1BKD
 
 | | COMPLEX OF HUMAN H-RAS WITH HUMAN SOS-1 | | 分子名称: | H-RAS, SON OF SEVENLESS-1 | | 著者 | Boriack-Sjodin, P.A, Margarit, S.M, Sagi, D.B, Kuriyan, J. | | 登録日 | 1998-07-06 | | 公開日 | 1999-01-13 | | 最終更新日 | 2024-02-07 | | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | | 主引用文献 | The structural basis of the activation of Ras by Sos.
Nature, 394, 1998
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1NVU
 | | Structural evidence for feedback activation by RasGTP of the Ras-specific nucleotide exchange factor SOS | | 分子名称: | GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, PHOSPHATE ION, ... | | 著者 | Margarit, S.M, Sondermann, H, Hall, B.E, Nagar, B, Hoelz, A, Pirruccello, M, Bar-Sagi, D, Kuriyan, J. | | 登録日 | 2003-02-04 | | 公開日 | 2003-04-01 | | 最終更新日 | 2023-08-16 | | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | | 主引用文献 | Structural evidence for feedback activation by RasGTP of the Ras-specific nucleotide exchange factor SOS
Cell(Cambridge,Mass.), 112, 2003
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1NVV
 | | Structural evidence for feedback activation by RasGTP of the Ras-specific nucleotide exchange factor SOS | | 分子名称: | MAGNESIUM ION, PHOSPHATE ION, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, ... | | 著者 | Margarit, S.M, Sondermann, H, Hall, B.E, Nagar, B, Hoelz, A, Pirruccello, M, Bar-Sagi, D, Kuriyan, J. | | 登録日 | 2003-02-04 | | 公開日 | 2003-04-01 | | 最終更新日 | 2023-08-16 | | 実験手法 | X-RAY DIFFRACTION (2.18 Å) | | 主引用文献 | Structural evidence for feedback activation by RasGTP of the
Ras-specific nucleotide exchange factor SOS
Cell(Cambridge,Mass.), 112, 2003
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1NVW
 | | Structural evidence for feedback activation by RasGTP of the Ras-specific nucleotide exchange factor SOS | | 分子名称: | MAGNESIUM ION, PHOSPHATE ION, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, ... | | 著者 | Margarit, S.M, Sondermann, H, Hall, B.E, Nagar, B, Hoelz, A, Pirruccello, M, Bar-Sagi, D, Kuriyan, J. | | 登録日 | 2003-02-04 | | 公開日 | 2003-04-01 | | 最終更新日 | 2023-08-16 | | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | | 主引用文献 | Structural evidence for feedback activation by RasGTP of the Ras-specific nucleotide exchange factor SOS
Cell(Cambridge,Mass.), 112, 2003
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1NVX
 | | Structural evidence for feedback activation by RasGTP of the Ras-specific nucleotide exchange factor SOS | | 分子名称: | GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, PHOSPHATE ION, ... | | 著者 | Margarit, S.M, Sondermann, H, Hall, B.E, Nagar, B, Hoelz, A, Pirruccello, M, Bar-Sagi, D, Kuriyan, J. | | 登録日 | 2003-02-04 | | 公開日 | 2003-04-01 | | 最終更新日 | 2023-08-16 | | 実験手法 | X-RAY DIFFRACTION (3.2 Å) | | 主引用文献 | Structural evidence for feedback activation by RasGTP of the Ras-specific nucleotide exchange factor SOS
Cell(Cambridge,Mass.), 112, 2003
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1XD2
 | | Crystal Structure of a ternary Ras:SOS:Ras*GDP complex | | 分子名称: | GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, PHOSPHATE ION, ... | | 著者 | Sondermann, H, Soisson, S.M, Boykevisch, S, Yang, S.S, Bar-Sagi, D, Kuriyan, J. | | 登録日 | 2004-09-03 | | 公開日 | 2004-11-02 | | 最終更新日 | 2023-08-23 | | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | | 主引用文献 | Structural analysis of autoinhibition in the ras activator son of sevenless.
Cell(Cambridge,Mass.), 119, 2004
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1XD4
 | | Crystal structure of the DH-PH-cat module of Son of Sevenless (SOS) | | 分子名称: | Son of sevenless protein homolog 1 | | 著者 | Sondermann, H, Soisson, S.M, Boykevisch, S, Yang, S.S, Bar-Sagi, D, Kuriyan, J. | | 登録日 | 2004-09-03 | | 公開日 | 2004-11-02 | | 最終更新日 | 2023-08-23 | | 実験手法 | X-RAY DIFFRACTION (3.64 Å) | | 主引用文献 | Structural analysis of autoinhibition in the ras activator son of sevenless.
Cell(Cambridge,Mass.), 119, 2004
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1XDV
 | | Experimentally Phased Structure of Human the Son of Sevenless protein at 4.1 Ang. | | 分子名称: | Son of sevenless protein homolog 1 | | 著者 | Sondermann, H, Soisson, S.M, Boykevisch, S, Yang, S.S, Bar-Sagi, D, Kuriyan, J. | | 登録日 | 2004-09-08 | | 公開日 | 2004-11-02 | | 最終更新日 | 2023-08-23 | | 実験手法 | X-RAY DIFFRACTION (4.1 Å) | | 主引用文献 | Structural analysis of autoinhibition in the ras activator son of sevenless.
Cell(Cambridge,Mass.), 119, 2004
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2BYV
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2II0
 | | Crystal Structure of catalytic domain of Son of sevenless (Rem-Cdc25) in the absence of Ras | | 分子名称: | Son of sevenless homolog 1 | | 著者 | Freedman, T.S, Sondermann, H, Friedland, G.D, Kortemme, T, Bar-Sagi, D, Marqusee, S, Kuriyan, J. | | 登録日 | 2006-09-27 | | 公開日 | 2006-10-31 | | 最終更新日 | 2023-08-30 | | 実験手法 | X-RAY DIFFRACTION (2.02 Å) | | 主引用文献 | A Ras-induced conformational switch in the Ras activator Son of sevenless.
Proc.Natl.Acad.Sci.Usa, 103, 2006
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2IJE
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3KSY
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3QXL
 | | Crystal structure of the CDC25 Domain from Ral-specific Guanine-nucleotide Exchange Factor RalGPS1a | | 分子名称: | Ras-specific guanine nucleotide-releasing factor RalGPS1 | | 著者 | Peng, W, Xu, J, Guan, X, Sun, Y, Li, X, Zhang, X.C, Rao, Z. | | 登録日 | 2011-03-02 | | 公開日 | 2011-05-11 | | 最終更新日 | 2024-02-21 | | 実験手法 | X-RAY DIFFRACTION (2.237 Å) | | 主引用文献 | Structural study of the Cdc25 domain from Ral-specific guanine-nucleotide exchange factor RalGPS1a.
Protein Cell, 2, 2011
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3T6A
 | | Structure of the C-terminal domain of BCAR3 | | 分子名称: | (20S)-2,5,8,11,14,17-HEXAMETHYL-3,6,9,12,15,18-HEXAOXAHENICOSANE-1,20-DIOL, Breast cancer anti-estrogen resistance protein 3, UNKNOWN ATOM OR ION | | 著者 | Mace, P.D, Robinson, H, Riedl, S.J. | | 登録日 | 2011-07-28 | | 公開日 | 2011-11-23 | | 最終更新日 | 2024-02-28 | | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | | 主引用文献 | NSP-Cas protein structures reveal a promiscuous interaction module in cell signaling.
Nat.Struct.Mol.Biol., 18, 2011
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3T6G
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4F7Z
 | | Conformational dynamics of exchange protein directly activated by cAMP | | 分子名称: | GLYCEROL, Rap guanine nucleotide exchange factor 4 | | 著者 | White, M.A, Tsalkova, T.N, Mei, F.C, Liu, T, Woods, V.L, Cheng, X. | | 登録日 | 2012-05-16 | | 公開日 | 2012-10-03 | | 最終更新日 | 2023-09-13 | | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | | 主引用文献 | Structural analyses of a constitutively active mutant of exchange protein directly activated by cAMP.
Plos One, 7, 2012
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4JGW
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4L9M
 | | Autoinhibited state of the Ras-specific exchange factor RasGRP1 | | 分子名称: | CITRIC ACID, GLYCEROL, RAS guanyl-releasing protein 1, ... | | 著者 | Iwig, J.S, Vercoulen, Y, Das, R, Barros, T, Limnander, A, Che, Y, Pelton, J.G, Wemmer, D.E, Roose, J.P, Kuriyan, J. | | 登録日 | 2013-06-18 | | 公開日 | 2013-08-21 | | 最終更新日 | 2023-09-20 | | 実験手法 | X-RAY DIFFRACTION (3 Å) | | 主引用文献 | Structural analysis of autoinhibition in the Ras-specific exchange factor RasGRP1.
Elife, 2, 2013
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4MGI
 | | Selective activation of Epac1 and Epac2 | | 分子名称: | ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE, Rap guanine nucleotide exchange factor 4, Ras-related protein Rap-1b, ... | | 著者 | Rehmann, H. | | 登録日 | 2013-08-28 | | 公開日 | 2014-09-03 | | 最終更新日 | 2023-09-20 | | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | | 主引用文献 | Selective activation of Epac1 and Epac2
To be Published
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4MGK
 | | Selective activation of Epac1 and Epac2 | | 分子名称: | ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE, Rap guanine nucleotide exchange factor 4, Ras-related protein Rap-1b, ... | | 著者 | Rehmann, H. | | 登録日 | 2013-08-28 | | 公開日 | 2014-09-03 | | 最終更新日 | 2023-09-20 | | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | | 主引用文献 | Selective activation of Epac1 and Epac2
To be Published
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4MGY
 | | Selective activation of Epac1 and Epac2 | | 分子名称: | (2S,4aR,6R,7R,7aR)-6-{6-amino-8-[(4-chlorophenyl)sulfanyl]-9H-purin-9-yl}-7-methoxytetrahydro-4H-furo[3,2-d][1,3,2]dioxaphosphinin-2-ol 2-oxide, Rap guanine nucleotide exchange factor 4, Ras-related protein Rap-1b, ... | | 著者 | Rehmann, H. | | 登録日 | 2013-08-29 | | 公開日 | 2014-09-03 | | 最終更新日 | 2023-09-20 | | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | | 主引用文献 | Selective activation of Epac1 and Epac2
To be Published
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4MGZ
 | | Selective activation of Epac1 and Epac2 | | 分子名称: | (2S,4aR,6R,7R,7aS)-6-[6-amino-8-(benzylsulfanyl)-9H-purin-9-yl]-2-sulfanyltetrahydro-4H-furo[3,2-d][1,3,2]dioxaphosphinin-7-ol 2-oxide, Rap guanine nucleotide exchange factor 4, Ras-related protein Rap-1b, ... | | 著者 | Rehmann, H. | | 登録日 | 2013-08-29 | | 公開日 | 2014-09-03 | | 最終更新日 | 2023-09-20 | | 実験手法 | X-RAY DIFFRACTION (3 Å) | | 主引用文献 | Selective activation of Epac1 and Epac2
To be Published
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4MH0
 | | Selective activation of Epac1 and Epac2 | | 分子名称: | (2S,4aR,6R,7R,7aS)-6-{6-amino-8-[(4-fluorobenzyl)sulfanyl]-9H-purin-9-yl}-2-sulfanyltetrahydro-4H-furo[3,2-d][1,3,2]dioxaphosphinin-7-ol 2-oxide, Rap guanine nucleotide exchange factor 4, Ras-related protein Rap-1b, ... | | 著者 | Rehmann, H. | | 登録日 | 2013-08-29 | | 公開日 | 2014-09-03 | | 最終更新日 | 2023-09-20 | | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | | 主引用文献 | Selective activation of Epac1 and Epac2
To be Published
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4NYI
 | | Approach for Targeting Ras with Small Molecules that Activate SOS-Mediated Nucleotide Exchange | | 分子名称: | GTPase HRas, MAGNESIUM ION, N-{1-[(5-methyl-1H-indol-3-yl)methyl]piperidin-4-yl}-L-tryptophanamide, ... | | 著者 | Burns, M.C, Sun, Q, Phan, J, Fesik, S.W. | | 登録日 | 2013-12-10 | | 公開日 | 2014-03-12 | | 最終更新日 | 2024-02-28 | | 実験手法 | X-RAY DIFFRACTION (2.9612 Å) | | 主引用文献 | Approach for targeting Ras with small molecules that activate SOS-mediated nucleotide exchange.
Proc.Natl.Acad.Sci.USA, 111, 2014
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4NYJ
 | | Approach for Targeting Ras with Small Molecules that Activate SOS-Mediated Nucleotide Exchange | | 分子名称: | GTPase HRas, MAGNESIUM ION, N-[1-(1H-indol-3-ylmethyl)piperidin-4-yl]glycinamide, ... | | 著者 | Burns, M.C, Sun, Q, Phan, J, Fesik, S.W. | | 登録日 | 2013-12-10 | | 公開日 | 2014-03-12 | | 最終更新日 | 2023-09-20 | | 実験手法 | X-RAY DIFFRACTION (2.8522 Å) | | 主引用文献 | Approach for targeting Ras with small molecules that activate SOS-mediated nucleotide exchange.
Proc.Natl.Acad.Sci.USA, 111, 2014
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