PDB: 17 件ウェブページステータス検索Chemie searchBIRD

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8QY6	Structure of interleukin 6 (gp130 P496L mutant). 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Interleukin-6, ... 著者 Gardner, S, Bubeck, D, Jin, Y. 登録日 2023-10-25 公開日 2024-02-21 実験手法 ELECTRON MICROSCOPY (3.16 Å) 主引用文献 Structure of interleukin 6 (gp130 P496L mutant). To Be Published
8QY5	Structure of interleukin 6. 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Interleukin-6, ... 著者 Gardner, S, Bubeck, D, Jin, Y. 登録日 2023-10-25 公開日 2024-02-21 実験手法 ELECTRON MICROSCOPY (3.1 Å) 主引用文献 Structure of interleukin 6. To Be Published
8D82	Cryo-EM structure of human IL-6 signaling complex in detergent: model containing full extracellular domains 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Interleukin-6, ... 著者 Zhou, Y, Franklin, M.C. 登録日 2022-06-07 公開日 2023-03-29 実験手法 ELECTRON MICROSCOPY (3.22 Å) 主引用文献 Structural insights into the assembly of gp130 family cytokine signaling complexes. Sci Adv, 9, 2023
7NXZ	Synthetic glycoform of Human Interleukin 6 分子名称: Interleukin-6 著者 Weyand, M, Unverzagt, C. 登録日 2021-03-19 公開日 2021-04-07 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (1.998 Å) 主引用文献 Natural Glycoforms of Human Interleukin 6 Show Atypical Plasma Clearance. Angew.Chem.Int.Ed.Engl., 60, 2021
5FUC	Biophysical and cellular characterisation of a junctional epitope antibody that locks IL-6 and gp80 together in a stable complex: implications for new therapeutic strategies 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, INTERLEUKIN-6, INTERLEUKIN-6 RECEPTOR SUBUNIT ALPHA, ... 著者 Adams, R, Griffin, R, Doyle, C, Ettorre, A. 登録日 2016-01-25 公開日 2017-01-25 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (2.7 Å) 主引用文献 Discovery of a junctional epitope antibody that stabilizes IL-6 and gp80 protein:protein interaction and modulates its downstream signaling. Sci Rep, 7, 2017
4ZS7	Structural mimicry of receptor interaction by antagonistic IL-6 antibodies 分子名称: Interleukin-6, Llama Fab fragment 68F2 heavy chain, Llama Fab fragment 68F2 light chain 著者 Blanchetot, C, De Jonge, N, Desmyter, A, Ongenae, N, Hofman, E, Klarenbeek, A, Sadi, A, Hultberg, A, Kretz-Rommel, A, Spinelli, S, Loris, R, Cambillau, C, de Haard, H. 登録日 2015-05-13 公開日 2016-05-04 最終更新日 2016-07-06 実験手法 X-RAY DIFFRACTION (2.93 Å) 主引用文献 Structural Mimicry of Receptor Interaction by Antagonistic Interleukin-6 (IL-6) Antibodies. J.Biol.Chem., 291, 2016
4O9H	Structure of Interleukin-6 in complex with a Camelid Fab fragment 分子名称: Heavy Chain of the Camelid Fab fragment 61H7, Interleukin-6, Light Chain of the Camelid Fab fragment 61H7 著者 Klarenbeek, A, Blanchetot, C, Schragel, G, Sadi, A.S, Ongenae, N, Hemrika, W, Wijdenes, J, Spinelli, S, Desmyter, A, Cambillau, C, Hultberg, A, Kretz-rommel, A, Dreier, T, De haard, H.J.W, Roovers, R.C. 登録日 2014-01-02 公開日 2015-04-15 最終更新日 2015-04-29 実験手法 X-RAY DIFFRACTION (2.42 Å) 主引用文献 Combining residues of naturally-occurring Camelid somatic affinity variants yields ultra-potent human therapeutic IL-6 antibodies To be Published
4NI9	Crystal structure of human interleukin 6 in complex with a modified nucleotide aptamer (SOMAMER SL1025), FORM 2 分子名称: Interleukin-6, SODIUM ION, SOMAmer SL1025 著者 Davies, D, Edwards, T, Gelinas, A, Jarvis, T, Clifton, M.C. 登録日 2013-11-05 公開日 2014-01-22 最終更新日 2024-04-03 実験手法 X-RAY DIFFRACTION (2.55 Å) 主引用文献 Crystal structure of interleukin-6 in complex with a modified nucleic Acid ligand. J.Biol.Chem., 289, 2014
4NI7	Crystal structure of human interleukin 6 in complex with a modified nucleotide aptamer (SOMAMER SL1025) 分子名称: Interleukin-6, SODIUM ION, SOMAmer SL1025 著者 Davies, D, Edwards, T, Gelinas, A, Jarvis, T, Clifton, M.C. 登録日 2013-11-05 公開日 2014-01-22 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Crystal structure of interleukin-6 in complex with a modified nucleic Acid ligand. J.Biol.Chem., 289, 2014
4J4L	Modular evolution and design of the protein binding interface 分子名称: Interleukin-6, Internalin B,REPEAT MODULES,Variable lymphocyte receptor B 著者 Cheong, H.K, Kim, H.J. 登録日 2013-02-07 公開日 2014-02-12 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Modular evolution and design of the protein binding interface To be Published
4CNI	Crystal structure of the Fab portion of Olokizumab in complex with IL- 6 分子名称: INTERLEUKIN-6, OLOKIZUMAB HEAVY CHAIN, FAB PORTION, ... 著者 Shaw, S, Bourne, T, Meier, C, Carrington, B, Gelinas, R, Henry, A, Popplewell, A, Adams, R, Baker, T, Rapecki, S, Marshall, D, Neale, H, Lawson, A. 登録日 2014-01-22 公開日 2014-04-30 最終更新日 2019-04-03 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Discovery and Characterization of Olokizumab: A Humanized Antibody Targeting Interleukin-6 and Neutralizing Gp130-Signaling. Mabs, 6, 2014
2L3Y	Solution structure of mouse IL-6 分子名称: Interleukin-6 著者 Veverka, V, Redpath, N.T, Carrington, B, Muskett, F.W, Taylor, R.J, Henry, A.J, Carr, M.D. 登録日 2010-09-25 公開日 2011-09-28 最終更新日 2013-01-02 実験手法 SOLUTION NMR 主引用文献 Conservation of functional sites on interleukin-6 and implications for evolution of signaling complex assembly and therapeutic intervention. J.Biol.Chem., 287, 2012
2IL6	HUMAN INTERLEUKIN-6, NMR, 32 STRUCTURES 分子名称: INTERLEUKIN-6 著者 Xu, G.Y, Yu, H.A, Hong, J, Stahl, M, Mcdonagh, T, Kay, L.E, Cumming, D.A. 登録日 1997-01-31 公開日 1998-02-04 最終更新日 2022-03-09 実験手法 SOLUTION NMR 主引用文献 Solution structure of recombinant human interleukin-6. J.Mol.Biol., 268, 1997
1P9M	Crystal structure of the hexameric human IL-6/IL-6 alpha receptor/gp130 complex 分子名称: Interleukin-6, Interleukin-6 receptor alpha chain, Interleukin-6 receptor beta chain 著者 Boulanger, M.J, Chow, D.C, Brevnova, E.E, Garcia, K.C. 登録日 2003-05-12 公開日 2003-07-01 最終更新日 2023-08-16 実験手法 X-RAY DIFFRACTION (3.65 Å) 主引用文献 Hexameric Structure and Assembly of the Interleukin-6/IL-6 alpha-Receptor/gp130 Complex Science, 300, 2003
1IL6	HUMAN INTERLEUKIN-6, NMR, MINIMIZED AVERAGE STRUCTURE 分子名称: INTERLEUKIN-6 著者 Xu, G.Y, Yu, H.A, Hong, J, Stahl, M, Mcdonagh, T, Kay, L.E, Cumming, D.A. 登録日 1997-01-31 公開日 1998-02-04 最終更新日 2022-02-23 実験手法 SOLUTION NMR 主引用文献 Solution structure of recombinant human interleukin-6. J.Mol.Biol., 268, 1997
1I1R	CRYSTAL STRUCTURE OF A CYTOKINE/RECEPTOR COMPLEX 分子名称: INTERLEUKIN-6 RECEPTOR BETA CHAIN, VIRAL IL-6 著者 Chow, D, He, X, Snow, A.L, Rose-John, S, Garcia, K.C. 登録日 2001-02-02 公開日 2001-03-28 最終更新日 2023-08-09 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Structure of an extracellular gp130 cytokine receptor signaling complex. Science, 291, 2001
1ALU	HUMAN INTERLEUKIN-6 分子名称: INTERLEUKIN-6, L(+)-TARTARIC ACID, SULFATE ION 著者 Somers, W.S, Stahl, M, Seehra, J.S. 登録日 1997-06-03 公開日 1998-06-03 最終更新日 2011-07-13 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 1.9 A crystal structure of interleukin 6: implications for a novel mode of receptor dimerization and signaling. EMBO J., 16, 1997