8SLR
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6RMJ
| Crystal structure of human NGR-TNF | 分子名称: | Tumor necrosis factor | 著者 | Degano, M, Garau, G. | 登録日 | 2019-05-07 | 公開日 | 2019-10-09 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (2.65 Å) | 主引用文献 | Mechanism of Action of the Tumor Vessel Targeting Agent NGR-hTNF: Role of Both NGR Peptide and hTNF in Cell Binding and Signaling. Int J Mol Sci, 20, 2019
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7X9G
| Crystal structure of human EDA and EDAR | 分子名称: | Ectodysplasin-A, secreted form, Tumor necrosis factor receptor superfamily member EDAR | 著者 | Yu, K, Wan, F, Huang, C, Wu, J, Lei, M. | 登録日 | 2022-03-15 | 公開日 | 2023-02-22 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | Structural insights into pathogenic mechanism of hypohidrotic ectodermal dysplasia caused by ectodysplasin A variants. Nat Commun, 14, 2023
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4ZCH
| Single-chain human APRIL-BAFF-BAFF Heterotrimer | 分子名称: | TRIS-HYDROXYMETHYL-METHYL-AMMONIUM, Tumor necrosis factor ligand superfamily member 13,Tumor necrosis factor ligand superfamily member 13B,Tumor necrosis factor ligand superfamily member 13B | 著者 | Lammens, A, Jiang, X, Maskos, K, Schneider, P. | 登録日 | 2015-04-16 | 公開日 | 2015-05-13 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (2.43 Å) | 主引用文献 | Stoichiometry of Heteromeric BAFF and APRIL Cytokines Dictates Their Receptor Binding and Signaling Properties. J.Biol.Chem., 290, 2015
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1ALY
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1A8M
| TUMOR NECROSIS FACTOR ALPHA, R31D MUTANT | 分子名称: | TUMOR NECROSIS FACTOR ALPHA | 著者 | Reed, C, Fu, Z.-Q, Wu, J, Xue, Y.-N, Harrison, R.W, Chen, M.-J, Weber, I.T. | 登録日 | 1998-03-27 | 公開日 | 1998-06-17 | 最終更新日 | 2023-08-02 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Crystal structure of TNF-alpha mutant R31D with greater affinity for receptor R1 compared with R2. Protein Eng., 10, 1997
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2AZ5
| Crystal Structure of TNF-alpha with a small molecule inhibitor | 分子名称: | 6,7-DIMETHYL-3-[(METHYL{2-[METHYL({1-[3-(TRIFLUOROMETHYL)PHENYL]-1H-INDOL-3-YL}METHYL)AMINO]ETHYL}AMINO)METHYL]-4H-CHROMEN-4-ONE, Tumor necrosis factor (TNF-alpha) (Tumor necrosis factor ligand superfamily member 2) (TNF-a) (Cachectin) [Contains: Tumor necrosis factor, membrane form; Tumor necrosis factor, ... | 著者 | He, M.M. | 登録日 | 2005-09-09 | 公開日 | 2005-11-29 | 最終更新日 | 2023-08-23 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Small-molecule inhibition of TNF-alpha. Science, 310, 2005
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7DOV
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7E57
| Crystal structure of murine GITR-GITRL complex | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, Tumor necrosis factor ligand superfamily member 18, Tumor necrosis factor receptor superfamily member 18, ... | 著者 | Zhao, M, Tan, S, Fu, L, Chai, Y, Qi, J, Gao, G.F. | 登録日 | 2021-02-18 | 公開日 | 2021-09-29 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (3.302 Å) | 主引用文献 | Atypical TNF-TNFR superfamily binding interface in the GITR-GITRL complex for T cell activation. Cell Rep, 36, 2021
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2E7A
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6X81
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7SGM
| Crystal structure of a Fab variant containing a fluorescent noncanonical amino acid with blocked excited state proton transfer and in complex with its antigen, CD40L | 分子名称: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, 5c8* Fab heavy chain, ... | 著者 | Henderson, J.N, Mills, J.H, Simmons, C.R. | 登録日 | 2021-10-06 | 公開日 | 2022-02-02 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Structural Basis for Blocked Excited State Proton Transfer in a Fluorescent, Photoacidic Non-Canonical Amino Acid-Containing Antibody Fragment. J.Mol.Biol., 434, 2022
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6X85
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7TA6
| Trimer-to-Monomer Disruption of Tumor Necrosis Factor-alpha (TNF-alpha) by unnatural alpha/beta-peptide-1 | 分子名称: | 1,2-ETHANEDIOL, AMINO GROUP, Alpha/Beta-peptide-1, ... | 著者 | Niu, J, Bingman, C.A, Gellman, S.H. | 登録日 | 2021-12-20 | 公開日 | 2022-06-29 | 最終更新日 | 2024-04-03 | 実験手法 | X-RAY DIFFRACTION (2.67 Å) | 主引用文献 | Trimer-to-Monomer Disruption Mechanism for a Potent, Protease-Resistant Antagonist of Tumor Necrosis Factor-alpha Signaling. J.Am.Chem.Soc., 144, 2022
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7TA3
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6OOY
| Asymmetric hTNF-alpha | 分子名称: | (4R)-2-METHYLPENTANE-2,4-DIOL, Tumor necrosis factor, {1-[(2,5-dimethylphenyl)methyl]-1H-benzimidazol-2-yl}methanol | 著者 | Arakaki, T.L, Edwards, T.E, Ceska, T. | 登録日 | 2019-04-23 | 公開日 | 2019-12-25 | 最終更新日 | 2024-04-03 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Small molecules that inhibit TNF signalling by stabilising an asymmetric form of the trimer. Nat Commun, 10, 2019
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3B9I
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5TSW
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6OOZ
| Asymmetric hTNF-alpha | 分子名称: | (S)-{1-[(2,5-dimethylphenyl)methyl]-1H-benzimidazol-2-yl}(pyridin-4-yl)methanol, CHLORIDE ION, Tumor necrosis factor | 著者 | Arakaki, T.L, Edwards, T.E, Fox III, D, Lecomte, F, Ceska, T. | 登録日 | 2019-04-23 | 公開日 | 2019-12-25 | 最終更新日 | 2024-04-03 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | Small molecules that inhibit TNF signalling by stabilising an asymmetric form of the trimer. Nat Commun, 10, 2019
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6OP0
| Asymmetric hTNF-alpha | 分子名称: | (R)-{1-[(2,5-dimethylphenyl)methyl]-6-(1-methyl-1H-pyrazol-4-yl)-1H-benzimidazol-2-yl}(pyridin-4-yl)methanol, Tumor necrosis factor | 著者 | Arakaki, T.L, Edwards, T.E, Fairman, J.W, Davies, D.R, Foley, A, Ceska, T. | 登録日 | 2019-04-23 | 公開日 | 2019-12-25 | 最終更新日 | 2024-04-03 | 実験手法 | X-RAY DIFFRACTION (2.55 Å) | 主引用文献 | Small molecules that inhibit TNF signalling by stabilising an asymmetric form of the trimer. Nat Commun, 10, 2019
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2X29
| Crystal structure of human4-1BB ligand ectodomain | 分子名称: | TUMOR NECROSIS FACTOR LIGAND SUPERFAMILY MEMBER 9 | 著者 | Won, E.Y, Cho, H.S. | 登録日 | 2010-01-12 | 公開日 | 2010-03-23 | 最終更新日 | 2011-07-13 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | The Structure of the Trimer of Human 4-1Bb Ligand is Unique Among Members of the Tumor Necrosis Factor Superfamily. J.Biol.Chem., 285, 2010
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4TSV
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5UUI
| Crystal Structure of Spin-Labeled T77C TNFa | 分子名称: | S-[(1-oxyl-2,2,5,5-tetramethyl-2,5-dihydro-1H-pyrrol-3-yl)methyl] methanesulfonothioate, Tumor necrosis factor | 著者 | Horanyi, P.S, Dranow, D.M, Ceska, T. | 登録日 | 2017-02-16 | 公開日 | 2017-08-02 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (1.4 Å) | 主引用文献 | Natural Conformational Sampling of Human TNF alpha Visualized by Double Electron-Electron Resonance. Biophys. J., 113, 2017
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4TWT
| Human TNFa dimer in complex with the semi-synthetic bicyclic peptide M21 | 分子名称: | (2,4,6-trimethylbenzene-1,3,5-triyl)trimethanol, ALA-CYS-PRO-PRO-CYS-LEU-TRP-GLN-VAL-LEU-CYS-GLY, GLYCEROL, ... | 著者 | Luzi, S, Kondo, Y, Bernard, E, Stadler, L, Winter, G, Holliger, P. | 登録日 | 2014-07-01 | 公開日 | 2015-02-04 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (2.85 Å) | 主引用文献 | Subunit disassembly and inhibition of TNF alpha by a semi-synthetic bicyclic peptide. Protein Eng.Des.Sel., 28, 2015
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6ZT0
| Crystal structure of the Eiger TNF domain/Grindelwald extracellular domain complex | 分子名称: | 1,2-ETHANEDIOL, Protein eiger, Protein grindelwald | 著者 | Palmerini, V, Cecatiello, V, Pasqualato, S, Mapelli, M. | 登録日 | 2020-07-17 | 公開日 | 2021-03-03 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (2.02 Å) | 主引用文献 | Drosophila TNFRs Grindelwald and Wengen bind Eiger with different affinities and promote distinct cellular functions. Nat Commun, 12, 2021
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