6VSK
| Crystal structure of the P-Rex1 DEP1 domain | 分子名称: | Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein | 著者 | Tesmer, J, Ravala, S.K. | 登録日 | 2020-02-11 | 公開日 | 2020-07-22 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (3.12 Å) | 主引用文献 | The first DEP domain of the RhoGEF P-Rex1 autoinhibits activity and contributes to membrane binding. J.Biol.Chem., 295, 2020
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5LNP
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7DKL
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1FSH
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2YSR
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5SUY
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5SUZ
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2CSO
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1UHW
| Solution structure of the DEP domain of mouse pleckstrin | 分子名称: | Pleckstrin | 著者 | Inoue, K, Yoshida, M, Hatta, R, Hayashi, F, Shirouzu, M, Terada, T, Kigawa, T, Inoue, M, Yabuki, T, Aoki, M, Seki, E, Matsuda, T, Hirota, H, Tanaka, A, Osanai, T, Matsuo, Y, Arakawa, T, Carninci, P, Kawai, J, Hayashizaki, Y, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | 登録日 | 2003-07-11 | 公開日 | 2004-01-11 | 最終更新日 | 2023-12-27 | 実験手法 | SOLUTION NMR | 主引用文献 | Solution structure of the DEP domain of mouse pleckstrin To be Published
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1V3F
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1W4M
| Structure of the human pleckstrin DEP domain by multidimensional NMR | 分子名称: | PLECKSTRIN | 著者 | Civera, C, Simon, B, Stier, G, Sattler, M, Macias, M.J. | 登録日 | 2004-07-26 | 公開日 | 2004-12-15 | 最終更新日 | 2011-07-13 | 実験手法 | SOLUTION NMR | 主引用文献 | Structure and Dynamics of the Human Pleckstrin Dep Domain: Distinct Molecular Features of a Novel Dep Domain Subfamily Proteins: Struct.,Funct., Genet., 58, 2005
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7PED
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3ML6
| a complex between Dishevelled2 and clathrin adaptor AP-2 | 分子名称: | Chimeric complex between protein Dishevelled2 homolog dvl-2 and clathrin adaptor AP-2 complex subunit mu | 著者 | Yu, A, Xing, Y, Harrison, S.C, Kirchhausen, T.L. | 登録日 | 2010-04-16 | 公開日 | 2010-08-11 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (3.5 Å) | 主引用文献 | Structural analysis of the interaction between Dishevelled2 and clathrin AP-2 adaptor, a critical step in noncanonical Wnt signaling. Structure, 18, 2010
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8FW5
| Chimeric HsGATOR1-SpGtr-SpLam complex | 分子名称: | ALUMINUM FLUORIDE, GATOR complex protein DEPDC5, GATOR complex protein NPRL2, ... | 著者 | Tettoni, S.D, Egri, S.B, Doxsey, D.D, Ouch, C, Chang, J, Song, K, Xu, C, Shen, K. | 登録日 | 2023-01-20 | 公開日 | 2023-07-26 | 最終更新日 | 2023-09-20 | 実験手法 | ELECTRON MICROSCOPY (3.08 Å) | 主引用文献 | Structure of the Schizosaccharomyces pombe Gtr-Lam complex reveals evolutionary divergence of mTORC1-dependent amino acid sensing. Structure, 31, 2023
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7RX9
| Structure of autoinhibited P-Rex1 | 分子名称: | Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein, Endolysin chimera, SULFATE ION | 著者 | Ellisdon, A.M, Chang, Y. | 登録日 | 2021-08-22 | 公開日 | 2022-08-10 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (3.22 Å) | 主引用文献 | Structure of the metastatic factor P-Rex1 reveals a two-layered autoinhibitory mechanism. Nat.Struct.Mol.Biol., 29, 2022
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6CET
| Cryo-EM structure of GATOR1 | 分子名称: | GATOR complex protein DEPDC5, GATOR complex protein NPRL2, GATOR complex protein NPRL3 | 著者 | Shen, K, Huang, R.K, Brignole, E.J, Yu, Z, Sabatini, D.M. | 登録日 | 2018-02-12 | 公開日 | 2018-03-28 | 最終更新日 | 2024-03-13 | 実験手法 | ELECTRON MICROSCOPY (4.4 Å) | 主引用文献 | Architecture of the human GATOR1 and GATOR1-Rag GTPases complexes. Nature, 556, 2018
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6CES
| Cryo-EM structure of GATOR1-RAG | 分子名称: | GATOR complex protein DEPDC5, GATOR complex protein NPRL2, GATOR complex protein NPRL3, ... | 著者 | Shen, K, Huang, R.K, Brignole, E.J, Yu, Z, Sabatini, D.M. | 登録日 | 2018-02-12 | 公開日 | 2018-03-28 | 最終更新日 | 2024-03-13 | 実験手法 | ELECTRON MICROSCOPY (4 Å) | 主引用文献 | Architecture of the human GATOR1 and GATOR1-Rag GTPases complexes. Nature, 556, 2018
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7SYF
| Reconstruction of full-length Prex-1 (PtdIns(3,4,5)P3-dependent Rac Exchanger 1) | 分子名称: | Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein,Endolysin chimera | 著者 | Lupton, C.J, Bayly-Jones, C, Ellisdon, A.M. | 登録日 | 2021-11-24 | 公開日 | 2022-07-27 | 最終更新日 | 2024-02-28 | 実験手法 | ELECTRON MICROSCOPY (4.2 Å) | 主引用文献 | Structure of the metastatic factor P-Rex1 reveals a two-layered autoinhibitory mechanism. Nat.Struct.Mol.Biol., 29, 2022
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7T3B
| GATOR1-RAG-RAGULATOR - GAP Complex | 分子名称: | ALUMINUM FLUORIDE, GATOR complex protein DEPDC5, GATOR complex protein NPRL2, ... | 著者 | Egri, S.B, Shen, K. | 登録日 | 2021-12-07 | 公開日 | 2022-04-06 | 最終更新日 | 2022-06-01 | 実験手法 | ELECTRON MICROSCOPY (3.9 Å) | 主引用文献 | Cryo-EM structures of the human GATOR1-Rag-Ragulator complex reveal a spatial-constraint regulated GAP mechanism. Mol.Cell, 82, 2022
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7T3A
| GATOR1-RAG-RAGULATOR - Inhibitory Complex | 分子名称: | GATOR complex protein DEPDC5, GATOR complex protein NPRL2, GATOR complex protein NPRL3, ... | 著者 | Egri, S.B, Shen, K. | 登録日 | 2021-12-07 | 公開日 | 2022-04-06 | 最終更新日 | 2022-06-01 | 実験手法 | ELECTRON MICROSCOPY (4 Å) | 主引用文献 | Cryo-EM structures of the human GATOR1-Rag-Ragulator complex reveal a spatial-constraint regulated GAP mechanism. Mol.Cell, 82, 2022
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7T3C
| GATOR1-RAG-RAGULATOR - Dual Complex | 分子名称: | ALUMINUM FLUORIDE, GATOR complex protein DEPDC5, GATOR complex protein NPRL2, ... | 著者 | Egri, S.B, Shen, K. | 登録日 | 2021-12-07 | 公開日 | 2022-04-06 | 最終更新日 | 2022-06-01 | 実験手法 | ELECTRON MICROSCOPY (4 Å) | 主引用文献 | Cryo-EM structures of the human GATOR1-Rag-Ragulator complex reveal a spatial-constraint regulated GAP mechanism. Mol.Cell, 82, 2022
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4F7Z
| Conformational dynamics of exchange protein directly activated by cAMP | 分子名称: | GLYCEROL, Rap guanine nucleotide exchange factor 4 | 著者 | White, M.A, Tsalkova, T.N, Mei, F.C, Liu, T, Woods, V.L, Cheng, X. | 登録日 | 2012-05-16 | 公開日 | 2012-10-03 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | Structural analyses of a constitutively active mutant of exchange protein directly activated by cAMP. Plos One, 7, 2012
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1O7F
| CRYSTAL STRUCTURE OF THE REGULATORY DOMAIN OF EPAC2 | 分子名称: | CAMP-DEPENDENT RAP1 GUANINE-NUCLEOTIDE EXCHANGE FACTOR | 著者 | Rehmann, H, Prakash, B, Wolf, E, Rueppel, A, De Rooij, J, Bos, J.L, Wittinghofer, A. | 登録日 | 2002-11-04 | 公開日 | 2002-11-11 | 最終更新日 | 2011-07-13 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Structure and Regulation of the Camp-Binding Domains of Epac2 Nat.Struct.Biol., 10, 2002
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6PCV
| Single Particle Reconstruction of Phosphatidylinositol (3,4,5) trisphosphate-dependent Rac exchanger 1 bound to G protein beta gamma subunits | 分子名称: | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Phosphatidylinositol (3,4,5) trisphosphate-dependent Rac exchanger 1 | 著者 | Cash, J.N, Cianfrocco, M.A, Tesmer, J.J.G. | 登録日 | 2019-06-18 | 公開日 | 2019-10-23 | 最終更新日 | 2024-03-20 | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | 主引用文献 | Cryo-electron microscopy structure and analysis of the P-Rex1-G beta gamma signaling scaffold. Sci Adv, 5, 2019
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2PBI
| The multifunctional nature of Gbeta5/RGS9 revealed from its crystal structure | 分子名称: | GLYCEROL, Guanine nucleotide-binding protein subunit beta 5, Regulator of G-protein signaling 9 | 著者 | Cheever, M.L, Snyder, J.T, Gershburg, S, Siderovski, D.P, Harden, T.K, Sondek, J. | 登録日 | 2007-03-28 | 公開日 | 2008-01-29 | 最終更新日 | 2024-02-21 | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | 主引用文献 | Crystal structure of the multifunctional Gbeta5-RGS9 complex. Nat.Struct.Mol.Biol., 15, 2008
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