8BO0
 
 | | Solution structure of Lqq4 toxin from Leiurus quinquestriatus quinquestriatus | | 分子名称: | Alpha-toxin Lqq4 | | 著者 | Mineev, K.S, Motov, V.V, Vassilevski, A.A, Chernykh, M.A, Kuzmenkov, A.I. | | 登録日 | 2022-11-14 | | 公開日 | 2023-09-20 | | 最終更新日 | 2023-10-04 | | 実験手法 | SOLUTION NMR | | 主引用文献 | A scorpion toxin affecting sodium channels shows double cis-trans isomerism.
Febs Lett., 597, 2023
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7XSU
 | | Cardiac sodium channel in complex with LqhIII | | 分子名称: | (3beta,14beta,17beta,25R)-3-[4-methoxy-3-(methoxymethyl)butoxy]spirost-5-en, 2-acetamido-2-deoxy-beta-D-glucopyranose, Alpha-like toxin Lqh3, ... | | 著者 | Jiang, D, Catterall, W.A. | | 登録日 | 2022-05-15 | | 公開日 | 2023-11-29 | | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | | 主引用文献 | Structural Basis for Nav1.5 Opening Modulated by a Gating Modifier Toxin
To Be Published
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7K18
 | | Cardiac Sodium channel with toxin bound | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Alpha-like toxin Lqh3, ... | | 著者 | Jiang, D, Catterall, W.A. | | 登録日 | 2020-09-07 | | 公開日 | 2021-01-20 | | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | | 主引用文献 | Structural basis for voltage-sensor trapping of the cardiac sodium channel by a deathstalker scorpion toxin.
Nat Commun, 12, 2021
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6VXW
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6THI
 | | Solution structure of MeuNaTxalpha-1 toxin from Mesobuthus Eupeus | | 分子名称: | Sodium channel neurotoxin MeuNaTxalpha-1 | | 著者 | Mineev, K.S, Kuzmenkov, A.I, Khusainov, G.A, Arseniev, A.S, Vassilevski, A.A. | | 登録日 | 2019-11-20 | | 公開日 | 2020-12-02 | | 最終更新日 | 2023-06-14 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Structure of MeuNaTx alpha-1 toxin from scorpion venom highlights the importance of the nest motif.
Proteins, 2021
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6NT4
 | | Cryo-EM structure of a human-cockroach hybrid Nav channel bound to alpha-scorpion toxin AaH2. | | 分子名称: | (7E,21R,24S)-27-amino-24-hydroxy-18,24-dioxo-19,23,25-trioxa-24lambda~5~-phosphaheptacos-7-en-21-yl (9Z,12E)-octadeca-9,12-dienoate, 1,2-DIPALMITOYL-PHOSPHATIDYL-GLYCEROLE, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | 著者 | Clairfeuille, T, Rohou, A, Payandeh, J. | | 登録日 | 2019-01-28 | | 公開日 | 2019-02-20 | | 最終更新日 | 2021-08-25 | | 実験手法 | ELECTRON MICROSCOPY (3.5 Å) | | 主引用文献 | Structural basis of alpha-scorpion toxin action on Na v channels.
Science, 363, 2019
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5MOU
 | | NMR spatial structure of scorpion alpha-like toxin BeM9 | | 分子名称: | Alpha-mammal toxin BeM9 | | 著者 | Mineev, K.S, Kuldushev, N.A, Berkut, A.A, Grishin, E.V, Vassilevski, A.A, Arseniev, A.S. | | 登録日 | 2016-12-14 | | 公開日 | 2018-01-17 | | 最終更新日 | 2023-06-14 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Refined structure of BeM9 reveals arginine hand, an overlooked structural motif in scorpion toxins affecting sodium channels.
Proteins, 86, 2018
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5CY0
 | | Total Chemical Synthesis, Covalent Structure Verification, and X-ray Structure of Bioactive Ts3 Toxin by Racemic Protein Crystallography | | 分子名称: | GLYCEROL, Ts3 Toxin | | 著者 | Dang, B, Kubota, T, Mandal, K, Correa, A.M, Bezanilla, F, Kent, S.B. | | 登録日 | 2015-07-29 | | 公開日 | 2016-06-01 | | 最終更新日 | 2023-09-27 | | 実験手法 | X-RAY DIFFRACTION (1.93 Å) | | 主引用文献 | Elucidation of the Covalent and Tertiary Structures of Biologically Active Ts3 Toxin.
Angew.Chem.Int.Ed.Engl., 55, 2016
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4V1D
 | | Ternary complex among two human derived single chain antibody fragments and Cn2 toxin from scorpion Centruroides noxius. | | 分子名称: | BETA-MAMMAL TOXIN CN2, SINGLE CHAIN ANTIBODY FRAGMENT LR, HEAVY CHAIN, ... | | 著者 | Riano-Umbarila, L, Serrano-Posada, H, Rojas-Trejo, S, Rudino-Pinera, E, Becerril, B. | | 登録日 | 2014-09-25 | | 公開日 | 2015-10-07 | | 最終更新日 | 2024-01-10 | | 実験手法 | X-RAY DIFFRACTION (3.1 Å) | | 主引用文献 | Optimal Neutralization of Centruroides Noxius Venom is Understood Through a Structural Complex between Two Antibody Fragments and the Cn2 Toxin.
J.Biol.Chem., 291, 2016
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4KYP
 | | Beta-Scorpion Toxin folded in the periplasm of E.coli | | 分子名称: | Beta-insect excitatory toxin Bj-xtrIT, TETRAETHYLENE GLYCOL, TRIETHYLENE GLYCOL | | 著者 | O'Reilly, A.O, Cole, A.R, Lopes, J.L, Lampert, A, Wallace, B.A. | | 登録日 | 2013-05-29 | | 公開日 | 2014-02-12 | | 最終更新日 | 2018-01-24 | | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | | 主引用文献 | Chaperone-mediated native folding of a beta-scorpion toxin in the periplasm of Escherichia coli.
Biochim.Biophys.Acta, 1840, 2014
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4HHF
 | | Crystal Structure of chemically synthesized scorpion alpha-toxin OD1 | | 分子名称: | (4S)-2-METHYL-2,4-PENTANEDIOL, Alpha-toxin OD1 | | 著者 | Wang, C.I.A, Lewis, R.J, Alewood, P.F, Durek, T. | | 登録日 | 2012-10-09 | | 公開日 | 2013-04-24 | | 最終更新日 | 2023-09-20 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | Chemical engineering and structural and pharmacological characterization of the alpha-scorpion toxin OD1.
Acs Chem.Biol., 8, 2013
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4AEI
 | | Crystal structure of the AaHII-Fab4C1 complex | | 分子名称: | 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, ALPHA-MAMMAL TOXIN AAH2, CHLORIDE ION, ... | | 著者 | Fabrichny, I.P, Mondielli, G, Conrod, S, Martin-Eauclaire, M.F, Bourne, Y, Marchot, P. | | 登録日 | 2012-01-10 | | 公開日 | 2012-03-07 | | 最終更新日 | 2023-12-20 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | Structural Insights Into Antibody Sequestering and Neutralizing of Na+-Channel & [Alpha]-Type Modulator from Old-World Scorpion Venom
J.Biol.Chem., 287, 2012
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2YEO
 | | A39L mutation of scorpion toxin lqh-alpha-it | | 分子名称: | 1,2-ETHANEDIOL, ALPHA-INSECT TOXIN LQHAIT, CHLORIDE ION, ... | | 著者 | Frolow, F, Kahn, R, Gurevitz, M. | | 登録日 | 2011-03-28 | | 公開日 | 2011-04-13 | | 最終更新日 | 2023-12-20 | | 実験手法 | X-RAY DIFFRACTION (1.08 Å) | | 主引用文献 | Crystal Structures of Scorpion Alpha-Toxinsmutants Reveal Conformational Constraints that Dictate Preference for Mammalian Brain Voltage-Gated Na- Channels
To be Published
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2YC1
 | | Crystal structure of the human derived single chain antibody fragment (scFv) 9004G in complex with Cn2 toxin from the scorpion Centruroides noxius Hoffmann | | 分子名称: | BETA-MAMMAL TOXIN CN2, GLYCEROL, SINGLE CHAIN ANTIBODY FRAGMENT 9004G | | 著者 | Canul-Tec, J.C, Riano-Umbarila, L, Rudino-Pinera, E, Becerril, B, Possani, L.D, Torres-Larios, A. | | 登録日 | 2011-03-10 | | 公開日 | 2011-04-13 | | 最終更新日 | 2023-12-20 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | Structural Basis of Neutralization of the Major Toxic Component from the Scorpion Centruroides Noxius Hoffmann by a Human-Derived Single Chain Antibody Fragment.
J.Biol.Chem., 286, 2011
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2YBR
 | | Crystal structure of the human derived single chain antibody fragment (scFv) 9004G in complex with Cn2 toxin from the scorpion Centruroides noxius Hoffmann | | 分子名称: | BETA-MAMMAL TOXIN CN2, SINGLE CHAIN ANTIBODY FRAGMENT 9004G | | 著者 | Canul-Tec, J.C, Riano-Umbarila, L, Rudino-Pinera, E, Becerril, B, Possani, L.D, Torres-Larios, A. | | 登録日 | 2011-03-09 | | 公開日 | 2011-04-13 | | 最終更新日 | 2023-12-20 | | 実験手法 | X-RAY DIFFRACTION (2.55 Å) | | 主引用文献 | Structural Basis of Neutralization of the Major Toxic Component from the Scorpion Centruroides Noxius Hoffmann by a Human-Derived Single Chain Antibody Fragment
J.Biol.Chem., 286, 2011
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2SN3
 | | STRUCTURE OF SCORPION TOXIN VARIANT-3 AT 1.2 ANGSTROMS RESOLUTION | | 分子名称: | (4S)-2-METHYL-2,4-PENTANEDIOL, SCORPION NEUROTOXIN (VARIANT 3) | | 著者 | Zhao, B, Carson, M, Ealick, S.E, Bugg, C.E. | | 登録日 | 1992-02-20 | | 公開日 | 1994-01-31 | | 最終更新日 | 2017-11-29 | | 実験手法 | X-RAY DIFFRACTION (1.2 Å) | | 主引用文献 | Structure of scorpion toxin variant-3 at 1.2 A resolution.
J.Mol.Biol., 227, 1992
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2LKB
 | | Evolutionary diversification of Mesobuthus alpha-scorpion toxins affecting sodium channels | | 分子名称: | Neurotoxin MeuNaTx-5 | | 著者 | Zhu, S, Peigneur, S, Gao, B, Lu, X, Cao, C, Tytgat, J. | | 登録日 | 2011-10-09 | | 公開日 | 2011-11-02 | | 最終更新日 | 2023-06-14 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Evolutionary diversification of Mesobuthus {alpha}-scorpion toxins affecting sodium channels
Mol.Cell Proteomics, 2011
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2LJM
 | | Solution Structure of CssII | | 分子名称: | Beta-mammal toxin Css2 | | 著者 | del Rio-Portilla, F, Saucedo, A.L, Corzo, G, Delepierre, M, Possani, L.D. | | 登録日 | 2011-09-20 | | 公開日 | 2012-02-15 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Solution structure of native and recombinant expressed toxin CssII from the venom of the scorpion Centruroides suffusus suffusus, and their effects on Nav1.5 Sodium channels.
Biochim.Biophys.Acta, 1824, 2012
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2LI7
 | | Solution Structure of CssII | | 分子名称: | Beta-mammal toxin Css2 | | 著者 | del Rio-Portilla, F, Saucedo, A.L, Corzo, G, Delepierre, M, Possani, L.D. | | 登録日 | 2011-08-24 | | 公開日 | 2012-02-15 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Solution structure of native and recombinant expressed toxin CssII from the venom of the scorpion Centruroides suffusus suffusus, and their effects on Nav1.5 Sodium channels.
Biochim.Biophys.Acta, 1824, 2012
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2KJA
 | | Chemical shift assignments, constraints, and coordinates for CN5 scorpion toxin | | 分子名称: | Beta-toxin Cn5 | | 著者 | Prochnicka-Chalufour, A, Corzo, G, Garcia, B.I, Possani, L.D, Delepierre, M. | | 登録日 | 2009-05-26 | | 公開日 | 2009-10-06 | | 最終更新日 | 2022-03-16 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Solution structure of Cn5, a crustacean toxin found in the venom of the scorpions Centruroides noxius and Centruroides suffusus suffusus.
Biochim.Biophys.Acta, 1794, 2009
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2KBK
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2KBJ
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2KBH
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2I61
 | | Depressant anti-insect neurotoxin, LqhIT2 from Leiurus quinquestriatus hebraeus | | 分子名称: | 1,2-ETHANEDIOL, ACETIC ACID, CARBON DIOXIDE, ... | | 著者 | Frolow, F, Gurevitz, M, Karbat, I, Turkov, M, Gordon, D. | | 登録日 | 2006-08-27 | | 公開日 | 2006-12-26 | | 最終更新日 | 2023-08-30 | | 実験手法 | X-RAY DIFFRACTION (1.2 Å) | | 主引用文献 | X-ray Structure and Mutagenesis of the Scorpion Depressant Toxin LqhIT2 Reveals Key Determinants Crucial for Activity and Anti-Insect Selectivity.
J.Mol.Biol., 366, 2007
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2E0H
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