PDB: 137 件ウェブページステータス検索Chemie searchBIRD

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1AB8	RAT TYPE II ADENYLYL CYCLASE C2 DOMAIN/FORSKOLIN COMPLEX 分子名称: ADENYLYL CYCLASE, FORSKOLIN 著者 Zhang, G, Hurley, J.H. 登録日 1997-02-04 公開日 1997-05-15 最終更新日 2024-02-07 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Structure of the adenylyl cyclase catalytic core. Nature, 386, 1997
6YII	Crystal structure of a Class III adenylyl cyclase-like ATP-binding protein from Pseudomonas aeruginosa 分子名称: ADENOSINE-5'-TRIPHOSPHATE, CALCIUM ION, MAGNESIUM ION, ... 著者 Moniot, S, Steegborn, C. 登録日 2020-04-01 公開日 2020-06-17 最終更新日 2020-07-15 実験手法 X-RAY DIFFRACTION (1.44 Å) 主引用文献 Crystal structure of a class III adenylyl cyclase-like ATP-binding protein from Pseudomonas aeruginosa. J.Struct.Biol., 211, 2020
7OVD	Human soluble adenylyl cyclase in complex with the inhibitor TDI10229 分子名称: 1,2-ETHANEDIOL, 4-chloranyl-6-[1,5-dimethyl-4-(phenylmethyl)pyrazol-3-yl]pyrimidin-2-amine, ACETATE ION, ... 著者 Steegborn, C, Quast, J. 登録日 2021-06-14 公開日 2021-10-06 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Discovery of TDI-10229: A Potent and Orally Bioavailable Inhibitor of Soluble Adenylyl Cyclase (sAC, ADCY10). Acs Med.Chem.Lett., 12, 2021
2BW7	A novel mechanism for adenylyl cyclase inhibition from the crystal structure of its complex with catechol estrogen 分子名称: 2,3,17BETA-TRIHYDROXY-1,3,5(10)-ESTRATRIENE, ADENYLATE CYCLASE, CALCIUM ION, ... 著者 Steegborn, C, Litvin, T.N, Hess, K.C, Capper, A.B, Taussig, R, Buck, J, Levin, L.R, Wu, H. 登録日 2005-07-12 公開日 2005-07-20 最終更新日 2011-07-13 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 A Novel Mechanism for Adenylyl Cyclase Inhibition from the Crystal Structure of its Complex with Catechol Estrogen J.Biol.Chem., 280, 2005
3R5G	Crystal structure of the adenylyl cyclase CyaB from P. aeruginosa 分子名称: CyaB, GLYCEROL 著者 Topal, H, Steegborn, C. 登録日 2011-03-18 公開日 2012-01-11 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (1.5 Å) 主引用文献 Crystal Structure and Regulation Mechanisms of the CyaB Adenylyl Cyclase from the Human Pathogen Pseudomonas aeruginosa. J.Mol.Biol., 416, 2012
3MR7	Crystal Structure of Adenylate/Guanylate Cyclase/Hydrolase from Silicibacter pomeroyi 分子名称: Adenylate/guanylate cyclase/hydrolase, alpha/beta fold family 著者 Kim, Y, Li, H, Clancy, S, Joachimiak, A, Midwest Center for Structural Genomics (MCSG) 登録日 2010-04-28 公開日 2010-06-23 最終更新日 2011-07-13 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 Crystal Structure of Adenylate/Guanylate Cyclase/Hydrolase from Silicibacter pomeroyi To be Published
2W01	Crystal structure of the guanylyl cyclase Cya2 分子名称: ADENYLATE CYCLASE 著者 Rauch, A, Leipelt, M, Russwurm, M, Steegborn, C. 登録日 2008-08-08 公開日 2008-09-30 最終更新日 2023-12-13 実験手法 X-RAY DIFFRACTION (2.31 Å) 主引用文献 Crystal Structure of the Guanylyl Cyclase Cya2. Proc.Natl.Acad.Sci.USA, 105, 2008
2WZ1	STRUCTURE OF THE CATALYTIC DOMAIN OF HUMAN SOLUBLE GUANYLATE CYCLASE 1 BETA 3. 分子名称: 1,2-ETHANEDIOL, GUANYLATE CYCLASE SOLUBLE SUBUNIT BETA-1 著者 Allerston, C.K, Cooper, C.D.O, Muniz, J, Pike, A.C.W, von Delft, F, Arrowsmith, C.H, Weigelt, J, Edwards, A, Bountra, C, Gileadi, O. 登録日 2009-11-23 公開日 2009-12-01 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (1.63 Å) 主引用文献 Crystal Structures of the Catalytic Domain of Human Soluble Guanylate Cyclase. Plos One, 8, 2013
5IV4	Crystal structure of the human soluble adenylyl cyclase in complex with the allosteric inhibitor LRE1 分子名称: 1,2-ETHANEDIOL, 6-chloro-N~4~-cyclopropyl-N~4~-[(thiophen-2-yl)methyl]pyrimidine-2,4-diamine, ACETATE ION, ... 著者 Kleinboelting, S, Steegborn, C. 登録日 2016-03-18 公開日 2016-08-17 最終更新日 2022-11-30 実験手法 X-RAY DIFFRACTION (1.79 Å) 主引用文献 Discovery of LRE1 as a specific and allosteric inhibitor of soluble adenylyl cyclase. Nat.Chem.Biol., 12, 2016
5IV3	Crystal structure of human soluble adenylyl cyclase in complex with alpha,beta-methyleneadenosine-5'-triphosphate and the allosteric inhibitor LRE1 分子名称: 1,2-ETHANEDIOL, 6-chloro-N~4~-cyclopropyl-N~4~-[(thiophen-2-yl)methyl]pyrimidine-2,4-diamine, ACETATE ION, ... 著者 Kleinboelting, S, Steegborn, C. 登録日 2016-03-18 公開日 2016-08-17 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (1.86 Å) 主引用文献 Discovery of LRE1 as a specific and allosteric inhibitor of soluble adenylyl cyclase. Nat.Chem.Biol., 12, 2016
3UVJ	Crystal structure of the catalytic domain of the heterodimeric human soluble guanylate cyclase 1. 分子名称: 1,2-ETHANEDIOL, GLYCEROL, Guanylate cyclase soluble subunit alpha-3, ... 著者 Allerston, C.K, Berridge, G, Chalk, R, Cooper, C.D.O, Savitsky, P, Vollmar, M, Arrowsmith, C.H, Weigelt, J, Edwards, A, Bountra, C, von Delft, F, Gileadi, O, Structural Genomics Consortium (SGC) 登録日 2011-11-30 公開日 2011-12-28 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (2.08 Å) 主引用文献 Crystal structures of the catalytic domain of human soluble guanylate cyclase. Plos One, 8, 2013
5O5K	X-ray structure of a bacterial adenylyl cyclase soluble domain 分子名称: 3'-O-(N-METHYLANTHRANILOYL)-GUANOSINE-5'-TRIPHOSPHATE, Adenylate cyclase, MANGANESE (II) ION, ... 著者 Vercellino, I, Korkhov, V.M. 登録日 2017-06-02 公開日 2017-11-01 最終更新日 2019-10-16 実験手法 X-RAY DIFFRACTION (3.4 Å) 主引用文献 Role of the nucleotidyl cyclase helical domain in catalytically active dimer formation. Proc. Natl. Acad. Sci. U.S.A., 114, 2017
5O5L	X-ray structure of a bacterial adenylyl cyclase soluble domain, solved at cryogenic temperature 分子名称: 3'-O-(N-METHYLANTHRANILOYL)-GUANOSINE-5'-TRIPHOSPHATE, Adenylate cyclase, MANGANESE (II) ION, ... 著者 Vercellino, I, Korkhov, V.M. 登録日 2017-06-02 公開日 2017-11-01 最終更新日 2019-10-16 実験手法 X-RAY DIFFRACTION (2.7 Å) 主引用文献 Role of the nucleotidyl cyclase helical domain in catalytically active dimer formation. Proc. Natl. Acad. Sci. U.S.A., 114, 2017
5OYH	crystal structure of the catalytic core of a rhodopsin-guanylyl cyclase with converted specificity in complex with ATPalphaS 分子名称: ADENOSINE-5'-SP-ALPHA-THIO-TRIPHOSPHATE, CALCIUM ION, GLYCEROL, ... 著者 Broser, M, Scheib, U, Hegemann, P. 登録日 2017-09-09 公開日 2018-06-06 実験手法 X-RAY DIFFRACTION (2.249 Å) 主引用文献 Rhodopsin-cyclases for photocontrol of cGMP/cAMP and 2.3 angstrom structure of the adenylyl cyclase domain. Nat Commun, 9, 2018
7YZ9	Structure of catalytic domain of Rv1625c bound to nanobody NB4 分子名称: 3'-O-(N-METHYLANTHRANILOYL)-GUANOSINE-5'-TRIPHOSPHATE, Adenylate cyclase, GLYCEROL, ... 著者 Khanppnavar, B, Mehta, V.J, Iype, T, Korkhov, V.M. 登録日 2022-02-19 公開日 2022-08-31 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (1.97 Å) 主引用文献 Structure of Mycobacterium tuberculosis Cya, an evolutionary ancestor of the mammalian membrane adenylyl cyclases. Elife, 11, 2022
4USW	Crystal structure of human soluble Adenylyl Cyclase with ATP 分子名称: ACETATE ION, ADENOSINE-5'-TRIPHOSPHATE, ADENYLATE CYCLASE TYPE 10, ... 著者 Kleinboelting, S, Steegborn, C. 登録日 2014-07-13 公開日 2014-07-30 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (2.05 Å) 主引用文献 Structural Analysis of Human Soluble Adenylyl Cyclase and Crystal Structures of its Nucleotide Complexes -Implications for Cyclase Catalysis and Evolution. FEBS J., 281, 2014
4USU	Crystal structure of human soluble Adenylyl Cyclase in complex with alpha,beta-methyleneadenosine-5'-triphosphate 分子名称: 1,2-ETHANEDIOL, ADENYLATE CYCLASE TYPE 10, CALCIUM ION, ... 著者 Kleinboelting, S, Steegborn, C. 登録日 2014-07-13 公開日 2014-07-30 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (1.95 Å) 主引用文献 Structural Analysis of Human Soluble Adenylyl Cyclase and Crystal Structures of its Nucleotide Complexes -Implications for Cyclase Catalysis and Evolution. FEBS J., 281, 2014
4UST	Crystal structure of human soluble Adenylyl Cyclase with pyrophosphate resulting from soaking with GTP and Magnesium 分子名称: 1,2-ETHANEDIOL, ACETATE ION, ADENYLATE CYCLASE TYPE 10, ... 著者 Kleinboelting, S, Steegborn, C. 登録日 2014-07-13 公開日 2014-07-30 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Structural Analysis of Human Soluble Adenylyl Cyclase and Crystal Structures of its Nucleotide Complexes -Implications for Cyclase Catalysis and Evolution. FEBS J., 281, 2014
4USV	Crystal structure of human soluble Adenylyl Cyclase with pyrophosphate resulting from soaking with ATP and Calcium 分子名称: 1,2-ETHANEDIOL, ACETATE ION, ADENYLATE CYCLASE TYPE 10, ... 著者 Kleinboelting, S, Steegborn, C. 登録日 2014-07-13 公開日 2014-07-30 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Structural Analysis of Human Soluble Adenylyl Cyclase and Crystal Structures of its Nucleotide Complexes -Implications for Cyclase Catalysis and Evolution. FEBS J., 281, 2014
6SIR	Crystal structure of the guanylate cyclase domain of RhGC from Catenaria anguillulae in complex with GTP 分子名称: CALCIUM ION, GLYCEROL, GUANOSINE-5'-TRIPHOSPHATE, ... 著者 Butryn, A, Orville, A.M. 登録日 2019-08-10 公開日 2019-12-18 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 Molecular basis for GTP recognition by light-activated guanylate cyclase RhGC. Febs J., 287, 2020
3ET6	The crystal structure of the catalytic domain of a eukaryotic guanylate cyclase 分子名称: PHOSPHATE ION, Soluble guanylyl cyclase beta 著者 Winger, J.A, Derbyshire, E.R, Lamers, M.H, Marletta, M.A, Kuriyan, J. 登録日 2008-10-07 公開日 2008-10-14 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (2.55 Å) 主引用文献 The crystal structure of the catalytic domain of a eukaryotic guanylate cyclase. Bmc Struct.Biol., 8, 2008
5D0G	Crystal structure of triple mutant (KDA to EGY) of adenylyl cyclase Ma1120 from Mycobacterium avium in complex with GTP and calcium ion 分子名称: CALCIUM ION, Cyclase, GUANOSINE-5'-TRIPHOSPHATE 著者 Bharambe, N.G, Suguna, K. 登録日 2015-08-03 公開日 2016-08-10 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (1.6 Å) 主引用文献 Substrate specificity determinants of class III nucleotidyl cyclases Febs J., 283, 2016
5D0R	Crystal structure of human soluble Adenylyl Cyclase with the inhibitor bithionol 分子名称: 1,2-ETHANEDIOL, 2,2'-sulfanediylbis(4,6-dichlorophenol), ACETATE ION, ... 著者 Kleinboelting, S, Steegborn, C. 登録日 2015-08-03 公開日 2016-03-16 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (2.24 Å) 主引用文献 Bithionol Potently Inhibits Human Soluble Adenylyl Cyclase through Binding to the Allosteric Activator Site. J.Biol.Chem., 291, 2016
5D15	Crystal structure of an adenylyl cyclase Ma1120 from Mycobacterium avium in complex with ATP and calcium ion 分子名称: 1,2-ETHANEDIOL, ADENOSINE-5'-TRIPHOSPHATE, CALCIUM ION, ... 著者 Bharambe, N.G, Barathy, D.V, Suguna, K. 登録日 2015-08-03 公開日 2016-08-10 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (1.5 Å) 主引用文献 Substrate specificity determinants of class III nucleotidyl cyclases Febs J., 283, 2016
5D0E	Crystal Structure of an adenylyl cyclase Ma1120-Cat in complex with GTP and calcium from Mycobacterium avium 分子名称: CALCIUM ION, CHLORIDE ION, Cyclase, ... 著者 Bharambe, N.G, Barathy, D.V, Suguna, K. 登録日 2015-08-03 公開日 2016-08-10 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (1.48 Å) 主引用文献 Substrate specificity determinants of class III nucleotidyl cyclases Febs J., 283, 2016

 

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