mou, T.-C. 登録日 2020-03-05 公開日 2021-03-10 最終更新日 2024-04-03 実験手法 X-RAY DIFFRACTION (1.1 Å) 主引用文献 High-Accuracy Prediction of Stabilizing Surface Mutations to the Three-Helix Bundle, UBA(1), with EmCAST. J.Am.Chem.Soc., 145, 2023
6W2H	Crystal Structure of the Internal UBA Domain of HHR23A 分子名称: SULFATE ION, UV excision repair protein RAD23 homolog A 著者 Bowler, B.E, Zeng, B, Becht, D.C, Rothfuss, M, Sprang, S.R, Mou, T.-C. 登録日 2020-03-05 公開日 2021-03-10 最終更新日 2024-04-03 実験手法 X-RAY DIFFRACTION (1.6 Å) 主引用文献 Residual Structure in the Denatured State of the Fast-Folding UBA(1) Domain from the Human DNA Excision Repair Protein HHR23A. Biochemistry, 61, 2022
6W2I	Crystal Structure of Y188G Variant of the Internal UBA Domain of HHR23A 分子名称: GLYCEROL, UV excision repair protein RAD23 homolog A 著者 Bowler, B.E, Zeng, B, Becht, D.C, Rothfuss, M, Sprang, S.R, Mou, T.-C. 登録日 2020-03-05 公開日 2021-03-10 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (1.45 Å) 主引用文献 High-Accuracy Prediction of Stabilizing Surface Mutations to the Three-Helix Bundle, UBA(1), with EmCAST. J.Am.Chem.Soc., 145, 2023
6UIN	Role of Beta-hairpin motifs in the DNA duplex opening by the Rad4/XPC nucleotide excision repair complex 分子名称: DNA (5'-D(*AP*TP*TP*GP*TP*AP*GP*NP*NP*NP*NP*GP*GP*AP*TP*GP*TP*CP*GP*AP*GP*TP*CP*A)-3'), DNA (5'-D(*TP*TP*GP*AP*CP*TP*CP*(G47)P*AP*CP*AP*TP*CP*CP*CP*CP*CP*CP*CP*TP*AP*CP*AP*A)-3'), DNA repair protein RAD4, ... 著者 Paul, D, Min, J.-H. 登録日 2019-10-01 公開日 2020-10-14 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (3.348 Å) 主引用文献 Tethering-facilitated DNA 'opening' and complementary roles of beta-hairpin motifs in the Rad4/XPC DNA damage sensor protein Nucleic Acids Res., 48, 2021
6UBF	Role of Beta-hairpin motifs in the DNA duplex opening by the Rad4/XPC nucleotide excision repair complex 分子名称: DNA (5'-D(*AP*TP*TP*GP*TP*AP*GP*CP*GP*GP*GP*AP*TP*GP*TP*CP*GP*AP*GP*TP*CP*A)-3'), DNA (5'-D(*TP*TP*GP*AP*CP*TP*CP*(G47)P*AP*CP*AP*TP*CP*CP*C*GP*CP*TP*AP*CP*AP*A)-3'), DNA repair protein RAD4, ... 著者 Paul, D, Min, J.H. 登録日 2019-09-11 公開日 2020-10-14 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (4.597 Å) 主引用文献 Kinetic gating mechanism of DNA damage recognition by Rad4/XPC. Nat Commun, 6, 2015
6JB6	Crystal structure of Ub-conjugated Ube2K C92K&K97A mutant (isopeptide linkage), 2.7 A resolution 分子名称: Ubiquitin, Ubiquitin-conjugating enzyme E2 K 著者 Lee, J.-G, Youn, H.-S, Lee, Y, An, J.Y, Park, K.R, Kang, J.Y, Mun, S.A, Park, J, Park, T, Jin, M.W, Yang, J, Eom, S.H. 登録日 2019-01-25 公開日 2019-03-20 最終更新日 2024-03-27 実験手法 X-RAY DIFFRACTION (2.7 Å) 主引用文献 Crystal structure of Ub-conjugated Ube2K C92K&K97A mutant (isopeptide linkage), 2.7 A resolution To Be Published
6JB7	Crystal structure of Ub-conjugated Ube2K C92K&K97A mutant (isopeptide linkage), 2.1 A resolution 分子名称: Ubiquitin, Ubiquitin-conjugating enzyme E2 K 著者 Lee, J.-G, Youn, H.-S, Lee, Y, An, J.Y, Park, K.R, Kang, J.Y, Mun, S.A, Park, J, Park, T, Jin, M.W, Yang, J, Eom, S.H. 登録日 2019-01-25 公開日 2019-03-20 最終更新日 2024-03-27 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Crystal structure of Ub-conjugated Ube2K C92K&K97A mutant (isopeptide linkage), 2.1 A resolution To Be Published

 

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