PDB: 105 件ウェブページステータス検索Chemie searchBIRD

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21BI	INTERLEUKIN-1 BETA (IL-1 BETA) (MUTANT WITH CYS 71 REPLACED BY ALA) (C71A) 分子名称: INTERLEUKIN-1 BETA 著者 Veerapandian, B, Poulos, T.L, Gilliland, G.L, Masui, Y, Hirai, Y. 登録日 1991-03-21 公開日 1992-04-15 最終更新日 2024-02-14 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献
2NVH	Determination of Solvent Content in Cavities in Interleukin-1 Using Experimentally-Phased Electron Density 分子名称: Interleukin-1 beta, SULFATE ION 著者 Quillin, M.L, Matthews, B.W. 登録日 2006-11-12 公開日 2006-12-12 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (1.53 Å) 主引用文献 Determination of solvent content in cavities in IL-1beta using experimentally phased electron density Proc.Natl.Acad.Sci.Usa, 103, 2006
5UC6	Structural insights into IL-1 alpha recognition by a naphthyl-modified aptamer that mimics IL-1RI Domain III 分子名称: DNA (5'-D(*CP*G)-R(P*(85Y))-D(P*GP*AP*G)-R(P*(85Y)P*(85Y))-D(P*A)-R(P*(85Y))-D(P*GP*GP*G)-R(P*(85Y)P*(85Y))-D(P*AP*GP*AP*G)-R(P*(85Y))-D(P*CP*GP*(ATD))-3'), Interleukin-1 alpha, MAGNESIUM ION, ... 著者 Ren, X, Pyle, A. 登録日 2016-12-21 公開日 2017-10-11 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Structural basis for IL-1 alpha recognition by a modified DNA aptamer that specifically inhibits IL-1 alpha signaling. Nat Commun, 8, 2017
5MVZ	Fab 4AB007 bound to Interleukin-1-beta 分子名称: Fab 4AB007 H-chain, Fab 4AB007 L-chain, GLYCEROL, ... 著者 Stark, W, Seibert, V. 登録日 2017-01-17 公開日 2017-02-15 最終更新日 2019-02-20 実験手法 X-RAY DIFFRACTION (2.15 Å) 主引用文献 Structure of a novel, fully Human Fab binding to Interleukin 1-beta. To Be Published
8C3U	Crystal Structure of human IL-1beta in complex with a low molecular weight antagonist 分子名称: (S)-4'-hydroxy-3'-(6-methyl-2-oxo-3-(1H-pyrazol-4-yl)indolin-3-yl)-[1,1'-biphenyl]-2,4-dicarboxylic acid, Interleukin-1 beta 著者 Rondeau, J.-M, Lehmann, S, Koch, E. 登録日 2022-12-28 公開日 2023-09-13 最終更新日 2024-03-27 実験手法 X-RAY DIFFRACTION (1.945 Å) 主引用文献 Discovery of a selective and biologically active low-molecular weight antagonist of human interleukin-1 beta. Nat Commun, 14, 2023
7I1B	HIGH-RESOLUTION THREE-DIMENSIONAL STRUCTURE OF INTERLEUKIN-1 BETA IN SOLUTION BY THREE-AND FOUR-DIMENSIONAL NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY 分子名称: INTERLEUKIN-1 BETA 著者 Clore, G.M, Gronenborn, A.M. 登録日 1991-01-22 公開日 1992-10-15 最終更新日 2022-03-23 実験手法 SOLUTION NMR 主引用文献 High-resolution three-dimensional structure of interleukin 1 beta in solution by three- and four-dimensional nuclear magnetic resonance spectroscopy. Biochemistry, 30, 1991
7Z4T	AAL160 FAB IN COMPLEX WITH HUMAN INTERLEUKIN-1 BETA 分子名称: AAL160 Fab heavy-chain, AAL160 light-chain, Interleukin-1 beta 著者 Rondeau, J.M, Lehmann, S. 登録日 2022-03-04 公開日 2023-02-08 最終更新日 2024-02-07 実験手法 X-RAY DIFFRACTION (3.3 Å) 主引用文献 "Redirecting an anti-IL-1 beta antibody to bind a new, unrelated and computationally predicted epitope on hIL-17A". Commun Biol, 6, 2023
3LTQ	Structure of Interleukin 1B solved by SAD using an inserted Lanthanide Binding Tag 分子名称: ACETATE ION, Interleukin-1 beta, SULFATE ION, ... 著者 Peisach, E, Allen, K.N. 登録日 2010-02-16 公開日 2011-02-16 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Engineering encodable lanthanide-binding tags into loop regions of proteins. J.Am.Chem.Soc., 133, 2011
5HN1	Crystal structure of Interleukin-37 分子名称: Interleukin-37, SULFATE ION 著者 Ellisdon, A.M, Nold-Petry, C.A, Nold, M.F, Whisstock, J.C. 登録日 2016-01-17 公開日 2017-02-22 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (2.25 Å) 主引用文献 Homodimerization attenuates the anti-inflammatory activity of interleukin-37. Sci Immunol, 2, 2017
6NCU	Interleukin-37 residues 53-206- dimer 分子名称: Interleukin-37 著者 Eisenmesser, E.Z. 登録日 2018-12-12 公開日 2019-03-13 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (3.5 Å) 主引用文献 Interleukin-37 monomer is the active form for reducing innate immunity. Proc. Natl. Acad. Sci. U.S.A., 116, 2019
6HPI	NMR structure of the pro-inflammatory cytokine interleukin-36alpha 分子名称: Interleukin-36 alpha 著者 Ohlenschlaeger, O, Imhof, D. 登録日 2018-09-21 公開日 2019-10-02 最終更新日 2023-06-14 実験手法 SOLUTION NMR 主引用文献 (1)H, (13)C, and (15)N resonance assignments for the pro-inflammatory cytokine interleukin-36alpha. Biomol NMR Assign, 10, 2016
8I1B	A COMPARISON OF THE HIGH RESOLUTION STRUCTURES OF HUMAN AND MURINE INTERLEUKIN-1B 分子名称: INTERLEUKIN-1 BETA 著者 Ohlendorf, D.H, Weber, P.C, Salemme, F.R. 登録日 1991-01-29 公開日 1992-07-15 最終更新日 2024-02-14 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 A Comparison of the High Resolution Structures of Human and Murine Interleukin-1B To be Published
5I1B	A COMPARISON OF THE HIGH RESOLUTION STRUCTURES OF HUMAN AND MURINE INTERLEUKIN-1B 分子名称: INTERLEUKIN-1 BETA 著者 Ohlendorf, D.H, Salemme, F.R. 登録日 1990-09-07 公開日 1992-01-15 最終更新日 2024-03-06 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 A Comparison of the High Resolution Structures of Human and Murine Interleukin-1B To be Published
6Y8I	Fragment KCL_I013 in complex with IL-1-beta 分子名称: 1-(5-bromanylpyridin-2-yl)-3-(2-hydroxyethyl)urea, Interleukin-1 beta, SULFATE ION 著者 De Nicola, G.F, Nichols, C.E. 登録日 2020-03-05 公開日 2020-06-17 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (1.46 Å) 主引用文献 Fragment KCL_I013 in complex with IL-1-beta To Be Published
6Y8M	Fragment bikinin bound to Interleukin 1 beta 分子名称: 4-[(5-bromopyridin-2-yl)amino]-4-oxobutanoic acid, Interleukin-1 beta, SULFATE ION 著者 De Nicola, G.F, Nichols, C.E. 登録日 2020-03-05 公開日 2020-03-18 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Fragment bikinin bound to Interleukin 1 beta To Be Published
6I1B	HIGH-RESOLUTION THREE-DIMENSIONAL STRUCTURE OF INTERLEUKIN-1 BETA IN SOLUTION BY THREE-AND FOUR-DIMENSIONAL NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY 分子名称: INTERLEUKIN-1 BETA 著者 Clore, G.M, Gronenborn, A.M. 登録日 1991-01-22 公開日 1992-10-15 最終更新日 2022-03-16 実験手法 SOLUTION NMR 主引用文献 High-resolution three-dimensional structure of interleukin 1 beta in solution by three- and four-dimensional nuclear magnetic resonance spectroscopy. Biochemistry, 30, 1991
6P9E	Crystal structure of IL-36gamma complexed to A-552 分子名称: (2S)-2-{[4-(3-amino-4-methylphenyl)-6-methylpyrimidin-2-yl]oxy}-3-methoxy-3,3-diphenylpropanoic acid, Interleukin-36 gamma 著者 Argiriadi, M.A, Todorovic, T, Su, Z, Putman, B, Kakavas, S.J, Salte, K.M, McDonald, H.A, Wetter, J.B, Paulsboe, S.E, Sun, Q, Gerstein, C.E, Medina, L, Sielaff, B, Sadhukhan, R, Stockmann, H, Richardson, P.L, Qiu, W, Henry, R.F, Herold, J.M, Shotwell, J.B, McGaraughty, S.P, Honore, P, Gopalakrishnan, S.M, Sun, C.C, Scott, V.E. 登録日 2019-06-10 公開日 2019-06-26 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Small Molecule IL-36 gamma Antagonist as a Novel Therapeutic Approach for Plaque Psoriasis. Sci Rep, 9, 2019
5BOW	CRYSTAL STRUCTURE OF IL-38 分子名称: 1,2-ETHANEDIOL, Interleukin-1 family member 10 著者 Guenther, S, Sundberg, E.J. 登録日 2015-05-27 公開日 2016-06-01 最終更新日 2017-11-22 実験手法 X-RAY DIFFRACTION (1.31 Å) 主引用文献 Crystal Structure of Interleukin-38 To Be Published
1HIB	THE STRUCTURE OF AN INTERLEUKIN-1 BETA MUTANT WITH REDUCED BIOACTIVITY SHOWS MULTIPLE SUBTLE CHANGES IN CONFORMATION THAT AFFECT PROTEIN-PROTEIN RECOGNITION 分子名称: INTERLEUKIN-1 BETA 著者 Camacho, N.P, Smith, D.R, Goldman, A, Schneider, B, Green, D, Young, P.R, Berman, H.M. 登録日 1993-03-29 公開日 1994-01-31 最終更新日 2024-02-07 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Structure of an interleukin-1 beta mutant with reduced bioactivity shows multiple subtle changes in conformation that affect protein-protein recognition. Biochemistry, 32, 1993
5BVP	The molecular mode of action and species specificity of canakinumab, a human monoclonal antibody neutralizing IL-1beta 分子名称: CHLORIDE ION, Canakinumab Fab light-chain, Interleukin-1 beta, ... 著者 Rondeau, J.M. 登録日 2015-06-05 公開日 2015-09-02 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 The molecular mode of action and species specificity of canakinumab, a human monoclonal antibody neutralizing IL-1 beta. Mabs, 7, 2015
1I1B	CRYSTAL STRUCTURE OF RECOMBINANT HUMAN INTERLEUKIN-1BETA AT 2.0 ANGSTROMS RESOLUTION 分子名称: INTERLEUKIN-1 BETA 著者 Finzel, B.C, Watenpaugh, K.D, Einspahr, H.M. 登録日 1989-12-05 公開日 1990-01-15 最終更新日 2024-02-07 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Crystal structure of recombinant human interleukin-1 beta at 2.0 A resolution. J.Mol.Biol., 209, 1989
9ILB	HUMAN INTERLEUKIN-1 BETA 分子名称: PROTEIN (HUMAN INTERLEUKIN-1 BETA) 著者 Yu, B, Blaber, M, Gronenborn, A.M, Clore, G.M, Caspar, D.L.D. 登録日 1998-10-22 公開日 1999-01-06 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (2.28 Å) 主引用文献 Disordered water within a hydrophobic protein cavity visualized by x-ray crystallography. Proc.Natl.Acad.Sci.USA, 96, 1999
8RYS	Human IL-1beta, unliganded 分子名称: Interleukin-1 beta, SULFATE ION 著者 Rondeau, J.-M, Lehmann, S. 登録日 2024-02-09 公開日 2024-03-06 実験手法 X-RAY DIFFRACTION (1.16 Å) 主引用文献 Ligandability assessment of IL-1beta by integrated hit identification approaches To be published
2VXT	Crystal structure of human IL-18 complexed to murine reference antibody 125-2H Fab 分子名称: CHLORIDE ION, INTERLEUKIN-18, MAGNESIUM ION, ... 著者 Argiriadi, M.A, Xiang, T, Wu, C, Ghayur, T, Borhani, D.W. 登録日 2008-07-10 公開日 2009-06-23 最終更新日 2023-12-13 実験手法 X-RAY DIFFRACTION (1.49 Å) 主引用文献 Unusual Water-Mediated Antigenic Recognition of the Proinflammatory Cytokine Interleukin-18. J.Biol.Chem., 284, 2009
3NJ5	Crystal structure of chicken IL-1 hydrophobic cavity mutant 157 分子名称: IL-1 beta 著者 Yin, H.S, Chen, Y.W. 登録日 2010-06-17 公開日 2011-06-22 最終更新日 2024-03-20 実験手法 X-RAY DIFFRACTION (1.67 Å) 主引用文献 Structural and functional comparison of cytokine interleukin-1 beta from chicken and human Mol.Immunol., 48, 2011

 

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