PDB: 140 件ウェブページステータス検索Chemie searchBIRD

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1BY1	DBL homology domain from beta-PIX 分子名称: PROTEIN (PIX) 著者 Aghazadeh, B, Zhu, K, Kubiseski, T.J, Liu, G.A, Pawson, T, Zheng, Y, Rosen, M.K. 登録日 1998-10-22 公開日 1999-10-24 最終更新日 2023-12-27 実験手法 SOLUTION NMR 主引用文献 Structure and Mutagenesis of the Dbl Homology Domain Nat.Struct.Biol., 5, 1998
5N7E	Crystal structure of the Dbl-homology domain of Bcr-Abl in complex with monobody Mb(Bcr-DH_4). 分子名称: Breakpoint cluster region protein, Mb(Bcr-DH_4) 著者 Reckel, S, Reynaud, A, Pojer, F, Hantschel, O. 登録日 2017-02-20 公開日 2017-12-27 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (1.647 Å) 主引用文献 Structural and functional dissection of the DH and PH domains of oncogenic Bcr-Abl tyrosine kinase. Nat Commun, 8, 2017
2KR9	Kalirin DH1 NMR structure 分子名称: Kalirin 著者 Gorbatyuk, V.Y, Schiller, M.R, Hoch, J.C. 登録日 2009-12-10 公開日 2010-12-15 最終更新日 2023-06-14 実験手法 SOLUTION NMR 主引用文献 The solution NMR structure of the first Dbl domain of RhoGEF Kalirin. To be Published
8C7D	Structure of the GEF Kalirin DH2 Domain 分子名称: Kalirin 著者 Callens, M.C, Thompson, A.P, Gray, J.L, Bountra, C, von Delft, F, Brennan, P.E. 登録日 2023-01-14 公開日 2024-01-24 実験手法 X-RAY DIFFRACTION (1.86 Å) 主引用文献 Structure-based alignment and analysis of RHO selectivity of RHO-DBL GTPase exchange factors to be published
4D0O	AKAP13 (AKAP-Lbc) DH domain 分子名称: A-KINASE ANCHOR PROTEIN 13 著者 Abdul Azeez, K.R, Shrestha, L, Krojer, T, Allerston, C, von Delft, F, Bountra, C, Arrowsmith, C, Edwards, A.M, Knapp, S, Klussmann, E, Elkins, J.M. 登録日 2014-04-29 公開日 2014-05-21 最終更新日 2014-11-26 実験手法 X-RAY DIFFRACTION (2.75 Å) 主引用文献 The Crystal Structure of the Rhoa : Akap-Lbc Dh-Ph Domain Complex. Biochem.J., 464, 2014
3EO2	Crystal structure of the RhoGEF domain of human neuroepithelial cell-transforming gene 1 protein 分子名称: Neuroepithelial cell-transforming gene 1 protein, UNKNOWN ATOM OR ION 著者 Nedyalkova, L, Tong, Y, Tempel, W, MacKenzie, F, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Weigelt, J, Bochkarev, A, Park, H, Structural Genomics Consortium (SGC) 登録日 2008-09-26 公開日 2008-10-07 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 Crystal structure of the RhoGEF domain of human neuroepithelial cell-transforming gene 1 protein To be Published
1F5X	NMR STRUCTURE OF THE Y174 AUTOINHIBITED DBL HOMOLOGY DOMAIN 分子名称: RHO-GEF VAV 著者 Aghazadeh, B, Rosen, M.K, Lowry, W.E, Huang, X.Y. 登録日 2000-06-18 公開日 2000-09-15 最終更新日 2022-02-16 実験手法 SOLUTION NMR 主引用文献 Structural basis for relief of autoinhibition of the Dbl homology domain of proto-oncogene Vav by tyrosine phosphorylation. Cell(Cambridge,Mass.), 102, 2000
4GYV	Crystal structure of the DH domain of FARP2 分子名称: FERM, RhoGEF and pleckstrin domain-containing protein 2 著者 He, X, Zhang, X. 登録日 2012-09-05 公開日 2013-03-13 最終更新日 2017-11-15 実験手法 X-RAY DIFFRACTION (2.9 Å) 主引用文献 Structural Basis for Autoinhibition of the Guanine Nucleotide Exchange Factor FARP2. Structure, 21, 2013
5N6R	Solution structure of the Dbl-homology domain of Bcr-Abl 分子名称: Breakpoint cluster region protein 著者 Reckel, S, Lohr, F, Buchner, L, Guntert, P, Dotsch, V, Hantschel, O. 登録日 2017-02-16 公開日 2017-12-27 最終更新日 2023-06-14 実験手法 SOLUTION NMR 主引用文献 Structural and functional dissection of the DH and PH domains of oncogenic Bcr-Abl tyrosine kinase. Nat Commun, 8, 2017
5HZI	Crystal structure of photoinhibitable Intersectin1 containing C450M mutant LOV2 domain 分子名称: FLAVIN MONONUCLEOTIDE, Intersectin-1,NPH1-1,Intersectin-1 著者 Tarnawski, M, Dagliyan, O, Chu, P.H, Shirvanyants, D, Dokholyan, N.V, Hahn, K.M, Schlichting, I. 登録日 2016-02-02 公開日 2016-12-21 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 Engineering extrinsic disorder to control protein activity in living cells. Science, 354, 2016
5HZJ	Crystal structure of photoinhibitable Intersectin1 containing wildtype LOV2 domain 分子名称: FLAVIN MONONUCLEOTIDE, Intersectin-1,NPH1-1,Intersectin-1 著者 Tarnawski, M, Dagliyan, O, Chu, P.H, Shirvanyants, D, Dokholyan, N.V, Hahn, K.M, Schlichting, I. 登録日 2016-02-02 公開日 2016-12-21 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 Engineering extrinsic disorder to control protein activity in living cells. Science, 354, 2016
5HZK	Crystal structure of photoinhibitable Intersectin1 containing wildtype LOV2 domain in complex with Cdc42 分子名称: Cell division control protein 42 homolog, FLAVIN MONONUCLEOTIDE, GUANOSINE-5'-DIPHOSPHATE, ... 著者 Tarnawski, M, Dagliyan, O, Chu, P.H, Shirvanyants, D, Dokholyan, N.V, Hahn, K.M, Schlichting, I. 登録日 2016-02-02 公開日 2016-12-21 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (3.3 Å) 主引用文献 Engineering extrinsic disorder to control protein activity in living cells. Science, 354, 2016
1TXD	Crystal Structure of the DH/PH domains of Leukemia-associated RhoGEF 分子名称: Rho guanine nucleotide exchange factor 12 著者 Kristelly, R, Gao, G, Tesmer, J.J. 登録日 2004-07-03 公開日 2004-09-21 最終更新日 2024-02-14 実験手法 X-RAY DIFFRACTION (2.13 Å) 主引用文献 Structural determinants of RhoA binding and nucleotide exchange in leukemia-associated Rho guanine-nucleotide exchange factor. J.Biol.Chem., 279, 2004
3GF9	Crystal structure of human Intersectin 2 RhoGEF domain 分子名称: Intersectin 2, UNKNOWN ATOM OR ION 著者 Shen, Y, Tong, Y, Tempel, W, Li, Y, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Weigelt, J, Bochkarev, A, Park, H, Structural Genomics Consortium (SGC) 登録日 2009-02-26 公開日 2009-03-10 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Crystal structure of human Intersectin 2 RhoGEF domain To be Published
3ODX	Crystal Structure of an N-terminally Truncated Linker-DH/PH Domains of p115-RhoGEF 分子名称: Rho guanine nucleotide exchange factor 1 著者 Chen, Z, Guo, L, Sprang, S.R, Sternweis, P.C. 登録日 2010-08-12 公開日 2011-01-05 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (3.2 Å) 主引用文献 Modulation of a GEF switch: Autoinhibition of the intrinsic guanine nucleotide exchange activity of p115-RhoREF Protein Sci., 20, 2011
3ODO	Crystal Structure of the DH/PH Domains of p115-RhoGEF 分子名称: Rho guanine nucleotide exchange factor 1 著者 Chen, Z, Guo, L, Sprang, S.R, Sternweis, P.C. 登録日 2010-08-11 公開日 2011-01-05 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (2.9 Å) 主引用文献 Modulation of a GEF switch: Autoinhibition of the intrinsic guanine nucleotide exchange activity of p115-RhoREF Protein Sci., 20, 2011
3ODW	Crystal Structure of the Linker-DH/PH domains of p115-RhoGEF 分子名称: Rho guanine nucleotide exchange factor 1 著者 Chen, Z, Guo, L, Sprang, S.R, Sternweis, P.C. 登録日 2010-08-11 公開日 2011-01-05 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (3.2 Å) 主引用文献 Modulation of a GEF switch: Autoinhibition of the intrinsic guanine nucleotide exchange activity of p115-RhoREF Protein Sci., 20, 2011
3P6A	Crystal Structure of the DH/PH domains of p115-RhoGEF (R399E mutant) 分子名称: Rho guanine nucleotide exchange factor 1 著者 Chen, Z, Guo, L, Sprang, S.R, Sternweis, P.C. 登録日 2010-10-11 公開日 2011-01-05 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Modulation of a GEF switch: Autoinhibition of the intrinsic guanine nucleotide exchange activity of p115-RhoREF Protein Sci., 20, 2011
6D8Z	Crystal Structure of the C-terminal Guanine Nucleotide Exchange Factor Module of Human Trio 分子名称: Triple functional domain protein 著者 Bandekar, S, Tesmer, J.J. 登録日 2018-04-27 公開日 2019-02-20 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (2.65 Å) 主引用文献 Structure of the C-terminal guanine nucleotide exchange factor module of Trio in an autoinhibited conformation reveals its oncogenic potential. Sci Signal, 12, 2019
3T06	Crystal Structure of the DH/PH fragment of PDZRHOGEF with N-terminal regulatory elements in complex with Human RhoA 分子名称: Rho guanine nucleotide exchange factor 11, Transforming protein RhoA 著者 Bielnicki, J.A, Derewenda, U, Derewenda, Z.S. 登録日 2011-07-19 公開日 2011-08-03 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (2.84 Å) 主引用文献 Insights into the Molecular Activation Mechanism of the RhoA-specific Guanine Nucleotide Exchange Factor, PDZRhoGEF. J.Biol.Chem., 286, 2011
7RX9	Structure of autoinhibited P-Rex1 分子名称: Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein, Endolysin chimera, SULFATE ION 著者 Ellisdon, A.M, Chang, Y. 登録日 2021-08-22 公開日 2022-08-10 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (3.22 Å) 主引用文献 Structure of the metastatic factor P-Rex1 reveals a two-layered autoinhibitory mechanism. Nat.Struct.Mol.Biol., 29, 2022
6L30	Crystal structure of the epithelial cell transforming 2 (ECT2) 分子名称: Protein ECT2 著者 Chen, Z.C, Chen, M.R, Pan, H, Sun, L.F, Shi, P. 登録日 2019-10-07 公開日 2020-01-01 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 Structure and regulation of human epithelial cell transforming 2 protein. Proc.Natl.Acad.Sci.USA, 117, 2020
7SJ4	Human Trio residues 1284-1959 in complex with Rac1 分子名称: Ras-related C3 botulinum toxin substrate 1, Triple functional domain protein 著者 Chen, C.-L, Ravala, S.K, Bandekar, S.J, Cash, J, Tesmer, J.J.G. 登録日 2021-10-15 公開日 2022-07-06 最終更新日 2022-08-24 実験手法 ELECTRON MICROSCOPY (2.86 Å) 主引用文献 Structural/functional studies of Trio provide insights into its configuration and show that conserved linker elements enhance its activity for Rac1. J.Biol.Chem., 298, 2022
8BNT	The DH domain of ARHGEF2 bound to RhoA 分子名称: DIMETHYL SULFOXIDE, FORMIC ACID, Rho guanine nucleotide exchange factor 2, ... 著者 Bradshaw, W.J, Katis, V.L, Grosjean, H, Bountra, C, von Delft, F, Brennan, P.E. 登録日 2022-11-25 公開日 2022-12-07 最終更新日 2024-02-07 実験手法 X-RAY DIFFRACTION (1.4 Å) 主引用文献 The DH domain of ARHGEF2 bound to RhoA To Be Published
7SYF	Reconstruction of full-length Prex-1 (PtdIns(3,4,5)P3-dependent Rac Exchanger 1) 分子名称: Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein,Endolysin chimera 著者 Lupton, C.J, Bayly-Jones, C, Ellisdon, A.M. 登録日 2021-11-24 公開日 2022-07-27 最終更新日 2024-02-28 実験手法 ELECTRON MICROSCOPY (4.2 Å) 主引用文献 Structure of the metastatic factor P-Rex1 reveals a two-layered autoinhibitory mechanism. Nat.Struct.Mol.Biol., 29, 2022

 

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